Gene name: AKR1B1
Protein name: Aldo-keto reductase family
List of molecules and drugs that interact with protein P15121
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P15121_0PY | 0PY | n/a | 1049 | CHEMBL266158 | pyridine | n/a | |
| 2 | P15121_1WW | 1WW | n/a | 72836896 | n/a | {5-chloro-2-[(4-iodobenzyl)carbamoyl]phenoxy}acetic acid | n/a | |
| 3 | P15121_1WX | 1WX | n/a | 72836895 | n/a | {2-[(4-bromo-2,3,5,6-tetrafluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid | n/a | |
| 4 | P15121_2CL | 2CL | n/a | 81058 | CHEMBL240293 | (2,6-DICHLOROPHENYL)ACETIC ACID | n/a | |
| 5 | P15121_2HZ | 2HZ | n/a | 90657087 | n/a | (2Z)-3-(3'-nitrobiphenyl-3-yl)prop-2-enoic acid | n/a | |
| 6 | P15121_2W8 | 2W8 | n/a | 91667409 | n/a | 3-(3'-nitrobiphenyl-3-yl)propanoic acid | n/a | |
| 7 | P15121_2W9 | 2W9 | n/a | 91667410 | n/a | 3-[3-(5-nitrofuran-2-yl)phenyl]propanoic acid | n/a | |
| 8 | P15121_2WB | 2WB | n/a | 91667411 | n/a | {2-[5-(3-nitrophenyl)furan-2-yl]phenyl}acetic acid | n/a | |
| 9 | P15121_2WQ | 2WQ | n/a | 91667416 | n/a | [5-fluoro-2-(prop-2-yn-1-ylcarbamoyl)phenoxy]acetic acid | n/a | |
| 10 | P15121_2WR | 2WR | n/a | 91667415 | n/a | (2-carbamoyl-5-fluorophenoxy)acetic acid | n/a | |
| 11 | P15121_2X9 | 2X9 | n/a | 10150300 | n/a | {2,6-dimethyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl}acetic acid | n/a | |
| 12 | P15121_2YZ | 2YZ | n/a | 91799592 | n/a | [2-(benzylcarbamoyl)-5-fluorophenoxy]acetic acid | n/a | |
| 13 | P15121_30L | 30L | n/a | 9798381 | n/a | {5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid | n/a | |
| 14 | P15121_37V | 37V | n/a | 91826664 | n/a | {2-[(1,3-benzothiazol-2-ylmethyl)carbamoyl]-5-fluorophenoxy}acetic acid | n/a | |
| 15 | P15121_388 | 388 | DB07028 | 16058629 | CHEMBL1230062 | (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID | n/a | IC50(nM) = 30.0 |
| 16 | P15121_393 | 393 | DB07030 | 16058630 | CHEMBL241577 | (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID | n/a | IC50(nM) = 6.0 Kd(nM) = 14.0 |
| 17 | P15121_3E2 | 3E2 | n/a | 685919 | CHEMBL1405739 | (3-thioxo-2,3-dihydro-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid | n/a | |
| 18 | P15121_3GR | 3GR | DB02536 | 79014 | n/a | D-Glyceraldehyde | n/a | |
| 19 | P15121_3NA | 3NA | DB07063 | 157839 | CHEMBL363387 | {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID | inhibitor | IC50(nM) = 5.0 |
| 20 | P15121_3UH | 3UH | n/a | 92044989 | n/a | ({3-[(3-nitrobenzyl)carbamoyl]biphenyl-4-yl}oxy)acetic acid | n/a | |
| 21 | P15121_47D | 47D | DB07093 | 10450624 | CHEMBL159820 | {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID | n/a | |
| 22 | P15121_48I | 48I | n/a | 10759546 | CHEMBL161556 | [3-(4-chloro-3-nitrobenzyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetic acid | n/a | |
| 23 | P15121_4G7 | 4G7 | n/a | 127053812 | n/a | 3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid | n/a | |
| 24 | P15121_4O8 | 4O8 | n/a | 72836894 | n/a | {2-[(4-bromo-2,6-difluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid | n/a | |
| 25 | P15121_4O9 | 4O9 | n/a | 72836898 | n/a | {5-chloro-2-[(2,6-difluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid | n/a | |
| 26 | P15121_53N | 53N | DB07139 | 25210476 | n/a | 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid | inhibitor | |
| 27 | P15121_62P | 62P | DB07187 | 6420118 | CHEMBL240725 | 6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE | inhibitor | IC50(nM) = 0.84 |
| 28 | P15121_64I | 64I | n/a | 630263 | n/a | 2,2',3,3',5,5',6,6'-octafluorobiphenyl-4,4'-diol | n/a | |
| 29 | P15121_6NA | 6NA | n/a | 8892 | CHEMBL14184 | HEXANOIC ACID | n/a | |
| 30 | P15121_ALR | ALR | DB02020 | 2120 | CHEMBL63055 | ALRESTATIN | inhibitor | Ki(nM) = 2000.0 IC50(nM) = 6500.0 |
| 31 | P15121_AV5 | AV5 | n/a | 137348952 | CHEMBL4160873 | 2-[5-(4-chlorophenyl)-3-methyl-1-oxidanylidene-pyrimido[4,5-c]quinolin-2-yl]ethanoic acid | n/a | |
| 32 | P15121_AVT | AVT | n/a | 137347753 | CHEMBL4168032 | 2-[9-fluoranyl-5-(4-methoxyphenyl)-3-methyl-1-oxidanylidene-pyrimido[4,5-c]quinolin-2-yl]ethanoic acid | n/a | |
| 33 | P15121_AW8 | AW8 | n/a | 133082034 | n/a | 2-[(1~{R})-5-(4-chlorophenyl)-9-fluoranyl-3-methyl-1-oxidanyl-1~{H}-pyrimido[4,5-c]quinolin-2-yl]ethanoic acid | n/a | |
| 34 | P15121_BFI | BFI | DB07450 | 447950 | CHEMBL292963 | 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE | n/a | IC50(nM) = 12.2 |
| 35 | P15121_BR | BR | n/a | 259 | n/a | BROMIDE ION | n/a | |
| 36 | P15121_BTO | BTO | DB07498 | 2797541 | n/a | 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID | n/a | |
| 37 | P15121_CAC | CAC | n/a | 167250 | n/a | CACODYLATE ION | n/a | |
| 38 | P15121_CIT | CIT | DB04272 | 311;19782904;88113319; | CHEMBL1261 | CITRIC ACID | inhibitor | |
| 39 | P15121_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 40 | P15121_DMF | DMF | DB01844 | 6228 | CHEMBL268291 | DIMETHYLFORMAMIDE | n/a | |
| 41 | P15121_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 42 | P15121_DOY | DOY | n/a | 25273095 | n/a | [(2S)-4-oxo-2-phenyl-3,4-dihydro-1,5-benzothiazepin-5(2H)-yl]acetic acid | n/a | |
| 43 | P15121_EPR | EPR | n/a | n/a | n/a | {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid | n/a | |
| 44 | P15121_F49 | F49 | n/a | 92044990 | n/a | [2,4-dioxo-3-(2,3,4,5-tetrabromo-6-methoxybenzyl)-3,4-dihydropyrimidin-1(2H)-yl]acetic acid | n/a | |
| 45 | P15121_FID | FID | DB02021 | 160024 | CHEMBL84446 | (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE | inhibitor | |
| 46 | P15121_FIR | FIR | n/a | 449156 | CHEMBL84060 | (2R,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE | n/a | |
| 47 | P15121_FIS | FIS | DB02101 | 449157 | CHEMBL189464 | (2S,4R)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE | inhibitor | IC50(nM) = 570.0 |
| 48 | P15121_G6P | G6P | DB02007 | 439284 | n/a | 6-O-phosphono-alpha-D-glucopyranose | inhibitor | |
| 49 | P15121_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 50 | P15121_I84 | I84 | DB01689 | 1944 | CHEMBL240719 | [2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE | inhibitor | IC50(nM) = 108.0 |
| 51 | P15121_I98 | I98 | n/a | 91820714 | CHEMBL5279085 | {2-[(4-amino-2-fluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid | n/a | |
| 52 | P15121_ID5 | ID5 | DB02834 | 448658 | CHEMBL399598 | [5-FLUORO-2-({[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]AMINO}CARBONYL)PHENOXY]ACETIC ACID | inhibitor | IC50(nM) = 11.0 |
| 53 | P15121_ITA | ITA | DB07999 | 11494891 | n/a | {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID | n/a | IC50(nM) = 550.0 |
| 54 | P15121_ITB | ITB | DB08000 | 11660035 | n/a | 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE | n/a | IC50(nM) = 140.0 |
| 55 | P15121_LDT | LDT | DB08084 | 448932;4369325; | CHEMBL395347 | IDD594 | inhibitor | IC50(nM) = 3.0 |
| 56 | P15121_LIT | LIT | DB08098 | 2817424 | n/a | {[5-(5-NITRO-2-FURYL)-1,3,4-OXADIAZOL-2-YL]THIO}ACETIC ACID | n/a | IC50(nM) = 4100.0 |
| 57 | P15121_LPA | LPA | DB00166 | 6112 | CHEMBL134342 | LIPOIC ACID | n/a | Ki(nM) = 25500.0 |
| 58 | P15121_LZO | LZO | n/a | 168451659 | n/a | 5-(5-(3-hydroxyphenyl)thiophen-2-yl)pentanoic acid | n/a | |
| 59 | P15121_M0K | M0K | n/a | 154702617 | n/a | 2-[2-(cyclopropylmethylcarbamoyl)-5-fluoranyl-phenoxy]ethanoic acid | n/a | |
| 60 | P15121_M15 | M15 | n/a | 72836897 | CHEMBL5267913 | {5-chloro-2-[(2-fluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid | n/a | |
| 61 | P15121_NAP | NAP | DB03461 | 5885;57525501; | CHEMBL295069 | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 62 | P15121_NDP | NDP | DB02338 | 5884;134821689; | CHEMBL407009 | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 63 | P15121_NTI | NTI | DB00507 | 41684 | CHEMBL1401 | 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate | n/a | IC50(nM) = 8220.0 |
| 64 | P15121_NXK | NXK | n/a | 155804464 | n/a | 2-(2-((3-boronobenzyl)carbamoyl)-5-fluorophenoxy)acetic acid | n/a | |
| 65 | P15121_NXQ | NXQ | n/a | n/a | n/a | 2-[5-fluoranyl-2-[[3-[methyl(oxidanyl)-$l^{3}-sulfanyl]phenyl]methylcarbamoyl]phenoxy]ethanoic acid | n/a | |
| 66 | P15121_OHP | OHP | n/a | 11970 | CHEMBL240714 | (2-HYDROXYPHENYL)ACETIC ACID | n/a | |
| 67 | P15121_PAC | PAC | DB09269 | 999 | CHEMBL1044 | 2-PHENYLACETIC ACID | n/a | Ki(nM) = 96000.0 IC50(nM) = 96000.0 |
| 68 | P15121_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 69 | P15121_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 70 | P15121_PG5 | PG5 | DB02078 | 8189 | CHEMBL1235255 | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE | n/a | |
| 71 | P15121_Q74 | Q74 | DB08449 | 10150441 | CHEMBL1235556 | 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid | n/a | IC50(nM) = 100000.0 |
| 72 | P15121_QXO | QXO | n/a | 6498201 | n/a | 2-(6-fluoranylindol-1-yl)ethanoic acid | n/a | |
| 73 | P15121_SBI | SBI | DB02712 | 337359 | CHEMBL266497 | SORBINIL | inhibitor | IC50(nM) = 67.0 |
| 74 | P15121_SFI | SFI | n/a | 5352624 | CHEMBL18797 | 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]ethanoic acid | n/a | |
| 75 | P15121_SLO | SLO | DB06246 | 5472495 | CHEMBL488025 | 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfonylphenyl)methylidene]inden-1-yl]ethanoic acid | inhibitor | |
| 76 | P15121_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 77 | P15121_TGG | TGG | n/a | 6857725 | n/a | GAMMA-GLUTAMYL-S-(1,2-DICARBOXYETHYL)CYSTEINYLGLYCINE | n/a | |
| 78 | P15121_TLT | TLT | DB00500 | 5509 | CHEMBL1020 | Tolmetin | n/a | IC50(nM) = 2390.0 |
| 79 | P15121_TOL | TOL | DB02383 | 53359 | CHEMBL436 | TOLRESTAT | inhibitor | IC50(nM) = 1.0 |
| 80 | P15121_W8X | W8X | n/a | 18468153 | CHEMBL4128992 | {2-[(4-bromobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid | n/a | |
| 81 | P15121_WY1 | WY1 | n/a | 5694 | CHEMBL295416 | 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID | n/a | |
| 82 | P15121_ZES | ZES | DB02132 | 5724 | CHEMBL10413 | [3-(4-BROMO-2-FLUORO-BENZYL)-7-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-QUINAZOLIN-1-YL]-ACETIC ACID | inhibitor | IC50(nM) = 8.0 |
| 83 | P15121_ZST | ZST | DB08772 | 1613 | CHEMBL10372 | 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID | modulator | Ki(nM) = 19.0 IC50(nM) = 1.9 |
| 84 | P15121_SUZ | SUZ | n/a | 16046677 | CHEMBL4525719 | [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid | n/a | |
| 85 | P15121_GSH | GSH | DB00143 | 124886;25246407;171390563; | CHEMBL1543 | Glutathione | n/a | |
| 86 | P15121_NAI | NAI | DB00157 | 439153 | CHEMBL1234616 | NADH | n/a | |
| 87 | P15121_DB00605 | n/a | DB00605 | n/a | n/a | Sulindac | inhibitor | |
| 88 | P15121_AYA | AYA | DB02518 | 88064 | CHEMBL1231115 | N-Acetylalanine | inhibitor | |
| 89 | P15121_CAD | CAD | DB02994 | 2513 | CHEMBL1231644 | Cacodylic acid | inhibitor | |
| 90 | P15121_DB05327 | n/a | DB05327 | n/a | n/a | Ranirestat | inhibitor | IC50(nM) = 15.0 |
| 91 | P15121_AGU | AGU | DB05383 | 2146 | CHEMBL225304 | Pimagedine | n/a | |
| 92 | P15121_DB16707 | n/a | DB16707 | n/a | n/a | Gavorestat | inhibitor |