Gene name:
Protein name: Dihydrofolate reductase (EC
List of molecules and drugs that interact with protein P16184
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P16184_33M | 33M | n/a | 71681191 | CHEMBL2382334 | N~6~-methyl-N~6~-(naphthalen-1-yl)pyrido[2,3-d]pyrimidine-2,4,6-triamine | n/a | |
| 2 | P16184_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 3 | P16184_COG | COG | DB02427 | 447021 | CHEMBL325434 | 2,4-DIAMINO-6-[N-(2',5'-DIMETHOXYBENZYL)-N-METHYLAMINO]QUINAZOLINE | n/a | IC50(nM) = 87.0 |
| 4 | P16184_COQ | COQ | DB03987 | 447022 | CHEMBL36245 | 2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE | n/a | IC50(nM) = 76.0 |
| 5 | P16184_D2J | D2J | n/a | 6481075 | CHEMBL188540 | 6-{3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy}hexanoic acid | n/a | |
| 6 | P16184_D2K | D2K | n/a | 6481086 | CHEMBL189796 | ethyl 4-{3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy}butanoate | n/a | |
| 7 | P16184_D2N | D2N | n/a | 6481088 | CHEMBL435938 | ethyl 6-{3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy}hexanoate | n/a | |
| 8 | P16184_D2O | D2O | n/a | 49866883 | n/a | 6-[2-methoxy-5-(2-phenylethoxy)benzyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine | n/a | |
| 9 | P16184_D2R | D2R | n/a | 6481081 | CHEMBL187595 | 6-{2-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenyl}hex-5-ynoic acid | n/a | |
| 10 | P16184_DH1 | DH1 | n/a | 490573 | CHEMBL37520 | 2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE | n/a | |
| 11 | P16184_DH3 | DH3 | n/a | 5271440 | CHEMBL300419 | 2,4-DIAMINO-5-[3',4'-DIMETHOXY-5'-(5-CARBOXYL-1-PENTYNYL)]BENZYL PYRIMIDINE | n/a | |
| 12 | P16184_FOL | FOL | DB00158 | 6037;5280354;135398658; | CHEMBL1622 | FOLIC ACID | n/a | |
| 13 | P16184_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 14 | P16184_GPB | GPB | n/a | 445207;5288461; | CHEMBL439973 | N-[4-[2-(2-AMINO-4-METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYL]GLUTAMIC ACID | n/a | |
| 15 | P16184_IXE | IXE | n/a | 71463580 | CHEMBL2382336 | N~6~-methyl-N~6~-(3,4,5-trifluorophenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine | n/a | |
| 16 | P16184_IXF | IXF | n/a | 71463581 | CHEMBL2382332 | N~6~-methyl-N~6~-[4-(propan-2-yl)phenyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine | n/a | |
| 17 | P16184_IXG | IXG | n/a | 71307952 | CHEMBL2382326 | N~6~-methyl-N~6~-phenylpyrido[2,3-d]pyrimidine-2,4,6-triamine | n/a | |
| 18 | P16184_MOT | MOT | DB02026 | 158376 | CHEMBL104829 | N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE | n/a | |
| 19 | P16184_MTX | MTX | DB00563 | 126941 | CHEMBL34259 | METHOTREXATE | n/a | Ki(nM) = 0.008 IC50(nM) = 1.0 |
| 20 | P16184_NAP | NAP | DB03461 | 5885;57525501; | CHEMBL295069 | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 21 | P16184_NDP | NDP | DB02338 | 5884;134821689; | CHEMBL407009 | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 22 | P16184_PMD | PMD | DB08406 | 446744 | CHEMBL301769 | [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE | n/a | IC50(nM) = 210.0 |
| 23 | P16184_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 24 | P16184_TOP | TOP | DB00440 | 5578 | CHEMBL22 | TRIMETHOPRIM | n/a | Ki(nM) = 151.36 IC50(nM) = 12000.0 |
| 25 | P16184_TQT | TQT | DB02559 | 17754203 | n/a | 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE | n/a | |
| 26 | P16184_TAB | TAB | n/a | n/a | CHEMBL55764 | ACETIC ACID N-[2-CHLORO-5-[6-ETHYL-2,4-DIAMINO-PYRIMID-5-YL]-PHENYL]-[BENZYL-TRIAZEN-3-YL]ETHYL ESTER | n/a |