Gene name: PRKACA
Protein name: cAMP-dependent protein kinase
List of molecules and drugs that interact with protein P17612
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P17612_1SB | 1SB | n/a | 135538036 | n/a | N'-[(1E)-(4-hydroxyphenyl)methylidene]-2-(3-methoxyphenyl)acetohydrazide | n/a | |
| 2 | P17612_2SB | 2SB | n/a | 137348079 | n/a | (2S)-2-amino-N'-[(1E)-(3-bromo-4-hydroxyphenyl)methylidene]-2-phenylethanehydrazide | n/a | |
| 3 | P17612_35R | 35R | DB05169 | 135398495 | CHEMBL495727 | 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea | n/a | |
| 4 | P17612_3SB | 3SB | n/a | 137348168 | n/a | (2S)-2-amino-N'-[(1E)-(2,4-dihydroxy-6-methylphenyl)methylidene]-2-phenylethanehydrazide | n/a | |
| 5 | P17612_495 | 495 | n/a | 2775142 | CHEMBL2381525 | 4-chlorophthalazin-1(2H)-one | n/a | |
| 6 | P17612_4L7 | 4L7 | n/a | 118986993;135566977; | n/a | 7-{(3S,4R)-4-[(5-bromothiophen-2-yl)carbonyl]pyrrolidin-3-yl}quinazolin-4(3H)-one | n/a | |
| 7 | P17612_4SB | 4SB | n/a | 137348280 | n/a | (2R)-4-amino-N'-[(1E)-(3-bromo-4-hydroxyphenyl)methylidene]-2-phenylbutanehydrazide | n/a | |
| 8 | P17612_4W1 | 4W1 | n/a | 2776342 | CHEMBL3358210 | 1-benzothiophen-3-ylmethanol | n/a | |
| 9 | P17612_504 | 504 | n/a | 11561968 | CHEMBL4245242 | 2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide | n/a | |
| 10 | P17612_6J9 | 6J9 | n/a | 18008465 | CHEMBL595554 | 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine | n/a | |
| 11 | P17612_796 | 796 | DB07235 | 16043304 | CHEMBL213618 | N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE | n/a | IC50(nM) = 0.1 |
| 12 | P17612_8BQ | 8BQ | n/a | 118986994;135566978; | n/a | 7-[(3S,4R)-4-(3-fluorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one | n/a | |
| 13 | P17612_A03 | A03 | n/a | 25190770 | CHEMBL505949 | (10R,20R,23R)-1-[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-20,23-bis(3-carbamimidamido propyl)-10-methyl-1,8,11,18,21-pentaoxo-2,9,12,19,22-pentaazatetracosan-24-amide | n/a | |
| 14 | P17612_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 15 | P17612_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ADENOSINE-5'-TRIPHOSPHATE | n/a | |
| 16 | P17612_BR | BR | n/a | 259 | n/a | BROMIDE ION | n/a | |
| 17 | P17612_BUD | BUD | n/a | 439888 | n/a | (2S,3S)-butane-2,3-diol | n/a | |
| 18 | P17612_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 19 | P17612_E3Z | E3Z | n/a | 132278591 | n/a | ~{N}-[3-[(5-chloranyl-2-phenylazanyl-pyrimidin-4-yl)amino]phenyl]prop-2-enamide | n/a | |
| 20 | P17612_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 21 | P17612_EE4 | EE4 | n/a | 122483505 | n/a | N-[(3R,4R)-4-{[4-(2-fluoro-3-methoxy-6-propoxybenzene-1-carbonyl)benzene-1-carbonyl]amino}pyrrolidin-3-yl]-1H-indazole-5-carboxamide | n/a | |
| 22 | P17612_I5G | I5G | n/a | 164946679 | n/a | 1-chloranyl-~{N}-[(~{S})-(3-chloranyl-4-cyano-phenyl)-[(2~{R},4~{S})-4-oxidanylpyrrolidin-2-yl]methyl]-7-methoxy-isoquinoline-6-carboxamide | n/a | |
| 23 | P17612_IPH | IPH | DB03255 | 996;20488062; | CHEMBL14060 | PHENOL | n/a | |
| 24 | P17612_IQB | IQB | DB07995 | 449241 | CHEMBL104264 | N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE | inhibitor | Ki(nM) = 48.0 |
| 25 | P17612_J4B | J4B | n/a | 66577017 | n/a | ~{N}'-[(2~{S})-2-[3,5-bis(fluoranyl)phenyl]-2-oxidanyl-ethanoyl]-2-ethyl-3-methyl-4-oxidanyl-benzohydrazide | n/a | |
| 26 | P17612_L9L | L9L | n/a | 23654166 | CHEMBL1081831 | 5-[2-({(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propyl}amino)-1,3-thiazol-5-yl]-1,3-dihydro-2H-indol-2-one | n/a | |
| 27 | P17612_L9M | L9M | n/a | n/a | n/a | (2S)-N~1~-[5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)propane-1,2-diamine | n/a | |
| 28 | P17612_L9N | L9N | n/a | 49837856 | n/a | (2S)-N~1~-[5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)propane-1,2-diamine | n/a | |
| 29 | P17612_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 30 | P17612_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 31 | P17612_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 32 | P17612_NVV | NVV | n/a | 118986991;135566975; | n/a | 7-[(3S,4R)-4-(3-iodanylphenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one | n/a | |
| 33 | P17612_NVX | NVX | n/a | 92132723;135566974; | n/a | 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one | n/a | |
| 34 | P17612_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 35 | P17612_S3N | S3N | n/a | 118986992;135566976; | n/a | 7-[(3S,4R)-4-[4-(trifluoromethyl)phenyl]carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one | n/a | |
| 36 | P17612_S69 | S69 | n/a | 137349984 | n/a | N'-[(E)-(2,4-dihydroxy-6-methylphenyl)methylidene]-2-(3-methoxyphenyl)acetohydrazide | n/a | |
| 37 | P17612_SKE | SKE | n/a | 5330790 | CHEMBL191003 | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide | n/a | |
| 38 | P17612_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 39 | P17612_VX6 | VX6 | n/a | 5494449 | CHEMBL572878 | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE | n/a | |
| 40 | P17612_XFE | XFE | n/a | 45480169 | CHEMBL1173273 | (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine | n/a | |
| 41 | P17612_YTP | YTP | n/a | 70135 | CHEMBL375739 | 1-(4-hydroxy-3-methylphenyl)ethanone | n/a | |
| 42 | P17612_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 43 | P17612_PTL | PTL | DB01919 | 8063 | CHEMBL18602 | Pentanal | n/a | |
| 44 | P17612_BD2 | BD2 | DB01940 | 10050566 | n/a | Balanol Analog 2 | n/a | |
| 45 | P17612_B8L | B8L | DB02155 | 448327 | n/a | 3-[(3-sec-butyl-4-hydroxybenzoyl)amino]azepan-4-yl 4-(2-hydroxy-5-methoxybenzoyl)benzoate | n/a | |
| 46 | P17612_D11 | D11 | DB02482 | n/a | n/a | Phosphonothreonine | n/a | |
| 47 | P17612_B1L | B1L | DB02611 | 448326 | n/a | Balanol Analog 1 | n/a | |
| 48 | P17612_TYI | TYI | DB03374 | 9305;7058163; | CHEMBL1236469 | 3,5-Diiodotyrosine | n/a | |
| 49 | P17612_DB04098 | n/a | DB04098 | n/a | n/a | Balanol | n/a | |
| 50 | P17612_SEP | SEP | DB04522 | 68841;57689797; | CHEMBL284377 | Dexfosfoserine | n/a | |
| 51 | P17612_CME | CME | DB04530 | n/a | n/a | S,S-(2-Hydroxyethyl)Thiocysteine | n/a | |
| 52 | P17612_HFS | HFS | DB04707 | 3064778 | CHEMBL1233300 | Hydroxyfasudil | n/a | |
| 53 | P17612_2EA | 2EA | DB06959 | 11840906 | n/a | (2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine | n/a | |
| 54 | P17612_2PY | 2PY | DB06977 | 49866474 | n/a | (2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamine | n/a | |
| 55 | P17612_4EA | 4EA | DB07107 | 6914613 | CHEMBL383541 | (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE | n/a | |
| 56 | P17612_4PY | 4PY | DB07124 | 46937052 | n/a | (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE | n/a | |
| 57 | P17612_6EA | 6EA | DB07204 | 6914614 | CHEMBL207496 | (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE | n/a | |
| 58 | P17612_BI4 | BI4 | DB07458 | 448642 | n/a | 3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione | n/a | |
| 59 | P17612_CQP | CQP | DB07583 | 5327110 | n/a | (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE | n/a | |
| 60 | P17612_GVI | GVI | DB07854 | 11608401 | CHEMBL376388 | N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE | n/a | |
| 61 | P17612_GVJ | GVJ | DB07855 | 16122632 | n/a | (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE | n/a | |
| 62 | P17612_GVK | GVK | DB07856 | 16122633 | CHEMBL228133 | 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE | n/a | |
| 63 | P17612_GVN | GVN | DB07857 | 15602983 | CHEMBL227924 | (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine | n/a | |
| 64 | P17612_GVO | GVO | DB07858 | 15602982 | CHEMBL223339 | (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine | n/a | |
| 65 | P17612_GVP | GVP | DB07859 | 11175137 | CHEMBL428462 | 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE | n/a | |
| 66 | P17612_GVQ | GVQ | DB07860 | 16122635 | n/a | (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE | n/a | |
| 67 | P17612_H52 | H52 | DB07876 | 448043 | CHEMBL406821 | (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE | n/a | |
| 68 | P17612_I5S | I5S | DB07947 | 5327109 | CHEMBL227381 | ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE | n/a | |
| 69 | P17612_DB07996 | n/a | DB07996 | n/a | n/a | 5-(2-methylpiperazine-1-sulfonyl)isoquinoline | n/a | IC50(nM) = 3000.0 |
| 70 | P17612_IQS | IQS | DB07997 | 3540 | CHEMBL148333 | N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE | n/a | |
| 71 | P17612_L15 | L15 | DB08070 | 16122634 | CHEMBL228224 | 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE | n/a | |
| 72 | P17612_L20 | L20 | DB08073 | 10172943 | CHEMBL379300 | (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE | n/a | |
| 73 | P17612_LL1 | LL1 | DB08113 | 12412578 | CHEMBL1234032 | 3-pyridin-4-yl-1H-indazole | n/a | |
| 74 | P17612_LL2 | LL2 | DB08114 | 691952 | CHEMBL1234033 | 5-benzyl-1,3-thiazol-2-amine | n/a | |
| 75 | P17612_M03 | M03 | DB08148 | 24762195 | CHEMBL406863 | 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine | n/a | |
| 76 | P17612_M04 | M04 | DB08149 | 11696113 | CHEMBL260000 | 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine | n/a | |
| 77 | P17612_M05 | M05 | DB08150 | 42627562 | n/a | 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium | n/a | |
| 78 | P17612_M77 | M77 | DB08162 | 3547 | CHEMBL38380 | Fasudil | n/a | IC50(nM) = 853.0 |
| 79 | P17612_MYR | MYR | DB08231 | 11005 | CHEMBL111077 | Myristic acid | n/a | |
| 80 | P17612_SS3 | SS3 | DB08568 | 11314340 | CHEMBL379218 | A-674563 | n/a | Kd(nM) = 56.0 |
| 81 | P17612_SS4 | SS4 | DB08569 | 16122642 | CHEMBL229855 | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE | n/a | |
| 82 | P17612_Y27 | Y27 | DB08756 | n/a | CHEMBL559147 | Y-27632 | n/a | |
| 83 | P17612_REF | REF | DB08846 | 5281855 | CHEMBL6246 | Ellagic acid | inhibitor | |
| 84 | P17612_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |