Gene name: ITGAL
Protein name: Integrin alpha-L (CD11
List of molecules and drugs that interact with protein P20701
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P20701_1HV | 1HV | n/a | 59951191 | n/a | 4-(3-{4-[(3-aminopropyl)carbamoyl]phenyl}-1H-indazol-1-yl)-N-methylbenzamide | n/a | |
| 2 | P20701_2IC | 2IC | n/a | 11635371 | CHEMBL214529 | 5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO-1,3,7-TRIAZASPIRO [4.4]NON-7-YL]METHYL]-3-THIOPHENECARBOXYLICACID | n/a | |
| 3 | P20701_2O7 | 2O7 | DB06972 | 16040268 | CHEMBL232942 | 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile | n/a | |
| 4 | P20701_803 | 803 | DB00227 | 53232 | CHEMBL503 | LOVASTATIN | inhibitor | IC50(nM) = 2400.0 Kd(nM) = 12900.0 |
| 5 | P20701_AAY | AAY | DB03932 | 449169 | n/a | 8-[2-((2S)-4-HYDROXY-1-{[5-(HYDROXYMETHYL)-6-METHOXY-2-NAPHTHYL]METHYL}-6-OXOPIPERIDIN-2-YL)ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL 2-METHYLBUTANOATE | inhibitor | |
| 6 | P20701_AB8 | AB8 | n/a | 449170 | CHEMBL82235 | (1S,3R,8AS)-8-(2-{(4S,6S)-3-(4-HYDROXY-3-METHOXYBENZYL)-4-[2-(METHYLAMINO)-2-OXOETHYL]-2-OXO-1,3-OXAZINAN-6-YL}ETHYL)-3 ,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL (2R)-2-METHYLBUTANOATE | n/a | |
| 7 | P20701_BJZ | BJZ | n/a | 11699447 | CHEMBL1098726 | 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]pyridine-3-carboxylic acid | n/a | |
| 8 | P20701_BQM | BQM | DB07486 | 11712628 | CHEMBL478464 | 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline | n/a | IC50(nM) = 1.7 |
| 9 | P20701_BQN | BQN | n/a | 24875307 | CHEMBL487705 | 4-{(2E)-3-[4-{[2-(pyridin-3-ylmethoxy)phenyl]sulfanyl}-2,3-bis(trifluoromethyl)phenyl]prop-2-enoyl}morpholine | n/a | |
| 10 | P20701_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 11 | P20701_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 12 | P20701_E2M | E2M | n/a | n/a | CHEMBL452882 | cis-4-{[2-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)phenoxy]methyl}cyclohexanecarboxylic acid | n/a | |
| 13 | P20701_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 14 | P20701_ICF | ICF | DB00753 | 4369440 | n/a | 1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER | n/a | |
| 15 | P20701_L08 | L08 | DB02177 | 448317 | CHEMBL1233907 | 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHENYL}PYRIDIN-2-YL)PIPERAZINE | n/a | |
| 16 | P20701_LA1 | LA1 | DB04724 | 5326914 | CHEMBL446435 | (2R)-2-[3-ISOBUTYL-2,5-DIOXO-4-(QUINOLIN-3-YLMETHYL)-1,4-DIAZEPAN-1-YL]-N-METHYL-3-(2-NAPHTHYL)PROPANAMIDE | n/a | |
| 17 | P20701_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 18 | P20701_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 19 | P20701_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 20 | P20701_NO3 | NO3 | DB14049 | 943 | CHEMBL186200 | NITRATE ION | n/a | |
| 21 | P20701_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 22 | P20701_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 23 | P20701_DB00641 | n/a | DB00641 | n/a | n/a | Simvastatin | inhibitory allosteric modulator | |
| 24 | P20701_DB01098 | n/a | DB01098 | n/a | n/a | Rosuvastatin | inhibitory allosteric modulator | |
| 25 | P20701_PV9 | PV9 | DB08860 | 5282452 | CHEMBL1201753 | Pitavastatin | n/a | |
| 26 | P20701_DB11611 | n/a | DB11611 | n/a | n/a | Lifitegrast | antagonist |