Gene name: S1PR1
Protein name: Sphingosine 1-phosphate receptor
List of molecules and drugs that interact with protein P21453
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P21453_7I4 | 7I4 | n/a | 117972004 | CHEMBL4097139 | 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid | n/a | |
| 2 | P21453_J89 | J89 | n/a | 11452022 | CHEMBL366208 | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol | n/a | |
| 3 | P21453_J8C | J8C | DB12371 | 44599207 | CHEMBL2336071 | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid | modulator | |
| 4 | P21453_JER | JER | DB12705 | 49871973 | CHEMBL4297505 | (2~{S})-3-[4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy]propane-1,2-diol | n/a | |
| 5 | P21453_JEU | JEU | DB12612 | 52938427 | CHEMBL3707247 | 5-[3-[(1~{S})-1-(2-hydroxyethylamino)-2,3-dihydro-1~{H}-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxy-benzenecarbonitrile | agonist | |
| 6 | P21453_JEX | JEX | n/a | 4077460 | CHEMBL224720 | 5-[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole | n/a | |
| 7 | P21453_ML5 | ML5 | n/a | 6857802;51892645; | CHEMBL1221649 | {(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl}phosphonic acid | n/a | |
| 8 | P21453_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 9 | P21453_PLM | PLM | DB03796 | 985;135369651; | CHEMBL82293 | PALMITIC ACID | n/a | |
| 10 | P21453_S1P | S1P | n/a | 5283560;10883396; | CHEMBL225155 | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate | n/a | |
| 11 | P21453_DB08868 | n/a | DB08868 | n/a | n/a | Fingolimod | modulator | IC50(nM) = 604.0 EC50(nM) = 0.3 |
| 12 | P21453_DB12016 | n/a | DB12016 | n/a | n/a | Ponesimod | agonist | |
| 13 | P21453_DB12371 | n/a | DB12371 | n/a | n/a | Siponimod | modulator |