Gene name: DRD1
Protein name: D(1A) dopamine receptor
List of molecules and drugs that interact with protein P21728
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P21728_86W | 86W | DB14899 | 86764100 | CHEMBL3697617 | 1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxy-phenyl]pyrimidine-2,4-dione | n/a | |
| 2 | P21728_CLR | CLR | DB04540 | 5997 | CHEMBL112570 | CHOLESTEROL | n/a | |
| 3 | P21728_G3C | G3C | n/a | 12668023;30026875; | CHEMBL1160786 | (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol | n/a | |
| 4 | P21728_G3O | G3O | n/a | n/a | n/a | (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol | n/a | |
| 5 | P21728_G3U | G3U | n/a | 86764103 | CHEMBL3697578 | 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione | n/a | |
| 6 | P21728_G4C | G4C | DB19034 | 86290953 | CHEMBL3421729 | 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone | n/a | |
| 7 | P21728_GBU | GBU | n/a | 6604003 | CHEMBL1416789 | (1S)-6-chloranyl-3-methyl-1-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol | n/a | |
| 8 | P21728_LDP | LDP | DB00988 | 681 | CHEMBL59 | L-DOPAMINE | agonist | Ki(nM) = 124.0 Kd(nM) = 2500.0 EC50(nM) = 2.6 |
| 9 | P21728_OR9 | OR9 | DB00714 | 6005 | CHEMBL53 | (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol | agonist | Ki(nM) = 4.6 Kd(nM) = 680.0 EC50(nM) = 3.8 |
| 10 | P21728_PLM | PLM | DB03796 | 985;135369651; | CHEMBL82293 | PALMITIC ACID | n/a | |
| 11 | P21728_R5F | R5F | DB05271 | 59227 | CHEMBL1303 | Rotigotine | agonist | Ki(nM) = 2172.0 |
| 12 | P21728_SK0 | SK0 | n/a | 12668019 | CHEMBL1160787 | (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol | n/a | |
| 13 | P21728_SK9 | SK9 | n/a | 9995976 | CHEMBL1618198 | (1R)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol | n/a | |
| 14 | P21728_DB00246 | n/a | DB00246 | n/a | n/a | Ziprasidone | antagonist | Ki(nM) = 9.5 |
| 15 | P21728_DB00248 | n/a | DB00248 | n/a | n/a | Cabergoline | agonist | Ki(nM) = 1.4 |
| 16 | P21728_DB00334 | n/a | DB00334 | n/a | n/a | Olanzapine | antagonist | Ki(nM) = 10.0 |
| 17 | P21728_H8D | H8D | DB00353 | 8226 | CHEMBL1201356 | Methylergometrine | antagonist | |
| 18 | P21728_DB00363 | n/a | DB00363 | n/a | n/a | Clozapine | antagonist | Ki(nM) = 7.5 |
| 19 | P21728_DB00397 | n/a | DB00397 | n/a | n/a | Phenylpropanolamine | partial agonist | |
| 20 | P21728_DB00408 | n/a | DB00408 | n/a | n/a | Loxapine | binder | |
| 21 | P21728_Z80 | Z80 | DB00477 | 2726 | CHEMBL71 | Chlorpromazine | inhibitor | Ki(nM) = 44.0 |
| 22 | P21728_GMJ | GMJ | DB00502 | 3559 | CHEMBL54 | Haloperidol | antagonist | Ki(nM) = 6.17 |
| 23 | P21728_DB00508 | n/a | DB00508 | n/a | n/a | Triflupromazine | antagonist | |
| 24 | P21728_DB00543 | n/a | DB00543 | n/a | n/a | Amoxapine | antagonist | |
| 25 | P21728_H8G | H8G | DB00589 | 28864 | CHEMBL157138 | Lisuride | antagonist | Ki(nM) = 0.34 |
| 26 | P21728_DB00623 | n/a | DB00623 | n/a | n/a | Fluphenazine | antagonist | Ki(nM) = 7.0 |
| 27 | P21728_DB00679 | n/a | DB00679 | n/a | n/a | Thioridazine | antagonist | Ki(nM) = 100.0 |
| 28 | P21728_DB00734 | n/a | DB00734 | n/a | n/a | Risperidone | antagonist | Ki(nM) = 21.0 |
| 29 | P21728_DB00800 | n/a | DB00800 | n/a | n/a | Fenoldopam | agonist | Ki(nM) = 17.0 Kd(nM) = 28.0 EC50(nM) = 2.8 |
| 30 | P21728_DB00805 | n/a | DB00805 | n/a | n/a | Minaprine | agonist | |
| 31 | P21728_DB00850 | n/a | DB00850 | n/a | n/a | Perphenazine | antagonist | |
| 32 | P21728_DB00875 | n/a | DB00875 | n/a | n/a | Flupentixol | antagonist | |
| 33 | P21728_DB01038 | n/a | DB01038 | n/a | n/a | Carphenazine | antagonist | |
| 34 | P21728_DB01186 | n/a | DB01186 | n/a | n/a | Pergolide | agonist | Ki(nM) = 338.84 |
| 35 | P21728_08Y | 08Y | DB01200 | 31101 | CHEMBL493 | Bromocriptine | agonist | Ki(nM) = 672.0 |
| 36 | P21728_DB01224 | n/a | DB01224 | n/a | n/a | Quetiapine | antagonist | Ki(nM) = 390.0 |
| 37 | P21728_DAH | DAH | DB01235 | 6047;6971033; | CHEMBL1009 | Levodopa | agonist | |
| 38 | P21728_9SC | 9SC | DB01238 | 60795 | CHEMBL1112 | Aripiprazole | antagonist | Ki(nM) = 310.0 |
| 39 | P21728_DB01239 | n/a | DB01239 | n/a | n/a | Chlorprothixene | antagonist | |
| 40 | P21728_DB01267 | n/a | DB01267 | n/a | n/a | Paliperidone | antagonist | |
| 41 | P21728_DB01403 | n/a | DB01403 | n/a | n/a | Methotrimeprazine | antagonist | |
| 42 | P21728_DB01608 | n/a | DB01608 | n/a | n/a | Periciazine | antagonist | |
| 43 | P21728_PMZ | PMZ | DB01614 | 6077 | CHEMBL39560 | Acepromazine | antagonist | |
| 44 | P21728_DB01621 | n/a | DB01621 | n/a | n/a | Pipotiazine | antagonist | |
| 45 | P21728_DB01622 | n/a | DB01622 | n/a | n/a | Thioproperazine | antagonist | |
| 46 | P21728_DB01623 | n/a | DB01623 | n/a | n/a | Thiothixene | antagonist | |
| 47 | P21728_DB01624 | n/a | DB01624 | n/a | n/a | Zuclopenthixol | antagonist | |
| 48 | P21728_DB04946 | n/a | DB04946 | n/a | n/a | Iloperidone | antagonist | Ki(nM) = 216.0 |
| 49 | P21728_DB05271 | n/a | DB05271 | n/a | n/a | Rotigotine | agonist | Ki(nM) = 2172.0 |
| 50 | P21728_92S | 92S | DB06077 | 21302490 | CHEMBL3306803 | Lumateperone | n/a | |
| 51 | P21728_DB06216 | n/a | DB06216 | n/a | n/a | Asenapine | antagonist | |
| 52 | P21728_DB09286 | n/a | DB09286 | n/a | n/a | Pipamperone | antagonist | |
| 53 | P21728_DB12093 | n/a | DB12093 | n/a | n/a | Tetrahydropalmatine | antagonist | |
| 54 | P21728_DB12890 | n/a | DB12890 | n/a | n/a | Dihydrexidine | inhibitor | |
| 55 | P21728_DB14185 | n/a | DB14185 | n/a | n/a | Aripiprazole lauroxil | n/a |