Gene name: GART
Protein name: Trifunctional purine biosynthetic
List of molecules and drugs that interact with protein P22102
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P22102_3Y9 | 3Y9 | n/a | 44398808;135567027; | CHEMBL365307 | N-{4-[4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamic acid | n/a | |
| 2 | P22102_3YA | 3YA | n/a | 24771725 | CHEMBL491104 | N-{4-[4-(2-amino-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamic acid | n/a | |
| 3 | P22102_3YB | 3YB | n/a | 57325614;135567030; | CHEMBL2158681 | N-({4-[4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid | n/a | |
| 4 | P22102_3YC | 3YC | n/a | 57325615;135567031; | CHEMBL2158682 | (S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)butyl]thiophene-3-carbonyl}amino)pentanedioic acid | n/a | |
| 5 | P22102_3YD | 3YD | n/a | 72711846;135567032; | CHEMBL3086865 | (S)-2-(7-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)heptanamido)pentanedioic acid | n/a | |
| 6 | P22102_3YE | 3YE | n/a | 72711847;135567033; | CHEMBL3086866 | (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid | n/a | |
| 7 | P22102_3YF | 3YF | n/a | 51347243;135567034; | CHEMBL3628344 | (S)-2-({4-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-2-carbonyl}-amino)-pentanedioic acid | n/a | |
| 8 | P22102_3YG | 3YG | n/a | 67093285;135567035; | CHEMBL3628346 | (S)-2-({5-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-3-carbonyl}-amino)-pentanedioic acid | n/a | |
| 9 | P22102_4DW | 4DW | n/a | 137348230 | n/a | N-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid | n/a | |
| 10 | P22102_83A | 83A | n/a | 73442845;135567163; | CHEMBL4437824 | N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid | n/a | |
| 11 | P22102_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ADENOSINE-5'-TRIPHOSPHATE | n/a | |
| 12 | P22102_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 13 | P22102_DQB | DQB | n/a | 5288111;5326974;135464483; | n/a | 4-[(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)METHYL]AMINO}BENZOYL)AMINO]BUTANOIC ACID | n/a | |
| 14 | P22102_DXY | DXY | n/a | 25053729;135566721; | CHEMBL452322 | N-({4-[(1S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-(methylsulfanyl)butyl]phenyl}carbonyl)-L-glutamic acid | n/a | |
| 15 | P22102_DXZ | DXZ | n/a | 25053728;135566722; | CHEMBL453090 | N-({4-[(1R)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-(methylsulfanyl)butyl]phenyl}carbonyl)-L-glutamic acid | n/a | |
| 16 | P22102_G71 | G71 | n/a | 46179980;135567028; | CHEMBL590740 | N-({5-[4-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid | n/a | |
| 17 | P22102_G94 | G94 | DB18023 | 45255910;135567029; | CHEMBL1834488 | N-({5-[3-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophen-2-yl}carbonyl)-L-glutamic acid | n/a | |
| 18 | P22102_GAR | GAR | DB02236 | 5288365 | n/a | GLYCINAMIDE RIBONUCLEOTIDE | n/a | |
| 19 | P22102_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 20 | P22102_GRF | GRF | n/a | 439905 | n/a | 5-O-phosphono-beta-D-ribofuranosylamine | n/a | |
| 21 | P22102_KEU | KEU | DB03546 | 131704252 | n/a | N-{4-[(1R)-4-[(2R,4R,5S)-2,4-DIAMINO-6-OXOHEXAHYDROPYRIMIDIN-5-YL]-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYL)BUTYL]BENZOYL}-D-GLUTAMIC ACID | n/a | |
| 22 | P22102_KT3 | KT3 | n/a | n/a | n/a | N-{4-4-(2,4-DIAMINO-6-OXO-1,6-DIHYDRO-PYRIMIDIN-5-YL)-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXY-ETHYL)-BUT-2-YL-BENZOYL}-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GLUTAMIC ACID | n/a | |
| 23 | P22102_KT5 | KT5 | n/a | n/a | n/a | N-{4-4-(2,4-DIAMINO-6-OXO-1,6-DIHYDRO-PYRIMIDIN-5-YL)-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXY-ETHYL)-BUT-2-YL-BENZOYL}-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GLUTAMIC ACID | n/a | |
| 24 | P22102_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 25 | P22102_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 26 | P22102_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 27 | P22102_V97 | V97 | n/a | 24770896 | CHEMBL4741259 | N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]thiophene-2-carbonyl}-L-glutamic acid | n/a | |
| 28 | P22102_V9A | V9A | n/a | 155818899 | CHEMBL4789686 | N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]furan-2-carbonyl}-L-glutamic acid | n/a | |
| 29 | P22102_V9V | V9V | n/a | 155818900 | CHEMBL4790375 | N-(5-{3-[(1S,7R,8R,9S)-4-amino-2-oxo-7lambda~4~-thia-3,5-diazatetracyclo[4.3.0.0~1,7~.0~7,9~]nona-3,5-dien-8-yl]propyl}thiophene-2-carbonyl)-L-glutamic acid | n/a | |
| 30 | P22102_XRR | XRR | n/a | 162658194 | CHEMBL4759798 | N-{4-[3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl}-L-glutamic acid | n/a | |
| 31 | P22102_XSI | XSI | n/a | 168010754 | n/a | N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]pyridine-2-carbonyl}-L-glutamic acid | n/a | |
| 32 | P22102_XSO | XSO | n/a | 168010755 | n/a | N-{5-[4-(2-amino-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]-3-fluoropyridine-2-carbonyl}-L-glutamic acid | n/a | |
| 33 | P22102_Y6U | Y6U | n/a | 10411029;135434099; | CHEMBL5431881 | N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]benzoyl}-L-glutamic acid | n/a | |
| 34 | P22102_Y72 | Y72 | n/a | 168477227 | CHEMBL5427804 | N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid | n/a | |
| 35 | P22102_Y79 | Y79 | n/a | 137525194 | CHEMBL5405010 | N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-glutamic acid | n/a | |
| 36 | P22102_Y7L | Y7L | n/a | 138504521 | CHEMBL5429283 | N-{5-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]thiophene-2-carbonyl}-L-glutamic acid | n/a | |
| 37 | P22102_LYA | LYA | DB00642 | 446556;5288715;135410875; | CHEMBL225072 | Pemetrexed | inhibitor | |
| 38 | P22102_DB02236 | n/a | DB02236 | n/a | n/a | Glycinamide Ribonucleotide | n/a |