Gene name: ACHE
Protein name: Acetylcholinesterase (AChE) (EC
List of molecules and drugs that interact with protein P22303
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P22303_1PE | 1PE | n/a | 62551 | CHEMBL1229766 | PENTAETHYLENE GLYCOL | n/a | |
| 2 | P22303_1YK | 1YK | n/a | 114734 | CHEMBL24686 | territrem B | n/a | |
| 3 | P22303_1YL | 1YL | n/a | 11425923 | CHEMBL227075 | Dihydrotanshinone I | n/a | |
| 4 | P22303_3VI | 3VI | n/a | 164922;5490824;135464156;135555426;136928592; | CHEMBL1181952 | 1,1'-methylenebis{4-[(E)-(hydroxyimino)methyl]pyridin-1-ium} | n/a | |
| 5 | P22303_7PE | 7PE | n/a | 526557 | n/a | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL | n/a | |
| 6 | P22303_AA | AA | n/a | 4601006;5124248; | n/a | 9-AMINOACRIDINE | n/a | |
| 7 | P22303_BR | BR | n/a | 259 | n/a | BROMIDE ION | n/a | |
| 8 | P22303_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 9 | P22303_CVZ | CVZ | n/a | 137349134 | n/a | 3-[(~{E})-5-[ethyl-[(2-nitrophenyl)methyl]amino]pent-1-enyl]-1-[5-[ethyl-[(2-nitrophenyl)methyl]amino]pentyl]-6-methyl-pyrimidine-2,4-dione | n/a | |
| 10 | P22303_DEP | DEP | DB02811 | 220224 | n/a | DIETHYL PHOSPHONATE | n/a | |
| 11 | P22303_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 12 | P22303_E20 | E20 | DB07701 | 1150567 | CHEMBL107316 | 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE | n/a | |
| 13 | P22303_EBW | EBW | n/a | 1338 | CHEMBL140020 | 4-(5-{4-[DIMETHYL(PROP-2-ENYL)AMMONIO]PHENYL}-3-OXOPENTYL)-N,N-DIMETHYL-N-PROP-2-ENYLBENZENAMINIUM | n/a | |
| 14 | P22303_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 15 | P22303_EFS | EFS | DB03822 | 74190 | n/a | ETHYL DIHYDROGEN PHOSPHATE | n/a | |
| 16 | P22303_ELT | ELT | n/a | 541907 | n/a | ethoxy-~{N},~{N}-dimethyl-phosphonamidic acid | n/a | |
| 17 | P22303_FP1 | FP1 | n/a | 49866995 | n/a | N-hydroxy-1-(1-methylpyridin-2(1H)-ylidene)methanamine | n/a | |
| 18 | P22303_FUC | FUC | DB04473 | 439554 | CHEMBL1232862 | alpha-L-fucopyranose | n/a | |
| 19 | P22303_GD8 | GD8 | DB07821 | 46937095;46937096;49867026; | n/a | (1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE | n/a | |
| 20 | P22303_GNT | GNT | DB00674 | 9651 | CHEMBL659 | (-)-GALANTHAMINE | inhibitor | Ki(nM) = 62.0 IC50(nM) = 100.0 EC50(nM) = 1100.0 |
| 21 | P22303_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 22 | P22303_H0L | H0L | n/a | 156583276 | n/a | (2R)-2-[[4-fluoranyl-1-[(4-fluorophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one | n/a | |
| 23 | P22303_H0R | H0R | n/a | 156583277 | n/a | (2S)-2-[[4-fluoranyl-1-[(2-fluorophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one | n/a | |
| 24 | P22303_H1R | H1R | n/a | 156583278 | n/a | (2S)-2-[[4-fluoranyl-1-[(3-fluorophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one | n/a | |
| 25 | P22303_HI6 | HI6 | n/a | 91615;6818286;101826767;135412778;135590423; | CHEMBL385181 | 4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM | n/a | |
| 26 | P22303_HLO | HLO | n/a | 108049;6308540;6849545;16214796;52947981;101601748;135398751;135520674;135666470;135752462;135889861;138397604;139031161;161501644;172916187; | CHEMBL1233344 | 1-[({2,4-BIS[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]-4-CARBAMOYLPYRIDINIUM | n/a | |
| 27 | P22303_HUP | HUP | DB04864 | 854026 | CHEMBL395280 | Huperzine A | inhibitor | Ki(nM) = 4.6 IC50(nM) = 47.0 |
| 28 | P22303_HUW | HUW | n/a | 71463576 | n/a | HUPRINE W | n/a | |
| 29 | P22303_L0S | L0S | n/a | 146672926 | n/a | methyl (R)-N-[(1E)-1-(diethylamino)ethylidene]-P-methylphosphonamidate | n/a | |
| 30 | P22303_L1M | L1M | n/a | n/a | n/a | ethyl (R)-N-[(1E)-1-(diethylamino)ethylidene]phosphonamidate | n/a | |
| 31 | P22303_L2Y | L2Y | n/a | 146672928 | n/a | (S)-N-[(1E)-1-(diethylamino)ethylidene]-P-methylphosphonamidic fluoride | n/a | |
| 32 | P22303_LND | LND | n/a | 76314587;118024428;136224222;136951133; | CHEMBL3139900 | 4-carbamoyl-1-(3-{2-[(E)-(hydroxyimino)methyl]-1H-imidazol-1-yl}propyl)pyridin-1-ium | n/a | |
| 33 | P22303_LWL | LWL | n/a | 101524264;117061078;137320192; | n/a | N,N,N-trimethyl-2-oxo-2-(2-(pyridin-2-ylmethylene)hydrazineyl)ethan-1-aminium | n/a | |
| 34 | P22303_LWU | LWU | n/a | 168451658 | n/a | 1-(2-(2-((6-(dihydroxymethyl)-2-phenylpyrimidin-4-yl)methylene)hydrazineyl)-2-oxoethyl)pyridin-1-ium | n/a | |
| 35 | P22303_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | inhibitor | |
| 36 | P22303_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 37 | P22303_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 38 | P22303_NO3 | NO3 | DB14049 | 943 | CHEMBL186200 | NITRATE ION | n/a | |
| 39 | P22303_NWA | NWA | n/a | 6914581 | n/a | 4,4-DIHYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM | n/a | |
| 40 | P22303_PE8 | PE8 | n/a | 78798 | n/a | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL | n/a | |
| 41 | P22303_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 42 | P22303_PQV | PQV | n/a | 6483804 | n/a | (2E)-N-[2-(azepan-1-yl)ethyl]-2-(hydroxyimino)acetamide | n/a | |
| 43 | P22303_PQY | PQY | n/a | 145946115 | n/a | (2E,2'E)-N,N'-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide] | n/a | |
| 44 | P22303_QRH | QRH | n/a | n/a | n/a | (2~{E},4~{E})-5-(1,3-benzodioxol-5-yl)-~{N}-[6-(triphenyl-$l^{5}-phosphanyl)hexyl]penta-2,4-dienamide | n/a | |
| 45 | P22303_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 46 | P22303_THA | THA | DB00382 | 1935 | CHEMBL95 | TACRINE | inhibitor | Ki(nM) = 6.9 IC50(nM) = 3.16 |
| 47 | P22303_UCJ | UCJ | n/a | 15778 | n/a | propan-2-yl hydrogen (S)-methylphosphonate | n/a | |
| 48 | P22303_UCY | UCY | n/a | n/a | n/a | (1S)-2,2-dimethylcyclopentyl (R)-methylphosphinate | n/a | |
| 49 | P22303_UNX | UNX | n/a | |||||
| 50 | P22303_VX | VX | n/a | 449085 | n/a | O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP | n/a | |
| 51 | P22303_WW2 | WW2 | n/a | 14366907 | n/a | cyclohexyl (S)-methylphosphonofluoridoate | n/a | |
| 52 | P22303_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 53 | P22303_CHT | CHT | DB00122 | 305 | CHEMBL920 | Choline | product of | IC50(nM) = 3013006.02 |
| 54 | P22303_DB00449 | n/a | DB00449 | n/a | n/a | Dipivefrin | inhibitor | |
| 55 | P22303_DB00483 | n/a | DB00483 | n/a | n/a | Gallamine triethiodide | inhibitor | Ki(nM) = 37000.0 IC50(nM) = 2110000.0 |
| 56 | P22303_DB00545 | n/a | DB00545 | n/a | n/a | Pyridostigmine | inhibitor | IC50(nM) = 350.0 |
| 57 | P22303_DB00677 | n/a | DB00677 | n/a | n/a | Isoflurophate | inhibitor | Ki(nM) = 6000.0 IC50(nM) = 120.0 Kd(nM) = 13000.0 kon(M-1-s-1) = 2170.0 |
| 58 | P22303_DB00733 | n/a | DB00733 | n/a | n/a | Pralidoxime | activator | Ki(nM) = 180000.0 IC50(nM) = 878000.0 |
| 59 | P22303_DB00805 | n/a | DB00805 | n/a | n/a | Minaprine | inhibitor | IC50(nM) = 85000.0 |
| 60 | P22303_DB00843 | n/a | DB00843 | n/a | n/a | Donepezil | inhibitor | Ki(nM) = 2.9 IC50(nM) = 2.0 Kd(nM) = 8.0 EC50(nM) = 43.0 |
| 61 | P22303_DB00863 | n/a | DB00863 | n/a | n/a | Ranitidine | inhibitor | |
| 62 | P22303_EOH | EOH | DB00898 | 702 | CHEMBL545 | Ethanol | activator | |
| 63 | P22303_DB00944 | n/a | DB00944 | n/a | n/a | Demecarium | inhibitor | |
| 64 | P22303_DB00981 | n/a | DB00981 | n/a | n/a | Physostigmine | inhibitor | IC50(nM) = 0.43 |
| 65 | P22303_DB00989 | n/a | DB00989 | n/a | n/a | Rivastigmine | inhibitor | Ki(nM) = 700.0 IC50(nM) = 37.0 kon(M-1-s-1) = 55.0 |
| 66 | P22303_EDR | EDR | DB01010 | 3202 | CHEMBL1104 | Edrophonium | inhibitor | Ki(nM) = 1.6 IC50(nM) = 200.0 |
| 67 | P22303_DB01122 | n/a | DB01122 | n/a | n/a | Ambenonium | inhibitor | Ki(nM) = 0.12 IC50(nM) = 0.7 |
| 68 | P22303_DB01199 | n/a | DB01199 | n/a | n/a | Tubocurarine | inhibitor | |
| 69 | P22303_DME | DME | DB01245 | 2968 | CHEMBL1190 | Decamethonium | inhibitor | Ki(nM) = 6000000.0 IC50(nM) = 1000.0 |
| 70 | P22303_DB01400 | n/a | DB01400 | n/a | n/a | Neostigmine | inhibitor | Ki(nM) = 23000.0 IC50(nM) = 0.043 |
| 71 | P22303_MIS | MIS | DB01805 | n/a | n/a | Monoisopropylphosphorylserine | n/a | |
| 72 | P22303_PRM | PRM | DB02166 | 4939;101643283; | CHEMBL332935 | Propidium | inhibitor | |
| 73 | P22303_TZ4 | TZ4 | DB02226 | 5289507;102194235; | CHEMBL455333 | 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium | n/a | |
| 74 | P22303_P3G | P3G | DB02343 | 78057 | n/a | 3,6,9,12,15-Pentaoxaheptadecane | inhibitor | |
| 75 | P22303_PE7 | PE7 | DB02404 | 446506 | n/a | 1-Deoxy-1-Thio-Heptaethylene Glycol | inhibitor | |
| 76 | P22303_GL8 | GL8 | DB02673 | 5288394 | CHEMBL490866 | (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium | inhibitor | |
| 77 | P22303_VXA | VXA | DB02825 | 3396559 | n/a | Methylphosphinate | n/a | |
| 78 | P22303_DB02845 | n/a | DB02845 | n/a | n/a | Methylphosphinic Acid | inhibitor | |
| 79 | P22303_TZ5 | TZ5 | DB03005 | 5289508;101360807; | CHEMBL117651 | 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium | n/a | |
| 80 | P22303_FUL | FUL | DB03283 | 444863 | CHEMBL1230861 | beta-L-fucose | inhibitor | |
| 81 | P22303_HUB | HUB | DB03348 | 5462442 | CHEMBL245079 | Huperzine B | n/a | |
| 82 | P22303_NAF | NAF | DB03359 | 3991 | n/a | M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene | n/a | |
| 83 | P22303_NDG | NDG | DB03740 | 82313 | CHEMBL1234669 | N-acetyl-alpha-D-glucosamine | inhibitor | |
| 84 | P22303_MF2 | MF2 | DB04021 | 5288799 | n/a | MF268 | inhibitor | |
| 85 | P22303_HUX | HUX | DB04114 | 5288588 | CHEMBL483716 | 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine | n/a | |
| 86 | P22303_SAF | SAF | DB04556 | 445892 | n/a | NAP-226-90 | inhibitor | |
| 87 | P22303_A1E | A1E | DB04614 | 5287575;5326966; | n/a | (R)-tacrine(10)-hupyridone | inhibitor | |
| 88 | P22303_A2E | A2E | DB04615 | 5287576;5326967; | n/a | (S)-tacrine(10)-hupyridone | inhibitor | |
| 89 | P22303_A8B | A8B | DB04616 | 656986 | CHEMBL1082738 | TACRINE(8)-4-AMINOQUINOLINE | inhibitor | IC50(nM) = 8.8 |
| 90 | P22303_A8N | A8N | DB04617 | 5287586 | n/a | (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM | n/a | |
| 91 | P22303_DB04859 | n/a | DB04859 | n/a | n/a | Zanapezil | inhibitor | IC50(nM) = 100.0 EC50(nM) = 1140.0 |
| 92 | P22303_DB04892 | n/a | DB04892 | n/a | n/a | Phenserine | inhibitor | IC50(nM) = 21.0 EC50(nM) = 25.0 |
| 93 | P22303_DB04924 | n/a | DB04924 | n/a | n/a | Itopride | inhibitor | |
| 94 | P22303_DB06525 | n/a | DB06525 | n/a | n/a | Ganstigmine | inhibitor | |
| 95 | P22303_CFQ | CFQ | DB07555 | n/a | n/a | Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammonium | n/a | |
| 96 | P22303_FBQ | FBQ | DB07756 | 1723 | n/a | 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL | n/a | |
| 97 | P22303_GSG | GSG | DB07846 | 74077203 | n/a | (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamate | n/a | |
| 98 | P22303_MBT | MBT | DB08167 | 4139 | CHEMBL191083 | Methylthioninium | inhibitor | |
| 99 | P22303_P4G | P4G | DB08357 | 8179 | CHEMBL1235106 | Diethylene glycol diethyl ether | inhibitor | |
| 100 | P22303_TFL | TFL | DB08615 | 24832019 | n/a | 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM | n/a | |
| 101 | P22303_DB08996 | n/a | DB08996 | n/a | n/a | Dimetacrine | antagonist | |
| 102 | P22303_DB12816 | n/a | DB12816 | n/a | n/a | Terpinen-4-ol | inhibitor | |
| 103 | P22303_DB14006 | n/a | DB14006 | n/a | n/a | Choline salicylate | product of |