Gene name: FGFR4
Protein name: Fibroblast growth factor
List of molecules and drugs that interact with protein P22455
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P22455_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | inhibitor | IC50(nM) = 7.1 |
| 2 | P22455_37O | 37O | n/a | 121426117 | n/a | N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide | n/a | |
| 3 | P22455_38O | 38O | DB05928 | 135398510 | CHEMBL522892 | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one | n/a | |
| 4 | P22455_40M | 40M | n/a | 137348201 | n/a | N-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)propanamide | n/a | |
| 5 | P22455_5JR | 5JR | n/a | 162679615 | n/a | N-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4H-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide | n/a | |
| 6 | P22455_6LF | 6LF | DB13022 | 46944259 | CHEMBL3828009 | 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol | n/a | |
| 7 | P22455_7IF | 7IF | n/a | 162639256 | n/a | N-[5-(aminomethyl)-4-(2-methoxyethylamino)pyridin-2-yl]-7-[2,2,2-tris(fluoranyl)ethanoyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide | n/a | |
| 8 | P22455_90F | 90F | n/a | 162679617 | n/a | ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | n/a | |
| 9 | P22455_99K | 99K | n/a | 137348794 | n/a | 3-chloranyl-~{N}-(3-nitropyridin-2-yl)-5-(trifluoromethyl)pyridin-2-amine | n/a | |
| 10 | P22455_9CT | 9CT | n/a | 137348804 | n/a | ~{N}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{H}-pyrazol-5-yl]-2-(propanoylamino)benzamide | n/a | |
| 11 | P22455_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 12 | P22455_AWX | AWX | n/a | 145945978 | CHEMBL4541330 | N-({4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}methyl)prop-2-enamide | n/a | |
| 13 | P22455_AX0 | AX0 | n/a | n/a | CHEMBL4446835 | N-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide | n/a | |
| 14 | P22455_BYU | BYU | n/a | 146035890 | CHEMBL4744686 | N-[2-[[6-[2-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]amino]pyridin-3-yl]pyrimidin-4-yl]amino]-3-methyl-phenyl]prop-2-enamide | n/a | |
| 15 | P22455_CU | CU | n/a | 27099 | n/a | COPPER (II) ION | n/a | |
| 16 | P22455_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 17 | P22455_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 18 | P22455_FGF | FGF | DB16845 | 118036971 | CHEMBL3908979 | N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide | antagonist | |
| 19 | P22455_FI3 | FI3 | n/a | 132265779 | n/a | N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide | n/a | |
| 20 | P22455_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 21 | P22455_GX3 | GX3 | n/a | 118295624 | CHEMBL4068509 | 6-[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one | n/a | |
| 22 | P22455_HHL | HHL | n/a | 155884458 | CHEMBL4757810 | N-[2-[[5-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]methoxy]pyrimidin-2-yl]amino]-3-methyl-phenyl]-2-fluoranyl-prop-2-enamide | n/a | |
| 23 | P22455_IH7 | IH7 | n/a | 165430632 | CHEMBL5220381 | ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | n/a | |
| 24 | P22455_IIQ | IIQ | n/a | 165430633 | CHEMBL5220465 | ~{N}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-propyl-pyrrolo[3,2-b]pyridine-3-carboxamide | n/a | |
| 25 | P22455_IIW | IIW | n/a | 165430635 | CHEMBL5220620 | 6-bromanyl-~{N}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | n/a | |
| 26 | P22455_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 27 | P22455_QS7 | QS7 | n/a | 90436886 | CHEMBL4761518 | N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide | n/a | |
| 28 | P22455_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 29 | P22455_XL5 | XL5 | n/a | 138753366 | n/a | N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-fluorophenyl]propanamide | n/a | |
| 30 | P22455_XL6 | XL6 | n/a | 138454915 | n/a | N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | n/a | |
| 31 | P22455_XL7 | XL7 | n/a | 138753367 | n/a | N-[3-chloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-5-fluorophenyl]propanamide | n/a | |
| 32 | P22455_XL8 | XL8 | n/a | 138753368 | n/a | N-[3,5-dichloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)phenyl]propanamide | n/a | |
| 33 | P22455_XL9 | XL9 | n/a | 138753369 | n/a | N-[(3S,4S)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}oxan-4-yl]propanamide | n/a | |
| 34 | P22455_LEV | LEV | DB09078 | 9823820 | CHEMBL1289601 | Lenvatinib | inhibitor | |
| 35 | P22455_07J | 07J | DB11886 | 53235510 | CHEMBL1852688 | Infigratinib | inhibitor | |
| 36 | P22455_5SF | 5SF | DB12147 | 67462786 | CHEMBL3545376 | Erdafitinib | inhibitor | |
| 37 | P22455_8ZF | 8ZF | DB15102 | 86705695 | CHEMBL4297522 | Pemigatinib | inhibitor | |
| 38 | P22455_TZ0 | TZ0 | DB15149 | 71621331 | CHEMBL3701238 | Futibatinib | inhibitor |