Gene name: Comt
Protein name: Catechol O-methyltransferase (EC
List of molecules and drugs that interact with protein P22734
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P22734_2X1 | 2X1 | n/a | 74331716 | n/a | 4-({[3-(aminomethyl)phenyl]carbamoyl}amino)benzenecarboximidamide | n/a | |
| 2 | P22734_542 | 542 | n/a | 44228994 | n/a | N-[(E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methylaminopurin-9-yl)oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxy-benzamide | n/a | |
| 3 | P22734_610 | 610 | n/a | 50919270 | n/a | N-[(E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-purin-9-yl-oxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitro-benzamide | n/a | |
| 4 | P22734_611 | 611 | n/a | 50919271 | n/a | N-[(E)-3-[(2R,3S,4R,5S)-3,4-dihydroxy-5-pyridin-4-ylsulfanyl-oxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitro-benzamide | n/a | |
| 5 | P22734_619 | 619 | n/a | 44228995 | n/a | N-[(E)-3-[(2R,3S,4R,5R)-5-(6-ethylaminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxy-benzamide | n/a | |
| 6 | P22734_637 | 637 | n/a | 50919268 | n/a | N-[(E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methylpurin-9-yl)oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxy-benzamide | n/a | |
| 7 | P22734_659 | 659 | n/a | 53301842 | n/a | N-[(E)-3-[(2R,3R,4S,5R)-3-fluoro-4-hydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxy-benzamide | n/a | |
| 8 | P22734_662 | 662 | n/a | 53301843 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-[(E)-3-[(2R,3R,4R,5R)-4-hydroxy-3-methyl-5-[6-(propylamino)purin-9-yl]oxolan-2-yl]prop-2-enyl]benzamide | n/a | |
| 9 | P22734_6OW | 6OW | n/a | 21345689 | CHEMBL4785476 | 2,7-dimethyl-3-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridine | n/a | |
| 10 | P22734_6OZ | 6OZ | n/a | 121595983 | CHEMBL4793611 | 2,4-dimethyl-5-[3-(2-phenylpropan-2-yl)-1H-pyrazol-5-yl]-1,3-thiazole | n/a | |
| 11 | P22734_6P0 | 6P0 | n/a | 121595987 | n/a | 5-[1-(4-methoxyphenyl)cyclopropyl]-1',3'-dimethyl-1'H,2H-3,4'-bipyrazole | n/a | |
| 12 | P22734_6P1 | 6P1 | n/a | 121595984 | CHEMBL4794007 | 5-{3-[(1R)-1-(4-methoxyphenyl)ethyl]-1H-pyrazol-5-yl}-2,4-dimethyl-1,3-thiazole | n/a | |
| 13 | P22734_6P2 | 6P2 | n/a | 121595986 | CHEMBL4755152 | 5-{3-[1-(4-methoxyphenyl)cyclopropyl]-1H-pyrazol-5-yl}-2,4-dimethyl-1,3-thiazole | n/a | |
| 14 | P22734_6P4 | 6P4 | n/a | 4168150 | CHEMBL4782173 | 2,6-dimethyl-3-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridine | n/a | |
| 15 | P22734_6P5 | 6P5 | n/a | 45588555 | CHEMBL4756395 | 4-methyl-2-(4-methylphenyl)-5-(1H-pyrazol-5-yl)-1,3-thiazole | n/a | |
| 16 | P22734_6PM | 6PM | n/a | 121595985 | n/a | 5-[(1S)-1-(4-methoxyphenyl)ethyl]-1',3'-dimethyl-1'H,2H-3,4'-bipyrazole | n/a | |
| 17 | P22734_6PQ | 6PQ | n/a | 121595981 | CHEMBL4741374 | 5-{3-[(4-methoxyphenyl)methyl]-1H-pyrazol-5-yl}-2,4-dimethyl-1,3-thiazole | n/a | |
| 18 | P22734_6PS | 6PS | n/a | 121595982 | CHEMBL4748625 | 2,4-dimethyl-5-{3-[(1R)-1-phenylethyl]-1H-pyrazol-5-yl}-1,3-thiazole | n/a | |
| 19 | P22734_705 | 705 | n/a | 44228996 | n/a | N-[(E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-propylaminopurin-9-yl)oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxy-benzamide | n/a | |
| 20 | P22734_719 | 719 | n/a | 44228998 | n/a | N-[(E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-hydroxyethylamino)purin-9-yl]oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxy-benzamide | n/a | |
| 21 | P22734_72M | 72M | n/a | 16090261 | n/a | ~{N}-[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]-5-[(4-methylphenyl)methyl]-2,3-bis(oxidanyl)benzamide | n/a | |
| 22 | P22734_72N | 72N | n/a | 122164614 | n/a | 3-cyclopropyl-5-methyl-4-phenyl-1,2,4-triazole | n/a | |
| 23 | P22734_72O | 72O | n/a | 2744226 | n/a | 2-[(3-chloranylphenoxy)methyl]-4-methyl-5-(1~{H}-pyrazol-5-yl)-1,3-thiazole | n/a | |
| 24 | P22734_72W | 72W | n/a | 122172839 | n/a | ~{N}-[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-ethylpurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-bis(oxidanyl)benzamide | n/a | |
| 25 | P22734_731 | 731 | n/a | 30848794 | n/a | [5-(2,4-dimethyl-1,3-thiazol-5-yl)-1~{H}-pyrazol-3-yl]-(4-phenylpiperazin-1-yl)methanone | n/a | |
| 26 | P22734_75Z | 75Z | n/a | 137348567 | n/a | N-[2-[5-(1H-benzimidazol-5-yl)-4H-1,2,4-triazol-3-yl]ethyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide | n/a | |
| 27 | P22734_763 | 763 | n/a | 129900118 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-[3-(pyrrolo[3,2-c]pyridin-1-ylmethoxy)propyl]benzamide | n/a | |
| 28 | P22734_766 | 766 | n/a | 129900119 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-(4-thieno[3,2-c]pyridin-2-ylbutyl)benzamide | n/a | |
| 29 | P22734_769 | 769 | n/a | 129900120 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-[(E)-5-pyrrolo[3,2-c]pyridin-1-ylpent-3-enyl]benzamide | n/a | |
| 30 | P22734_76B | 76B | n/a | 129900121 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-[2-[5-(2-methylpyridin-4-yl)-4H-1,2,4-triazol-3-yl]ethyl]benzamide | n/a | |
| 31 | P22734_76G | 76G | n/a | 129900122 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-(4-thieno[2,3-c]pyridin-2-ylbutyl)benzamide | n/a | |
| 32 | P22734_76S | 76S | n/a | 129900123 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-[2-(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)ethyl]benzamide | n/a | |
| 33 | P22734_76T | 76T | n/a | 129900124 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-[[3-[(1H-indazol-5-ylamino)methyl]phenyl]methyl]benzamide | n/a | |
| 34 | P22734_77G | 77G | n/a | 129900125 | n/a | N-[5-(6-aminopurin-9-yl)pentyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide | n/a | |
| 35 | P22734_77H | 77H | n/a | 129900126 | n/a | N-[5-(2-aminopurin-9-yl)pentyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide | n/a | |
| 36 | P22734_77K | 77K | n/a | 129900127 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-[(1-methylimidazol-4-yl)methyl]benzamide | n/a | |
| 37 | P22734_77L | 77L | n/a | 129900128 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-(2-hydroxyethyl)benzamide | n/a | |
| 38 | P22734_77M | 77M | n/a | 129900129 | n/a | N-[2-[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanylethyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide | n/a | |
| 39 | P22734_77N | 77N | n/a | 129900130 | n/a | N-[2-[2-(6-aminopurin-9-yl)ethoxy]ethyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide | n/a | |
| 40 | P22734_77P | 77P | n/a | 129900131;135567263; | n/a | N-[2-[[5-(4-fluorophenyl)-2,3-dihydroxybenzoyl]amino]ethyl]-6-hydroxypyrimidine-4-carboxamide | n/a | |
| 41 | P22734_77Q | 77Q | n/a | 129900132 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-(5-pyrrolo[3,2-c]pyridin-1-ylpentyl)benzamide | n/a | |
| 42 | P22734_77R | 77R | n/a | 129900133 | n/a | 5-(4-fluorophenyl)-2,3-dihydroxy-N-(5-imidazol-1-ylpentyl)benzamide | n/a | |
| 43 | P22734_77S | 77S | n/a | 129900134 | n/a | N-[2-(5-benzyl-1H-1,2,4-triazol-3-yl)ethyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide | n/a | |
| 44 | P22734_7JD | 7JD | n/a | 76900562;135567269; | n/a | 6-(4-fluorophenyl)-8-oxidanyl-3~{H}-quinazolin-4-one | n/a | |
| 45 | P22734_7JE | 7JE | n/a | 131801415 | n/a | 5-(4-fluorophenyl)-~{N}-[[3-[(~{R})-(1-methylindazol-5-yl)-oxidanyl-methyl]phenyl]methyl]-2,3-bis(oxidanyl)benzamide | n/a | |
| 46 | P22734_7JF | 7JF | n/a | 90257620;135567264; | n/a | 7-fluoranyl-5,6-bis(4-fluorophenyl)-8-oxidanyl-3~{H}-quinazolin-4-one | n/a | |
| 47 | P22734_7JG | 7JG | n/a | 76072921;135567265; | n/a | 5,6-bis(4-fluorophenyl)-8-oxidanyl-3~{H}-quinazolin-4-one | n/a | |
| 48 | P22734_7JH | 7JH | n/a | 90258502;135567266; | n/a | 6-(2,4-dimethyl-1,3-thiazol-5-yl)-8-oxidanyl-3~{H}-quinazolin-4-one | n/a | |
| 49 | P22734_7JJ | 7JJ | n/a | 90257713;135567267; | n/a | 5-chloranyl-6-(4-fluorophenyl)-8-oxidanyl-3~{H}-quinazolin-4-one | n/a | |
| 50 | P22734_7JK | 7JK | n/a | 90258644;135567268; | n/a | 6-[3-methyl-5-(4-methylpiperazin-1-yl)carbonyl-thiophen-2-yl]-8-oxidanyl-3~{H}-quinazolin-4-one | n/a | |
| 51 | P22734_7JL | 7JL | n/a | 90257861;135567270; | n/a | 6-bromanyl-8-oxidanyl-3~{H}-quinazolin-4-one | n/a | |
| 52 | P22734_7JM | 7JM | n/a | 90257776;135567271; | n/a | 6-(2-methylpyridin-3-yl)-8-oxidanyl-3~{H}-quinazolin-4-one | n/a | |
| 53 | P22734_7JN | 7JN | n/a | 131801417 | n/a | 4'-fluoro-4,5-dihydroxy-N-{[(1R,2R)-2-{(2S,4R,5R)-4-hydroxy-5-[6-(methylamino)-9H-purin-9-yl]oxolan-2-yl}cyclopropyl]methyl}[1,1'-biphenyl]-3-carboxamide | n/a | |
| 54 | P22734_7JO | 7JO | n/a | 131801418 | n/a | N-[1-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]propan-2-yl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide | n/a | |
| 55 | P22734_7JP | 7JP | n/a | 131801419 | n/a | 6-(4-fluorophenyl)-8-oxidanyl-3-(5-pyrrolo[3,2-c]pyridin-1-ylpentyl)quinazolin-4-one | n/a | |
| 56 | P22734_7JQ | 7JQ | n/a | 131801420 | n/a | 6-(4-fluorophenyl)quinazolin-8-ol | n/a | |
| 57 | P22734_7JR | 7JR | n/a | 131801421 | n/a | 1-methyl-3-oxidanyl-5-phenyl-pyridin-2-one | n/a | |
| 58 | P22734_7JS | 7JS | n/a | 131801423 | n/a | 6-(4-fluorophenyl)quinolin-8-ol | n/a | |
| 59 | P22734_7JU | 7JU | n/a | 90258104;135567272; | n/a | 7-fluoranyl-6-(4-fluorophenyl)-8-oxidanyl-3~{H}-quinazolin-4-one | n/a | |
| 60 | P22734_7JV | 7JV | n/a | 76903203;135567273; | n/a | 6-[2-(methoxymethyl)phenyl]-8-oxidanyl-1~{H}-quinazolin-4-one | n/a | |
| 61 | P22734_7JW | 7JW | n/a | 135567274 | n/a | 7-(4-fluorophenyl)quinoxalin-5-ol | n/a | |
| 62 | P22734_7JX | 7JX | n/a | 384175 | CHEMBL2006044 | 6-bromanyl-3-chloranyl-quinolin-8-ol | n/a | |
| 63 | P22734_8JE | 8JE | n/a | 131801416 | n/a | 5-(4-fluorophenyl)-~{N}-[[3-[(~{S})-(1-methylindazol-5-yl)-oxidanyl-methyl]phenyl]methyl]-2,3-bis(oxidanyl)benzamide | n/a | |
| 64 | P22734_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 65 | P22734_BIA | BIA | DB03336 | 4369285 | CHEMBL387347 | 1-(3,4,DIHYDROXY-5-NITROPHENYL)-3-{4-[3-(TRIFLUOROMETHYL) PHENYL] PIPERAZIN-1-YL}PROPAN-1-ONE | n/a | |
| 66 | P22734_BIE | BIE | DB07462 | 6914595 | n/a | (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE | n/a | |
| 67 | P22734_BR | BR | n/a | 259 | n/a | BROMIDE ION | n/a | |
| 68 | P22734_BTB | BTB | n/a | 81462 | n/a | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | n/a | |
| 69 | P22734_BU3 | BU3 | n/a | 225936 | n/a | (R,R)-2,3-BUTANEDIOL | n/a | |
| 70 | P22734_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 71 | P22734_CL4 | CL4 | DB03907 | 4369234 | n/a | N-{3-[5-(6-AMINO-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDRO-FURAN-2-YL]-ALLYL}-2,3-DIHYDROXY-5-NITRO-BENZAMIDE | n/a | |
| 72 | P22734_CXS | CXS | DB02219 | 70815;12546061; | n/a | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID | n/a | |
| 73 | P22734_D1D | D1D | DB02693 | 445528 | n/a | (4S,5S)-1,2-DITHIANE-4,5-DIOL | n/a | |
| 74 | P22734_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 75 | P22734_DNC | DNC | DB02105 | 3870203 | CHEMBL168276 | 3,5-DINITROCATECHOL | n/a | IC50(nM) = 12.0 |
| 76 | P22734_DNI | DNI | DB11632 | 135565903 | CHEMBL1089318 | Opicapone | n/a | |
| 77 | P22734_DTD | DTD | DB01822 | 439407 | n/a | DITHIANE DIOL | n/a | |
| 78 | P22734_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
| 79 | P22734_EAO | EAO | n/a | 5464105 | CHEMBL167055 | 3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,4-dione | n/a | |
| 80 | P22734_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 81 | P22734_FBN | FBN | n/a | 46870011 | n/a | 5'-deoxy-5'-[4-({[(2,3-dihydroxy-5-nitrophenyl)carbonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]adenosine | n/a | |
| 82 | P22734_FGQ | FGQ | n/a | 122441965 | CHEMBL4177089 | 7-fluoranyl-5-(4-methylphenyl)sulfonyl-quinolin-8-ol | n/a | |
| 83 | P22734_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 84 | P22734_IPA | IPA | DB02325 | 3776 | CHEMBL582 | ISOPROPYL ALCOHOL | n/a | |
| 85 | P22734_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 86 | P22734_KOM | KOM | DB08049 | 5413034 | CHEMBL1233867 | 7,8-dihydroxy-4-phenyl-2H-chromen-2-one | n/a | |
| 87 | P22734_LU1 | LU1 | n/a | 56593140 | n/a | 4'-fluoro-4,5-dihydroxy-N-{(2E)-3-[(2S,4R,5R)-4-hydroxy-5-(6-methyl-9H-purin-9-yl)tetrahydrofuran-2-yl]prop-2-en-1-yl}biphenyl-3-carboxamide | n/a | |
| 88 | P22734_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 89 | P22734_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 90 | P22734_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 91 | P22734_NHE | NHE | DB03309 | 66898;3852474; | n/a | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | n/a | |
| 92 | P22734_O01 | O01 | n/a | 121595996 | n/a | [5-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methanamine | n/a | |
| 93 | P22734_OZR | OZR | n/a | 50919275 | n/a | N-[(E)-3-[(2R,3S,4S)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitro-benzamide | n/a | |
| 94 | P22734_OZS | OZS | n/a | 50919276 | n/a | N-[(E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(trifluoromethyl)imidazol-1-yl]oxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitro-benzamide | n/a | |
| 95 | P22734_OZZ | OZZ | n/a | 50919277 | n/a | N-[(E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxopyridin-1-yl)oxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitro-benzamide | n/a | |
| 96 | P22734_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 97 | P22734_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 98 | P22734_SAH | SAH | DB01752 | 439155;25246222; | CHEMBL418052 | S-ADENOSYL-L-HOMOCYSTEINE | n/a | |
| 99 | P22734_SAM | SAM | DB00118 | n/a | CHEMBL1235831 | S-ADENOSYLMETHIONINE | n/a | |
| 100 | P22734_SFG | SFG | DB01910 | 65482 | CHEMBL1214186 | SINEFUNGIN | n/a | |
| 101 | P22734_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 102 | P22734_TCW | TCW | DB00323 | 4659569 | CHEMBL1324 | Tolcapone | n/a | IC50(nM) = 0.91 |
| 103 | P22734_TLA | TLA | DB09459 | 444305 | CHEMBL1236315 | L(+)-TARTARIC ACID | n/a |