Gene name: MMP8
Protein name: Neutrophil collagenase (EC
List of molecules and drugs that interact with protein P22894
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P22894_01S | 01S | n/a | 5496618 | CHEMBL2372437 | N-[(2R)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-alanylglycinamide | n/a | |
| 2 | P22894_0D3 | 0D3 | n/a | 5496617 | CHEMBL2372446 | N-[(2S)-2-benzyl-3-sulfanylpropanoyl]-L-alanylglycinamide | n/a | |
| 3 | P22894_0DY | 0DY | n/a | 5288566 | n/a | N~1~-(3-aminobenzyl)-N~2~-[(2R)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-aspartamide | n/a | |
| 4 | P22894_0ZB | 0ZB | n/a | 5288567 | n/a | N-benzyl-N~2~-[(2R)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-alpha-asparagine | n/a | |
| 5 | P22894_2NI | 2NI | DB06971 | 5326979 | CHEMBL200435 | N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA | n/a | IC50(nM) = 1200000.0 |
| 6 | P22894_5XT | 5XT | n/a | 122198467 | n/a | ~{N}-[3,4-bis(oxidanyl)phenyl]-4-phenyl-benzenesulfonamide | n/a | |
| 7 | P22894_7FY | 7FY | n/a | 137348612 | n/a | ~{N}-[4,5-bis(oxidanylidene)cyclohexen-1-yl]-4-phenyl-benzenesulfonamide | n/a | |
| 8 | P22894_AXA | AXA | DB07397 | 25174099 | n/a | (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide | n/a | |
| 9 | P22894_AXB | AXB | n/a | 25144971 | CHEMBL460725 | N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl}-4-oxo-3,5,6,8-tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidine-2-carboxamide 7,7-dioxide | n/a | |
| 10 | P22894_BAT | BAT | DB03880 | 5362422 | CHEMBL279786 | 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE | n/a | IC50(nM) = 700.0 |
| 11 | P22894_BBT | BBT | DB03622 | 446505 | CHEMBL1231240 | 2-HYDROXY-5-[4-(2-HYDROXY-ETHYL)-PIPERIDIN-1-YL]-5-PHENYL-1H-PYRIMIDINE-4,6-DIONE | n/a | IC50(nM) = 1700.0 |
| 12 | P22894_BSI | BSI | DB03207 | 444698 | n/a | 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID | n/a | |
| 13 | P22894_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 14 | P22894_E1S | E1S | n/a | 57336492 | n/a | N~2~-{3-[4-(5-methylthiophen-2-yl)phenyl]propanoyl}-L-alpha-glutamine | n/a | |
| 15 | P22894_EIN | EIN | DB07713 | 6540261 | CHEMBL382201 | (1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID | n/a | |
| 16 | P22894_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 17 | P22894_FIN | FIN | DB07772 | 6852147 | CHEMBL202932 | (1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID | n/a | Ki(nM) = 700.0 IC50(nM) = 810.0 |
| 18 | P22894_HAE | HAE | DB00551 | 1990 | CHEMBL734 | ACETOHYDROXAMIC ACID | n/a | |
| 19 | P22894_HLE | HLE | DB07900 | 5288561 | n/a | 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE | n/a | |
| 20 | P22894_JST | JST | DB08028 | 4636204;135521746; | n/a | BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE | n/a | |
| 21 | P22894_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 22 | P22894_PLH | PLH | DB08403 | 194777 | CHEMBL11306 | METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID | inhibitor | Ki(nM) = 1.0 IC50(nM) = 0.046 |
| 23 | P22894_QZK | QZK | n/a | 53361485 | CHEMBL3291009 | {[(biphenyl-4-ylsulfonyl)amino]methanediyl}bis(phosphonic acid) | n/a | |
| 24 | P22894_RIN | RIN | DB08476 | 446676 | n/a | 3-AMINO-AZACYCLOTRIDECAN-2-ONE | inhibitor | |
| 25 | P22894_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 26 | P22894_097 | 097 | DB00786 | 119031 | CHEMBL279785 | Marimastat | inhibitor | IC50(nM) = 0.47 |
| 27 | P22894_DB02326 | n/a | DB02326 | n/a | n/a | 1-Hydroxyamine-2-Isobutylmalonic Acid | inhibitor | |
| 28 | P22894_DB02953 | n/a | DB02953 | n/a | n/a | 2-Thiomethyl-3-Phenylpropanoic Acid | inhibitor | |
| 29 | P22894_GM1 | GM1 | DB03636 | 69020 | CHEMBL86954 | Glycinamide | inhibitor |