Gene name: JAK1
Protein name: Tyrosine-protein kinase JAK1
List of molecules and drugs that interact with protein P23458
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P23458_0NH | 0NH | n/a | 56973424 | CHEMBL2152409 | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | n/a | |
| 2 | P23458_0NL | 0NL | n/a | 53341503 | CHEMBL2152296 | tert-butyl [(1R,3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclopentyl]carbamate | n/a | |
| 3 | P23458_0NT | 0NT | n/a | 53341544 | CHEMBL2152405 | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl][(2S)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | n/a | |
| 4 | P23458_0Q2 | 0Q2 | n/a | 137347881 | n/a | (1R,3R)-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(8H)-yl)cyclohexanol | n/a | |
| 5 | P23458_0UJ | 0UJ | n/a | 66557868 | CHEMBL2206059 | N-({1-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}methyl)methanesulfonamide | n/a | |
| 6 | P23458_15T | 15T | n/a | n/a | CHEMBL2386636 | 3-(trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexyl)propanenitrile | n/a | |
| 7 | P23458_1J5 | 1J5 | n/a | n/a | CHEMBL2386633 | trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile | n/a | |
| 8 | P23458_1J6 | 1J6 | n/a | n/a | CHEMBL2386635 | (trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexyl)acetonitrile | n/a | |
| 9 | P23458_1Q3 | 1Q3 | n/a | 137347978 | n/a | (1R,2S)-2-{[8-oxo-2-(1H-pyrazol-4-yl)-5,8-dihydropyrido[3,4-d]pyrimidin-4-yl]amino}cyclopentanecarbonitrile | n/a | |
| 10 | P23458_1Q4 | 1Q4 | n/a | 71737832 | CHEMBL2434989 | 4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-8(7H)-one | n/a | |
| 11 | P23458_5JG | 5JG | n/a | 92045136 | CHEMBL3746463 | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-amine | n/a | |
| 12 | P23458_66P | 66P | n/a | n/a | CHEMBL3780091 | 4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one | n/a | |
| 13 | P23458_6TE | 6TE | n/a | n/a | CHEMBL4100431 | ~{N}-[3-[methyl(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | n/a | |
| 14 | P23458_9T6 | 9T6 | n/a | n/a | n/a | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide | n/a | |
| 15 | P23458_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 16 | P23458_B7V | B7V | n/a | 131839645 | CHEMBL4071005 | 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3R,4S)-4-cyanooxan-3-yl]-1H-pyrazole-4-carboxamide | n/a | |
| 17 | P23458_BFK | BFK | n/a | 134817793 | CHEMBL4171692 | [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol | n/a | |
| 18 | P23458_C5I | C5I | n/a | n/a | CHEMBL2392500 | 3-oxo-3-[(3R)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6H)-yl)piperidin-1-yl]propanenitrile | n/a | |
| 19 | P23458_CIT | CIT | DB04272 | 311;19782904;88113319; | CHEMBL1261 | CITRIC ACID | n/a | |
| 20 | P23458_D7D | D7D | DB14973 | n/a | CHEMBL3655081 | N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | inhibitor | |
| 21 | P23458_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 22 | P23458_EYQ | EYQ | n/a | 138376574 | CHEMBL4588587 | ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | n/a | |
| 23 | P23458_G4J | G4J | DB15003 | 118878093 | CHEMBL4297477 | [(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | inhibitor | |
| 24 | P23458_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 25 | P23458_GYQ | GYQ | n/a | n/a | n/a | 2-[4-[8-oxidanylidene-2-[(~{E})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{H}-purin-9-yl]cyclohexyl]ethanenitrile | n/a | |
| 26 | P23458_JAK | JAK | n/a | 57339437 | CHEMBL2159141 | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | n/a | |
| 27 | P23458_KEJ | KEJ | n/a | 49856845 | CHEMBL2178801 | N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 28 | P23458_KEP | KEP | n/a | 66847152 | CHEMBL4777342 | N-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 29 | P23458_KES | KES | n/a | 118522410 | CHEMBL4744172 | N-{5-[5-chloro-2-(difluoromethoxy)phenyl]-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 30 | P23458_KEV | KEV | n/a | 137797031 | CHEMBL4781423 | N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-2-methyl-2H-pyrazolo[4,3-c]pyridine-7-carboxamide | n/a | |
| 31 | P23458_KEY | KEY | n/a | 137797032 | CHEMBL4788474 | N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-1H-pyrazolo[4,3-c]pyridine-7-carboxamide | n/a | |
| 32 | P23458_KF1 | KF1 | n/a | 137797033 | CHEMBL4742382 | N-[5-(3-methoxynaphthalen-2-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 33 | P23458_KF4 | KF4 | n/a | 138753291 | CHEMBL4755725 | N-[5-(6-methoxy-1H-indazol-5-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 34 | P23458_KGZ | KGZ | n/a | 146673491 | n/a | 1-[(3~{R},4~{R})-4-(cyanomethyl)-1-[[4-(cyclohexen-1-yl)phenyl]methyl]-3-fluoranyl-piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | n/a | |
| 35 | P23458_KH5 | KH5 | n/a | 132088493 | n/a | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | n/a | |
| 36 | P23458_KH8 | KH8 | n/a | 132088394 | n/a | 1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | n/a | |
| 37 | P23458_KHE | KHE | n/a | 132088378 | n/a | 1-[(3~{R},4~{R})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | n/a | |
| 38 | P23458_KHH | KHH | n/a | 146673492 | n/a | methyl ~{N}-[4-aminocarbonyl-1-[(3~{R},4~{R})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate | n/a | |
| 39 | P23458_LKQ | LKQ | n/a | 146025986 | CHEMBL4441479 | ~{N}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{H}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | n/a | |
| 40 | P23458_LKT | LKT | n/a | 59589095 | n/a | 2-chloranyl-6-[(3~{S})-3-[(1~{S})-2-cyano-1-[4-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | n/a | |
| 41 | P23458_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 42 | P23458_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 43 | P23458_NTQ | NTQ | n/a | n/a | CHEMBL4639973 | (1~{S})-2,2-bis(fluoranyl)-~{N}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide | n/a | |
| 44 | P23458_NTW | NTW | n/a | n/a | CHEMBL4645814 | 2-[4-(3-methyl-6-oxidanylidene-1,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]ethanenitrile | n/a | |
| 45 | P23458_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 46 | P23458_R4S | R4S | n/a | 146018275 | CHEMBL4640981 | N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide | n/a | |
| 47 | P23458_MYC | MYC | DB02375 | 5281672 | CHEMBL164 | Myricetin | n/a | |
| 48 | P23458_IZA | IZA | DB04716 | 5494425 | CHEMBL21156 | 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one | n/a | IC50(nM) = 4.0 |
| 49 | P23458_RXT | RXT | DB08877 | 25126798 | CHEMBL1789941 | Ruxolitinib | inhibitor | Ki(nM) = 0.09 IC50(nM) = 0.09 Kd(nM) = 3.4 EC50(nM) = 24.0 |
| 50 | P23458_MI1 | MI1 | DB08895 | 9926791 | CHEMBL221959 | Tofacitinib | inhibitor | |
| 51 | P23458_3JW | 3JW | DB11817 | 44205240 | CHEMBL2105759 | Baricitinib | inhibitor | |
| 52 | P23458_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 53 | P23458_2TA | 2TA | DB12500 | 16722836 | CHEMBL1287853 | Fedratinib | inhibitor | |
| 54 | P23458_2HB | 2HB | DB14845 | 49831257 | CHEMBL3301607 | Filgotinib | inhibitor | |
| 55 | P23458_DB15091 | n/a | DB15091 | n/a | n/a | Upadacitinib | inhibitor | |
| 56 | P23458_Q4J | Q4J | DB15822 | n/a | CHEMBL4297597 | Pralsetinib | inhibitor | |
| 57 | P23458_DB16756 | n/a | DB16756 | n/a | n/a | Ivarmacitinib | inhibitor |