Gene name: SLC6A2
Protein name: Sodium-dependent noradrenaline transporter
List of molecules and drugs that interact with protein P23975
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P23975_DB00182 | n/a | DB00182 | n/a | n/a | Amphetamine | agonist | Ki(nM) = 7.1 |
| 2 | P23975_DB00191 | n/a | DB00191 | n/a | n/a | Phentermine | inhibitor | |
| 3 | P23975_DB00193 | n/a | DB00193 | n/a | n/a | Tramadol | inhibitor | IC50(nM) = 790.0 |
| 4 | P23975_DB00226 | n/a | DB00226 | n/a | n/a | Guanadrel | partial agonist | |
| 5 | P23975_41X | 41X | DB00234 | 127151 | CHEMBL383921 | Reboxetine | inhibitor | Ki(nM) = 0.3 IC50(nM) = 2.0 |
| 6 | P23975_CXQ | CXQ | DB00245 | n/a | CHEMBL1201203 | Benzatropine | inhibitor | |
| 7 | P23975_DB00285 | n/a | DB00285 | n/a | n/a | Venlafaxine | inhibitor | Ki(nM) = 210.0 IC50(nM) = 149.0 Kd(nM) = 1060.0 |
| 8 | P23975_DB00289 | n/a | DB00289 | n/a | n/a | Atomoxetine | inhibitor | IC50(nM) = 3.0 Kd(nM) = 2.0 |
| 9 | P23975_TP0 | TP0 | DB00321 | 2160 | CHEMBL629 | Amitriptyline | inhibitor | Ki(nM) = 13.3 |
| 10 | P23975_DB00344 | n/a | DB00344 | n/a | n/a | Protriptyline | inhibitor | Ki(nM) = 1.41 IC50(nM) = 1.7 Kd(nM) = 1.4 |
| 11 | P23975_DB00408 | n/a | DB00408 | n/a | n/a | Loxapine | binder | |
| 12 | P23975_DB00422 | n/a | DB00422 | n/a | n/a | Methylphenidate | inhibitor | Ki(nM) = 340.0 IC50(nM) = 61.0 |
| 13 | P23975_DB00454 | n/a | DB00454 | n/a | n/a | Meperidine | inhibitor | |
| 14 | P23975_IXX | IXX | DB00458 | 3696 | CHEMBL11 | Imipramine | inhibitor | Ki(nM) = 16.0 IC50(nM) = 74.0 |
| 15 | P23975_29E | 29E | DB00476 | 60835 | CHEMBL1175 | Duloxetine | inhibitor | Ki(nM) = 4.6 IC50(nM) = 1.6 |
| 16 | P23975_DB00514 | n/a | DB00514 | n/a | n/a | Dextromethorphan | inhibitor | |
| 17 | P23975_21B | 21B | DB00540 | 4543 | CHEMBL445 | Nortriptyline | inhibitor | Ki(nM) = 1.49 |
| 18 | P23975_DB00543 | n/a | DB00543 | n/a | n/a | Amoxapine | inhibitor | Ki(nM) = 16.0 |
| 19 | P23975_DB00579 | n/a | DB00579 | n/a | n/a | Mazindol | inhibitor | Ki(nM) = 0.46 IC50(nM) = 0.92 |
| 20 | P23975_8PR | 8PR | DB00715 | 43815 | CHEMBL490 | Paroxetine | inhibitor | Ki(nM) = 40.0 IC50(nM) = 100.0 Kd(nM) = 40.0 |
| 21 | P23975_DB00726 | n/a | DB00726 | n/a | n/a | Trimipramine | inhibitor | Ki(nM) = 2450.0 |
| 22 | P23975_DB00830 | n/a | DB00830 | n/a | n/a | Phenmetrazine | inhibitor | |
| 23 | P23975_DB00852 | n/a | DB00852 | n/a | n/a | Pseudoephedrine | inhibitor | |
| 24 | P23975_COC | COC | DB00907 | 446220 | CHEMBL370805 | Cocaine | inhibitor | Ki(nM) = 108.0 IC50(nM) = 186.0 EC50(nM) = 385.0 |
| 25 | P23975_DB00924 | n/a | DB00924 | n/a | n/a | Cyclobenzaprine | inhibitor | |
| 26 | P23975_DB00934 | n/a | DB00934 | n/a | n/a | Maprotiline | inhibitor | |
| 27 | P23975_DB00937 | n/a | DB00937 | n/a | n/a | Diethylpropion | inhibitor | |
| 28 | P23975_LDP | LDP | DB00988 | 681 | CHEMBL59 | Dopamine | inhibitor | Ki(nM) = 323.0 IC50(nM) = 6.6 |
| 29 | P23975_SRE | SRE | DB01104 | 68617 | CHEMBL809 | Sertraline | inhibitor | IC50(nM) = 825.0 Kd(nM) = 420.0 |
| 30 | P23975_DB01105 | n/a | DB01105 | n/a | n/a | Sibutramine | inhibitor | |
| 31 | P23975_DB01114 | n/a | DB01114 | n/a | n/a | Chlorpheniramine | inhibitor | |
| 32 | P23975_DB01142 | no_lig_id | DB01142 | n/a | n/a | Doxepin | inhibitor | |
| 33 | P23975_DB01149 | n/a | DB01149 | n/a | n/a | Nefazodone | inhibitor | Ki(nM) = 360.0 Kd(nM) = 360.0 |
| 34 | P23975_DSM | DSM | DB01151 | 2995 | CHEMBL72 | Desipramine | inhibitor | Ki(nM) = 0.49 IC50(nM) = 0.93 Kd(nM) = 0.83 |
| 35 | P23975_DB01156 | n/a | DB01156 | n/a | n/a | Bupropion | inhibitor | Ki(nM) = 3642.0 IC50(nM) = 443.0 |
| 36 | P23975_DB01170 | n/a | DB01170 | n/a | n/a | Guanethidine | inducer | |
| 37 | P23975_DB01173 | n/a | DB01173 | n/a | n/a | Orphenadrine | inhibitor | |
| 38 | P23975_68P | 68P | DB01175 | 146570 | CHEMBL1508 | Escitalopram | inhibitor | |
| 39 | P23975_DB01221 | n/a | DB01221 | n/a | n/a | Ketamine | inhibitor | |
| 40 | P23975_CXX | CXX | DB01242 | 2801 | CHEMBL415 | Clomipramine | inhibitor | Ki(nM) = 38.0 IC50(nM) = 65.0 |
| 41 | P23975_DB01364 | n/a | DB01364 | n/a | n/a | Ephedrine | inverse agonist | |
| 42 | P23975_DB01442 | n/a | DB01442 | n/a | n/a | MMDA | negative modulator | |
| 43 | P23975_DB01454 | n/a | DB01454 | n/a | n/a | Midomafetamine | negative modulator | Ki(nM) = 10000.0 IC50(nM) = 405.0 EC50(nM) = 1000.0 |
| 44 | P23975_1WE | 1WE | DB01576 | 5826 | CHEMBL612 | Dextroamphetamine | negative modulator | EC50(nM) = 7.1 |
| 45 | P23975_B40 | B40 | DB01577 | 10836 | CHEMBL1201201 | Metamfetamine | negative modulator | |
| 46 | P23975_DB01579 | n/a | DB01579 | n/a | n/a | Phendimetrazine | negative modulator | |
| 47 | P23975_DB04821 | n/a | DB04821 | n/a | n/a | Nomifensine | n/a | Ki(nM) = 3.8 |
| 48 | P23975_DB04836 | n/a | DB04836 | n/a | n/a | Amineptine | n/a | |
| 49 | P23975_DB04840 | n/a | DB04840 | n/a | n/a | Debrisoquine | inducer | |
| 50 | P23975_DB04889 | n/a | DB04889 | n/a | n/a | Bicifadine | modulator | IC50(nM) = 55.0 |
| 51 | P23975_DB04896 | n/a | DB04896 | n/a | n/a | Milnacipran | inhibitor | Ki(nM) = 22.0 IC50(nM) = 5500.0 |
| 52 | P23975_DB05642 | n/a | DB05642 | n/a | n/a | DDP-225 | n/a | |
| 53 | P23975_DB05964 | n/a | DB05964 | n/a | n/a | Amitifadine | inhibitor | |
| 54 | P23975_DB06148 | n/a | DB06148 | n/a | n/a | Mianserin | inhibitor | |
| 55 | P23975_DB06156 | n/a | DB06156 | n/a | n/a | Tesofensine | n/a | |
| 56 | P23975_DB06204 | n/a | DB06204 | n/a | n/a | Tapentadol | inhibitor | |
| 57 | P23975_DB06333 | n/a | DB06333 | n/a | n/a | Trodusquemine | n/a | |
| 58 | P23975_DB06700 | n/a | DB06700 | n/a | n/a | Desvenlafaxine | inhibitor | Ki(nM) = 531.3 IC50(nM) = 538.0 |
| 59 | P23975_DB06701 | n/a | DB06701 | n/a | n/a | Dexmethylphenidate | inhibitor | |
| 60 | P23975_DB08918 | n/a | DB08918 | n/a | n/a | Levomilnacipran | inhibitor | IC50(nM) = 11.0 |
| 61 | P23975_DB09068 | n/a | DB09068 | n/a | n/a | Vortioxetine | blocker | |
| 62 | P23975_DB09167 | n/a | DB09167 | n/a | n/a | Dosulepin | inhibitor | |
| 63 | P23975_DB09185 | n/a | DB09185 | n/a | n/a | Viloxazine | inhibitor | Ki(nM) = 155.0 Kd(nM) = 155.0 |
| 64 | P23975_ZOT | ZOT | DB09225 | 5736 | CHEMBL285802 | Zotepine | antagonist | |
| 65 | P23975_DB12305 | n/a | DB12305 | n/a | n/a | Dasotraline | inhibitor | |
| 66 | P23975_DB13931 | n/a | DB13931 | n/a | n/a | Netarsudil | inhibitor | |
| 67 | P23975_DB14754 | n/a | DB14754 | n/a | n/a | Solriamfetol | n/a | |
| 68 | P23975_DB16629 | n/a | DB16629 | n/a | n/a | Serdexmethylphenidate | inhibitor |