Gene name: EDNRA
Protein name: Endothelin-1 receptor (Endothelin
List of molecules and drugs that interact with protein P25101
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P25101_K86 | K86 | DB00559 | 104865 | CHEMBL957 | Bosentan | antagonist | Ki(nM) = 6.5 IC50(nM) = 4.7 |
| 2 | P25101_AIN | AIN | DB00945 | 2244 | CHEMBL25 | Acetylsalicylic acid | inhibitor | |
| 3 | P25101_DIU | DIU | DB04674 | 8631 | CHEMBL1232243 | 2-HYDROXY-3,5-DIIODOBENZOIC ACID | inhibitor | |
| 4 | P25101_DB04883 | n/a | DB04883 | n/a | n/a | Darusentan | antagonist | Ki(nM) = 6.0 IC50(nM) = 0.8 |
| 5 | P25101_DB06199 | n/a | DB06199 | n/a | n/a | Atrasentan | antagonist | |
| 6 | P25101_DB06268 | n/a | DB06268 | n/a | n/a | Sitaxentan | antagonist | Ki(nM) = 0.43 IC50(nM) = 1.4 |
| 7 | P25101_DB06403 | n/a | DB06403 | n/a | n/a | Ambrisentan | antagonist | |
| 8 | P25101_DB06460 | n/a | DB06460 | n/a | n/a | Enrasentan | modulator | |
| 9 | P25101_DB06558 | n/a | DB06558 | n/a | n/a | Tezosentan | n/a | |
| 10 | P25101_DB06677 | n/a | DB06677 | n/a | n/a | Clazosentan | antagonist | |
| 11 | P25101_DB08932 | n/a | DB08932 | n/a | n/a | Macitentan | antagonist | IC50(nM) = 0.5 |
| 12 | P25101_DB12548 | n/a | DB12548 | n/a | n/a | Sparsentan | antagonist |