Gene name: DPP4
Protein name: Dipeptidyl peptidase 4
List of molecules and drugs that interact with protein P27487
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P27487_01T | 01T | n/a | 11996845;72200279; | CHEMBL1614722 | [5-(aminomethyl)-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid | n/a | |
| 2 | P27487_0WG | 0WG | n/a | 11632502 | CHEMBL2159182 | 7-amino-6-(aminomethyl)-5-(2-bromophenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione | n/a | |
| 3 | P27487_10T | 10T | n/a | 11220682;72200281; | CHEMBL1614729 | 5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carboxic acid | n/a | |
| 4 | P27487_13Z | 13Z | n/a | 44629524 | CHEMBL1229644 | 2-[(2-{(2S,4S)-2-[(R)-(5-tert-butyl-1,3,4-oxadiazol-2-yl)(hydroxy)methyl]-4-fluoropyrrolidin-1-yl}-2-oxoethyl)amino]-2-methylpropan-1-ol | n/a | |
| 5 | P27487_1MD | 1MD | n/a | 15950755 | CHEMBL2441952 | 2-[3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-N,N-dimethylacetamide | n/a | |
| 6 | P27487_1WH | 1WH | n/a | 15950463 | CHEMBL2441836 | 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one | n/a | |
| 7 | P27487_23Q | 23Q | n/a | 46216692 | CHEMBL1229820 | (2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine | n/a | |
| 8 | P27487_277 | 277 | DB06939 | n/a | CHEMBL1229855 | N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDE | n/a | |
| 9 | P27487_2KS | 2KS | n/a | n/a | CHEMBL3112961 | 1-(cis-1-phenyl-4-{[(2E)-3-phenylprop-2-en-1-yl]oxy}cyclohexyl)methanamine | n/a | |
| 10 | P27487_2KV | 2KV | n/a | n/a | CHEMBL3112966 | 1-[cis-4-(aminomethyl)-4-(3-chlorophenyl)cyclohexyl]piperidin-2-one | n/a | |
| 11 | P27487_2VH | 2VH | n/a | 46209242 | n/a | (2R,3S,5R)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine | n/a | |
| 12 | P27487_315 | 315 | DB06993 | 60206636 | n/a | (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine | n/a | |
| 13 | P27487_317 | 317 | DB06994 | 24768547 | CHEMBL1185242 | (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine | n/a | IC50(nM) = 0.21 |
| 14 | P27487_34Q | 34Q | DB07015 | 24752844 | CHEMBL1230044 | (3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine | n/a | |
| 15 | P27487_356 | 356 | DB08882 | 10096344 | CHEMBL237500 | 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione | inhibitor | IC50(nM) = 0.1 Kd(nM) = 0.0066 EC50(nM) = 3.1 |
| 16 | P27487_361 | 361 | DB07021 | 15953860 | CHEMBL1194345 | (7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amine | n/a | IC50(nM) = 8.3 EC50(nM) = 112.0 |
| 17 | P27487_417 | 417 | DB07072 | 11538992 | CHEMBL233360 | (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE | n/a | IC50(nM) = 21.0 |
| 18 | P27487_448 | 448 | DB07081 | 23661697 | CHEMBL250787 | (2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE | n/a | IC50(nM) = 25.0 |
| 19 | P27487_474 | 474 | DB07092 | n/a | CHEMBL437557 | (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE | n/a | IC50(nM) = 4.8 |
| 20 | P27487_524 | 524 | DB07135 | n/a | CHEMBL400841 | (2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOH EXYL)BUTANAMIDE | n/a | IC50(nM) = 2.3 |
| 21 | P27487_565 | 565 | DB07154 | 10450114 | CHEMBL385711 | (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE | n/a | IC50(nM) = 6.6 |
| 22 | P27487_5AP | 5AP | DB02004 | 448436 | CHEMBL34062 | 5-(AMINOMETHYL)-6-(2,4-DICHLOROPHENYL)-2-(3,5-DIMETHOXYPHENYL)PYRIMIDIN-4-AMINE | n/a | IC50(nM) = 0.1 |
| 23 | P27487_605 | 605 | DB07181 | 24832041 | CHEMBL452289 | 4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide | n/a | IC50(nM) = 32.0 |
| 24 | P27487_677 | 677 | DB07193 | 11710963 | CHEMBL1197118 | (2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine | n/a | |
| 25 | P27487_6AJ | 6AJ | n/a | 71203748 | CHEMBL3687984 | 2-({2-[(3R)-3-aminopiperidin-1-yl]-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl}methyl)-4-fluorobenzonitrile | n/a | |
| 26 | P27487_6DG | 6DG | n/a | 24951732 | CHEMBL3806216 | (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)oxan-3-amine | n/a | |
| 27 | P27487_6RL | 6RL | DB15323 | 15983988 | CHEMBL1650443 | 2-[[6-[(3~{R})-3-azanylpiperidin-1-yl]-3-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]methyl]-4-fluoranyl-benzenecarboni trile | inhibitor | |
| 28 | P27487_715 | 715 | DB01261 | 4369359 | CHEMBL1422 | (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE | inhibitor | Ki(nM) = 18.0 IC50(nM) = 0.87 Kd(nM) = 5.3 |
| 29 | P27487_75J | 75J | n/a | 122172856 | n/a | 2-({2-[(3R)-3-aminopiperidin-1-yl]-3-(but-2-yn-1-yl)-4-oxo-3,4-dihydro-5H-imidazo[2,1-b]purin-5-yl}methyl)benzonitrile | n/a | |
| 30 | P27487_75L | 75L | n/a | 122172854 | CHEMBL4557196 | 2-[(3R)-3-aminopiperidin-1-yl]-3-(but-2-yn-1-yl)-6-[(4-methylquinazolin-2-yl)methyl]-6,7,8,9-tetrahydropyrimido[2,1-b]purin-4(3H)-one | n/a | |
| 31 | P27487_75M | 75M | n/a | 122172855 | n/a | 4-({2-[(3R)-3-aminopiperidin-1-yl]-3-(but-2-yn-1-yl)-4-oxo-3,4-dihydro-5H-imidazo[2,1-b]purin-5-yl}methyl)benzonitrile | n/a | |
| 32 | P27487_75N | 75N | n/a | 137348565 | n/a | 2-[(3R)-3-aminopiperidin-1-yl]-3-(but-2-yn-1-yl)-5-[(4-methylquinazolin-2-yl)methyl]-3H-imidazo[2,1-b]purin-4(5H)-one | n/a | |
| 33 | P27487_7AC | 7AC | DB07239 | 11572962 | CHEMBL272114 | 7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile | n/a | IC50(nM) = 8.0 |
| 34 | P27487_872 | 872 | DB07271 | 10024590 | CHEMBL230910 | (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-(2,2,2-TRIFLUOROETHYL)-1,4-DIAZEPAN-2-ONE | n/a | IC50(nM) = 2.6 |
| 35 | P27487_8O3 | 8O3 | n/a | 137551959 | n/a | (R)-4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)piperazin-2-one | n/a | |
| 36 | P27487_8OL | 8OL | n/a | 25056009 | n/a | (S)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one | n/a | |
| 37 | P27487_8VU | 8VU | DB12625 | 25022354 | CHEMBL1779710 | (R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazine-2-one | inhibitor | |
| 38 | P27487_9EL | 9EL | n/a | 130391959 | CHEMBL4550812 | (2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile | n/a | |
| 39 | P27487_A3M | A3M | DB01884 | 447256 | CHEMBL383705 | 2-AMINO-3-METHYL-1-PYRROLIDIN-1-YL-BUTAN-1-ONE | inhibitor | Ki(nM) = 470.0 IC50(nM) = 3000.0 |
| 40 | P27487_AAF | AAF | DB07328 | 11840913 | CHEMBL1230763 | METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATE | n/a | |
| 41 | P27487_ACF | ACF | n/a | 11840914 | CHEMBL1230804 | 3-{[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHOXY}-4-CHLOROBENZOIC ACID | n/a | |
| 42 | P27487_ADF | ADF | n/a | n/a | CHEMBL1230826 | 4-{[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHOXY}-3-TERT-BUTYLBENZOIC ACID | n/a | |
| 43 | P27487_AJH | AJH | n/a | 25021195;44629730; | CHEMBL1186902 | 4-({4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl}carbonyl)benzoic acid | n/a | |
| 44 | P27487_AXD | AXD | n/a | 49866654 | n/a | 2-[4-({2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-2-OXOETHYL}AMINO)-4-METHYLPIPERIDIN-1-YL]ISONICOTINIC ACID | n/a | |
| 45 | P27487_AZV | AZV | n/a | 52946447 | CHEMBL1614845 | N-(4-{[({(2R)-3-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidin-2-yl}carbonyl)amino]methyl}phenyl)-D-valine | n/a | |
| 46 | P27487_B1Q | B1Q | DB12268 | 11417567 | CHEMBL591118 | (4S)-1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-(fluoromethyl)pyrrolidin-2-one | n/a | |
| 47 | P27487_B2Q | B2Q | n/a | 44543662 | n/a | (2S,3R,11bR)-3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine | n/a | |
| 48 | P27487_B2Y | B2Y | DB07412 | 263366 | CHEMBL257036 | 1-biphenyl-2-ylmethanamine | inhibitor | IC50(nM) = 30000.0 |
| 49 | P27487_BJM | BJM | DB07465 | n/a | n/a | (2~{S})-2-azanyl-1-[(1~{S},3~{S},5~{S})-3-(iminomethyl)-2-azabicyclo[3.1.0]hexan-2-yl]-2-[(5~{R},7~{S})-3-oxidanyl-1-ad amantyl]ethanone | n/a | |
| 50 | P27487_C8S | C8S | n/a | n/a | n/a | (2S)-2-amino-1-[(1S,3S,5S)-3-(aminomethyl)-2-azabicyclo[3.1.0]hexan-2-yl]-2-[(1r,3R,5S,7S)-3,5-dihydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-one | n/a | |
| 51 | P27487_CJP | CJP | n/a | 91623329 | n/a | 1-[2-(2,4-dichlorophenyl)-1-(methylsulfonyl)-1H-indol-3-yl]methanamine | n/a | |
| 52 | P27487_D1C | D1C | n/a | 70702292 | n/a | 4-[({[(2R)-2-amino-3-(2,4,5-trifluorophenyl)propyl]sulfamoyl}amino)methyl]benzenesulfonamide | n/a | |
| 53 | P27487_D3C | D3C | n/a | 72715987 | n/a | N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-6-(trifluoromethyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide | n/a | |
| 54 | P27487_D5C | D5C | n/a | 70702294 | n/a | N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-3'-(trifluoromethyl)biphenyl-4-carboxamide | n/a | |
| 55 | P27487_DC3 | DC3 | n/a | 70702293 | n/a | (2R)-4-[4-(3-methylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine | n/a | |
| 56 | P27487_DFP | DFP | DB04491 | 3072 | n/a | DIISOPROPYL PHOSPHONATE | inhibitor | |
| 57 | P27487_DLI | DLI | DB07666 | 16750059 | CHEMBL1232261 | (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE | n/a | Ki(nM) = 3.4 |
| 58 | P27487_FPB | FPB | DB07779 | 5494422 | CHEMBL425584 | N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE | n/a | IC50(nM) = 90.0 |
| 59 | P27487_FUC | FUC | DB04473 | 439554 | CHEMBL1232862 | alpha-L-fucopyranose | n/a | |
| 60 | P27487_GGO | GGO | DB07830 | 16040279 | CHEMBL225210 | (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE | n/a | Ki(nM) = 3.2 |
| 61 | P27487_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 62 | P27487_GVB | GVB | DB07851 | 24798721 | n/a | (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE | n/a | |
| 63 | P27487_HG | HG | n/a | 26623 | n/a | MERCURY (II) ION | n/a | |
| 64 | P27487_HL1 | HL1 | n/a | 126456388 | CHEMBL3941804 | (2~{S},3~{R})-8,9-dimethoxy-3-[2,4,5-tris(fluoranyl)phenyl]-2,3-dihydro-1~{H}-benzo[f]chromen-2-amine | n/a | |
| 65 | P27487_JNH | JNH | DB08024 | 5459374 | n/a | 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE | n/a | |
| 66 | P27487_KIQ | KIQ | DB08044 | 11974440 | n/a | (1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5-TRIFLUOROPHENYL)CYCLOHEX-3-EN-1-AMINE | inhibitor | |
| 67 | P27487_KR2 | KR2 | DB08051 | 16739331 | CHEMBL513425 | (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE | n/a | IC50(nM) = 70.0 |
| 68 | P27487_KXA | KXA | n/a | n/a | CHEMBL1909991 | 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)-2-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one | n/a | |
| 69 | P27487_KXB | KXB | n/a | 15950615 | CHEMBL1910114 | 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one | n/a | |
| 70 | P27487_LF7 | LF7 | n/a | n/a | n/a | 2-{[(1r,3s,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]amino}-1-{(2S)-2-[(E)-iminomethyl]pyrrolidin-1-yl}ethan-1-o ne | n/a | |
| 71 | P27487_LGE | LGE | n/a | 15950538 | CHEMBL1910111 | methyl [3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]acetate | n/a | |
| 72 | P27487_LUI | LUI | n/a | 10271081 | CHEMBL1851820 | 2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]oxy}acetamide | n/a | |
| 73 | P27487_M51 | M51 | DB11950 | 11949652 | CHEMBL2147777 | {(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-yl}(1,3-thiazolidin-3-yl)methanone | modulator | |
| 74 | P27487_MA9 | MA9 | DB08164 | 16058650 | CHEMBL1234200 | (3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINE | n/a | Ki(nM) = 4.0 |
| 75 | P27487_N7F | N7F | n/a | 23633348 | CHEMBL1951424 | 6-[(3S)-3-AMINOPIPERIDIN-1-YL]-5-BENZYL-4-OXO-3-(QUINOLIN-4-YLMETHYL)-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBONITRILE | n/a | |
| 76 | P27487_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 77 | P27487_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 78 | P27487_NXZ | NXZ | n/a | 56587939 | n/a | 1-[(3S,4S)-4-amino-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-yl]piperidin-2-one | n/a | |
| 79 | P27487_PF2 | PF2 | DB08382 | 11516136 | CHEMBL515387 | 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine | inhibitor | IC50(nM) = 11.0 |
| 80 | P27487_PS4 | PS4 | DB08429 | 42608447 | CHEMBL564249 | N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide | n/a | IC50(nM) = 0.38 |
| 81 | P27487_PZF | PZF | DB08445 | 24180585 | CHEMBL237786 | (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE | n/a | IC50(nM) = 37.0 |
| 82 | P27487_RUF | RUF | n/a | 979136 | CHEMBL1235760 | 7-(2-chlorobenzyl)-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione | n/a | |
| 83 | P27487_RUM | RUM | n/a | 11246214 | CHEMBL1235761 | 2-({2-[(3R)-3-aminopiperidin-1-yl]-5-bromo-6-oxopyrimidin-1(6H)-yl}methyl)benzonitrile | n/a | |
| 84 | P27487_S14 | S14 | DB08504 | 10320144 | CHEMBL237337 | 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM | n/a | Ki(nM) = 4.3 IC50(nM) = 4.0 |
| 85 | P27487_SKK | SKK | DB12417 | 44513473 | CHEMBL1929396 | N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide | modulator | |
| 86 | P27487_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 87 | P27487_U1N | U1N | DB08672 | 15991577 | CHEMBL218289 | 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE | n/a | IC50(nM) = 84.0 |
| 88 | P27487_W61 | W61 | n/a | 57525787 | CHEMBL2058971 | 1,3-thiazolidin-3-yl[(2S,4S)-4-{4-[2-(trifluoromethyl)quinolin-4-yl]piperazin-1-yl}pyrrolidin-2-yl]methanone | n/a | |
| 89 | P27487_W94 | W94 | n/a | 66545741 | CHEMBL2147710 | [(2S,4S)-4-{4-[1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]piperidin-1-yl}pyrrolidin-2-yl](1,3-thiazolidin-3-yl)methanone | n/a | |
| 90 | P27487_XIH | XIH | DB08743 | 6914643 | n/a | 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE | n/a | |
| 91 | P27487_SY1 | SY1 | DB08588 | 23647311 | CHEMBL227954 | 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE | n/a | IC50(nM) = 13.0 |
| 92 | P27487_T22 | T22 | DB06203 | 11450633 | CHEMBL376359 | 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile | inhibitor | IC50(nM) = 0.9 Kd(nM) = 2.4 |
| 93 | P27487_117 | 117 | DB01076 | 60823 | CHEMBL1487 | Atorvastatin | inhibitor | |
| 94 | P27487_P2Y | P2Y | DB03253 | 2734054 | n/a | (2s)-Pyrrolidin-2-Ylmethylamine | inhibitor | |
| 95 | P27487_PHI | PHI | DB03660 | 134497;6950455; | n/a | 4-Iodo-L-phenylalanine | inhibitor | |
| 96 | P27487_007 | 007 | DB04577 | 205131 | CHEMBL382127 | 1-(1-phenylcyclopentyl)methylamine | inhibitor | IC50(nM) = 33000.0 |
| 97 | P27487_008 | 008 | DB04578 | 5494385 | CHEMBL381806 | (S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | n/a | IC50(nM) = 23.0 |
| 98 | P27487_DB04876 | n/a | DB04876 | n/a | n/a | Vildagliptin | inhibitor | Ki(nM) = 3.0 IC50(nM) = 0.58 Kd(nM) = 2.4 |
| 99 | P27487_DB06011 | n/a | DB06011 | n/a | n/a | AMG-222 | n/a | |
| 100 | P27487_DB06127 | n/a | DB06127 | n/a | n/a | Bisegliptin | n/a | |
| 101 | P27487_DB06335 | n/a | DB06335 | n/a | n/a | Saxagliptin | inhibitor | Ki(nM) = 0.6 IC50(nM) = 0.6 Kd(nM) = 0.3 |
| 102 | P27487_1AD | 1AD | DB06880 | 11840904 | n/a | (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE | n/a | |
| 103 | P27487_3TP | 3TP | DB07067 | 23645698 | CHEMBL374936 | (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE | n/a | IC50(nM) = 122.0 |
| 104 | P27487_AIA | AIA | DB07356 | 11840917 | n/a | (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE | n/a | |
| 105 | P27487_BPR | BPR | DB07482 | 10198228 | CHEMBL63895 | (2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDE | n/a | Ki(nM) = 3.0 IC50(nM) = 1.1 |
| 106 | P27487_SC3 | SC3 | DB08530 | 4747355;4747357; | n/a | 7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONE | n/a | |
| 107 | P27487_DB11723 | n/a | DB11723 | n/a | n/a | Dutogliptin | inhibitor |