Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
P28223 5HT2A_HUMAN
Gene name: HTR2A
Protein name: 5-hydroxytryptamine receptor 2A

List of molecules and drugs that interact with protein P28223

# DrugDomain Data PBD ligand DrugBank Accession PubChem ChEMBL Name Drug action Affinity data
1 P28223_1PE 1PE n/a 62551 CHEMBL1229766 PENTAETHYLENE GLYCOL n/a
2 P28223_3IQ 3IQ n/a 164575847 n/a (3R)-3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridin-1-ium n/a
3 P28223_7LD 7LD DB04829 5761 CHEMBL263881 (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide inhibitor Ki(nM) = 0.89
Kd(nM) = 21.17
EC50(nM) = 5.2
4 P28223_7RU 7RU DB06016 n/a CHEMBL2028019 3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea antagonist Ki(nM) = 19.0
IC50(nM) = 191.0
5 P28223_89F 89F n/a 7059581 CHEMBL428892 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine n/a
6 P28223_8NU 8NU DB00734 5073 CHEMBL85 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one antagonist Ki(nM) = 0.14
IC50(nM) = 0.707946
7 P28223_91Q 91Q n/a 4980 CHEMBL65547 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol n/a
8 P28223_92S 92S DB06077 21302490 CHEMBL3306803 1-(4-fluorophenyl)-4-[(10~{R},15~{S})-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one antagonist
9 P28223_93F 93F n/a 162421364 n/a (10~{R},15~{S})-12-[3-(2-methoxyphenyl)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5(16),6,8-triene n/a
10 P28223_9SC 9SC DB01238 60795 CHEMBL1112 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one antagonist Ki(nM) = 0.8
IC50(nM) = 1100.0
11 P28223_A6L A6L DB13171 5283468 CHEMBL428593 2,3-dihydroxypropyl (9Z)-octadec-9-enoate n/a
12 P28223_CLR CLR DB04540 5997 CHEMBL112570 CHOLESTEROL n/a
13 P28223_H8G H8G DB00589 28864 CHEMBL157138 N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea agonist Ki(nM) = 5.4
IC50(nM) = 0.97
EC50(nM) = 343.0
14 P28223_MG MG n/a 888 n/a MAGNESIUM ION n/a
15 P28223_NDS NDS DB02618 5221296 CHEMBL1234674 ETHYL DIMETHYL AMMONIO PROPANE SULFONATE n/a
16 P28223_OLA OLA n/a 445639 CHEMBL8659 OLEIC ACID n/a
17 P28223_OLC OLC n/a 11451146 n/a (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate n/a
18 P28223_PEG PEG n/a 8117 CHEMBL1235226 DI(HYDROXYETHYL)ETHER n/a
19 P28223_PLM PLM DB03796 985;135369651; CHEMBL82293 PALMITIC ACID n/a
20 P28223_PO4 PO4 DB14523 1061 n/a PHOSPHATE ION n/a
21 P28223_ZN ZN n/a 32051 CHEMBL1236970 ZINC ION n/a
22 P28223_ZOT ZOT DB09225 5736 CHEMBL285802 2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine antagonist Ki(nM) = 0.5
23 P28223_SRO SRO DB08839 5202 CHEMBL39 SEROTONIN inhibitor
24 P28223_DB00246 n/a DB00246 n/a n/a Ziprasidone antagonist Ki(nM) = 0.08
IC50(nM) = 0.42
25 P28223_DB00247 n/a DB00247 n/a n/a Methysergide antagonist
26 P28223_DB00248 n/a DB00248 n/a n/a Cabergoline agonist
27 P28223_DB00315 n/a DB00315 n/a n/a Zolmitriptan agonist
28 P28223_2GM 2GM DB00320 10531 CHEMBL1732 Dihydroergotamine agonist
29 P28223_TP0 TP0 DB00321 2160 CHEMBL629 Amitriptyline antagonist
30 P28223_DB00334 n/a DB00334 n/a n/a Olanzapine antagonist Ki(nM) = 0.42
IC50(nM) = 7.0
31 P28223_DB00363 n/a DB00363 n/a n/a Clozapine antagonist Ki(nM) = 1.4
IC50(nM) = 12.0
32 P28223_DB00370 n/a DB00370 n/a n/a Mirtazapine antagonist Ki(nM) = 8.2
33 P28223_DB00408 n/a DB00408 n/a n/a Loxapine antagonist Ki(nM) = 2.0
34 P28223_DB00409 n/a DB00409 n/a n/a Remoxipride other/unknown Ki(nM) = 3100.0
35 P28223_P2Z P2Z DB00420 4926 CHEMBL564 Promazine antagonist
36 P28223_C7H C7H DB00434 2913 CHEMBL516 Cyproheptadine antagonist Ki(nM) = 0.46
37 P28223_IXX IXX DB00458 3696 CHEMBL11 Imipramine antagonist Ki(nM) = 94.0
38 P28223_Z80 Z80 DB00477 2726 CHEMBL71 Chlorpromazine antagonist Ki(nM) = 1.8
39 P28223_GMJ GMJ DB00502 3559 CHEMBL54 Haloperidol antagonist Ki(nM) = 20.0
IC50(nM) = 288.0
40 P28223_21B 21B DB00540 4543 CHEMBL445 Nortriptyline antagonist
41 P28223_DB00543 n/a DB00543 n/a n/a Amoxapine antagonist Ki(nM) = 1.77
42 P28223_DB00555 n/a DB00555 n/a n/a Lamotrigine inhibitor
43 P28223_DB00574 n/a DB00574 n/a n/a Fenfluramine agonist Ki(nM) = 3801.89
44 P28223_DB00604 n/a DB00604 n/a n/a Cisapride agonist
45 P28223_DB00623 n/a DB00623 n/a n/a Fluphenazine n/a Ki(nM) = 3.2
46 P28223_DB00656 n/a DB00656 n/a n/a Trazodone antagonist Ki(nM) = 44.67
IC50(nM) = 243.0
47 P28223_DB00679 n/a DB00679 n/a n/a Thioridazine antagonist Ki(nM) = 10.0
48 P28223_ERM ERM DB00696 8223 CHEMBL442 Ergotamine agonist Ki(nM) = 0.64
49 P28223_OR9 OR9 DB00714 6005 CHEMBL53 Apomorphine agonist Ki(nM) = 120.0
50 P28223_8PR 8PR DB00715 43815 CHEMBL490 Paroxetine n/a agonist Ki(nM) = 10000.0
51 P28223_DB00726 n/a DB00726 n/a n/a Trimipramine agonist
52 P28223_DB00734 n/a DB00734 n/a n/a Risperidone antagonist Ki(nM) = 0.14
IC50(nM) = 0.707946
53 P28223_DB00751 n/a DB00751 n/a n/a Epinastine antagonist
54 P28223_DB00777 n/a DB00777 n/a n/a Propiomazine antagonist
55 P28223_DB00805 n/a DB00805 n/a n/a Minaprine antagonist
56 P28223_DB00843 n/a DB00843 n/a n/a Donepezil inducer
57 P28223_DB00875 n/a DB00875 n/a n/a Flupentixol antagonist
58 P28223_DB00924 n/a DB00924 n/a n/a Cyclobenzaprine antagonist
59 P28223_DB00933 n/a DB00933 n/a n/a Mesoridazine antagonist
60 P28223_DB00934 n/a DB00934 n/a n/a Maprotiline binder
61 P28223_DB01079 n/a DB01079 n/a n/a Tegaserod antagonist
62 P28223_DB01142 no_lig_id DB01142 n/a n/a Doxepin antagonist
63 P28223_DB01149 n/a DB01149 n/a n/a Nefazodone antagonist Ki(nM) = 5.8
64 P28223_DSM DSM DB01151 2995 CHEMBL72 Desipramine antagonist Ki(nM) = 160.0
65 P28223_68P 68P DB01175 146570 CHEMBL1508 Escitalopram inhibitor
66 P28223_DB01186 n/a DB01186 n/a n/a Pergolide agonist Ki(nM) = 8.32
67 P28223_08Y 08Y DB01200 31101 CHEMBL493 Bromocriptine agonist Ki(nM) = 107.15
68 P28223_DB01224 n/a DB01224 n/a n/a Quetiapine antagonist Ki(nM) = 31.0
69 P28223_DB01239 n/a DB01239 n/a n/a Chlorprothixene inhibitor
70 P28223_CXX CXX DB01242 2801 CHEMBL415 Clomipramine antagonist Ki(nM) = 35.5
71 P28223_DB01267 n/a DB01267 n/a n/a Paliperidone antagonist Ki(nM) = 0.43
IC50(nM) = 5.2
72 P28223_DB01392 n/a DB01392 n/a n/a Yohimbine antagonist Ki(nM) = 252.0
73 P28223_DB01403 n/a DB01403 n/a n/a Methotrimeprazine antagonist
74 P28223_DB01442 n/a DB01442 n/a n/a MMDA agonist
75 P28223_DB01454 n/a DB01454 n/a n/a Midomafetamine agonist
76 P28223_DB01488 n/a DB01488 n/a n/a Dimethyltryptamine inhibitor Ki(nM) = 40.0
IC50(nM) = 150.0
EC50(nM) = 22.0
77 P28223_DB01537 n/a DB01537 n/a n/a 4-Bromo-2,5-dimethoxyphenethylamine partial agonist Ki(nM) = 0.66
EC50(nM) = 1.888
78 P28223_PMZ PMZ DB01614 6077 CHEMBL39560 Acepromazine antagonist
79 P28223_DB01618 n/a DB01618 n/a n/a Molindone antagonist Ki(nM) = 320.0
80 P28223_DB01621 n/a DB01621 n/a n/a Pipotiazine antagonist
81 P28223_DB01623 n/a DB01623 n/a n/a Thiothixene antagonist
82 P28223_DB01624 n/a DB01624 n/a n/a Zuclopenthixol antagonist
83 P28223_4MP 4MP DB04599 2196 CHEMBL36994 Aniracetam inhibitor
84 P28223_DB04842 n/a DB04842 n/a n/a Fluspirilene antagonist Ki(nM) = 9.5
85 P28223_DB04908 n/a DB04908 n/a n/a Flibanserin antagonist
86 P28223_DB04946 n/a DB04946 n/a n/a Iloperidone antagonist Ki(nM) = 0.12
87 P28223_DB05316 n/a DB05316 n/a n/a Pimavanserin inverse agonist Ki(nM) = 0.24
IC50(nM) = 1.9
88 P28223_NP1 NP1 DB05492 5276854 CHEMBL609728 Epicept NP-1 n/a
89 P28223_DB06144 n/a DB06144 n/a n/a Sertindole antagonist Ki(nM) = 0.14
90 P28223_DB06148 n/a DB06148 n/a n/a Mianserin antagonist
91 P28223_DB06153 n/a DB06153 n/a n/a Pizotifen antagonist
92 P28223_DB06216 n/a DB06216 n/a n/a Asenapine antagonist Ki(nM) = 0.26
93 P28223_DB06229 n/a DB06229 n/a n/a Ocaperidone modulator
94 P28223_DB06288 n/a DB06288 n/a n/a Amisulpride antagonist Ki(nM) = 631.0
95 P28223_DB06446 n/a DB06446 n/a n/a Dotarizine n/a
96 P28223_DB06512 n/a DB06512 n/a n/a Deramciclane antagonist
97 P28223_DB08810 n/a DB08810 n/a n/a Cinitapride antagonist
98 P28223_DB08815 n/a DB08815 n/a n/a Lurasidone antagonist Ki(nM) = 2.0
99 P28223_DB08922 n/a DB08922 n/a n/a Perospirone inverse agonist
100 P28223_DB08927 n/a DB08927 n/a n/a Amperozide antagonist
101 P28223_P0T P0T DB09061 644019 CHEMBL190461 Cannabidiol agonist
102 P28223_DB09128 n/a DB09128 n/a n/a Brexpiprazole antagonist Ki(nM) = 0.47
103 P28223_DB09167 n/a DB09167 n/a n/a Dosulepin antagonist
104 P28223_DB09194 n/a DB09194 n/a n/a Etoperidone antagonist
105 P28223_DB09195 n/a DB09195 n/a n/a Lorpiprazole antagonist
106 P28223_DB09223 n/a DB09223 n/a n/a Blonanserin antagonist Ki(nM) = 0.81
107 P28223_DB09286 n/a DB09286 n/a n/a Pipamperone agonist Ki(nM) = 5.4
108 P28223_DB12163 n/a DB12163 n/a n/a Sarpogrelate inverse agonist
109 P28223_DB12177 n/a DB12177 n/a n/a Eplivanserin n/a
110 P28223_DB12465 n/a DB12465 n/a n/a Ketanserin inverse agonist
111 P28223_DB12555 n/a DB12555 n/a n/a Nelotanserin modulator
112 P28223_E2J E2J DB12693 5074 CHEMBL267777 Ritanserin inverse agonist
113 P28223_DB13940 n/a DB13940 n/a n/a 2,5-Dimethoxy-4-ethylthioamphetamine agonist
114 P28223_U0G U0G DB13948 90489020 CHEMBL5184791 N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine agonist
115 P28223_DB14010 n/a DB14010 n/a n/a 5-methoxy-N,N-dimethyltryptamine agonist
116 P28223_DB14011 n/a DB14011 n/a n/a Nabiximols n/a
117 P28223_DB14185 n/a DB14185 n/a n/a Aripiprazole lauroxil antagonist
118 P28223_DB16351 n/a DB16351 n/a n/a Volinanserin antagonist