Gene name: HTR2C
Protein name: 5-hydroxytryptamine receptor 2C
List of molecules and drugs that interact with protein P28335
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P28335_91Q | 91Q | n/a | 4980 | CHEMBL65547 | 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol | n/a | |
| 2 | P28335_CLR | CLR | DB04540 | 5997 | CHEMBL112570 | CHOLESTEROL | n/a | |
| 3 | P28335_E2J | E2J | DB12693 | 5074 | CHEMBL267777 | 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one | antagonist | |
| 4 | P28335_ERM | ERM | DB00696 | 8223 | CHEMBL442 | Ergotamine | agonist | Ki(nM) = 9.77 |
| 5 | P28335_OLA | OLA | n/a | 445639 | CHEMBL8659 | OLEIC ACID | n/a | |
| 6 | P28335_OLC | OLC | n/a | 11451146 | n/a | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | n/a | |
| 7 | P28335_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 8 | P28335_T4U | T4U | DB04871 | 11658860 | CHEMBL360328 | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | agonist | |
| 9 | P28335_DB00193 | n/a | DB00193 | n/a | n/a | Tramadol | antagonist | |
| 10 | P28335_DB00246 | n/a | DB00246 | n/a | n/a | Ziprasidone | antagonist | Ki(nM) = 0.55 |
| 11 | P28335_DB00247 | n/a | DB00247 | n/a | n/a | Methysergide | antagonist | |
| 12 | P28335_DB00248 | n/a | DB00248 | n/a | n/a | Cabergoline | agonist | |
| 13 | P28335_2GM | 2GM | DB00320 | 10531 | CHEMBL1732 | Dihydroergotamine | agonist | |
| 14 | P28335_TP0 | TP0 | DB00321 | 2160 | CHEMBL629 | Amitriptyline | antagonist | Ki(nM) = 18.0 |
| 15 | P28335_DB00334 | n/a | DB00334 | n/a | n/a | Olanzapine | antagonist | Ki(nM) = 2.8 IC50(nM) = 71.0 |
| 16 | P28335_DB00363 | n/a | DB00363 | n/a | n/a | Clozapine | antagonist | Ki(nM) = 2.9 IC50(nM) = 10.0 |
| 17 | P28335_DB00370 | n/a | DB00370 | n/a | n/a | Mirtazapine | antagonist | Ki(nM) = 39.0 |
| 18 | P28335_DB00408 | n/a | DB00408 | n/a | n/a | Loxapine | antagonist | Ki(nM) = 1.69 |
| 19 | P28335_P2Z | P2Z | DB00420 | 4926 | CHEMBL564 | Promazine | antagonist | Ki(nM) = 15.87 |
| 20 | P28335_C7H | C7H | DB00434 | 2913 | CHEMBL516 | Cyproheptadine | antagonist | Ki(nM) = 2.23 |
| 21 | P28335_IXX | IXX | DB00458 | 3696 | CHEMBL11 | Imipramine | antagonist | Ki(nM) = 150.0 |
| 22 | P28335_DB00472 | n/a | DB00472 | n/a | n/a | Fluoxetine | antagonist | Ki(nM) = 72.0 IC50(nM) = 160.0 |
| 23 | P28335_Z80 | Z80 | DB00477 | 2726 | CHEMBL71 | Chlorpromazine | binder | Ki(nM) = 1.4 |
| 24 | P28335_GMJ | GMJ | DB00502 | 3559 | CHEMBL54 | Haloperidol | antagonist | Ki(nM) = 35.71 IC50(nM) = 10000.0 |
| 25 | P28335_21B | 21B | DB00540 | 4543 | CHEMBL445 | Nortriptyline | antagonist | Ki(nM) = 41.0 |
| 26 | P28335_DB00543 | n/a | DB00543 | n/a | n/a | Amoxapine | antagonist | |
| 27 | P28335_DB00574 | n/a | DB00574 | n/a | n/a | Fenfluramine | agonist | Ki(nM) = 1412.54 |
| 28 | P28335_H8G | H8G | DB00589 | 28864 | CHEMBL157138 | Lisuride | agonist | Ki(nM) = 10000.0 IC50(nM) = 26.0 Kd(nM) = 50119.0 EC50(nM) = 203.1 |
| 29 | P28335_DB00623 | n/a | DB00623 | n/a | n/a | Fluphenazine | n/a | Ki(nM) = 188.67 |
| 30 | P28335_DB00656 | n/a | DB00656 | n/a | n/a | Trazodone | agonist | Ki(nM) = 25.0 |
| 31 | P28335_OR9 | OR9 | DB00714 | 6005 | CHEMBL53 | Apomorphine | agonist | Ki(nM) = 102.33 |
| 32 | P28335_DB00726 | n/a | DB00726 | n/a | n/a | Trimipramine | antagonist | |
| 33 | P28335_DB00734 | n/a | DB00734 | n/a | n/a | Risperidone | antagonist | Ki(nM) = 2.4 IC50(nM) = 1.8 |
| 34 | P28335_DB00777 | n/a | DB00777 | n/a | n/a | Propiomazine | antagonist | |
| 35 | P28335_DB00805 | n/a | DB00805 | n/a | n/a | Minaprine | antagonist | |
| 36 | P28335_DB00875 | n/a | DB00875 | n/a | n/a | Flupentixol | antagonist | |
| 37 | P28335_DB00924 | n/a | DB00924 | n/a | n/a | Cyclobenzaprine | antagonist | |
| 38 | P28335_DB00934 | n/a | DB00934 | n/a | n/a | Maprotiline | binder | |
| 39 | P28335_DB01079 | n/a | DB01079 | n/a | n/a | Tegaserod | antagonist | |
| 40 | P28335_DB01142 | no_lig_id | DB01142 | n/a | n/a | Doxepin | antagonist | |
| 41 | P28335_DB01149 | n/a | DB01149 | n/a | n/a | Nefazodone | antagonist | Ki(nM) = 26.0 |
| 42 | P28335_DSM | DSM | DB01151 | 2995 | CHEMBL72 | Desipramine | binder | Ki(nM) = 350.0 |
| 43 | P28335_68P | 68P | DB01175 | 146570 | CHEMBL1508 | Escitalopram | inhibitor | |
| 44 | P28335_DB01186 | n/a | DB01186 | n/a | n/a | Pergolide | agonist | Ki(nM) = 295.12 |
| 45 | P28335_DB01191 | n/a | DB01191 | n/a | n/a | Dexfenfluramine | agonist | Ki(nM) = 2080.0 |
| 46 | P28335_08Y | 08Y | DB01200 | 31101 | CHEMBL493 | Bromocriptine | agonist | Ki(nM) = 741.31 |
| 47 | P28335_DB01224 | n/a | DB01224 | n/a | n/a | Quetiapine | ligand | Ki(nM) = 615.0 |
| 48 | P28335_9SC | 9SC | DB01238 | 60795 | CHEMBL1112 | Aripiprazole | antagonist | Ki(nM) = 18.0 IC50(nM) = 1380.0 |
| 49 | P28335_CXX | CXX | DB01242 | 2801 | CHEMBL415 | Clomipramine | antagonist | Ki(nM) = 64.6 |
| 50 | P28335_DB01267 | n/a | DB01267 | n/a | n/a | Paliperidone | antagonist | Ki(nM) = 48.0 |
| 51 | P28335_DB01392 | n/a | DB01392 | n/a | n/a | Yohimbine | antagonist | Ki(nM) = 645.65 |
| 52 | P28335_DB01403 | n/a | DB01403 | n/a | n/a | Methotrimeprazine | antagonist | |
| 53 | P28335_DB01454 | n/a | DB01454 | n/a | n/a | Midomafetamine | agonist | |
| 54 | P28335_DB01537 | n/a | DB01537 | n/a | n/a | 4-Bromo-2,5-dimethoxyphenethylamine | partial agonist | Ki(nM) = 89.5 EC50(nM) = 0.0311 |
| 55 | P28335_DB04884 | n/a | DB04884 | n/a | n/a | Dapoxetine | n/a | |
| 56 | P28335_DB04948 | n/a | DB04948 | n/a | n/a | Lofexidine | agonist | |
| 57 | P28335_DB05316 | n/a | DB05316 | n/a | n/a | Pimavanserin | inverse agonist | Ki(nM) = 1.5 IC50(nM) = 91.0 |
| 58 | P28335_NP1 | NP1 | DB05492 | 5276854 | CHEMBL609728 | Epicept NP-1 | n/a | |
| 59 | P28335_7RU | 7RU | DB06016 | n/a | CHEMBL2028019 | Cariprazine | antagonist | Ki(nM) = 198.0 |
| 60 | P28335_DB06144 | n/a | DB06144 | n/a | n/a | Sertindole | antagonist | Ki(nM) = 0.2 |
| 61 | P28335_DB06148 | n/a | DB06148 | n/a | n/a | Mianserin | antagonist | |
| 62 | P28335_DB06153 | n/a | DB06153 | n/a | n/a | Pizotifen | antagonist | |
| 63 | P28335_DB06216 | n/a | DB06216 | n/a | n/a | Asenapine | antagonist | Ki(nM) = 0.2 |
| 64 | P28335_DB06229 | n/a | DB06229 | n/a | n/a | Ocaperidone | n/a | |
| 65 | P28335_DB06446 | n/a | DB06446 | n/a | n/a | Dotarizine | n/a | |
| 66 | P28335_DB06512 | n/a | DB06512 | n/a | n/a | Deramciclane | inverse agonist | |
| 67 | P28335_AWY | AWY | DB06594 | 82148 | CHEMBL10878 | Agomelatine | antagonist | Ki(nM) = 630.0 IC50(nM) = 4.52 |
| 68 | P28335_DB09014 | n/a | DB09014 | n/a | n/a | Captodiame | antagonist | |
| 69 | P28335_DB09185 | n/a | DB09185 | n/a | n/a | Viloxazine | agonist | |
| 70 | P28335_DB09194 | n/a | DB09194 | n/a | n/a | Etoperidone | agonist | Ki(nM) = 36.0 |
| 71 | P28335_DB09195 | n/a | DB09195 | n/a | n/a | Lorpiprazole | antagonist | |
| 72 | P28335_DB12110 | n/a | DB12110 | n/a | n/a | m-Chlorophenylpiperazine | agonist | |
| 73 | P28335_DB12163 | n/a | DB12163 | n/a | n/a | Sarpogrelate | n/a | |
| 74 | P28335_DB12177 | n/a | DB12177 | n/a | n/a | Eplivanserin | n/a | |
| 75 | P28335_DB13940 | n/a | DB13940 | n/a | n/a | 2,5-Dimethoxy-4-ethylthioamphetamine | agonist | |
| 76 | P28335_DB14185 | n/a | DB14185 | n/a | n/a | Aripiprazole lauroxil | n/a |