Gene name: tgt
Protein name: Queuine tRNA-ribosyltransferase (EC
List of molecules and drugs that interact with protein P28720
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P28720_0EV | 0EV | n/a | 137347855 | n/a | 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-[(2-phenylethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 2 | P28720_0EX | 0EX | n/a | 137347856 | n/a | 6-amino-4-[2-(benzylamino)ethyl]-2-[(2-phenylethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 3 | P28720_0O1 | 0O1 | n/a | 71677786;135566755; | n/a | 6-amino-4-{2-[(cyclopentylmethyl)amino]ethyl}-2-[(2-phenylethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 4 | P28720_0UX | 0UX | n/a | n/a | n/a | 6-amino-2-(methylamino)-4-(2-{[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-ylmethyl]amino}ethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 5 | P28720_0V2 | 0V2 | n/a | n/a | n/a | 6-amino-4-[2-({[trans-4-(biphenyl-4-ylethynyl)cyclohexyl]methyl}amino)ethyl]-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 6 | P28720_0V3 | 0V3 | n/a | n/a | n/a | 6-amino-2-(methylamino)-4-[2-({[trans-4-(pyridin-3-ylethynyl)cyclohexyl]methyl}amino)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 7 | P28720_0WW | 0WW | n/a | 71677782;135566750; | n/a | 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-[(thiophen-2-ylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 8 | P28720_0WX | 0WX | n/a | 137347904 | n/a | 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-{[2-(morpholin-4-yl)ethyl]amino}-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 9 | P28720_0WY | 0WY | n/a | 71677785;135566754; | n/a | 6-amino-4-{2-[(cyclohexylmethyl)amino]ethyl}-2-[(2-phenylethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 10 | P28720_1UD | 1UD | n/a | 117071863;135566833; | n/a | methyl 6-[6-amino-2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-4-yl]-5,6-dideoxy-3-O-methyl-beta-D-ribo-hexofuranoside | n/a | |
| 11 | P28720_1WJ | 1WJ | n/a | 117071872;135566850; | n/a | methyl 6-[6-amino-2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-4-yl]-5,6-dideoxy-2-O-methyl-beta-D-ribo-hexofuranoside | n/a | |
| 12 | P28720_1WK | 1WK | n/a | 117071874;135566851; | n/a | methyl 6-[6-amino-2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-4-yl]-5,6-dideoxy-beta-D-ribo-hexofuranoside | n/a | |
| 13 | P28720_2MQ | 2MQ | n/a | 44483203;135566460; | n/a | 6-amino-4-(2-aminoethyl)-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 14 | P28720_2WU | 2WU | n/a | 24741807;135566919; | CHEMBL3298015 | 6-amino-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 15 | P28720_2YL | 2YL | n/a | 20841;135408760; | n/a | 6-amino-4-phenyl-1,3,5-triazin-2(1H)-one | n/a | |
| 16 | P28720_2YM | 2YM | n/a | 75277395;135566927; | CHEMBL3298181 | 6-amino-2-{[2-(piperidin-1-yl)ethyl]amino}-3,5-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 17 | P28720_2YO | 2YO | n/a | 75277396;135566928; | CHEMBL3298182 | 2-{[2-(piperidin-1-yl)ethyl]amino}-3,5-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 18 | P28720_2YV | 2YV | n/a | 57339810;135566931; | CHEMBL4474826 | 6-amino-2-[(2-phenylethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 19 | P28720_2YW | 2YW | n/a | 91757943;135566932; | CHEMBL4469249 | methyl 4-{2-[(6-amino-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-2-yl)amino]ethyl}benzoate | n/a | |
| 20 | P28720_2YX | 2YX | n/a | 91757944;135566933; | CHEMBL4483739 | 4-{2-[(6-amino-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-2-yl)amino]ethyl}benzonitrile | n/a | |
| 21 | P28720_2YY | 2YY | n/a | 91757945;135566934; | CHEMBL4476149 | 4-{2-[(6-amino-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-2-yl)amino]ethyl}benzoic acid | n/a | |
| 22 | P28720_344 | 344 | DB07012 | 11287125;135483591; | n/a | 6-AMINO-3,7-DIHYDRO-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE | n/a | |
| 23 | P28720_46L | 46L | n/a | 99209 | CHEMBL394288 | 6-(dimethylamino)pyridine-3-carboxylic acid | n/a | |
| 24 | P28720_5NT | 5NT | n/a | 122199222;135567091; | n/a | 2-azanyl-7-[(2~{S},3~{R},5~{S})-5-(hydroxymethyl)-3-oxidanyl-pyrrolidin-2-yl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one | n/a | |
| 25 | P28720_62D | 62D | n/a | 57383469;135566592; | n/a | 6-(ethylamino)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 26 | P28720_6H8 | 6H8 | n/a | 126970783 | CHEMBL4646981 | N-[2-(methylamino)-1H-benzimidazol-6-yl]guanidine | n/a | |
| 27 | P28720_6H9 | 6H9 | n/a | 126970782 | CHEMBL4639064 | 2-(methylamino)-1H-benzimidazole-5-carbohydrazide | n/a | |
| 28 | P28720_6HD | 6HD | n/a | 126970781 | CHEMBL4639735 | 2-(methylamino)-1H-benzimidazole-5-carboxamide | n/a | |
| 29 | P28720_6JX | 6JX | n/a | 126961708;135567183; | n/a | allyl (2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl)carbamate | n/a | |
| 30 | P28720_6MM | 6MM | n/a | 126970786;135567188; | n/a | 6-amino-2-({[(3a'R,4S,6'R,6a'R)-2,2,2',2'-tetramethyldihydro-3a'H-spiro[1,3-dioxolane-4,4'-furo[3,4-d][1,3]dioxol]-6'-yl]methyl}amino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one (non-preferred name) | n/a | |
| 31 | P28720_6MQ | 6MQ | n/a | 126970785;135567187; | n/a | methyl 5-[(6-amino-8-oxo-7,8-dihydro-3H-imidazo[4,5-g]quinazolin-2-yl)amino]-5-deoxy-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | n/a | |
| 32 | P28720_6N1 | 6N1 | n/a | 137348491 | CHEMBL4642133 | 2-{[2-(morpholin-4-yl)ethyl]amino}-1H-benzimidazole-6-carbohydrazide | n/a | |
| 33 | P28720_6N2 | 6N2 | n/a | 137348492 | CHEMBL4637521 | N-(2-{[2-(morpholin-4-yl)ethyl]amino}-1H-benzimidazol-5-yl)guanidine | n/a | |
| 34 | P28720_6NK | 6NK | n/a | 137348496 | CHEMBL4635368 | 2-{[2-(morpholin-4-yl)ethyl]amino}-1H-benzimidazole-6-carboxamide | n/a | |
| 35 | P28720_6OK | 6OK | n/a | 121488113;135567189; | CHEMBL4435900 | 6-amino-2-({2-[4-(2-hydroxyethyl)phenyl]ethyl}amino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 36 | P28720_725 | 725 | n/a | 129900088;135567217; | n/a | 6-amino-2-(methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5-trimethoxytetrahydrofuran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one | n/a | |
| 37 | P28720_726 | 726 | n/a | 129900092;135567221; | n/a | 6-azanyl-2-(methylamino)-4-[2-[(2~{R},3~{R},4~{S},5~{R},6~{S})-3,4,5,6-tetramethoxyoxan-2-yl]ethyl]-1,7-dihydroimidazo[4,5-g]quinazolin-8-one | n/a | |
| 38 | P28720_72C | 72C | n/a | 129900090;135567219; | n/a | 4-[2-[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-methoxy-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one | n/a | |
| 39 | P28720_810 | 810 | n/a | 126961707;135567182; | n/a | ethyl [2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl]carbamate | n/a | |
| 40 | P28720_9DG | 9DG | DB04356 | 100684;5287566;135461003; | CHEMBL367746 | 9-DEAZAGUANINE | n/a | |
| 41 | P28720_AAQ | AAQ | n/a | 44483202;135566459; | n/a | 6-amino-4-[2-(benzylamino)ethyl]-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 42 | P28720_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 43 | P28720_AEK | AEK | n/a | 57339125;135566577; | n/a | 4-{2-[(cyclopentylmethyl)amino]ethyl}-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 44 | P28720_AFQ | AFQ | n/a | 44483204;135566462; | n/a | 6-amino-4-{2-[(cyclopentylmethyl)amino]ethyl}-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 45 | P28720_AIQ | AIQ | DB04543 | 446622;5287658;135460962; | n/a | 2,6-DIAMINO-8-(1H-IMIDAZOL-2-YLSULFANYLMETHYL)-3H-QUINAZOLINE-4-ONE | n/a | |
| 46 | P28720_AMH | AMH | DB00302 | n/a | CHEMBL877 | TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID | n/a | |
| 47 | P28720_APQ | APQ | DB02599 | 446623;5287693;135461936; | n/a | 2,6-DIAMINO-8-PROPYLSULFANYLMETHYL-3H-QUINAZOLINE-4-ONE | n/a | |
| 48 | P28720_APZ | APZ | DB02041 | 95014;5287696; | CHEMBL14882 | 4-AMINOPHTHALHYDRAZIDE | n/a | Ki(nM) = 8300.0 |
| 49 | P28720_AQO | AQO | DB03780 | 242831;5287697;135403814; | CHEMBL6993 | 2-AMINOQUINAZOLIN-4(3H)-ONE | n/a | |
| 50 | P28720_AZA | AZA | DB01875 | 15113;5287721;135400688; | CHEMBL219341 | 8-AZAXANTHINE | n/a | |
| 51 | P28720_BDI | BDI | DB02441 | 3465283;5287752; | CHEMBL280051 | 2-BUTYL-5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE | n/a | Ki(nM) = 83000.0 |
| 52 | P28720_BGU | BGU | DB07452 | 24741806;135566394; | n/a | 2,6-diamino-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | Ki(nM) = 77.0 |
| 53 | P28720_BHB | BHB | DB04004 | 448017;5287783;135445363; | n/a | 2,6-DIAMINO-8-(2-DIMETHYLAMINOETHYLSULFANYLMETHYL)-3H-QUINAZOLIN-4-ONE | n/a | |
| 54 | P28720_BPQ | BPQ | DB07481 | 25113137;135566413; | n/a | tert-butyl [(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]carbamate | n/a | |
| 55 | P28720_CKR | CKR | DB07564 | 23643565;135566918; | CHEMBL1231806 | 6-amino-2-[(2-morpholin-4-ylethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 56 | P28720_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 57 | P28720_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 58 | P28720_DPZ | DPZ | DB04169 | 1616;5288110; | n/a | 3,5-DIAMINOPHTHALHYDRAZIDE | n/a | |
| 59 | P28720_DQU | DQU | DB03505 | 448010;5288112;135413405; | n/a | 2,6-DIAMINO-3H-QUINAZOLIN-4-ONE | n/a | |
| 60 | P28720_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
| 61 | P28720_E48 | E48 | n/a | 138753175 | n/a | 6-azanyl-2-[[(1~{R},2~{S},6~{S},9~{R})-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methylamino]-3,7-dihydroimidazo[4,5-g]quinazolin-8-one | n/a | |
| 62 | P28720_E4E | E4E | n/a | 138753176 | n/a | 6-azanyl-2-[[(2~{R},3~{S},4~{R},5~{R})-5-methoxy-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-3,7-dihydroimidazo[4,5-g]quinazolin-8-one | n/a | |
| 63 | P28720_E89 | E89 | DB07704 | 5326930;135476766; | CHEMBL487739 | 6-AMINO-4-[2-(4-METHOXYPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE | n/a | |
| 64 | P28720_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 65 | P28720_F63 | F63 | n/a | 7164635 | CHEMBL1921971 | N-methyl-1-[5-(pyridin-3-yloxy)furan-2-yl]methanamine | n/a | |
| 66 | P28720_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 67 | P28720_GGB | GGB | DB01833 | 439202;46224610; | CHEMBL443732 | L-CANAVANINE | n/a | |
| 68 | P28720_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 69 | P28720_GUN | GUN | DB02377 | 764;5274253;135398634; | CHEMBL219568 | GUANINE | n/a | |
| 70 | P28720_HRD | HRD | n/a | 56947162;135566560; | n/a | 2,6-bis(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 71 | P28720_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 72 | P28720_ITE | ITE | n/a | 44820625;135566565; | CHEMBL3298016 | 2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 73 | P28720_K75 | K75 | n/a | 146048113 | n/a | (8~{R})-~{N}2-methyl-8-prop-1-ynyl-7,8-dihydro-3~{H}-imidazo[4,5-g]quinazoline-2,6-diamine | n/a | |
| 74 | P28720_K7H | K7H | n/a | 146048114 | CHEMBL4645921 | ~{N}2-methyl-7,8-dihydro-3~{H}-imidazo[4,5-g]quinazoline-2,6-diamine | n/a | |
| 75 | P28720_KMB | KMB | DB04239 | 5288673;6323390;135509113; | n/a | 2-AMINO-6-AMINOMETHYL-8-PHENYLSULFANYLMETHYL-3H-QUINAZOLIN-4-ONE | n/a | |
| 76 | P28720_MAQ | MAQ | DB01825 | 448488;5288774;135460982; | n/a | 2-AMINO-8-METHYLQUINAZOLIN-4(3H)-ONE | n/a | |
| 77 | P28720_NE8 | NE8 | DB08267 | 5326928;135438475; | n/a | 6-AMINO-4-(2-PHENYLETHYL)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE | n/a | |
| 78 | P28720_NEZ | NEZ | DB08268 | 5326929;135414394; | n/a | 6-AMINO-4-[2-(4-METHYLPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE | n/a | |
| 79 | P28720_OQH | OQH | n/a | 94151129 | n/a | ~{N}-ethyl-4-oxidanylidene-4-phenyl-butanamide | n/a | |
| 80 | P28720_OQN | OQN | n/a | 146018283 | n/a | 6-amino-2-(methylamino)-4-phenethyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 81 | P28720_OQQ | OQQ | n/a | 146018281 | n/a | 6-amino-2-(methylamino)-4-(4-(trifluoromethyl)phenethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 82 | P28720_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 83 | P28720_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 84 | P28720_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 85 | P28720_PK2 | PK2 | n/a | 44199329;135566446; | n/a | 6-amino-4-{2-[(cyclohexylmethyl)amino]ethyl}-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 86 | P28720_PK3 | PK3 | n/a | 44199330;135566447; | n/a | 6-amino-4-(2-hydroxyethyl)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 87 | P28720_PQ0 | PQ0 | DB03074 | 446357;135446206; | CHEMBL577120 | 2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE | n/a | |
| 88 | P28720_PRF | PRF | DB03304 | 171;5289204;135398563; | CHEMBL1235432 | 7-DEAZA-7-AMINOMETHYL-GUANINE | n/a | |
| 89 | P28720_QEI | QEI | DB14732 | 114881;5280439;135398670; | n/a | 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | n/a | |
| 90 | P28720_QTQ | QTQ | n/a | 1270001 | n/a | (3~{R},4~{R})-1,1-bis(oxidanylidene)thiolane-3,4-diol | n/a | |
| 91 | P28720_QXB | QXB | n/a | 31347 | CHEMBL3186899 | sulfolane | n/a | |
| 92 | P28720_QXE | QXE | n/a | 7059047 | n/a | 3-hydroxythietane-1,1-dioxide | n/a | |
| 93 | P28720_QZT | QZT | n/a | 1128 | CHEMBL1207 | thiolane 1-oxide | n/a | |
| 94 | P28720_R1E | R1E | n/a | 105427954 | n/a | trans-4,4-difluorocyclopentane-1,2-diol | n/a | |
| 95 | P28720_R4W | R4W | n/a | 79059 | n/a | 1-methylsulfonylethane | n/a | |
| 96 | P28720_RGN | RGN | n/a | 72218529 | CHEMBL4531025 | (1~{R},2~{R})-4,4-bis(fluoranyl)cyclopentane-1,2-diol | n/a | |
| 97 | P28720_S60 | S60 | DB08511 | 24741805;135566422; | CHEMBL1235810 | 6-amino-2-methyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | Ki(nM) = 1500.0 |
| 98 | P28720_S79 | S79 | DB08512 | 16750097;135566329; | n/a | 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 99 | P28720_S98 | S98 | DB08514 | 24741808;135800218; | CHEMBL1235818 | 6-amino-2-[(thiophen-2-ylmethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | Ki(nM) = 3.5 |
| 100 | P28720_SAQ | SAQ | n/a | 49867635;135566929; | CHEMBL1235832 | 2-[(thiophen-2-ylmethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a | |
| 101 | P28720_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 102 | P28720_SQO | SQO | n/a | 49867679;135566930; | CHEMBL1236036 | 2-{[2-(4-Morpholinyl)ethyl]amino}-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | n/a |