Gene name: HSD11B1
Protein name: 11-beta-hydroxysteroid dehydrogenase 1
List of molecules and drugs that interact with protein P28845
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P28845_07M | 07M | n/a | 53470409 | CHEMBL1911701 | 8-{[(2-cyanopyridin-3-yl)methyl]sulfanyl}-6-hydroxy-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile | n/a | |
| 2 | P28845_14M | 14M | DB14875 | 24946280 | CHEMBL2153191 | {(3S)-1-[5-(cyclohexylcarbamoyl)-6-(propylsulfanyl)pyridin-2-yl]piperidin-3-yl}acetic acid | inhibitor | |
| 3 | P28845_17R | 17R | n/a | 24906237 | CHEMBL518303 | (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-{[3-(1H-1,2,4-triazol-1-yl)phenyl]sulfonyl}piperazine | n/a | |
| 4 | P28845_19V | 19V | n/a | n/a | n/a | 4-[5-(4-tert-butylpiperazin-1-yl)pyridin-2-yl]-N-[(1R,2S,3S,5S,7s)-5-carbamoyltricyclo[3.3.1.1~3,7~]dec-2-yl]-3,4-dihydroquinoxaline-1(2H)-carboxamide | n/a | |
| 5 | P28845_1EN | 1EN | n/a | 57809000 | CHEMBL3318965 | 3-[1-(4-chlorophenyl)cyclopropyl]-8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridine | n/a | |
| 6 | P28845_1EO | 1EO | n/a | n/a | n/a | (1s,4s)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]heptan-1-ol | n/a | |
| 7 | P28845_1EQ | 1EQ | n/a | 118709259 | CHEMBL3318978 | 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2,4]triazolo[4,3-a]pyridine | n/a | |
| 8 | P28845_21T | 21T | n/a | n/a | n/a | 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid | n/a | |
| 9 | P28845_311 | 311 | DB06992 | 24808495 | CHEMBL406572 | (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone | n/a | IC50(nM) = 0.1 |
| 10 | P28845_33T | 33T | n/a | 44160268 | CHEMBL550175 | 3-chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)benzamide | n/a | |
| 11 | P28845_352 | 352 | DB07017 | 25023710;135566449; | CHEMBL455907 | (5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one | n/a | Ki(nM) = 35.0 IC50(nM) = 34.0 |
| 12 | P28845_3CZ | 3CZ | DB07049 | 24812720 | CHEMBL427896 | (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine | n/a | IC50(nM) = 3.0 EC50(nM) = 57.0 |
| 13 | P28845_3OQ | 3OQ | n/a | 53249959 | n/a | 3-(2-fluoroethyl)-4-({4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl}sulfonyl)benzonitrile | n/a | |
| 14 | P28845_3PJ | 3PJ | n/a | n/a | CHEMBL1642593 | N-[trans-4-(3-amino-3-oxopropyl)-4-phenylcyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide | n/a | |
| 15 | P28845_4JX | 4JX | n/a | n/a | n/a | N-[(1R,2s,3S,5s,7s)-5-hydroxytricyclo[3.3.1.1~3,7~]dec-2-yl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 16 | P28845_4YQ | 4YQ | n/a | n/a | n/a | 4-cyclopropyl-2-(2-hydroxyethyloxy)-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-1,3-thiazole-5-carboxamide | n/a | |
| 17 | P28845_7H6 | 7H6 | n/a | 24854349 | CHEMBL4529787 | (1S,4S,5S,9S)-9-hydroxy-8-methyl-4-(propan-2-yl)spiro[4.5]dec-7-ene-1-carboxylic acid | n/a | |
| 18 | P28845_8K4 | 8K4 | n/a | n/a | n/a | 2-[2-(4-fluorophenyl)-2-adamantyl]-1-(3-methoxyazetidin-1-yl)ethanone | n/a | |
| 19 | P28845_8K7 | 8K7 | n/a | n/a | n/a | 1-(3-HYDROXYAZETIDIN-1-YL)-2-[(2S,5R)-2-(4-FLUOROPHENYL)-5-METHOXYADAMANTAN-2-YL]ETHAN-1-ONE | n/a | |
| 20 | P28845_8KA | 8KA | n/a | n/a | n/a | 2-[(1R,3S,5R,7S)-2-[4-(4-FLUOROPHENYL)PHENYL]-6-HYDROXYADAMANTAN-2-YL]-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE | n/a | |
| 21 | P28845_8KD | 8KD | n/a | n/a | n/a | 2-(2-BENZYL-6-HYDROXYADAMANTAN-2-YL)-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE | n/a | |
| 22 | P28845_8KG | 8KG | n/a | n/a | n/a | 2-[(5R,7S)-6-HYDROXY-2-PHENYLADAMANTAN-2-YL]-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE | n/a | |
| 23 | P28845_A21 | A21 | DB07310 | 16105493;135513268; | CHEMBL218006 | (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one | n/a | Ki(nM) = 22.0 |
| 24 | P28845_A49 | A49 | DB07316 | 25263223 | CHEMBL453620 | N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide | n/a | IC50(nM) = 14.0 |
| 25 | P28845_CBO | CBO | DB02329 | 636403 | CHEMBL499915 | CARBENOXOLONE | inhibitor | |
| 26 | P28845_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 27 | P28845_CPS | CPS | n/a | 107670 | CHEMBL450950 | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | n/a | |
| 28 | P28845_D3E | D3E | DB07619 | n/a | CHEMBL452587 | N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide | n/a | IC50(nM) = 1.4 |
| 29 | P28845_D4N | D4N | DB07624 | 24856362 | CHEMBL460962 | 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide | n/a | Ki(nM) = 1.1 IC50(nM) = 0.7 |
| 30 | P28845_DZL | DZL | n/a | n/a | n/a | 2-ethyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-4-[(2R)-oxolan-2-yl]-1,3-thiazole-5-carboxamide | n/a | |
| 31 | P28845_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 32 | P28845_H11 | H11 | DB07866 | 24866443;135566419; | n/a | (5S)-2-(cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one | n/a | |
| 33 | P28845_HD1 | HD1 | n/a | n/a | n/a | 6-(4-methylpiperazin-1-yl)-N-[(1R,3S)-5-oxidanyl-2-adamantyl]-2-propylsulfanyl-pyridine-3-carboxamide | n/a | |
| 34 | P28845_HD2 | HD2 | n/a | n/a | n/a | 4-cyclopentyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-2-[[(3S)-oxolan-3-yl]amino]pyrimidine-5-carboxamide | n/a | |
| 35 | P28845_HJG | HJG | n/a | 42634627 | CHEMBL4301600 | 2-{3-[1-(4-chlorophenyl)cyclopropyl][1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol | n/a | |
| 36 | P28845_IIG | IIG | n/a | n/a | CHEMBL526305 | N-cyclopropyl-N-(cis-4-cyclopropyl-4-hydroxycyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide | n/a | |
| 37 | P28845_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | inhibitor | |
| 38 | P28845_NAP | NAP | DB03461 | 5885;57525501; | CHEMBL295069 | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 39 | P28845_NDP | NDP | DB02338 | 5884;134821689; | CHEMBL407009 | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 40 | P28845_NI | NI | n/a | 934 | n/a | NICKEL (II) ION | n/a | |
| 41 | P28845_NN1 | NN1 | DB08277 | n/a | n/a | 2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE | n/a | |
| 42 | P28845_NN4 | NN4 | DB08280 | n/a | n/a | (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE | n/a | |
| 43 | P28845_S05 | S05 | n/a | 24895969 | CHEMBL1761844 | 3,4-dihydroquinolin-1(2H)-yl[4-(1H-imidazol-5-yl)piperidin-1-yl]methanone | n/a | |
| 44 | P28845_SFF | SFF | n/a | 66550645;135566823; | CHEMBL2409730 | (4aS,8aR)-N-cyclohexyl-4a,5,6,7,8,8a-hexahydro-4,1,2-benzoxathiazin-3-amine 1,1-dioxide | n/a | |
| 45 | P28845_ZMG | ZMG | DB08771 | 23644575;135566336; | CHEMBL392452 | (5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one | n/a | |
| 46 | P28845_T30 | T30 | n/a | 24941247 | CHEMBL476142 | 3-[1-(4-fluorophenyl)cyclopropyl]-4-(1-methylethyl)-5-[4-(trifluoromethoxy)phenyl]-4H-1,2,4-triazole | n/a | |
| 47 | P28845_NAI | NAI | DB00157 | 439153 | CHEMBL1234616 | NADH | n/a | |
| 48 | P28845_C0R | C0R | DB04652 | 5753 | CHEMBL110739 | Corticosterone | substrate | |
| 49 | P28845_3G4 | 3G4 | DB07056 | 11545694 | CHEMBL495597 | 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide | n/a | Ki(nM) = 287.0 |
| 50 | P28845_DB13751 | n/a | DB13751 | n/a | n/a | Glycyrrhizic acid | antagonist |