Gene name: ADORA2A
Protein name: Adenosine receptor A2a
List of molecules and drugs that interact with protein P29274
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P29274_6DV | 6DV | n/a | 44394716 | CHEMBL184061 | N~5~-{2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl}-2-(furan-2-yl)[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine | n/a | |
| 2 | P29274_6DX | 6DX | n/a | 44394688 | CHEMBL187810 | 2-(furan-2-yl)-N~5~-[3-(4-phenylpiperazin-1-yl)propyl][1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine | n/a | |
| 3 | P29274_6DY | 6DY | n/a | 86302363 | CHEMBL3937413 | 2-(furan-2-yl)-N~5~-[2-(4-phenylpiperidin-1-yl)ethyl][1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine | n/a | |
| 4 | P29274_6DZ | 6DZ | n/a | 121225598 | CHEMBL3934661 | 2-(furan-2-yl)-N~5~-[2-(4-methylpiperazin-1-yl)ethyl][1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine | n/a | |
| 5 | P29274_8D1 | 8D1 | n/a | 124081196 | n/a | 5-amino-N-[(2-methoxyphenyl)methyl]-2-(3-methylphenyl)-2H-1,2,3-triazole-4-carboximidamide | n/a | |
| 6 | P29274_8E2 | 8E2 | n/a | 162677683 | n/a | Preladenant conjugate PSB-2113 | n/a | |
| 7 | P29274_8IM | 8IM | n/a | 162677684 | n/a | 2-[2-[2-[2-[2-[2-[4-[4-[2-[7-azanyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2,4,7,11-pentaen-10-yl]ethyl]piperazin-1-yl]phenoxy]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]-~{N}-[5-[2,2-bis(fluoranyl)-4,6,10,12-tetramethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-8-yl]pentyl]ethanamide | n/a | |
| 8 | P29274_8JN | 8JN | n/a | n/a | n/a | 1-butyl-3-[(~{E})-3-oxidanylprop-1-enyl]-8-[(1~{R},5~{S})-3-tricyclo[3.3.1.0^{3,7}]nonanyl]-7~{H}-purine-2,6-dione | n/a | |
| 9 | P29274_8K6 | 8K6 | n/a | 11635 | n/a | Octadecane | n/a | |
| 10 | P29274_9XT | 9XT | DB06625 | 21874557 | CHEMBL447664 | 3-[(4-azanyl-3-methyl-phenyl)methyl]-7-(furan-2-yl)-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine | antagonist | |
| 11 | P29274_9XW | 9XW | DB12203 | 11618368 | CHEMBL2105747 | ~{N}-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-4-methyl-4-oxidanyl-piperidine-1-carboxamide | antagonist | |
| 12 | P29274_9Y2 | 9Y2 | n/a | 16122818 | CHEMBL1671936 | 4-(3,3-dimethylbutanoylamino)-3,5-bis(fluoranyl)-~{N}-(1,3-thiazol-2-yl)benzamide | n/a | |
| 13 | P29274_ADN | ADN | DB00640 | 60961 | CHEMBL477 | ADENOSINE | agonist | Ki(nM) = 20.0 Kd(nM) = 17.0 EC50(nM) = 25.0 |
| 14 | P29274_CFF | CFF | DB00201 | 2519 | CHEMBL113 | CAFFEINE | antagonist | Ki(nM) = 5011.87 IC50(nM) = 9600.0 Kd(nM) = 5510.0 |
| 15 | P29274_CIT | CIT | DB04272 | 311;19782904;88113319; | CHEMBL1261 | CITRIC ACID | n/a | |
| 16 | P29274_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 17 | P29274_CLR | CLR | DB04540 | 5997 | CHEMBL112570 | CHOLESTEROL | n/a | |
| 18 | P29274_D10 | D10 | n/a | 15600 | CHEMBL134537 | DECANE | n/a | |
| 19 | P29274_D12 | D12 | n/a | 8182 | CHEMBL30959 | DODECANE | n/a | |
| 20 | P29274_EDT | EDT | DB00974 | 6049;5232305; | CHEMBL858 | {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID | n/a | |
| 21 | P29274_ER0 | ER0 | n/a | 155289095 | n/a | [(2~{R},3~{S})-2,3,4-tris(oxidanyl)butyl] (5~{R},9~{R},13~{R})-5,9,13,17-tetramethyloctadecanoate | n/a | |
| 22 | P29274_ETF | ETF | DB03226 | 6409 | CHEMBL116675 | TRIFLUOROETHANOL | n/a | |
| 23 | P29274_F9Q | F9Q | DB16192 | 86676119 | CHEMBL4594442 | 6-(2-chloranyl-6-methyl-pyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine | antagonist | |
| 24 | P29274_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 25 | P29274_HEX | HEX | n/a | 8058 | CHEMBL15939 | HEXANE | n/a | |
| 26 | P29274_HTO | HTO | DB04079 | 444397 | n/a | HEPTANE-1,2,3-TRIOL | n/a | |
| 27 | P29274_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 28 | P29274_JQ9 | JQ9 | DB11757 | 5311037 | CHEMBL431770 | 8-[(~{E})-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione | antagonist | |
| 29 | P29274_JQR | JQR | n/a | 23144148 | CHEMBL5314441 | ~{N}-[4-(furan-2-yl)-5-(oxan-4-ylcarbonyl)-1,3-thiazol-2-yl]-6-methyl-pyridine-3-carboxamide | n/a | |
| 30 | P29274_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 31 | P29274_LJX | LJX | n/a | 164885960 | CHEMBL5203469 | (2R,3R,4R)-2-[(8P)-6-amino-2-(hex-1-yn-1-yl)-8-(thiophen-2-yl)-9H-purin-9-yl]oxolane-3,4-diol | n/a | |
| 32 | P29274_LMT | LMT | n/a | 114880 | CHEMBL1234047 | DODECYL-BETA-D-MALTOSIDE | n/a | |
| 33 | P29274_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 34 | P29274_MYS | MYS | n/a | 12391 | CHEMBL1234557 | PENTADECANE | n/a | |
| 35 | P29274_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 36 | P29274_NEC | NEC | DB03719 | 448222 | CHEMBL464859 | N-ETHYL-5'-CARBOXAMIDO ADENOSINE | n/a | |
| 37 | P29274_NGI | NGI | n/a | 3086599 | CHEMBL331372 | 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE | n/a | |
| 38 | P29274_OCT | OCT | n/a | 356 | CHEMBL134886 | N-OCTANE | n/a | |
| 39 | P29274_OLA | OLA | n/a | 445639 | CHEMBL8659 | OLEIC ACID | n/a | |
| 40 | P29274_OLB | OLB | n/a | 12178130 | n/a | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | n/a | |
| 41 | P29274_OLC | OLC | n/a | 11451146 | n/a | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | n/a | |
| 42 | P29274_PE4 | PE4 | n/a | 448032 | n/a | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL | n/a | |
| 43 | P29274_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 44 | P29274_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 45 | P29274_QGE | QGE | n/a | 740769 | CHEMBL2030687 | [3-(4-methyl-1,3-thiazol-2-yl)-4-oxidanylidene-6-propyl-chromen-7-yl] ethanoate | n/a | |
| 46 | P29274_QGW | QGW | n/a | 984073 | n/a | [2-methyl-3-(4-methyl-1,3-thiazol-2-yl)-4-oxidanylidene-6-propyl-chromen-7-yl] ethanoate | n/a | |
| 47 | P29274_RVZ | RVZ | n/a | 11174953 | CHEMBL124345 | 2-azanyl-6-(1~{H}-imidazol-2-ylmethylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrile | n/a | |
| 48 | P29274_SCN | SCN | n/a | 9322 | n/a | THIOCYANATE ION | n/a | |
| 49 | P29274_TAR | TAR | DB01694 | 439655 | CHEMBL1200861 | D(-)-TARTARIC ACID | n/a | |
| 50 | P29274_TEP | TEP | DB00277 | 2153 | CHEMBL190 | THEOPHYLLINE | antagonist | Ki(nM) = 0.6 Kd(nM) = 3630.0 EC50(nM) = 28200.0 |
| 51 | P29274_TKO | TKO | n/a | 105526064 | CHEMBL5206530 | (4M)-6-bromo-4-(furan-2-yl)quinazolin-2-amine | n/a | |
| 52 | P29274_TRD | TRD | n/a | 12388 | CHEMBL135694 | TRIDECANE | n/a | |
| 53 | P29274_U30 | U30 | DB17506 | 135242184 | CHEMBL4740383 | 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile | antagonist | |
| 54 | P29274_UKA | UKA | DB12691 | 9833519 | CHEMBL1096896 | 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide | agonist | |
| 55 | P29274_UND | UND | n/a | 14257 | CHEMBL132474 | UNDECANE | n/a | |
| 56 | P29274_VBF | VBF | n/a | 168451710 | CHEMBL5440290 | 3-[2-azanyl-6-[2-oxidanylidene-1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]pyridin-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile | n/a | |
| 57 | P29274_XAC | XAC | n/a | 5697 | CHEMBL273094 | N-(2-aminoethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy]acetamide | n/a | |
| 58 | P29274_ZMA | ZMA | DB08770 | 176407 | CHEMBL113142 | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol | inhibitor | Ki(nM) = 0.1 IC50(nM) = 0.678 Kd(nM) = 0.22 |
| 59 | P29274_SOG | SOG | DB08558 | 656909 | n/a | octyl 1-thio-beta-D-glucopyranoside | n/a | |
| 60 | P29274_STE | STE | DB03193 | 5281;139057051; | CHEMBL46403 | STEARIC ACID | n/a | |
| 61 | P29274_T4E | T4E | n/a | 135566609 | CHEMBL2024114 | 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol | n/a | |
| 62 | P29274_T4G | T4G | n/a | 56844240 | CHEMBL2024115 | 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine | n/a | |
| 63 | P29274_DB00358 | n/a | DB00358 | n/a | n/a | Mefloquine | antagonist | |
| 64 | P29274_DB00555 | n/a | DB00555 | n/a | n/a | Lamotrigine | inhibitor | |
| 65 | P29274_DB00651 | n/a | DB00651 | n/a | n/a | Dyphylline | antagonist | Ki(nM) = 10000.0 |
| 66 | P29274_PNX | PNX | DB00806 | 4740 | CHEMBL628 | Pentoxifylline | agonist | Ki(nM) = 10000.0 |
| 67 | P29274_DB00824 | n/a | DB00824 | n/a | n/a | Enprofylline | inhibitor | Ki(nM) = 4730.0 EC50(nM) = 7200.0 |
| 68 | P29274_DB01303 | n/a | DB01303 | n/a | n/a | Oxtriphylline | antagonist | |
| 69 | P29274_37T | 37T | DB01412 | 5429 | CHEMBL1114 | Theobromine | antagonist | Ki(nM) = 10000.0 IC50(nM) = 250000.0 |
| 70 | P29274_DB04853 | n/a | DB04853 | n/a | n/a | Binodenoson | agonist | |
| 71 | P29274_DB05009 | n/a | DB05009 | n/a | n/a | Apadenoson | agonist | |
| 72 | P29274_DB06213 | n/a | DB06213 | n/a | n/a | Regadenoson | agonist | Ki(nM) = 290.0 |
| 73 | P29274_DB09273 | n/a | DB09273 | n/a | n/a | Doxofylline | antagonist | |
| 74 | P29274_DB11757 | n/a | DB11757 | n/a | n/a | Istradefylline | antagonist | |
| 75 | P29274_H33 | H33 | DB14132 | 10661 | CHEMBL88611 | 8-chlorotheophylline | antagonist |