Gene name: EPHA2
Protein name: Ephrin type-A receptor
List of molecules and drugs that interact with protein P29317
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P29317_1N1 | 1N1 | DB01254 | 3062316 | CHEMBL1421 | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | antagonist | IC50(nM) = 0.8 Kd(nM) = 0.85 |
| 2 | P29317_29N | 29N | n/a | 35506 | n/a | 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one | n/a | |
| 3 | P29317_627 | 627 | DB11778 | 11442891 | CHEMBL402548 | N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE | n/a | |
| 4 | P29317_88Z | 88Z | DB12307 | 42642645 | CHEMBL1230609 | N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | n/a | |
| 5 | P29317_8ZH | 8ZH | n/a | 127053577 | n/a | ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-(piperidin-4-ylcarbamoyl)phenyl]amino]-1,3-thiazole-5-carboxamide | n/a | |
| 6 | P29317_8ZK | 8ZK | n/a | 127053593 | n/a | ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-ethyl-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-1,3-thiazole-5-carboxamide | n/a | |
| 7 | P29317_8ZN | 8ZN | n/a | 127053592 | n/a | ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-(piperidin-4-ylcarbamoyl)-5-(trifluoromethyl)phenyl]amino]-1,3-thiazole-5-carboxamide | n/a | |
| 8 | P29317_8ZQ | 8ZQ | n/a | 127053594 | n/a | 2-[[3-(2-aminophenyl)-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | n/a | |
| 9 | P29317_8ZT | 8ZT | n/a | 127053588 | n/a | ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[(3,5-dimorpholin-4-ylphenyl)amino]-1,3-thiazole-5-carboxamide | n/a | |
| 10 | P29317_8ZW | 8ZW | n/a | 127053595 | n/a | ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[(3-methylsulfonyl-5-morpholin-4-yl-phenyl)amino]-1,3-thiazole-5-carboxamide | n/a | |
| 11 | P29317_8ZZ | 8ZZ | n/a | 127053580 | n/a | ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{R},4~{R})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | n/a | |
| 12 | P29317_90B | 90B | n/a | 127053591 | n/a | 2-[[3-bromanyl-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | n/a | |
| 13 | P29317_90E | 90E | n/a | 127053582 | n/a | 2-[[3-[[(4~{R})-3,3-bis(fluoranyl)piperidin-4-yl]carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | n/a | |
| 14 | P29317_90K | 90K | n/a | 127053583 | n/a | 2-[[3-[(3-aminophenyl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | n/a | |
| 15 | P29317_90N | 90N | n/a | 127053579 | n/a | 2-[[3-[(4-azanyl-6-methyl-1,3,5-triazin-2-yl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | n/a | |
| 16 | P29317_90T | 90T | n/a | 127053589 | n/a | (3~{S})-1-[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylpyrrolidine-3-carboxylic acid | n/a | |
| 17 | P29317_90W | 90W | n/a | n/a | n/a | ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(4-oxidanylcyclohexyl)carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | n/a | |
| 18 | P29317_90Z | 90Z | n/a | 127053585 | n/a | ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(2,2,6,6-tetramethyl-1-oxidanyl-piperidin-4-yl)carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | n/a | |
| 19 | P29317_912 | 912 | n/a | n/a | n/a | (2~{Z})-~{N}-(2-chloranyl-6-methyl-phenyl)-2-[3-[(4-methyl-4-oxidanyl-cyclohexyl)carbamoyl]phenyl]imino-1,3-thiazolidine-5-carboxamide | n/a | |
| 20 | P29317_91E | 91E | n/a | 127053578 | n/a | 2-[[3-[(3-azanyl-2,2-dimethyl-propyl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | n/a | |
| 21 | P29317_91H | 91H | n/a | n/a | n/a | 4-[[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylamino]cyclohexane-1-carboxylic acid | n/a | |
| 22 | P29317_91K | 91K | n/a | 127053590 | n/a | 2-[(3~{R})-1-[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylpyrrolidin-3-yl]ethanoic acid | n/a | |
| 23 | P29317_92Q | 92Q | n/a | 127053581 | n/a | ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{S})-pyrrolidin-3-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | n/a | |
| 24 | P29317_A5B | A5B | DB05220 | 24771867 | CHEMBL483158 | alisertib | n/a | |
| 25 | P29317_ACA | ACA | DB00513 | 564;517030; | CHEMBL1046 | 6-AMINOHEXANOIC ACID | n/a | |
| 26 | P29317_ACP | ACP | DB03909 | 91532 | CHEMBL133463 | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | n/a | |
| 27 | P29317_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 28 | P29317_AGS | AGS | DB02930 | 440317;444377; | CHEMBL131890 | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | n/a | |
| 29 | P29317_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 30 | P29317_BTN | BTN | DB00121 | 171548 | CHEMBL857 | BIOTIN | n/a | |
| 31 | P29317_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 32 | P29317_CS | CS | n/a | 104967 | n/a | CESIUM ION | n/a | |
| 33 | P29317_DB8 | DB8 | DB06616 | 5328940 | CHEMBL288441 | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | n/a | IC50(nM) = 2.0 Kd(nM) = 18.0 |
| 34 | P29317_DWT | DWT | n/a | 117602383 | n/a | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 35 | P29317_DXH | DXH | n/a | 16747388 | CHEMBL3752910 | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 36 | P29317_DXK | DXK | n/a | 134693866 | n/a | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 37 | P29317_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 38 | P29317_FZW | FZW | n/a | 138857898 | n/a | 3-[(4,6-dipyridin-3-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 39 | P29317_G02 | G02 | n/a | 16747004 | n/a | 4-methyl-3-[(1-methyl-6-pyrazin-2-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 40 | P29317_G0E | G0E | n/a | 138857897 | n/a | 4-methyl-3-[(1-methyl-6-pyrimidin-5-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 41 | P29317_G0H | G0H | n/a | 138857893 | n/a | 4-methyl-3-[(2-pyridin-3-ylquinazolin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 42 | P29317_G0K | G0K | n/a | 138857896 | n/a | 4-methyl-3-[(2-pyridin-3-ylpyrido[2,3-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 43 | P29317_G0N | G0N | n/a | 138857895 | n/a | 3-[(4,6-dipyridin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 44 | P29317_G0Q | G0Q | n/a | 138857894 | n/a | ~{N}-(3-chlorophenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | n/a | |
| 45 | P29317_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 46 | P29317_GV0 | GV0 | DB11977 | 16118392 | CHEMBL3039525 | golvatinib | n/a | |
| 47 | P29317_HMW | HMW | n/a | 145722474 | n/a | 3-[[4-imidazol-1-yl-6-[(3~{R})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 48 | P29317_HNZ | HNZ | n/a | 145722475 | n/a | 3-[(4-imidazol-1-yl-6-piperazin-1-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 49 | P29317_HO5 | HO5 | n/a | 145722471 | n/a | 3-[[4-imidazol-1-yl-6-[(3~{S})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 50 | P29317_HO8 | HO8 | n/a | 145722476 | n/a | 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 51 | P29317_HOK | HOK | n/a | 145722472 | n/a | 3-[[4-imidazol-1-yl-6-[(3~{S})-3-oxidanylpiperidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 52 | P29317_HOT | HOT | n/a | 145722473 | n/a | 3-[[4-imidazol-1-yl-6-(4-oxidanylpiperidin-1-yl)-1,3,5-triazin-2-yl]amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 53 | P29317_L66 | L66 | n/a | 44478401 | CHEMBL566515 | 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione | n/a | |
| 54 | P29317_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 55 | P29317_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 56 | P29317_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 57 | P29317_P17 | P17 | DB02567 | 447077 | CHEMBL386051 | 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE | n/a | IC50(nM) = 7.9 Kd(nM) = 3.8 |
| 58 | P29317_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 59 | P29317_QJI | QJI | n/a | 46175113 | CHEMBL1198514 | ~{N}-(2-chlorophenyl)-6-piperidin-4-yl-imidazo[1,2-a]pyridine-3-carboxamide | n/a | |
| 60 | P29317_QRD | QRD | n/a | 165430671 | CHEMBL5417915 | 8-(4-azanylbutyl)-6-[2-chloranyl-5-(trifluoromethyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | n/a | |
| 61 | P29317_QRR | QRR | n/a | 165430672 | CHEMBL5401391 | 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | n/a | |
| 62 | P29317_QTX | QTX | n/a | 166638204 | n/a | ~{N}-[3,5-bis(chloranyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | n/a | |
| 63 | P29317_QU6 | QU6 | n/a | 166638207 | n/a | ~{N}-(3-methoxyphenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | n/a | |
| 64 | P29317_QUU | QUU | n/a | 16747334 | n/a | ~{N}-[4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]phenyl]-3-(trifluoromethyl)benzamide | n/a | |
| 65 | P29317_R0O | R0O | n/a | 146621676 | n/a | 4-methyl-~{N}-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | n/a | |
| 66 | P29317_R0T | R0T | n/a | 166638205 | n/a | 4-methyl-~{N}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | n/a | |
| 67 | P29317_R0X | R0X | n/a | 166638206 | n/a | ~{N}-(3,5-dimethoxyphenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | n/a | |
| 68 | P29317_R3L | R3L | n/a | 164989530 | n/a | 4-methyl-~{N}-(3-methylphenyl)-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | n/a | |
| 69 | P29317_UNX | UNX | n/a | |||||
| 70 | P29317_WT3 | WT3 | n/a | 169491048 | n/a | 6-(4-fluoranyl-3-methoxy-phenyl)-13$l^{6}-thia-2,4,8,12,19-pentazatricyclo[12.3.1.1^{3,7}]nonadeca-1(18),3,5,7(19),14,16-hexaene 13,13-dioxide | n/a | |
| 71 | P29317_ZZL | ZZL | DB13061 | 11712649 | CHEMBL259084 | 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID | n/a | |
| 72 | P29317_A0P | A0P | DB04395 | 44462678 | n/a | Phosphoaminophosphonic Acid-Adenylate Ester | n/a | |
| 73 | P29317_DB08896 | n/a | DB08896 | n/a | n/a | Regorafenib | inhibitor | Kd(nM) = 869.0 |
| 74 | P29317_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |