Gene name: NOS3
Protein name: Nitric oxide synthase
List of molecules and drugs that interact with protein P29474
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P29474_327 | 327 | DB07001 | 24941263 | CHEMBL1230023 | (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine | n/a | |
| 2 | P29474_5NI | 5NI | DB04534 | 21501 | CHEMBL165372 | 5-NITROINDAZOLE | inhibitor | |
| 3 | P29474_6NI | 6NI | DB03100 | 24239 | CHEMBL54277 | 6-NITROINDAZOLE | inhibitor | |
| 4 | P29474_7NI | 7NI | DB02207 | 1893 | CHEMBL247378 | 7-NITROINDAZOLE | inhibitor | |
| 5 | P29474_7R2 | 7R2 | n/a | 25014627 | CHEMBL2219913 | N-(1-{2-[ethyl(methyl)amino]ethyl}-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide | n/a | |
| 6 | P29474_8EV | 8EV | n/a | 124136877 | CHEMBL4116969 | 3-[(2-aminoquinolin-7-yl)methoxy]-5-[(methylamino)methyl]benzonitrile | n/a | |
| 7 | P29474_8EY | 8EY | n/a | 124136858 | CHEMBL4079543 | 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(methylamino)methyl]benzonitrile | n/a | |
| 8 | P29474_8FD | 8FD | n/a | 124136901 | CHEMBL4105240 | 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2S)-2-(methylamino)propyl]benzonitrile | n/a | |
| 9 | P29474_8J4 | 8J4 | n/a | 124136897 | CHEMBL4117695 | 7-({3-ethyl-5-[(methylamino)methyl]phenoxy}methyl)quinolin-2-amine | n/a | |
| 10 | P29474_9OG | 9OG | n/a | 121250401 | CHEMBL4064297 | 4-(2-{[(2-amino-4-methylquinolin-7-yl)methyl]amino}ethyl)benzonitrile | n/a | |
| 11 | P29474_9OJ | 9OJ | n/a | 121250406 | CHEMBL4092027 | 4-(2-{[(2-amino-4-methylquinolin-7-yl)methyl]amino}ethyl)-2-methylbenzonitrile | n/a | |
| 12 | P29474_9P7 | 9P7 | n/a | 121250396 | CHEMBL4068062 | 4-(2-{[(2-aminoquinolin-7-yl)methyl]amino}ethyl)-2-methylbenzonitrile | n/a | |
| 13 | P29474_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | inhibitor | |
| 14 | P29474_ARG | ARG | DB00125 | 1549073;5287702;52941769;59294017;59904234;88031296; | n/a | ARGININE | n/a | |
| 15 | P29474_BTB | BTB | n/a | 81462 | n/a | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | n/a | |
| 16 | P29474_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 17 | P29474_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 18 | P29474_CLW | CLW | DB00356 | 2733 | CHEMBL1371 | CHLORZOXAZONE | n/a | IC50(nM) = 8700.0 |
| 19 | P29474_F2J | F2J | n/a | 134821993 | n/a | N-[1-(piperidin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide | n/a | |
| 20 | P29474_GD | GD | n/a | 23982 | n/a | GADOLINIUM ATOM | n/a | |
| 21 | P29474_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 22 | P29474_H4B | H4B | DB00360 | 44257;5282445;135398654; | CHEMBL1201774 | 5,6,7,8-TETRAHYDROBIOPTERIN | cofactor | |
| 23 | P29474_HAR | HAR | DB03144 | 123895;25799416; | CHEMBL260629 | N-OMEGA-HYDROXY-L-ARGININE | inhibitor | |
| 24 | P29474_HEC | HEC | DB03317 | n/a | n/a | HEME C | n/a | |
| 25 | P29474_HEM | HEM | DB18267 | n/a | n/a | PROTOPORPHYRIN IX CONTAINING FE | inhibitor | |
| 26 | P29474_INE | INE | DB01997 | 1649 | CHEMBL479014 | 3-BROMO-7-NITROINDAZOLE | inhibitor | |
| 27 | P29474_IPA | IPA | DB02325 | 3776 | CHEMBL582 | ISOPROPYL ALCOHOL | inhibitor | |
| 28 | P29474_K7U | K7U | n/a | 164513486 | CHEMBL5192809 | 6-[3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl]-4-methylpyridin-2-amine | n/a | |
| 29 | P29474_K8F | K8F | n/a | 164513485 | CHEMBL5204779 | 6-[3-(3,3-difluoroazetidin-1-yl)propyl]-4-methylpyridin-2-amine | n/a | |
| 30 | P29474_K8O | K8O | n/a | 164513484 | CHEMBL5188800 | 6-[3-(4,4-difluoropiperidin-1-yl)prop-1-yn-1-yl]-4-methylpyridin-2-amine | n/a | |
| 31 | P29474_K90 | K90 | n/a | 158447564 | CHEMBL5172237 | 4-methyl-6-[3-(4-methylpiperazin-1-yl)prop-1-yn-1-yl]pyridin-2-amine | n/a | |
| 32 | P29474_K9C | K9C | n/a | 162463139 | CHEMBL5176637 | 4-methyl-6-[3-(methylamino)prop-1-yn-1-yl]pyridin-2-amine | n/a | |
| 33 | P29474_KKU | KKU | n/a | 162463142 | CHEMBL5191295 | 4-methyl-6-[3-(methylamino)propyl]pyridin-2-amine | n/a | |
| 34 | P29474_KL0 | KL0 | n/a | 158447563 | CHEMBL5189279 | 6-[3-(dimethylamino)propyl]-4-methylpyridin-2-amine | n/a | |
| 35 | P29474_KMI | KMI | n/a | 164513487 | n/a | 4-methyl-6-{3-[(methylamino)methyl]phenyl}pyridin-2-amine | n/a | |
| 36 | P29474_KMR | KMR | n/a | 158447566 | CHEMBL5204256 | 4-methyl-6-[3-(4-methylpiperazin-1-yl)propyl]pyridin-2-amine | n/a | |
| 37 | P29474_M16 | M16 | n/a | 70697585 | CHEMBL2097929 | 7-[4-(2-aminoethyl)phenyl]-4-methylquinolin-2-amine | n/a | |
| 38 | P29474_M4R | M4R | n/a | 124136872 | CHEMBL4084387 | 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2R)-2-(methylamino)propyl]benzonitrile | n/a | |
| 39 | P29474_M5L | M5L | n/a | 164513490 | CHEMBL5182377 | 6-[3-(4,4-difluoropiperidin-1-yl)propyl]-4-methylpyridin-2-amine | n/a | |
| 40 | P29474_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 41 | P29474_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 42 | P29474_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 43 | P29474_OS7 | OS7 | n/a | 146025976 | CHEMBL4535045 | 7-{3-(aminomethyl)-4-[(pyridin-2-yl)methoxy]phenyl}-4-methylquinolin-2-amine | n/a | |
| 44 | P29474_OSD | OSD | n/a | 146025973 | CHEMBL4465509 | 7-{3-(aminomethyl)-4-[(propan-2-yl)oxy]phenyl}-4-methylquinolin-2-amine | n/a | |
| 45 | P29474_OSG | OSG | n/a | 146025972 | CHEMBL4588416 | 7-[3-(aminomethyl)-4-propoxyphenyl]-4-methylquinolin-2-amine | n/a | |
| 46 | P29474_OSJ | OSJ | n/a | 146025971 | CHEMBL4464663 | 7-[3-(aminomethyl)-4-ethoxyphenyl]-4-methylquinolin-2-amine | n/a | |
| 47 | P29474_OU1 | OU1 | n/a | 146025975 | CHEMBL4449970 | 7-[3-(aminomethyl)-4-(cyclopropylmethoxy)phenyl]-4-methylquinolin-2-amine | n/a | |
| 48 | P29474_OUA | OUA | n/a | 146025970 | CHEMBL4598341 | 7-[5-(aminomethyl)pyridin-3-yl]-4-methylquinolin-2-amine | n/a | |
| 49 | P29474_OUG | OUG | n/a | 146025968 | CHEMBL4598339 | 7-[3-(aminomethyl)phenyl]-4-methylquinolin-2-amine | n/a | |
| 50 | P29474_OUM | OUM | n/a | 146025981 | CHEMBL4473567 | 4-{[2-(aminomethyl)-4-(2-amino-4-methylquinolin-7-yl)phenoxy]methyl}benzonitrile | n/a | |
| 51 | P29474_OUP | OUP | n/a | 146025974 | CHEMBL4521790 | 7-[3-(aminomethyl)-4-(cyclobutylmethoxy)phenyl]-4-methylquinolin-2-amine | n/a | |
| 52 | P29474_OUS | OUS | n/a | 146025977 | CHEMBL4576585 | 7-{3-(aminomethyl)-4-[(pyridin-3-yl)methoxy]phenyl}-4-methylquinolin-2-amine | n/a | |
| 53 | P29474_Q16 | Q16 | n/a | 73386633 | CHEMBL3109188 | 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine | n/a | |
| 54 | P29474_V5G | V5G | n/a | 155926529 | n/a | 7-({3-[2-(6-aminopyridin-2-yl)ethyl]phenoxy}methyl)quinolin-2-amine | n/a | |
| 55 | P29474_V80 | V80 | n/a | 158032525 | CHEMBL5499684 | 4-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)-6-methylpyrimidin-2-amine | n/a | |
| 56 | P29474_W68 | W68 | n/a | 130449136 | CHEMBL4079135 | 6-(2-{3-fluoro-5-[3-(methylamino)propyl]phenyl}ethyl)-4-methylpyridin-2-amine | n/a | |
| 57 | P29474_W69 | W69 | n/a | 130449158 | CHEMBL4094689 | 6-(2-{3-[3-(dimethylamino)propyl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine | n/a | |
| 58 | P29474_XVA | XVA | n/a | 158032527 | CHEMBL5499165 | 4-(difluoromethyl)-6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)pyridin-2-amine | n/a | |
| 59 | P29474_XVF | XVF | n/a | 158032529 | CHEMBL5499669 | 6-(2-{5-[2-(diethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methylpyridin-2-amine | n/a | |
| 60 | P29474_XVK | XVK | n/a | 157833848 | CHEMBL5498745 | 6-(2-{2,3-difluoro-5-[2-(4-methylpiperazin-1-yl)ethyl]phenyl}ethyl)-4-methylpyridin-2-amine | n/a | |
| 61 | P29474_XVO | XVO | n/a | 157514708 | CHEMBL5500018 | 6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)pyridin-2-amine | n/a | |
| 62 | P29474_XVU | XVU | n/a | 158032526 | CHEMBL5499419 | 6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methylpyridin-2-amine | n/a | |
| 63 | P29474_XVZ | XVZ | n/a | 168654809 | CHEMBL5500035 | 6-{2-[5-(2-aminoethyl)-2,3-difluorophenyl]ethyl}-4-methylpyridin-2-amine | n/a | |
| 64 | P29474_XW5 | XW5 | n/a | 158447567 | CHEMBL5500021 | 6-(2-{5-[2-(dimethylamino)ethyl]-2,3-difluorophenyl}ethyl)-4-methoxypyridin-2-amine | n/a | |
| 65 | P29474_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 66 | P29474_DB00125 | n/a | DB00125 | n/a | n/a | Arginine | n/a | |
| 67 | P29474_CIR | CIR | DB00155 | 9750;6992098; | CHEMBL444814 | Citrulline | n/a | |
| 68 | P29474_DB00435 | n/a | DB00435 | n/a | n/a | Nitric Oxide | product of | |
| 69 | P29474_DB01110 | n/a | DB01110 | n/a | n/a | Miconazole | inhibitor | |
| 70 | P29474_DA2 | DA2 | DB01686 | 123831 | CHEMBL457530 | N,N-dimethylarginine | inhibitor | |
| 71 | P29474_DP1 | DP1 | DB01821 | 656910;136252265; | CHEMBL44833 | L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide | n/a | |
| 72 | P29474_GGB | GGB | DB01833 | 439202;46224610; | CHEMBL443732 | Canavanine | inhibitor | |
| 73 | P29474_DP3 | DP3 | DB02027 | 656911;135440034;136114948; | CHEMBL227937 | N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine | n/a | |
| 74 | P29474_14W | 14W | DB02044 | 1433 | CHEMBL107251 | N-[3-(aminomethyl)benzyl]acetamidine | inhibitor | Ki(nM) = 75000.0 |
| 75 | P29474_TZC | TZC | DB02048 | 3387240 | n/a | 1,2,4-Triazole-Carboxamidine | inhibitor | |
| 76 | P29474_DP9 | DP9 | DB02077 | 656912;155293240;172954931; | CHEMBL228077 | L-N(omega)-nitroarginine-(4R)-amino-L-proline amide | n/a | |
| 77 | P29474_4BT | 4BT | DB02141 | 1337 | CHEMBL444422 | S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea | n/a | |
| 78 | P29474_ITU | ITU | DB02234 | 5139 | CHEMBL321691 | S-Ethylisothiourea | inhibitor | |
| 79 | P29474_ATQ | ATQ | DB02335 | 15689 | CHEMBL362148 | 2-Aminothiazoline | inhibitor | IC50(nM) = 1100.0 |
| 80 | P29474_ISU | ISU | DB02589 | 449633 | n/a | Se-Ethyl-Isoselenourea | inhibitor | |
| 81 | P29474_AP6 | AP6 | DB02911 | 445109 | n/a | 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine | inhibitor | |
| 82 | P29474_NTU | NTU | DB02979 | 11740154 | n/a | N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane | inhibitor | |
| 83 | P29474_CAD | CAD | DB02994 | 2513 | CHEMBL1231644 | Cacodylic acid | inhibitor | |
| 84 | P29474_7I2 | 7I2 | DB03065 | 1894 | n/a | 7-Nitroindazole-2-Carboxamidine | inhibitor | |
| 85 | P29474_ILO | ILO | DB03305 | 107984 | CHEMBL11471 | N(G)-Iminoethylornithine | inhibitor | |
| 86 | P29474_AP4 | AP4 | DB03332 | 5287687;6323220;135509077; | n/a | 5,6-Cyclic-Tetrahydropteridine | inhibitor | |
| 87 | P29474_PTU | PTU | DB03707 | 347590 | CHEMBL451666 | S-Ethyl-N-Phenyl-Isothiourea | inhibitor | |
| 88 | P29474_3BT | 3BT | DB03910 | 1331 | CHEMBL107201 | S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea | n/a | Ki(nM) = 9000.0 |
| 89 | P29474_BHS | BHS | DB03918 | 5287786;6323235;135509079; | n/a | 6S-5,6,7,8-Tetrahydrobiopterin | inhibitor | |
| 90 | P29474_CAS | CAS | DB03963 | n/a | n/a | S-(Dimethylarsenic)Cysteine | n/a | |
| 91 | P29474_HRG | HRG | DB03974 | 9085 | CHEMBL589752 | L-homoarginine | inhibitor | |
| 92 | P29474_IPU | IPU | DB04018 | 445319 | CHEMBL483091 | S-Isopropyl-Isothiourea | inhibitor | Ki(nM) = 22.0 |
| 93 | P29474_NRG | NRG | DB04223 | 440005;28360916;135409365;135453301;155903772; | CHEMBL227744 | Nitroarginine | inhibitor | |
| 94 | P29474_PH3 | PH3 | DB04559 | 181426 | CHEMBL323202 | N-(Chlorophenyl)-N'-hydroxyguanidine | inhibitor | |
| 95 | P29474_7IG | 7IG | DB07244 | 6914633 | CHEMBL230153 | 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE | n/a | |
| 96 | P29474_AT2 | AT2 | DB07388 | 11149707 | CHEMBL420671 | ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE | n/a | IC50(nM) = 50000.0 |
| 97 | P29474_JI3 | JI3 | DB08018 | 24798097 | CHEMBL474637 | N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE | n/a | Ki(nM) = 85160.0 |
| 98 | P29474_JI7 | JI7 | DB08019 | 25021186 | CHEMBL526688 | N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine | n/a | |
| 99 | P29474_6UB | 6UB | DB09237 | 9822750 | CHEMBL2111097 | Levamlodipine | agonist |