Gene name: TYK2
Protein name: Non-receptor tyrosine-protein kinase
List of molecules and drugs that interact with protein P29597
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P29597_0X2 | 0X2 | n/a | 137347906 | n/a | 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | n/a | |
| 2 | P29597_0X5 | 0X5 | n/a | 49839561 | CHEMBL2387224 | 2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | n/a | |
| 3 | P29597_0X6 | 0X6 | n/a | 59618273 | CHEMBL2387124 | 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | n/a | |
| 4 | P29597_0XH | 0XH | n/a | 59618368 | CHEMBL2387127 | 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | n/a | |
| 5 | P29597_0XP | 0XP | n/a | 59618511 | CHEMBL2387221 | 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | n/a | |
| 6 | P29597_2TT | 2TT | n/a | 59618286 | n/a | 2-chloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | n/a | |
| 7 | P29597_2YK | 2YK | n/a | 77068229 | CHEMBL3326128 | 6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine | n/a | |
| 8 | P29597_3SM | 3SM | n/a | 24825710 | CHEMBL1923983 | 2-methoxy-N-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | n/a | |
| 9 | P29597_5U3 | 5U3 | n/a | 78427952 | n/a | 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one | n/a | |
| 10 | P29597_5U4 | 5U4 | n/a | 105539869 | CHEMBL3763864 | 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one | n/a | |
| 11 | P29597_7GL | 7GL | n/a | 129626433 | CHEMBL4279157 | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | n/a | |
| 12 | P29597_9T6 | 9T6 | n/a | n/a | n/a | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide | n/a | |
| 13 | P29597_9ZS | 9ZS | n/a | 67387753 | CHEMBL4064189 | N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | n/a | |
| 14 | P29597_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 15 | P29597_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 16 | P29597_AGS | AGS | DB02930 | 440317;444377; | CHEMBL131890 | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | n/a | |
| 17 | P29597_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 18 | P29597_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 19 | P29597_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
| 20 | P29597_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 21 | P29597_G4J | G4J | DB15003 | 118878093 | CHEMBL4297477 | [(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | inhibitor | |
| 22 | P29597_G5D | G5D | n/a | 134812674 | CHEMBL4519857 | 4-({4-[(1S,4S)-5-(cyanoacetyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyrimidin-2-yl}amino)-N-ethylbenzamide | n/a | |
| 23 | P29597_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 24 | P29597_IK1 | IK1 | n/a | 6419765 | CHEMBL404609 | 5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE | n/a | |
| 25 | P29597_IZA | IZA | DB04716 | 5494425 | CHEMBL21156 | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE | inhibitor | IC50(nM) = 1.0 |
| 26 | P29597_KZJ | KZJ | n/a | 118139924 | CHEMBL4453441 | 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-N-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | n/a | |
| 27 | P29597_L8Y | L8Y | n/a | 118473558 | CHEMBL4537678 | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-N-methylpyridine-3-carboxamide | n/a | |
| 28 | P29597_L91 | L91 | n/a | 90153688 | CHEMBL4526283 | 6-[(5-fluoropyridin-2-yl)amino]-N-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | n/a | |
| 29 | P29597_L9A | L9A | n/a | 118072307 | CHEMBL4438202 | 6-[(cyclopropanecarbonyl)amino]-N-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | n/a | |
| 30 | P29597_LAJ | LAJ | n/a | 138756257 | CHEMBL4598367 | N-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | n/a | |
| 31 | P29597_LB4 | LB4 | n/a | 138756256 | CHEMBL4474729 | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-N-methylpyridine-3-carboxamide | n/a | |
| 32 | P29597_LB7 | LB7 | n/a | 138713709 | CHEMBL4596392 | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide | n/a | |
| 33 | P29597_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 34 | P29597_MI1 | MI1 | DB08895 | 9926791 | CHEMBL221959 | 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | n/a | |
| 35 | P29597_N9G | N9G | n/a | 121374385 | CHEMBL4636795 | 6-({4-[(3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-N,N-dimethylpyridine-3-carboxamide | n/a | |
| 36 | P29597_NM7 | NM7 | DB17058 | 9903786 | CHEMBL257167 | 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide | n/a | |
| 37 | P29597_OV0 | OV0 | n/a | 164885969 | n/a | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5H-pyrrolo[3,4-b]pyridin-5-one | n/a | |
| 38 | P29597_OV5 | OV5 | n/a | 164885970 | n/a | 6-{[(2M)-2-(2-chloro-6-fluorophenyl)-5-oxo-5H-pyrrolo[3,4-b]pyridin-4-yl]amino}-N-ethylpyridine-3-carboxamide | n/a | |
| 39 | P29597_OVC | OVC | n/a | 164885971 | n/a | 2-(2,6-difluorophenyl)-4-(4-methoxyanilino)-5H-pyrrolo[3,4-d]pyrimidin-5-one | n/a | |
| 40 | P29597_OVI | OVI | n/a | 164885972 | n/a | 2-(4-{[2-(2,6-difluorophenyl)-5-oxo-5H-pyrrolo[3,4-d]pyrimidin-4-yl]amino}phenyl)-N-ethylacetamide | n/a | |
| 41 | P29597_R4S | R4S | n/a | 146018275 | CHEMBL4640981 | N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide | n/a | |
| 42 | P29597_R4V | R4V | n/a | 118878262 | CHEMBL4635625 | (1S)-2,2-difluoro-N-[(1S,5R,6R)-3-{5-fluoro-2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-6-methyl-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | n/a | |
| 43 | P29597_R4Y | R4Y | n/a | 146018274 | CHEMBL4638906 | (1S,2S)-2-cyano-N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | n/a | |
| 44 | P29597_R5D | R5D | n/a | 146018273 | CHEMBL4644138 | (1R,2R)-2-cyano-N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | n/a | |
| 45 | P29597_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 46 | P29597_TZ1 | TZ1 | n/a | 2727559 | n/a | N-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide | n/a | |
| 47 | P29597_UNL | UNL | n/a | |||||
| 48 | P29597_UWM | UWM | DB18709 | n/a | CHEMBL4459585 | trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}cyclobutane-1-carbonitrile | n/a | |
| 49 | P29597_UWP | UWP | n/a | 155804555 | CHEMBL4778704 | [3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | n/a | |
| 50 | P29597_VZG | VZG | n/a | 156024957 | CHEMBL4803775 | 6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide | n/a | |
| 51 | P29597_VZJ | VZJ | n/a | 156024956 | CHEMBL4804058 | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide | n/a | |
| 52 | P29597_ZOI | ZOI | n/a | 139464692 | CHEMBL5401070 | N-[(3M)-3-{6-[(3R)-3-methoxyoxolan-3-yl]pyridin-2-yl}-1-methyl-1H-pyrrolo[2,3-c]pyridin-5-yl]urea | n/a | |
| 53 | P29597_ZOQ | ZOQ | n/a | 168665433 | CHEMBL5408759 | N-{(3P)-3-[3-(dimethylsulfamoyl)phenyl]-1H-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide | n/a | |
| 54 | P29597_ZRU | ZRU | n/a | 137449661 | CHEMBL5415951 | (8S)-N-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 55 | P29597_ZS3 | ZS3 | n/a | 137449296 | CHEMBL5405569 | (8S)-N-[(1R,2S)-2-fluorocyclopropyl]-5-{[(1M,2'M)-3'-fluoro-2-oxo-2H-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 56 | P29597_ZSB | ZSB | DB19278 | 137441492 | CHEMBL5314423 | (8S)-N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1P,2'P)-2-oxo-2H-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 57 | P29597_RXT | RXT | DB08877 | 25126798 | CHEMBL1789941 | Ruxolitinib | inhibitor | Ki(nM) = 0.5 IC50(nM) = 0.4 Kd(nM) = 0.9 |
| 58 | P29597_3JW | 3JW | DB11817 | 44205240 | CHEMBL2105759 | Baricitinib | inhibitor | |
| 59 | P29597_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 60 | P29597_D7D | D7D | DB14973 | n/a | CHEMBL3655081 | Abrocitinib | inhibitor | |
| 61 | P29597_DB16650 | n/a | DB16650 | n/a | n/a | Deucravacitinib | inhibitor |