Gene name: WEE1
Protein name: Wee1-like protein kinase
List of molecules and drugs that interact with protein P30291
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P30291_05J | 05J | DB18028 | 139467635 | CHEMBL5095036 | 1-[(7R)-7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | n/a | |
| 2 | P30291_330 | 330 | DB07006 | 10364585 | CHEMBL512341 | 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE | n/a | IC50(nM) = 30.0 |
| 3 | P30291_34W | 34W | DB13059 | 51346455 | CHEMBL4289017 | N-{2-[(1S,4R)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide | n/a | |
| 4 | P30291_396 | 396 | n/a | 23627206 | CHEMBL272267 | 4-(2-chlorophenyl)-9-hydroxy-6-methyl-1,3-dioxo-N-(2-pyrrolidin-1-ylethyl)pyrrolo[3,4-g]carbazole-8-carboxamide | n/a | |
| 5 | P30291_61E | 61E | n/a | 9847909 | CHEMBL410261 | 4-(2-chlorophenyl)-8-[3-(dimethylamino)propoxy]-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | n/a | |
| 6 | P30291_770 | 770 | DB07226 | 24778473 | n/a | N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE | n/a | |
| 7 | P30291_809 | 809 | DB07257 | 11602832 | n/a | 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione | n/a | |
| 8 | P30291_824 | 824 | DB04608 | 4369491 | CHEMBL214253 | 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE | n/a | IC50(nM) = 97.0 |
| 9 | P30291_839 | 839 | DB07265 | 9978312 | CHEMBL462170 | 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID | n/a | IC50(nM) = 23.0 |
| 10 | P30291_8X7 | 8X7 | DB11740 | 24856436 | CHEMBL1976040 | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | inhibitor | |
| 11 | P30291_96M | 96M | n/a | 5311382 | CHEMBL49120 | 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | n/a | |
| 12 | P30291_98D | 98D | n/a | 67171057 | n/a | 1-{6-[(1S)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | n/a | |
| 13 | P30291_98G | 98G | n/a | 67170974 | n/a | 1-{6-[(1R)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | n/a | |
| 14 | P30291_98M | 98M | n/a | 132472996 | n/a | 6-{[3-chloro-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | n/a | |
| 15 | P30291_99J | 99J | n/a | 132472994 | n/a | 6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1-{6-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]pyridin-2-yl}-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | n/a | |
| 16 | P30291_99M | 99M | n/a | 129081115 | n/a | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(morpholin-4-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo [3,4-d]pyrimidin-3-one | n/a | |
| 17 | P30291_99V | 99V | n/a | 132472995 | n/a | 6-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | n/a | |
| 18 | P30291_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 19 | P30291_DB8 | DB8 | DB06616 | 5328940 | CHEMBL288441 | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | n/a | Kd(nM) = 44.0 |
| 20 | P30291_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 21 | P30291_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 22 | P30291_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 23 | P30291_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 24 | P30291_P48 | P48 | DB16232 | 16718576 | CHEMBL564829 | N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE | n/a | |
| 25 | P30291_P91 | P91 | DB08365 | 11691442 | n/a | 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide | n/a | |
| 26 | P30291_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 27 | P30291_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 28 | P30291_QT9 | QT9 | n/a | 168266208 | CHEMBL5274503 | 2-(2-methoxyphenyl)-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]pyrazolo[3,4-d]pyrimidin-3-one | n/a | |
| 29 | P30291_XZN | XZN | n/a | 60202320 | CHEMBL4067978 | 4-[(3,5-DICHLORO-4-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE | n/a | |
| 30 | P30291_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |