Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
P31645 SC6A4_HUMAN
Gene name: SLC6A4
Protein name: Sodium-dependent serotonin transporter

List of molecules and drugs that interact with protein P31645

# DrugDomain Data PBD ligand DrugBank Accession PubChem ChEMBL Name Drug action Affinity data
1 P31645_68P 68P DB01175 146570 CHEMBL1508 (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile inhibitor Ki(nM) = 1.0
IC50(nM) = 2.1
Kd(nM) = 2.6
EC50(nM) = 5100.0
2 P31645_69D 69D n/a 118987032 n/a (1S)-1-(4-bromophenyl)-1-[3-(dimethylamino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile n/a
3 P31645_8PR 8PR DB00715 43815 CHEMBL490 Paroxetine inhibitor Ki(nM) = 0.04
IC50(nM) = 0.2
Kd(nM) = 0.13
4 P31645_ACA ACA DB00513 564;517030; CHEMBL1046 6-AMINOHEXANOIC ACID n/a
5 P31645_C14 C14 n/a 12389 CHEMBL135488 TETRADECANE n/a
6 P31645_CL CL n/a 312 n/a CHLORIDE ION n/a
7 P31645_CLR CLR DB04540 5997 CHEMBL112570 CHOLESTEROL n/a
8 P31645_D10 D10 n/a 15600 CHEMBL134537 DECANE n/a
9 P31645_D12 D12 n/a 8182 CHEMBL30959 DODECANE n/a
10 P31645_FVX FVX DB00176 5324346 CHEMBL814 Fluvoxamine inhibitor
11 P31645_HEX HEX n/a 8058 CHEMBL15939 HEXANE n/a
12 P31645_HJM HJM n/a 197060 CHEMBL1215855 (5beta)-12-methoxyibogamine n/a
13 P31645_HP6 HP6 n/a 8900 CHEMBL134658 HEPTANE n/a
14 P31645_IXX IXX DB00458 3696 CHEMBL11 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE inhibitor Ki(nM) = 0.15
IC50(nM) = 0.88
15 P31645_KWC KWC n/a 8027201 n/a 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine n/a
16 P31645_LMT LMT n/a 114880 CHEMBL1234047 DODECYL-BETA-D-MALTOSIDE n/a
17 P31645_LNK LNK n/a 8003 CHEMBL16102 PENTANE n/a
18 P31645_NA NA n/a 923 n/a SODIUM ION n/a
19 P31645_NAG NAG DB00141 24139 CHEMBL447878 2-acetamido-2-deoxy-beta-D-glucopyranose n/a
20 P31645_R16 R16 n/a 11006 CHEMBL134994 HEXADECANE n/a
21 P31645_RFS RFS n/a 145994859 CHEMBL4848081 Br-paroxetine n/a
22 P31645_RFY RFY n/a 145994860 n/a I-paroxetine n/a
23 P31645_Y01 Y01 n/a 65082 n/a CHOLESTEROL HEMISUCCINATE n/a
24 P31645_YG7 YG7 DB06684 6918314 CHEMBL439849 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide inhibitor Ki(nM) = 0.5
IC50(nM) = 0.4
25 P31645_SRE SRE DB01104 68617 CHEMBL809 (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine inhibitor IC50(nM) = 0.19
Kd(nM) = 0.29
26 P31645_SRO SRO DB08839 5202 CHEMBL39 SEROTONIN n/a
27 P31645_DB00182 n/a DB00182 n/a n/a Amphetamine binder
28 P31645_DB00191 n/a DB00191 n/a n/a Phentermine inhibitor
29 P31645_DB00193 n/a DB00193 n/a n/a Tramadol inhibitor IC50(nM) = 1100.0
30 P31645_DB00215 n/a DB00215 n/a n/a Citalopram inhibitor Ki(nM) = 0.78
IC50(nM) = 3.0
EC50(nM) = 8700.0
31 P31645_CXQ CXQ DB00245 n/a CHEMBL1201203 Benzatropine inhibitor IC50(nM) = 24100.0
32 P31645_DB00285 n/a DB00285 n/a n/a Venlafaxine inhibitor Ki(nM) = 7.5
IC50(nM) = 20.0
Kd(nM) = 8.9
33 P31645_DB00289 n/a DB00289 n/a n/a Atomoxetine binder IC50(nM) = 48.0
Kd(nM) = 8.9
34 P31645_TP0 TP0 DB00321 2160 CHEMBL629 Amitriptyline inhibitor Ki(nM) = 2.8
35 P31645_DB00344 n/a DB00344 n/a n/a Protriptyline inhibitor Ki(nM) = 19.6
36 P31645_DB00408 n/a DB00408 n/a n/a Loxapine binder
37 P31645_DB00454 n/a DB00454 n/a n/a Meperidine binder
38 P31645_DB00472 n/a DB00472 n/a n/a Fluoxetine inhibitor Ki(nM) = 0.72
IC50(nM) = 2.5
Kd(nM) = 0.81
EC50(nM) = 2.7
39 P31645_29E 29E DB00476 60835 CHEMBL1175 Duloxetine inhibitor Ki(nM) = 0.2
IC50(nM) = 0.316228
40 P31645_DB00514 n/a DB00514 n/a n/a Dextromethorphan inhibitor
41 P31645_21B 21B DB00540 4543 CHEMBL445 Nortriptyline inhibitor Ki(nM) = 15.0
42 P31645_DB00543 n/a DB00543 n/a n/a Amoxapine inhibitor Ki(nM) = 58.0
43 P31645_DB00574 n/a DB00574 n/a n/a Fenfluramine substrate
44 P31645_DB00579 n/a DB00579 n/a n/a Mazindol inhibitor Ki(nM) = 45.0
IC50(nM) = 54.0
45 P31645_DB00656 n/a DB00656 n/a n/a Trazodone inhibitor Ki(nM) = 160.0
46 P31645_DB00661 n/a DB00661 n/a n/a Verapamil unknown
47 P31645_DB00726 n/a DB00726 n/a n/a Trimipramine inhibitor Ki(nM) = 149.0
48 P31645_DB00805 n/a DB00805 n/a n/a Minaprine inhibitor
49 P31645_DB00852 n/a DB00852 n/a n/a Pseudoephedrine inhibitor
50 P31645_COC COC DB00907 446220 CHEMBL370805 Cocaine inhibitor Ki(nM) = 155.0
IC50(nM) = 270.0
EC50(nM) = 318.0
51 P31645_DB00924 n/a DB00924 n/a n/a Cyclobenzaprine inhibitor
52 P31645_LDP LDP DB00988 681 CHEMBL59 Dopamine inhibitor Ki(nM) = 1100000.0
IC50(nM) = 30000.0
53 P31645_DB01105 n/a DB01105 n/a n/a Sibutramine inhibitor
54 P31645_DB01114 n/a DB01114 n/a n/a Chlorpheniramine inhibitor
55 P31645_DB01142 no_lig_id DB01142 n/a n/a Doxepin inhibitor
56 P31645_DB01149 n/a DB01149 n/a n/a Nefazodone inhibitor Ki(nM) = 200.0
Kd(nM) = 200.0
57 P31645_DSM DSM DB01151 2995 CHEMBL72 Desipramine inhibitor Ki(nM) = 17.6
IC50(nM) = 64.0
58 P31645_DB01191 n/a DB01191 n/a n/a Dexfenfluramine inhibitor
59 P31645_9SC 9SC DB01238 60795 CHEMBL1112 Aripiprazole modulator Ki(nM) = 32.0
60 P31645_CXX CXX DB01242 2801 CHEMBL415 Clomipramine inhibitor Ki(nM) = 0.05
IC50(nM) = 70.0
61 P31645_DB01442 n/a DB01442 n/a n/a MMDA negative modulator
62 P31645_DB01454 n/a DB01454 n/a n/a Midomafetamine negative modulator Ki(nM) = 0.73
IC50(nM) = 384.0
EC50(nM) = 1000.0
63 P31645_DB01472 n/a DB01472 n/a n/a 4-Methoxyamphetamine inhibitor
64 P31645_B40 B40 DB01577 10836 CHEMBL1201201 Metamfetamine negative modulator
65 P31645_DB04821 n/a DB04821 n/a n/a Nomifensine n/a Ki(nM) = 874.0
66 P31645_DB04832 n/a DB04832 n/a n/a Zimelidine inhibitor
67 P31645_DB04836 n/a DB04836 n/a n/a Amineptine n/a
68 P31645_DB04889 n/a DB04889 n/a n/a Bicifadine modulator IC50(nM) = 117.0
69 P31645_DB04896 n/a DB04896 n/a n/a Milnacipran inhibitor Ki(nM) = 8.44
IC50(nM) = 64.0
70 P31645_DB05422 n/a DB05422 n/a n/a OPC-14523 n/a
71 P31645_DB05964 n/a DB05964 n/a n/a Amitifadine inhibitor
72 P31645_92S 92S DB06077 21302490 CHEMBL3306803 Lumateperone inhibitor
73 P31645_DB06148 n/a DB06148 n/a n/a Mianserin inhibitor
74 P31645_DB06156 n/a DB06156 n/a n/a Tesofensine n/a
75 P31645_DB06204 n/a DB06204 n/a n/a Tapentadol inhibitor
76 P31645_DB06700 n/a DB06700 n/a n/a Desvenlafaxine inhibitor Ki(nM) = 4.1
IC50(nM) = 53.0
77 P31645_DB06701 n/a DB06701 n/a n/a Dexmethylphenidate inhibitor
78 P31645_DB08918 n/a DB08918 n/a n/a Levomilnacipran inhibitor IC50(nM) = 320.0
79 P31645_DB09068 n/a DB09068 n/a n/a Vortioxetine inhibitor
80 P31645_DB09167 n/a DB09167 n/a n/a Dosulepin inhibitor
81 P31645_DB09186 n/a DB09186 n/a n/a Nisoxetine inhibitor Ki(nM) = 30.0
IC50(nM) = 20.0
82 P31645_DB09195 n/a DB09195 n/a n/a Lorpiprazole antagonist
83 P31645_ZOT ZOT DB09225 5736 CHEMBL285802 Zotepine antagonist Ki(nM) = 1000.0
84 P31645_DB12305 n/a DB12305 n/a n/a Dasotraline inhibitor