Gene name: AKT1
Protein name: RAC-alpha serine/threonine-protein kinase
List of molecules and drugs that interact with protein P31749
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P31749_0R4 | 0R4 | n/a | 56965952 | CHEMBL2177836 | N-(4-{5-[3-(acetylamino)phenyl]-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl}benzyl)-3-fluorobenzamide | n/a | |
| 2 | P31749_0RF | 0RF | DB11743 | 24788740 | CHEMBL2177390 | (2S)-2-(4-chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one | inhibitor | |
| 3 | P31749_0XZ | 0XZ | DB12218 | 25227436 | CHEMBL2325741 | 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide | inhibitor | |
| 4 | P31749_4IP | 4IP | DB01863 | n/a | CHEMBL23552 | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE | inhibitor | |
| 5 | P31749_6S1 | 6S1 | DB14982 | 53262401 | CHEMBL4297188 | 3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine | inhibitor | |
| 6 | P31749_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 7 | P31749_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 8 | P31749_CQU | CQU | DB07584 | 24798741 | CHEMBL428963 | N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | IC50(nM) = 151.0 |
| 9 | P31749_CQW | CQW | DB07585 | 24798742 | CHEMBL259833 | 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine | n/a | |
| 10 | P31749_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 11 | P31749_EX4 | EX4 | n/a | 133054002 | CHEMBL4128457 | (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one | n/a | |
| 12 | P31749_G4H | G4H | n/a | 137349391 | n/a | ~{N}-[1-methyl-2-oxidanylidene-3-[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]benzimidazol-5-yl]propanamide | n/a | |
| 13 | P31749_G4K | G4K | n/a | 122668104 | n/a | Borussertib | n/a | |
| 14 | P31749_G4N | G4N | n/a | 137349392 | n/a | ~{N}-[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]-3-(propanoylamino)benzamide | n/a | |
| 15 | P31749_G4Q | G4Q | n/a | 137349393 | n/a | ~{N}-[4-[4-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperazin-1-yl]phenyl]propanamide | n/a | |
| 16 | P31749_G4T | G4T | n/a | 137349394 | n/a | ~{N}-[2-chloranyl-5-[[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]carbamoylamino]phenyl]propanamide | n/a | |
| 17 | P31749_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 18 | P31749_GVF | GVF | n/a | 16058667 | CHEMBL595349 | BENZENE-1,2,3,4-TETRAYL TETRAKIS[DIHYDROGEN (PHOSPHATE)] | n/a | |
| 19 | P31749_IQO | IQO | n/a | 10196499 | CHEMBL258844 | 1-(1-(4-(7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | n/a | |
| 20 | P31749_L1W | L1W | n/a | 145946057 | n/a | ~{N}-[3-[1-[[4-[5-[(4-hydroxyphenyl)methyl]-6-oxidanylidene-2-phenyl-1~{H}-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide | n/a | |
| 21 | P31749_L1Z | L1Z | n/a | 145946058 | n/a | ~{N}-[3-[1-[[4-(5-methyl-6-oxidanylidene-3-phenyl-1~{H}-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide | n/a | |
| 22 | P31749_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 23 | P31749_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 24 | P31749_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 25 | P31749_SBT | SBT | DB02606 | 444683 | n/a | 2-BUTANOL | n/a | |
| 26 | P31749_SM9 | SM9 | n/a | 51000425 | n/a | N-(2-ethoxyethyl)-N-{(2S)-2-hydroxy-3-[(5R)-2-(quinazolin-4-yl)-2,7-diazaspiro[4.5]dec-7-yl]propyl}-2,6-dimethylbenzenesulfonamide | n/a | |
| 27 | P31749_SMH | SMH | n/a | 50990925 | n/a | N-(2-ethoxyethyl)-N-{(2S)-2-hydroxy-3-[(2R)-6-hydroxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,3'-piperidin]-1'-yl]propyl}-2,6-dimethylbenzenesulfonamide | n/a | |
| 28 | P31749_SMR | SMR | n/a | 50990926 | n/a | N-{(2S)-3-[(3S)-8',9'-dihydro-1H,3'H-spiro[piperidine-3,7'-pyrano[3,2-e]indazol]-1-yl]-2-hydroxypropyl}-N-(2-ethoxyethyl)-2,6-dimethylbenzenesulfonamide | n/a | |
| 29 | P31749_SMY | SMY | n/a | 46942379 | CHEMBL1235979 | (2R)-3-(1H-indol-3-yl)-1-{4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine | n/a | |
| 30 | P31749_UC8 | UC8 | n/a | 156596346 | n/a | ~{N}-methyl-6-[4-[[4-[2-oxidanylidene-6-(propanoylamino)-3~{H}-benzimidazol-1-yl]piperidin-1-yl]methyl]phenyl]-5-phenyl-pyridine-3-carboxamide | n/a | |
| 31 | P31749_UCE | UCE | n/a | 156596347 | n/a | ~{N}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide | n/a | |
| 32 | P31749_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 33 | P31749_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ATP | n/a | |
| 34 | P31749_DB01169 | n/a | DB01169 | n/a | n/a | Arsenic trioxide | inducer | |
| 35 | P31749_GEN | GEN | DB01645 | 5280961 | CHEMBL44 | Genistein | n/a | IC50(nM) = 70000.0 |
| 36 | P31749_STL | STL | DB02709 | 445154 | CHEMBL165 | Resveratrol | inhibitor | |
| 37 | P31749_DB06486 | n/a | DB06486 | n/a | n/a | Enzastaurin | inhibitor | |
| 38 | P31749_DB06641 | n/a | DB06641 | n/a | n/a | Perifosine | n/a |