Gene name: ATIC
Protein name: Bifunctional purine biosynthesis
List of molecules and drugs that interact with protein P31939
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P31939_354 | 354 | n/a | 5287491;6323190;135509069; | n/a | N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID | n/a | |
| 2 | P31939_8UM | 8UM | n/a | 137348756 | n/a | 5-[(5S)-5-ethyl-5-methyl-6-oxo-1,4,5,6-tetrahydropyridin-3-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide | n/a | |
| 3 | P31939_8US | 8US | n/a | 121378588 | CHEMBL4063104 | N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide | n/a | |
| 4 | P31939_AMZ | AMZ | DB01700 | 65110 | CHEMBL483849 | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE | n/a | |
| 5 | P31939_BW2 | BW2 | n/a | 10413235;135514616; | n/a | N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACID | n/a | |
| 6 | P31939_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 7 | P31939_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 8 | P31939_XMP | XMP | DB02309 | n/a | n/a | XANTHOSINE-5'-MONOPHOSPHATE | n/a | |
| 9 | P31939_DB00116 | n/a | DB00116 | n/a | n/a | Tetrahydrofolic acid | cofactor | |
| 10 | P31939_MTX | MTX | DB00563 | 126941 | CHEMBL34259 | Methotrexate | inhibitor | Ki(nM) = 880.0 IC50(nM) = 20000.0 |
| 11 | P31939_LYA | LYA | DB00642 | 446556;5288715;135410875; | CHEMBL225072 | Pemetrexed | inhibitor | |
| 12 | P31939_G | G | DB01972 | 6804;5280325;135398631; | CHEMBL283807 | Guanosine-5'-Monophosphate | n/a | |
| 13 | P31939_326 | 326 | DB03442 | n/a | n/a | Acid yellow 54 free acid | n/a | |
| 14 | P31939_MS1 | MS1 | DB04057 | 5288848;6323417;135451908; | n/a | N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid | n/a |