Gene name: TTK
Protein name: Dual specificity protein
List of molecules and drugs that interact with protein P33981
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P33981_052 | 052 | n/a | 90176196 | CHEMBL4570284 | N-cyclopropyl-2-methyl-4-(7-{[2-(morpholin-4-yl)ethyl]amino}-5-phenoxypyrazolo[1,5-a]pyrimidin-3-yl)benzamide | n/a | |
| 2 | P33981_0SQ | 0SQ | n/a | 22618347 | CHEMBL5279965 | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea | n/a | |
| 3 | P33981_1KA | 1KA | n/a | 176960 | n/a | (2-hydroxyethoxy)acetaldehyde | n/a | |
| 4 | P33981_1O5 | 1O5 | n/a | 71576779 | CHEMBL2380583 | 5-[5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl]-2-methylbenzenesulfonamide | n/a | |
| 5 | P33981_1PE | 1PE | n/a | 62551 | CHEMBL1229766 | PENTAETHYLENE GLYCOL | n/a | |
| 6 | P33981_1PF | 1PF | n/a | 137347974 | n/a | 4-(cyclohexylmethoxy)-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-2H-indazole | n/a | |
| 7 | P33981_1PH | 1PH | n/a | 67455813 | CHEMBL3330255 | 2-phenyl-N-[3-(3-sulfamoylphenyl)-2H-indazol-5-yl]acetamide | n/a | |
| 8 | P33981_2QK | 2QK | n/a | 86711023 | CHEMBL3422063 | N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide | n/a | |
| 9 | P33981_3D7 | 3D7 | n/a | 91667406 | CHEMBL4288628 | 3-amino-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2(1H)-one | n/a | |
| 10 | P33981_4T9 | 4T9 | n/a | 68291131 | CHEMBL3109932 | N-(3,4-dimethoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine | n/a | |
| 11 | P33981_537 | 537 | DB01782 | 8515 | CHEMBL7064 | 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE | inhibitor | IC50(nM) = 98.0 |
| 12 | P33981_5NW | 5NW | n/a | 73387064 | CHEMBL3809252 | N2-(2-Methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine | n/a | |
| 13 | P33981_5O1 | 5O1 | n/a | 73386878 | CHEMBL3808500 | ~{N}8-cyclohexyl-~{N}2-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine | n/a | |
| 14 | P33981_5O4 | 5O4 | n/a | 119025602 | CHEMBL3809487 | 4-(furan-3-yl)-3-phenyl-2~{H}-pyrazolo[4,3-c]pyridine | n/a | |
| 15 | P33981_5O7 | 5O7 | n/a | 119025603 | CHEMBL3810175 | ~{N}-(2,4-dimethoxyphenyl)-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amine | n/a | |
| 16 | P33981_5OE | 5OE | n/a | 73386768 | CHEMBL3809656 | ~{N}-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amine | n/a | |
| 17 | P33981_5OQ | 5OQ | n/a | 73386764 | CHEMBL3809446 | ~{N}-(2,4-dimethoxyphenyl)-5-(1-methylpyrazol-4-yl)isoquinolin-3-amine | n/a | |
| 18 | P33981_7CE | 7CE | n/a | 66548458 | CHEMBL3109962 | N-(2-methoxyphenyl)-2-(1,3-oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine | n/a | |
| 19 | P33981_7PE | 7PE | n/a | 526557 | n/a | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL | n/a | |
| 20 | P33981_7RO | 7RO | n/a | 68310278 | CHEMBL3109933 | tert-butyl 6-((2-chloro-4-(dimethylcarbamoyl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate | n/a | |
| 21 | P33981_8PT | 8PT | n/a | 46909588 | CHEMBL2047943 | ~{N}6-cyclohexyl-~{N}2-(2-methyl-4-morpholin-4-yl-phenyl)-7~{H}-purine-2,6-diamine | n/a | |
| 22 | P33981_8Q5 | 8Q5 | n/a | 67974488 | CHEMBL3410060 | ~{N}-cyclopropyl-4-[8-(2-methylpropylamino)imidazo[1,2-a]pyrazin-3-yl]benzamide | n/a | |
| 23 | P33981_8QE | 8QE | n/a | 70682875 | CHEMBL2089255 | 4-[[4-azanyl-6-(~{tert}-butylamino)-5-cyano-pyridin-2-yl]amino]benzamide | n/a | |
| 24 | P33981_8QW | 8QW | n/a | 71599640 | CHEMBL4303241 | (2~{R})-2-(4-fluorophenyl)-~{N}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide | n/a | |
| 25 | P33981_8QZ | 8QZ | n/a | 122632889 | CHEMBL5401292 | ~{N}-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]pyrazol-4-yl]-2-[[2-methoxy-4-[4-(2-methoxyethanoyl)piperazin-1-yl]phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide | n/a | |
| 26 | P33981_8RH | 8RH | n/a | 78320750 | CHEMBL4456085 | BAY 1217389 | n/a | |
| 27 | P33981_92M | 92M | n/a | 25271586 | CHEMBL1230645 | 9-cyclopentyl-2-(4-(4-hydroxypiperidin-1-yl)-2-methoxyphenylamino)-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin -6(7H)-one | n/a | |
| 28 | P33981_AD5 | AD5 | DB07340 | 210332 | CHEMBL188343 | N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine | n/a | |
| 29 | P33981_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ADENOSINE-5'-TRIPHOSPHATE | n/a | |
| 30 | P33981_AU5 | AU5 | n/a | 56973724 | CHEMBL2140523 | 9-CYCLOPENTYL-2-[[2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]-PHENYL]AMINO]-7-METHYL-7,9-DIHYDRO-8H-PURIN-8-ONE | n/a | |
| 31 | P33981_C5N | C5N | n/a | 44537856 | CHEMBL4757879 | ~{N}-(2,6-diethylphenyl)-8-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide | n/a | |
| 32 | P33981_CAC | CAC | n/a | 167250 | n/a | CACODYLATE ION | n/a | |
| 33 | P33981_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 34 | P33981_CQ7 | CQ7 | n/a | 117881270 | CHEMBL4062218 | 4-{[4-(cyclopentyloxy)-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxy-N-methylbenzamide | n/a | |
| 35 | P33981_CX4 | CX4 | n/a | 1491124 | n/a | 7-chloro-N-(cyclopropylmethyl)quinazolin-4-amine | n/a | |
| 36 | P33981_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 37 | P33981_DYK | DYK | n/a | 91668530 | CHEMBL3421972 | N-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine | n/a | |
| 38 | P33981_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 39 | P33981_FMW | FMW | DB15498 | 73386890 | CHEMBL3924132 | ~{N}8-(2,2-dimethylpropyl)-~{N}2-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methyl-pyrido[3,4-d]pyrimidine-2,8-diamine | inhibitor | |
| 40 | P33981_FZF | FZF | n/a | 155907519 | CHEMBL5092617 | 4-(cyclohexylamino)-2-[(2-methoxy-4-morpholin-4-ylcarbonyl-phenyl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 41 | P33981_FZL | FZL | n/a | 155118903 | CHEMBL5092060 | 4-(cyclohexylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 42 | P33981_FZO | FZO | n/a | 155118974 | CHEMBL5088755 | 2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(oxan-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 43 | P33981_FZR | FZR | n/a | 155907520 | CHEMBL5079268 | 4-(cyclohexylamino)-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 44 | P33981_G0U | G0U | n/a | 155118973 | CHEMBL5079244 | 4-(cyclopentylmethylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 45 | P33981_G5C | G5C | n/a | 155109148 | CHEMBL5092259 | 2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 46 | P33981_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 47 | P33981_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 48 | P33981_IPA | IPA | DB02325 | 3776 | CHEMBL582 | ISOPROPYL ALCOHOL | n/a | |
| 49 | P33981_KE7 | KE7 | n/a | n/a | CHEMBL4546504 | 4-({5-chloro-4-[(cis-4-hydroxy-4-methylcyclohexyl)oxy]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)-N,N-dimethyl-3-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}benzamide | n/a | |
| 50 | P33981_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 51 | P33981_MLI | MLI | DB02201 | 9084 | n/a | MALONATE ION | n/a | |
| 52 | P33981_N66 | N66 | n/a | 122632882 | CHEMBL4449557 | ~{N}-(2,6-diethylphenyl)-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide | n/a | |
| 53 | P33981_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 54 | P33981_NN5 | NN5 | n/a | 146035907 | CHEMBL4646785 | [4-[[6-(3,5-dimethyl-4-oxidanyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-morpholin-4-yl-methanone | n/a | |
| 55 | P33981_O17 | O17 | n/a | n/a | n/a | (2E)-3-[4-({4-amino-5-cyano-6-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylamino]pyridin-2-yl}amino)-2-(cyanomethoxy)phenyl]-N-(2-methoxyethyl)prop-2-enamide | n/a | |
| 56 | P33981_O22 | O22 | n/a | 57339131 | CHEMBL2089254 | 4-[(4-amino-5-cyano-6-ethoxypyridin-2-yl)amino]benzamide | n/a | |
| 57 | P33981_O23 | O23 | n/a | 57382314 | CHEMBL3410069 | N-cyclopropyl-4-{8-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]pyrazin-3-yl}benzamide | n/a | |
| 58 | P33981_O38 | O38 | n/a | 70799413 | n/a | 6-{[3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino}-2-(cyclohexylamino)pyridine-3-carbonitrile | n/a | |
| 59 | P33981_O43 | O43 | n/a | 87057562 | CHEMBL3410080 | 4-{6-(cyclohexylamino)-8-[(tetrahydro-2H-pyran-4-ylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}-N-cyclopropylbenzamide | n/a | |
| 60 | P33981_P4C | P4C | n/a | 449607 | n/a | O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL | n/a | |
| 61 | P33981_PB | PB | n/a | 73212 | n/a | LEAD (II) ION | n/a | |
| 62 | P33981_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 63 | P33981_PG0 | PG0 | n/a | 8134 | CHEMBL1235250 | 2-(2-METHOXYETHOXY)ETHANOL | n/a | |
| 64 | P33981_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 65 | P33981_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 66 | P33981_PGF | PGF | n/a | 81860 | n/a | 2,5,8,11-TETRAOXATRIDECANE | n/a | |
| 67 | P33981_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 68 | P33981_PWU | PWU | n/a | 66546159 | n/a | ISOPROPYL 6-((4-(1,2-DIMETHYL-1H-IMIDAZOL-5-YL)PHENYL)AMINO)-2-(1-METHYL-1H-PYRAZOL-4-YL)-1H-PYRROLO[3,2-C]PYRIDINE-1-CARBOXYLATE | n/a | |
| 69 | P33981_S22 | S22 | n/a | 25195352 | CHEMBL1235786 | 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol | n/a | |
| 70 | P33981_TOE | TOE | n/a | 8178 | CHEMBL1794613 | 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL | n/a | |
| 71 | P33981_W2K | W2K | n/a | 11646783 | CHEMBL4286130 | 4-(4-Methylpiperazin-1-yl)-N-(2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin-3-yl)benzamide | n/a | |
| 72 | P33981_WBI | WBI | n/a | 52936434 | CHEMBL1765097 | N-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)-4-(piperidin-1-yl)benzamide | n/a | |
| 73 | P33981_X20 | X20 | n/a | 66548104 | CHEMBL3109940 | tert-butyl 6-{[2-chloro-4-(dimethylcarbamoyl)phenyl]amino}-2-(1,3-oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate | n/a | |
| 74 | P33981_X21 | X21 | n/a | 66547425 | CHEMBL3109945 | tert-butyl 6-{[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino}-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate | n/a | |
| 75 | P33981_YB4 | YB4 | n/a | 162639277 | CHEMBL5077230 | ~{N}-(2,6-diethylphenyl)-2-[[4-(4-methylpiperazin-1-yl)-2-(propanoylamino)phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide | n/a | |
| 76 | P33981_Z0B | Z0B | n/a | 818823 | n/a | thieno[2,3-c][2,6]naphthyridine | n/a | |
| 77 | P33981_Z0W | Z0W | n/a | 770811 | n/a | 5H-pyrimido[5,4-b]indole | n/a | |
| 78 | P33981_ZO6 | ZO6 | n/a | 901689 | n/a | thieno[3,2-c][2,6]naphthyridine | n/a | |
| 79 | P33981_ZO8 | ZO8 | n/a | 901691 | n/a | thieno[2,3-c][2,7]naphthyridine | n/a | |
| 80 | P33981_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 81 | P33981_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | |
| 82 | P33981_SVE | SVE | n/a | 44556162 | CHEMBL1236095 | N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE | n/a | |
| 83 | P33981_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |