Gene name: EPHX2
Protein name: Bifunctional epoxide hydrolase
List of molecules and drugs that interact with protein P34913
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P34913_15P | 15P | n/a | 16755630 | n/a | POLYETHYLENE GLYCOL (N=34) | n/a | |
| 2 | P34913_1LF | 1LF | n/a | 59447733 | CHEMBL2392714 | 1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide | n/a | |
| 3 | P34913_1P8 | 1P8 | n/a | 2773289 | CHEMBL2381492 | 6-bromo-1,3-dihydro-2H-indol-2-one | n/a | |
| 4 | P34913_24D | 24D | n/a | 24748513 | CHEMBL589136 | N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamide | n/a | |
| 5 | P34913_2RU | 2RU | n/a | 24898133 | CHEMBL3327064 | 1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea | n/a | |
| 6 | P34913_2RV | 2RV | n/a | 44142782 | CHEMBL1258904 | 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea | n/a | |
| 7 | P34913_33N | 33N | n/a | 3530525 | CHEMBL560537 | N-(3,3-diphenylpropyl)pyridine-3-carboxamide | n/a | |
| 8 | P34913_34N | 34N | n/a | 16725330 | CHEMBL556717 | 4-cyano-N-{(3S)-3-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}benzamide | n/a | |
| 9 | P34913_3C5 | 3C5 | n/a | 7060576 | CHEMBL3402235 | N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine | n/a | |
| 10 | P34913_49G | 49G | n/a | 7017351 | CHEMBL3402234 | N-[(1-methyl-1H-pyrazol-3-yl)methyl]-2-phenylethanamine | n/a | |
| 11 | P34913_49N | 49N | n/a | 2777786 | CHEMBL45663 | 1-[3-(trifluoromethyl)pyridin-2-yl]piperazine | n/a | |
| 12 | P34913_49O | 49O | n/a | 2737203 | CHEMBL48137 | 2-(piperazin-1-yl)pyridine-3-carbonitrile | n/a | |
| 13 | P34913_49P | 49P | n/a | 2783031 | CHEMBL3402236 | 1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-4-ol | n/a | |
| 14 | P34913_49Q | 49Q | n/a | 2764076 | CHEMBL3402237 | 3-[4-(benzyloxy)phenyl]propan-1-ol | n/a | |
| 15 | P34913_49R | 49R | n/a | 40478904 | n/a | tert-butyl (3R)-1,2,3,4-tetrahydroquinolin-3-ylcarbamate | n/a | |
| 16 | P34913_49Z | 49Z | n/a | 1817785 | CHEMBL1375713 | 2-(2-fluorophenyl)-N-[(5-methylthiophen-2-yl)methyl]ethanamine | n/a | |
| 17 | P34913_4A0 | 4A0 | n/a | n/a | n/a | 2-[({2-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-yl]ethyl}amino)methyl]phenol | n/a | |
| 18 | P34913_4A5 | 4A5 | n/a | 19576771 | CHEMBL3402239 | (4-bromo-3-cyclopropyl-1H-pyrazol-1-yl)acetic acid | n/a | |
| 19 | P34913_4UA | 4UA | n/a | 91754976 | n/a | 4-[[(2-methoxy-5-methyl-phenyl)sulfonylamino]methyl]-4-phenyl-N-(p-tolylmethyl)piperidine-1-carboxamide | n/a | |
| 20 | P34913_4VY | 4VY | n/a | 10657129 | n/a | 2-[(5-BROMO-2-PYRIDYL)-METHYL-AMINO]ETHANOL | n/a | |
| 21 | P34913_4XH | 4XH | n/a | 817321 | n/a | 5-BROMOQUINOLINE | n/a | |
| 22 | P34913_5DQ | 5DQ | n/a | 91754984 | CHEMBL4451596 | N-CYCLOPENTYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-3H-IMIDAZO[4,5-B]PYRIDINE-7-SULFONAMIDE | n/a | |
| 23 | P34913_5IV | 5IV | n/a | 164513400 | CHEMBL5084336 | ~{N}-[[4-(cyclopropylsulfonylamino)-2-(trifluoromethyl)phenyl]methyl]-1-[(3-fluorophenyl)methyl]indole-5-carboxamide | n/a | |
| 24 | P34913_5ZM | 5ZM | n/a | 82088664 | n/a | 5-(4-FLUOROPHENYL)-3,3-DIMETHYL-INDOLIN-2-ONE | n/a | |
| 25 | P34913_6N0 | 6N0 | n/a | 91754971 | CHEMBL4465514 | N-(5,5-dioxodibenzothiophen-2-yl)-4,4-difluoro-piperidine-1-carboxamide | n/a | |
| 26 | P34913_6N4 | 6N4 | n/a | 146084 | CHEMBL4561138 | 2-(1H-BENZIMIDAZOL-2-YLSULFANYL)ETHANOL | n/a | |
| 27 | P34913_6N6 | 6N6 | n/a | 644639 | CHEMBL1469977 | 5-(2-thienyl)-1,3,4-thiadiazol-2-amine | n/a | |
| 28 | P34913_6N8 | 6N8 | n/a | 91754973 | n/a | N-(3,3-DIPHENYLPROPYL)PYRROLIDINE-1-CARBOXAMIDE | n/a | |
| 29 | P34913_6NF | 6NF | n/a | 91754972 | n/a | N-(CYCLOHEXYLMETHYL)-3-(4-PYRIDYL)-1H-PYRAZOL-5-AMINE | n/a | |
| 30 | P34913_6NJ | 6NJ | n/a | 20644763 | n/a | 3-(2-phenylethyl)-1H-indazole | n/a | |
| 31 | P34913_6NM | 6NM | n/a | 3575503 | CHEMBL4476705 | 4-[5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]pyridine | n/a | |
| 32 | P34913_6NX | 6NX | n/a | 308344 | n/a | 1-CYCLOHEXYL-3-METHYL-UREA | n/a | |
| 33 | P34913_6NZ | 6NZ | n/a | 91754991 | CHEMBL4435068 | 5-cyclohexyl-3-propyl-1H-pyridin-2-one | n/a | |
| 34 | P34913_6TZ | 6TZ | n/a | 2774736 | n/a | 3-(3-fluorophenyl)-1H-pyrazole | n/a | |
| 35 | P34913_7GM | 7GM | n/a | 91754979 | n/a | (3R)-1-(cyclopropylmethyl)-3-methyl-3-(4-methylsulfanylphenoxy)pyrrolidine | n/a | |
| 36 | P34913_7WI | 7WI | n/a | 350221 | n/a | 1-(3-chlorophenyl)-3-(2-methoxyethyl)urea | n/a | |
| 37 | P34913_8NY | 8NY | n/a | 21894739 | CHEMBL391348 | 5-iodanyl-1H-indazole | n/a | |
| 38 | P34913_8S9 | 8S9 | n/a | 132281867 | CHEMBL4572648 | 3-[4-(3,4-dichlorophenyl)-5-phenyl-1,3-oxazol-2-yl]benzoic acid | n/a | |
| 39 | P34913_8TM | 8TM | n/a | 91754983 | n/a | N-[4-(TRIFLUOROMETHYLSULFANYL)PHENYL]QUINAZOLIN-4-AMINE | n/a | |
| 40 | P34913_9XZ | 9XZ | n/a | 91754985 | CHEMBL4588560 | 3-(2-methyltetrazol-5-yl)-5-(3-thienyl)pyridin-2-amine | n/a | |
| 41 | P34913_A0J | A0J | n/a | 91754980 | n/a | 3-BENZYL-3-METHYL-5-(1-METHYLPYRAZOL-4-YL)INDOLIN-2-ONE | n/a | |
| 42 | P34913_AUB | AUB | n/a | n/a | n/a | 4-[(trans-4-{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylcarbamoyl]amino}cyclohexyl)oxy]benzoic acid | n/a | |
| 43 | P34913_B7H | B7H | n/a | 91754988 | CHEMBL4531666 | 5-(7-fluoranyl-3,3-dimethyl-2-oxidanylidene-1H-indol-5-yl)-4-methyl-1H-pyrazole-3-carbonitrile | n/a | |
| 44 | P34913_BSU | BSU | DB07496 | 7595 | CHEMBL354676 | 1,3-DIPHENYLUREA | inhibitor | IC50(nM) = 390.0 |
| 45 | P34913_BXV | BXV | n/a | n/a | CHEMBL2397148 | 4-{[trans-4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)cyclohexyl]oxy}benzoic acid | n/a | |
| 46 | P34913_CIU | CIU | DB02029 | 4357 | CHEMBL1231797 | N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA | inhibitor | |
| 47 | P34913_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 48 | P34913_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 49 | P34913_DUL | DUL | n/a | 91754987 | CHEMBL4587512 | 5-(3-ethylsulfanylphenyl)thiophene-2-carboxamide | n/a | |
| 50 | P34913_E3N | E3N | n/a | 137349226 | n/a | 1-[(4~{S})-9-propan-2-ylsulfonyl-1-oxa-9-azaspiro[5.5]undecan-4-yl]-3-[[4-(trifluoromethyloxy)phenyl]methyl]urea | n/a | |
| 51 | P34913_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 52 | P34913_FCW | FCW | n/a | 23363908 | CHEMBL4577264 | 5-cyclohexyl-1,3-dihydroindol-2-one | n/a | |
| 53 | P34913_FVS | FVS | n/a | 57300161 | n/a | (7beta,9beta,13alpha,17beta)-7-{9-[(R)-(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diol | n/a | |
| 54 | P34913_G3Q | G3Q | n/a | 156154 | n/a | R-Talinolol | n/a | |
| 55 | P34913_G3T | G3T | n/a | 138454247 | n/a | 1-[4-[[(2~{S})-4-~{tert}-butylmorpholin-2-yl]methoxy]phenyl]-3-cyclohexyl-urea | n/a | |
| 56 | P34913_G3W | G3W | n/a | 138756786 | CHEMBL4463223 | 2-(4-fluorophenyl)-~{N}-[(4-phenoxyphenyl)methyl]ethanamine | n/a | |
| 57 | P34913_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 58 | P34913_GVG | GVG | n/a | 139601 | CHEMBL228114 | 3-METHYL-4-PHENYL-1H-PYRAZOLE | n/a | |
| 59 | P34913_GZP | GZP | n/a | 91754982 | n/a | 1-(3-PHENYL-1H-PYRAZOL-5-YL)CYCLOPENTANOL | n/a | |
| 60 | P34913_HD2 | HD2 | n/a | n/a | n/a | 4-cyclopentyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-2-[[(3S)-oxolan-3-yl]amino]pyrimidine-5-carboxamide | n/a | |
| 61 | P34913_I23 | I23 | n/a | 2110176 | CHEMBL469792 | N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide | n/a | |
| 62 | P34913_I5T | I5T | n/a | 44593665 | CHEMBL496189 | 4-oxidanylidene-N-[(1S,2R)-2-phenylcyclopropyl]spiro[3H-chromene-2,4'-piperidine]-1'-carboxamide | n/a | |
| 63 | P34913_II6 | II6 | n/a | 7329610 | n/a | [(1R,3S,5R)-3-(aminomethyl)-5-methyl-cyclohexyl]methanol | n/a | |
| 64 | P34913_J0U | J0U | n/a | 11982640 | CHEMBL453641 | (2S)-2-[2,4-bis(oxidanyl)phenyl]-5-methoxy-8-[(2R)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]-7-oxidanyl-2,3-dihydrochromen-4-one | n/a | |
| 65 | P34913_JF6 | JF6 | n/a | 139132 | CHEMBL487818 | 4-PHENYL-1,2,5-OXADIAZOL-3-AMINE | n/a | |
| 66 | P34913_JQN | JQN | n/a | 137349604 | CHEMBL4462187 | 5-[2-(4-methylphenyl)sulfanylethanoyl]-1,3-dihydroindol-2-one | n/a | |
| 67 | P34913_K2T | K2T | n/a | 17335 | CHEMBL94512 | 6-methyl-1,3-benzothiazol-2-amine | n/a | |
| 68 | P34913_K78 | K78 | n/a | 91754970 | n/a | 2-bromo-4-tert-butyl-6-{[(3-phenylpropyl)amino]methyl}phenol | n/a | |
| 69 | P34913_KJU | KJU | n/a | 309259 | n/a | 6-chloro-2H-1,4-benzoxazin-3(4H)-one | n/a | |
| 70 | P34913_KUF | KUF | n/a | 15693876 | n/a | 7-METHYL-2H-ISOQUINOLIN-1-ONE | n/a | |
| 71 | P34913_KWB | KWB | n/a | 40546119;54750023; | n/a | 5-cyclohexyl-2-hydroxybenzoate | n/a | |
| 72 | P34913_LWS | LWS | n/a | 91754989 | CHEMBL4534216 | 7-fluoranyl-3,3-dimethyl-5-(1-methylpyrrol-2-yl)-1H-indol-2-one | n/a | |
| 73 | P34913_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 74 | P34913_MVJ | MVJ | n/a | 91754990 | CHEMBL4469387 | 5-cyclohexylspiro[1H-indole-3,4'-oxane]-2-one | n/a | |
| 75 | P34913_MZL | MZL | n/a | 9820664 | CHEMBL1234565 | N-[4-(5-ethyl-3-pyridin-3-yl-1H-pyrazol-1-yl)phenyl]pyridine-3-carboxamide | n/a | |
| 76 | P34913_NC3 | NC3 | DB08256 | 4149241 | CHEMBL66380 | N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE | inhibitor | IC50(nM) = 100000.0 |
| 77 | P34913_NC4 | NC4 | DB08257 | 6420119 | CHEMBL219695 | 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID | inhibitor | IC50(nM) = 36000.0 |
| 78 | P34913_NC6 | NC6 | DB08258 | 6420120 | CHEMBL434374 | 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID | inhibitor | IC50(nM) = 100000.0 |
| 79 | P34913_NC7 | NC7 | DB08259 | 6420121 | n/a | 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID | n/a | |
| 80 | P34913_OE1 | OE1 | n/a | 15995775 | n/a | 2-phenyl-N,N-dipropyl-1H-benzimidazole-5-sulfonamide | n/a | |
| 81 | P34913_ONR | ONR | n/a | 4199500 | CHEMBL4541308 | 4-chloro-2-isoxazol-5-yl-phenol | n/a | |
| 82 | P34913_OWW | OWW | n/a | 154702644 | n/a | 3-[(3~{R})-3-[aminocarbonyl(oxidanyl)amino]but-1-ynyl]-~{N}-[(3~{S})-3-phenyl-3-[4-(trifluoromethyloxy)phenyl]propyl]benzamide | n/a | |
| 83 | P34913_P6G | P6G | n/a | 17472 | CHEMBL1235082 | HEXAETHYLENE GLYCOL | n/a | |
| 84 | P34913_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 85 | P34913_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 86 | P34913_PTG | PTG | DB08435 | 23654841 | CHEMBL1210221 | (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid | n/a | |
| 87 | P34913_Q3B | Q3B | n/a | 91754977 | n/a | 1-[3-[5-(7-aminothiazolo[5,4-d]pyrimidin-2-yl)-1-[[(2S)-tetrahydrofuran-2-yl]methyl]imidazol-4-yl]phenyl]-3-(4-methoxyphenyl)urea | n/a | |
| 88 | P34913_QYD | QYD | n/a | 91754981 | n/a | N-(4-NITROPHENYL)-2-PHENYL-THIOMORPHOLINE-4-CARBOXAMIDE | n/a | |
| 89 | P34913_R4N | R4N | n/a | 91754975 | n/a | 4-[(3-chlorophenyl)methyl]-N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-3-oxidanylidene-1,4-benzothiazine-6-carboxamide | n/a | |
| 90 | P34913_S0A | S0A | n/a | 51473388 | n/a | 1-[(1R)-1-cyclopropylethyl]-3-phenylurea | n/a | |
| 91 | P34913_S0B | S0B | n/a | 934585 | n/a | (5R)-5-methyl-N-(2-phenylethyl)-4,5-dihydro-1,3-thiazol-2-amine | n/a | |
| 92 | P34913_S0C | S0C | n/a | 2666601 | CHEMBL3233604 | 2-cyclopentyl-N-(1,3-thiazol-2-yl)acetamide | n/a | |
| 93 | P34913_S0D | S0D | n/a | 16227558 | CHEMBL3233605 | 2-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazole | n/a | |
| 94 | P34913_S0E | S0E | n/a | 2735955 | CHEMBL442384 | 6-(trifluoromethyl)-1,3-benzothiazol-2-amine | n/a | |
| 95 | P34913_S0F | S0F | n/a | 727750 | CHEMBL3233606 | 5-(4-bromobenzyl)-1,3-thiazol-2-amine | n/a | |
| 96 | P34913_S0G | S0G | n/a | 2497562 | CHEMBL3233607 | 6-amino-1-methyl-5-(piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione | n/a | |
| 97 | P34913_S0I | S0I | n/a | 759495 | CHEMBL2094355 | 4-benzyl-3,4-dihydroquinoxalin-2(1H)-one | n/a | |
| 98 | P34913_S0J | S0J | n/a | 2497363 | n/a | 4-{2,5-dimethyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrrol-3-yl}-1,3-thiazol-2-amine | n/a | |
| 99 | P34913_S0K | S0K | n/a | 2813415 | CHEMBL3233609 | N-[2-(morpholin-4-yl)phenyl]thiophene-3-carboxamide | n/a | |
| 100 | P34913_S38 | S38 | n/a | 49837852 | CHEMBL1615212 | 4-cyano-N-[(1S,2R)-2-phenylcyclopropyl]benzamide | n/a | |
| 101 | P34913_S74 | S74 | n/a | n/a | CHEMBL3401634 | 3-{4-[(1-{[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl}piperidin-4-yl)oxy]phenyl}propanoic acid | n/a | |
| 102 | P34913_S82 | S82 | n/a | n/a | CHEMBL1615216 | 4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-N-[(1S,2R)-2-phenylcyclopropyl]piperidine-1-carboxamide | n/a | |
| 103 | P34913_S94 | S94 | n/a | 76325076 | CHEMBL3114611 | 4-phenoxy-N-[(1S,2R)-2-phenylcyclopropyl]piperidine-1-carboxamide | n/a | |
| 104 | P34913_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 105 | P34913_TGX | TGX | n/a | 689104 | CHEMBL4591406 | 7-methyl-2H-1,4-benzothiazin-3(4H)-one | n/a | |
| 106 | P34913_TK9 | TK9 | n/a | 129520967 | CHEMBL5077503 | (2~{R})-2-[[4-[[4-methoxy-2-(trifluoromethyl)phenyl]methylcarbamoyl]phenyl]methyl]butanoic acid | n/a | |
| 107 | P34913_V2Z | V2Z | n/a | 14775256 | n/a | 3-PROPYL-5-(3-PYRIDYL)-1H-PYRAZIN-2-ONE | n/a | |
| 108 | P34913_W9L | W9L | n/a | 5129204 | n/a | 1-ethyl-3-naphthalen-1-ylurea | n/a | |
| 109 | P34913_W9M | W9M | n/a | 3120 | CHEMBL278489 | 3-(3,4-dichlorophenyl)-1,1-dimethyl-urea | n/a | |
| 110 | P34913_WMR | WMR | n/a | 4519806 | CHEMBL1502265 | 5-butyl-8,8-dimethyl-3,6,8,9-tetrahydropyrazolo[3,4-b]thiopyrano[4,3-d]pyridin-1-amine | n/a | |
| 111 | P34913_XM0 | XM0 | n/a | 76310 | CHEMBL1188176 | INDAN-2-AMINE | n/a | |
| 112 | P34913_XQ9 | XQ9 | n/a | n/a | n/a | 1-(1-adamantyl)-3-(1-methylsulfonylpiperidin-4-yl)urea | n/a | |
| 113 | P34913_YPN | YPN | n/a | 2774937 | n/a | 2-[(5-CHLORO-2-PYRIDYL)SULFANYL]ETHANOL | n/a | |
| 114 | P34913_ZYI | ZYI | n/a | 20965265 | CHEMBL1689794 | N-(5-chloro-1,3-benzoxazol-2-yl)-2-cyclopentylacetamide | n/a | |
| 115 | P34913_SZC | SZC | n/a | 118704920 | n/a | N-cyclopentyl-2-[4-(trifluoromethyl)phenyl]-3H-benzimidazole-4-sulfonamide | n/a | |
| 116 | P34913_T5J | T5J | n/a | 135567046 | n/a | 2-(3-fluoro-4-methyl-anilino)-4-methyl-quinolin-5-ol | n/a | |
| 117 | P34913_CDU | CDU | DB03677 | 4359 | CHEMBL67158 | N-Cyclohexyl-N'-Decylurea | inhibitor | IC50(nM) = 140.0 |
| 118 | P34913_CPU | CPU | DB04213 | 4358 | CHEMBL1231909 | N-Cyclohexyl-N'-(Propyl)Phenyl Urea | inhibitor | |
| 119 | P34913_DB06345 | n/a | DB06345 | n/a | n/a | AR-9281 | inhibitor | |
| 120 | P34913_DB12610 | n/a | DB12610 | n/a | n/a | Ebselen | inhibitor |