Gene name: NOS2
Protein name: Nitric oxide synthase,
List of molecules and drugs that interact with protein P35228
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P35228_ARG | ARG | DB00125 | 1549073;5287702;52941769;59294017;59904234;88031296; | n/a | ARGININE | n/a | |
| 2 | P35228_AT2 | AT2 | DB07388 | 11149707 | CHEMBL420671 | ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE | n/a | IC50(nM) = 350.0 |
| 3 | P35228_FMN | FMN | DB03247 | 643976 | CHEMBL1201794 | FLAVIN MONONUCLEOTIDE | n/a | |
| 4 | P35228_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 5 | P35228_H2B | H2B | DB02562 | 133246;135398653; | n/a | 2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE | n/a | |
| 6 | P35228_H4B | H4B | DB00360 | 44257;5282445;135398654; | CHEMBL1201774 | 5,6,7,8-TETRAHYDROBIOPTERIN | n/a | |
| 7 | P35228_HEC | HEC | DB03317 | n/a | n/a | HEME C | n/a | |
| 8 | P35228_HEM | HEM | DB18267 | n/a | n/a | PROTOPORPHYRIN IX CONTAINING FE | inhibitor | |
| 9 | P35228_IMD | IMD | DB03366 | 444234;4434133;21983501; | n/a | IMIDAZOLE | n/a | |
| 10 | P35228_ITU | ITU | DB02234 | 5139 | CHEMBL321691 | ETHYLISOTHIOUREA | inhibitor | |
| 11 | P35228_S71 | S71 | n/a | 73659118 | CHEMBL3262026 | (R)-6-(3-amino-2-(5-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-3-yl)propyl)-4-methylpyridin-2-amine | n/a | |
| 12 | P35228_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 13 | P35228_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 14 | P35228_DB00125 | n/a | DB00125 | n/a | n/a | Arginine | n/a | |
| 15 | P35228_CIR | CIR | DB00155 | 9750;6992098; | CHEMBL444814 | Citrulline | n/a | |
| 16 | P35228_DB00244 | n/a | DB00244 | n/a | n/a | Mesalazine | inhibitor | |
| 17 | P35228_MIY | MIY | DB01017 | n/a | CHEMBL1434 | Minocycline | inhibitor | |
| 18 | P35228_DB01110 | n/a | DB01110 | n/a | n/a | Miconazole | inhibitor | |
| 19 | P35228_DEX | DEX | DB01234 | 5743 | CHEMBL384467 | Dexamethasone | negative modulator | |
| 20 | P35228_DA2 | DA2 | DB01686 | 123831 | CHEMBL457530 | N,N-dimethylarginine | inhibitor | |
| 21 | P35228_I58 | I58 | DB01835 | 448269 | n/a | 4R-Fluoro-N6-ethanimidoyl-L-lysine | inhibitor | |
| 22 | P35228_INE | INE | DB01997 | 1649 | CHEMBL479014 | 3-Bromo-7-Nitroindazole | inhibitor | |
| 23 | P35228_14W | 14W | DB02044 | 1433 | CHEMBL107251 | N-[3-(aminomethyl)benzyl]acetamidine | inhibitor | Ki(nM) = 140.0 |
| 24 | P35228_7NI | 7NI | DB02207 | 1893 | CHEMBL247378 | 7-Nitroindazole | inhibitor | |
| 25 | P35228_FC1 | FC1 | DB02462 | 657073 | n/a | Thiocoumarin | inhibitor | |
| 26 | P35228_3AR | 3AR | DB02644 | 5287494;22524581;36688234; | n/a | N-omega-propyl-L-arginine | n/a | |
| 27 | P35228_6NI | 6NI | DB03100 | 24239 | CHEMBL54277 | 6-Nitroindazole | inhibitor | |
| 28 | P35228_HAR | HAR | DB03144 | 123895;25799416; | CHEMBL260629 | N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine | inhibitor | |
| 29 | P35228_DB03366 | n/a | DB03366 | n/a | n/a | Imidazole | n/a | |
| 30 | P35228_ARR | ARR | DB03449 | 449021 | CHEMBL293212 | N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide | n/a | |
| 31 | P35228_SCI | SCI | DB03953 | 448539;2733514;6992122; | CHEMBL93247 | Thiocitrulline | inhibitor | |
| 32 | P35228_HBI | HBI | DB04400 | 119055;5288515;135398687; | n/a | L-erythro-7,8-dihydrobiopterin | inhibitor | |
| 33 | P35228_5NI | 5NI | DB04534 | 21501 | CHEMBL165372 | 5-Nitroindazole | inhibitor | |
| 34 | P35228_DB05252 | n/a | DB05252 | n/a | n/a | Fenoxaprop-ethyl | n/a | |
| 35 | P35228_AGU | AGU | DB05383 | 2146 | CHEMBL225304 | Pimagedine | inhibitor | |
| 36 | P35228_1A2 | 1A2 | DB06879 | 46937031 | n/a | 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE | n/a | |
| 37 | P35228_228 | 228 | DB06916 | 16115747 | CHEMBL376632 | N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE | n/a | IC50(nM) = 0.29 |
| 38 | P35228_328 | 328 | DB07002 | 9797857 | CHEMBL114500 | 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile | inhibitor | IC50(nM) = 71.0 |
| 39 | P35228_329 | 329 | DB07003 | 24894153 | CHEMBL1221702 | (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine | n/a | IC50(nM) = 40.0 |
| 40 | P35228_332 | 332 | DB07007 | 24894155 | n/a | (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine | n/a | IC50(nM) = 400.0 |
| 41 | P35228_333 | 333 | DB07008 | 9969613 | CHEMBL243978 | 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE | n/a | IC50(nM) = 55.0 |
| 42 | P35228_342 | 342 | DB07011 | 11740318 | CHEMBL232827 | (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE | n/a | IC50(nM) = 72.0 |
| 43 | P35228_391 | 391 | DB07029 | 10157080 | CHEMBL390674 | 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE | n/a | IC50(nM) = 90.0 |
| 44 | P35228_A11 | A11 | DB07306 | 24894151 | CHEMBL1221660 | ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE | n/a | |
| 45 | P35228_A55 | A55 | DB07318 | 24941258 | n/a | N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE | n/a | |
| 46 | P35228_AT6 | AT6 | DB07389 | 10221335 | CHEMBL1221659 | N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE | n/a | IC50(nM) = 120.0 |
| 47 | P35228_B14 | B14 | DB07405 | 9886249 | CHEMBL447183 | 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE | inhibitor | IC50(nM) = 35.0 |
| 48 | P35228_MSR | MSR | DB08214 | 82315 | CHEMBL275339 | 4-(1H-IMIDAZOL-1-YL)PHENOL | inhibitor | |
| 49 | P35228_XXZ | XXZ | DB08750 | 24894149 | CHEMBL1221657 | 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE | n/a | IC50(nM) = 130.0 |
| 50 | P35228_DB08814 | n/a | DB08814 | n/a | n/a | Triflusal | agonist | |
| 51 | P35228_6UB | 6UB | DB09237 | 9822750 | CHEMBL2111097 | Levamlodipine | agonist | |
| 52 | P35228_DB11327 | n/a | DB11327 | n/a | n/a | Dipyrithione | antagonist | |
| 53 | P35228_DB14649 | n/a | DB14649 | n/a | n/a | Dexamethasone acetate | negative modulator |