Gene name: ADRA1A
Protein name: Alpha-1A adrenergic receptor
List of molecules and drugs that interact with protein P35348
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P35348_DB00211 | n/a | DB00211 | n/a | n/a | Midodrine | agonist | |
| 2 | P35348_DB00246 | n/a | DB00246 | n/a | n/a | Ziprasidone | antagonist | Ki(nM) = 2.6 IC50(nM) = 11.0 |
| 3 | P35348_DB00248 | n/a | DB00248 | n/a | n/a | Cabergoline | binder | |
| 4 | P35348_DB00298 | n/a | DB00298 | n/a | n/a | Dapiprazole | antagonist | |
| 5 | P35348_TP0 | TP0 | DB00321 | 2160 | CHEMBL629 | Amitriptyline | antagonist | Ki(nM) = 4.4 |
| 6 | P35348_DB00334 | n/a | DB00334 | n/a | n/a | Olanzapine | antagonist | Ki(nM) = 15.0 |
| 7 | P35348_DB00346 | n/a | DB00346 | n/a | n/a | Alfuzosin | antagonist | Ki(nM) = 3.16 IC50(nM) = 23.0 |
| 8 | P35348_DB00363 | n/a | DB00363 | n/a | n/a | Clozapine | antagonist | Ki(nM) = 19.0 |
| 9 | P35348_LNR | LNR | DB00368 | 439260 | CHEMBL1437 | Norepinephrine | agonist | Ki(nM) = 1500.0 EC50(nM) = 9.1 |
| 10 | P35348_DB00388 | n/a | DB00388 | n/a | n/a | Phenylephrine | agonist | EC50(nM) = 55.0 |
| 11 | P35348_DB00408 | n/a | DB00408 | n/a | n/a | Loxapine | binder | Ki(nM) = 27.77 |
| 12 | P35348_P2Z | P2Z | DB00420 | 4926 | CHEMBL564 | Promazine | antagonist | Ki(nM) = 5.88 |
| 13 | P35348_DB00449 | n/a | DB00449 | n/a | n/a | Dipivefrin | agonist | |
| 14 | P35348_USS | USS | DB00450 | 3168 | CHEMBL1108 | Droperidol | antagonist | |
| 15 | P35348_XRA | XRA | DB00457 | 4893 | CHEMBL2 | Prazosin | antagonist | Ki(nM) = 0.03 IC50(nM) = 1.2 |
| 16 | P35348_IXX | IXX | DB00458 | 3696 | CHEMBL11 | Imipramine | antagonist | Ki(nM) = 32.0 |
| 17 | P35348_Z80 | Z80 | DB00477 | 2726 | CHEMBL71 | Chlorpromazine | antagonist | Ki(nM) = 0.28 |
| 18 | P35348_GMJ | GMJ | DB00502 | 3559 | CHEMBL54 | Haloperidol | n/a | Ki(nM) = 6.1 |
| 19 | P35348_21B | 21B | DB00540 | 4543 | CHEMBL445 | Nortriptyline | antagonist | Ki(nM) = 55.0 |
| 20 | P35348_DB00543 | n/a | DB00543 | n/a | n/a | Amoxapine | antagonist | |
| 21 | P35348_DB00555 | n/a | DB00555 | n/a | n/a | Lamotrigine | inhibitor | |
| 22 | P35348_CLU | CLU | DB00575 | 2803 | CHEMBL134 | Clonidine | agonist | |
| 23 | P35348_DB00590 | n/a | DB00590 | n/a | n/a | Doxazosin | antagonist | Ki(nM) = 0.537 |
| 24 | P35348_DB00610 | n/a | DB00610 | n/a | n/a | Metaraminol | agonist | |
| 25 | P35348_DB00622 | n/a | DB00622 | n/a | n/a | Nicardipine | antagonist | |
| 26 | P35348_DB00656 | n/a | DB00656 | n/a | n/a | Trazodone | antagonist | Ki(nM) = 12.0 |
| 27 | P35348_DB00661 | n/a | DB00661 | n/a | n/a | Verapamil | antagonist | |
| 28 | P35348_ALE | ALE | DB00668 | 5816;139148732; | CHEMBL679 | Epinephrine | agonist | Ki(nM) = 2000.0 EC50(nM) = 400.0 |
| 29 | P35348_DB00679 | n/a | DB00679 | n/a | n/a | Thioridazine | antagonist | Ki(nM) = 5.0 |
| 30 | P35348_DB00692 | n/a | DB00692 | n/a | n/a | Phentolamine | antagonist | Ki(nM) = 0.6 IC50(nM) = 1.1 |
| 31 | P35348_ERM | ERM | DB00696 | 8223 | CHEMBL442 | Ergotamine | partial agonist | |
| 32 | P35348_DB00699 | n/a | DB00699 | n/a | n/a | Nicergoline | antagonist | |
| 33 | P35348_DB00706 | n/a | DB00706 | n/a | n/a | Tamsulosin | antagonist | Ki(nM) = 0.029 IC50(nM) = 0.32 EC50(nM) = 0.07 |
| 34 | P35348_DB00723 | n/a | DB00723 | n/a | n/a | Methoxamine | agonist | Ki(nM) = 10000.0 EC50(nM) = 720.0 |
| 35 | P35348_DB00726 | n/a | DB00726 | n/a | n/a | Trimipramine | antagonist | |
| 36 | P35348_DB00734 | n/a | DB00734 | n/a | n/a | Risperidone | antagonist | Ki(nM) = 0.7 IC50(nM) = 10.0 |
| 37 | P35348_DB00751 | n/a | DB00751 | n/a | n/a | Epinastine | unknown | |
| 38 | P35348_DB00777 | n/a | DB00777 | n/a | n/a | Propiomazine | antagonist | |
| 39 | P35348_DB00797 | n/a | DB00797 | n/a | n/a | Tolazoline | antagonist | |
| 40 | P35348_DB00800 | n/a | DB00800 | n/a | n/a | Fenoldopam | inhibitor | Ki(nM) = 151.0 |
| 41 | P35348_TFP | TFP | DB00831 | 5566 | CHEMBL422 | Trifluoperazine | antagonist | Ki(nM) = 23.8 |
| 42 | P35348_DB00852 | n/a | DB00852 | n/a | n/a | Pseudoephedrine | agonist | |
| 43 | P35348_DB00865 | n/a | DB00865 | n/a | n/a | Benzphetamine | agonist | |
| 44 | P35348_DB00875 | n/a | DB00875 | n/a | n/a | Flupentixol | antagonist | |
| 45 | P35348_QDN | QDN | DB00908 | 441074 | CHEMBL1294 | Quinidine | antagonist | |
| 46 | P35348_DB00925 | n/a | DB00925 | n/a | n/a | Phenoxybenzamine | antagonist | |
| 47 | P35348_J5C | J5C | DB00935 | 4636 | CHEMBL762 | Oxymetazoline | partial agonist | Ki(nM) = 15.84 EC50(nM) = 20.0 |
| 48 | P35348_DB00964 | n/a | DB00964 | n/a | n/a | Apraclonidine | agonist | |
| 49 | P35348_DB01136 | n/a | DB01136 | n/a | n/a | Carvedilol | antagonist | |
| 50 | P35348_DB01142 | no_lig_id | DB01142 | n/a | n/a | Doxepin | antagonist | |
| 51 | P35348_DB01149 | n/a | DB01149 | n/a | n/a | Nefazodone | antagonist | Ki(nM) = 5.5 |
| 52 | P35348_DB01162 | n/a | DB01162 | n/a | n/a | Terazosin | antagonist | Ki(nM) = 1.82 IC50(nM) = 5.0 EC50(nM) = 51.0 |
| 53 | P35348_DB01186 | n/a | DB01186 | n/a | n/a | Pergolide | agonist | Ki(nM) = 1047.13 |
| 54 | P35348_08Y | 08Y | DB01200 | 31101 | CHEMBL493 | Bromocriptine | antagonist | Ki(nM) = 4.17 |
| 55 | P35348_9SC | 9SC | DB01238 | 60795 | CHEMBL1112 | Aripiprazole | antagonist | Ki(nM) = 8.9 IC50(nM) = 170.0 |
| 56 | P35348_DB01253 | n/a | DB01253 | n/a | n/a | Ergometrine | agonist | |
| 57 | P35348_DB01267 | n/a | DB01267 | n/a | n/a | Paliperidone | antagonist | Ki(nM) = 10.1 |
| 58 | P35348_DB01295 | n/a | DB01295 | n/a | n/a | Bevantolol | antagonist | |
| 59 | P35348_DB01364 | n/a | DB01364 | n/a | n/a | Ephedrine | agonist | |
| 60 | P35348_DB01403 | n/a | DB01403 | n/a | n/a | Methotrimeprazine | antagonist | |
| 61 | P35348_DB01472 | n/a | DB01472 | n/a | n/a | 4-Methoxyamphetamine | agonist | |
| 62 | P35348_DB01579 | n/a | DB01579 | n/a | n/a | Phendimetrazine | agonist | |
| 63 | P35348_PMZ | PMZ | DB01614 | 6077 | CHEMBL39560 | Acepromazine | antagonist | |
| 64 | P35348_DB01622 | n/a | DB01622 | n/a | n/a | Thioproperazine | antagonist | |
| 65 | P35348_DB01624 | n/a | DB01624 | n/a | n/a | Zuclopenthixol | antagonist | |
| 66 | P35348_DB04855 | n/a | DB04855 | n/a | n/a | Dronedarone | antagonist | |
| 67 | P35348_DB04946 | n/a | DB04946 | n/a | n/a | Iloperidone | antagonist | Ki(nM) = 0.31 |
| 68 | P35348_DB04948 | n/a | DB04948 | n/a | n/a | Lofexidine | agonist | |
| 69 | P35348_NP1 | NP1 | DB05492 | 5276854 | CHEMBL609728 | Epicept NP-1 | n/a | |
| 70 | P35348_7RU | 7RU | DB06016 | n/a | CHEMBL2028019 | Cariprazine | antagonist | |
| 71 | P35348_DB06144 | n/a | DB06144 | n/a | n/a | Sertindole | n/a | Ki(nM) = 1.8 |
| 72 | P35348_DB06153 | n/a | DB06153 | n/a | n/a | Pizotifen | antagonist | |
| 73 | P35348_DB06207 | n/a | DB06207 | n/a | n/a | Silodosin | antagonist | Ki(nM) = 0.036 IC50(nM) = 1.8 |
| 74 | P35348_DB06216 | n/a | DB06216 | n/a | n/a | Asenapine | antagonist | Ki(nM) = 1.1 |
| 75 | P35348_DB06229 | n/a | DB06229 | n/a | n/a | Ocaperidone | n/a | |
| 76 | P35348_DB06262 | n/a | DB06262 | n/a | n/a | Droxidopa | agonist | |
| 77 | P35348_DB06694 | n/a | DB06694 | n/a | n/a | Xylometazoline | agonist | Ki(nM) = 91.0 |
| 78 | P35348_DB06706 | n/a | DB06706 | n/a | n/a | Isometheptene | agonist | |
| 79 | P35348_DB06711 | n/a | DB06711 | n/a | n/a | Naphazoline | agonist | EC50(nM) = 63.0 |
| 80 | P35348_DB08950 | n/a | DB08950 | n/a | n/a | Indoramin | antagonist | |
| 81 | P35348_DB09202 | n/a | DB09202 | n/a | n/a | Cirazoline | agonist | EC50(nM) = 13.0 |
| 82 | P35348_DB09239 | n/a | DB09239 | n/a | n/a | Niguldipine | antagonist | |
| 83 | P35348_DB12278 | n/a | DB12278 | n/a | n/a | Propiverine | antagonist | |
| 84 | P35348_DB14185 | n/a | DB14185 | n/a | n/a | Aripiprazole lauroxil | antagonist |