Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
P35367 HRH1_HUMAN
Gene name: HRH1
Protein name: Histamine H1 receptor

List of molecules and drugs that interact with protein P35367

# DrugDomain Data PBD ligand DrugBank Accession PubChem ChEMBL Name Drug action Affinity data
1 P35367_5EH 5EH n/a 667477 CHEMBL860 (3E)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine n/a
2 P35367_D7V D7V DB14750 667468 CHEMBL101740 (3Z)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine n/a
3 P35367_HSM HSM DB05381 774 CHEMBL90 HISTAMINE agonist
4 P35367_OLC OLC n/a 11451146 n/a (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate n/a
5 P35367_PO4 PO4 DB14523 1061 n/a PHOSPHATE ION n/a
6 P35367_DB00215 n/a DB00215 n/a n/a Citalopram binder
7 P35367_CXQ CXQ DB00245 n/a CHEMBL1201203 Benzatropine antagonist
8 P35367_DB00246 n/a DB00246 n/a n/a Ziprasidone antagonist Ki(nM) = 4.6
9 P35367_DB00283 n/a DB00283 n/a n/a Clemastine antagonist
10 P35367_TP0 TP0 DB00321 2160 CHEMBL629 Amitriptyline antagonist Ki(nM) = 0.67
11 P35367_DB00334 n/a DB00334 n/a n/a Olanzapine antagonist Ki(nM) = 1.2
Kd(nM) = 0.087
12 P35367_DB00341 n/a DB00341 n/a n/a Cetirizine antagonist Ki(nM) = 3.16
13 P35367_DB00342 n/a DB00342 n/a n/a Terfenadine antagonist Ki(nM) = 40.0
IC50(nM) = 1.0
14 P35367_DB00354 n/a DB00354 n/a n/a Buclizine antagonist
15 P35367_DB00363 n/a DB00363 n/a n/a Clozapine antagonist Ki(nM) = 1.0
Kd(nM) = 3.1
16 P35367_DB00366 n/a DB00366 n/a n/a Doxylamine antagonist
17 P35367_DB00370 n/a DB00370 n/a n/a Mirtazapine antagonist Ki(nM) = 1.6
18 P35367_DB00405 n/a DB00405 n/a n/a Dexbrompheniramine antagonist
19 P35367_DB00408 n/a DB00408 n/a n/a Loxapine binder Ki(nM) = 4.9
20 P35367_P2Z P2Z DB00420 4926 CHEMBL564 Promazine antagonist Ki(nM) = 2.0
IC50(nM) = 2454.71
21 P35367_DB00427 n/a DB00427 n/a n/a Triprolidine antagonist Ki(nM) = 1.0
22 P35367_P77 P77 DB00433 4917 CHEMBL728 Prochlorperazine antagonist Ki(nM) = 18.86
23 P35367_C7H C7H DB00434 2913 CHEMBL516 Cyproheptadine antagonist Ki(nM) = 0.06
Kd(nM) = 5400.0
24 P35367_DB00455 n/a DB00455 n/a n/a Loratadine antagonist Ki(nM) = 37.0
IC50(nM) = 290.0
Kd(nM) = 190.0
25 P35367_IXX IXX DB00458 3696 CHEMBL11 Imipramine antagonist Ki(nM) = 10.0
IC50(nM) = 27.0
26 P35367_Z80 Z80 DB00477 2726 CHEMBL71 Chlorpromazine antagonist Ki(nM) = 3.0
IC50(nM) = 12.0
27 P35367_GMJ GMJ DB00502 3559 CHEMBL54 Haloperidol n/a Ki(nM) = 260.0
28 P35367_21B 21B DB00540 4543 CHEMBL445 Nortriptyline antagonist Ki(nM) = 6.3
29 P35367_DB00543 n/a DB00543 n/a n/a Amoxapine antagonist
30 P35367_DB00555 n/a DB00555 n/a n/a Lamotrigine antagonist
31 P35367_DB00557 n/a DB00557 n/a n/a Hydroxyzine inverse agonist Ki(nM) = 1.0
32 P35367_N90 N90 DB00568 1547484 CHEMBL43064 Cinnarizine antagonist
33 P35367_XB7 XB7 DB00637 2247 CHEMBL296419 Astemizole antagonist Ki(nM) = 0.8
34 P35367_DB00656 n/a DB00656 n/a n/a Trazodone antagonist Ki(nM) = 1100.0
35 P35367_8PR 8PR DB00715 43815 CHEMBL490 Paroxetine inhibitor Ki(nM) = 10000.0
36 P35367_DB00719 n/a DB00719 n/a n/a Azatadine antagonist
37 P35367_DB00726 n/a DB00726 n/a n/a Trimipramine antagonist Ki(nM) = 1.4
38 P35367_DB00734 n/a DB00734 n/a n/a Risperidone antagonist Ki(nM) = 2.6
IC50(nM) = 454.0
39 P35367_DB00737 n/a DB00737 n/a n/a Meclizine antagonist
40 P35367_DB00748 n/a DB00748 n/a n/a Carbinoxamine antagonist
41 P35367_DB00751 n/a DB00751 n/a n/a Epinastine antagonist
42 P35367_DB00767 n/a DB00767 n/a n/a Benzquinamide antagonist
43 P35367_DB00768 n/a DB00768 n/a n/a Olopatadine antagonist
44 P35367_DB00777 n/a DB00777 n/a n/a Propiomazine antagonist
45 P35367_DB00792 n/a DB00792 n/a n/a Tripelennamine antagonist IC50(nM) = 40.0
46 P35367_DB00797 n/a DB00797 n/a n/a Tolazoline agonist
47 P35367_DB00835 n/a DB00835 n/a n/a Brompheniramine antagonist Ki(nM) = 6.06
48 P35367_DB00902 n/a DB00902 n/a n/a Methdilazine antagonist
49 P35367_BJX BJX DB00912 65981 CHEMBL1272 Repaglinide antagonist
50 P35367_DB00920 n/a DB00920 n/a n/a Ketotifen antagonist Ki(nM) = 0.158
IC50(nM) = 1.0
51 P35367_DB00934 n/a DB00934 n/a n/a Maprotiline antagonist
52 P35367_DB00950 n/a DB00950 n/a n/a Fexofenadine antagonist Ki(nM) = 10.0
IC50(nM) = 15.0
53 P35367_DB00967 n/a DB00967 n/a n/a Desloratadine antagonist Ki(nM) = 0.97
IC50(nM) = 1.8
Kd(nM) = 24.0
54 P35367_DB00972 n/a DB00972 n/a n/a Azelastine antagonist Ki(nM) = 1.2
Kd(nM) = 0.2
55 P35367_DB00985 n/a DB00985 n/a n/a Dimenhydrinate antagonist
56 P35367_DB01069 n/a DB01069 n/a n/a Promethazine antagonist IC50(nM) = 5.4
57 P35367_DB01071 n/a DB01071 n/a n/a Mequitazine antagonist
58 P35367_2PM 2PM DB01075 3100 CHEMBL657 Diphenhydramine antagonist Ki(nM) = 11.7
IC50(nM) = 84000.0
59 P35367_DB01084 n/a DB01084 n/a n/a Emedastine antagonist
60 P35367_DB01106 n/a DB01106 n/a n/a Levocabastine antagonist
61 P35367_DB01114 n/a DB01114 n/a n/a Chlorpheniramine antagonist Ki(nM) = 2.51
IC50(nM) = 66.0
62 P35367_DB01142 no_lig_id DB01142 n/a n/a Doxepin antagonist
63 P35367_DB01146 n/a DB01146 n/a n/a Diphenylpyraline antagonist
64 P35367_DSM DSM DB01151 2995 CHEMBL72 Desipramine antagonist Ki(nM) = 60.0
65 P35367_DB01173 n/a DB01173 n/a n/a Orphenadrine antagonist IC50(nM) = 97723.72
66 P35367_68P 68P DB01175 146570 CHEMBL1508 Escitalopram inhibitor
67 P35367_DB01176 n/a DB01176 n/a n/a Cyclizine antagonist
68 P35367_DB01224 n/a DB01224 n/a n/a Quetiapine antagonist Ki(nM) = 2.2
69 P35367_DB01237 n/a DB01237 n/a n/a Bromodiphenhydramine antagonist
70 P35367_9SC 9SC DB01238 60795 CHEMBL1112 Aripiprazole antagonist Ki(nM) = 25.0
IC50(nM) = 420.0
71 P35367_DB01239 n/a DB01239 n/a n/a Chlorprothixene antagonist
72 P35367_DB01246 n/a DB01246 n/a n/a Alimemazine antagonist
73 P35367_DB01267 n/a DB01267 n/a n/a Paliperidone antagonist Ki(nM) = 3.4
74 P35367_DB01403 n/a DB01403 n/a n/a Methotrimeprazine antagonist
75 P35367_DB01615 n/a DB01615 n/a n/a Aceprometazine antagonist
76 P35367_DB01619 n/a DB01619 n/a n/a Phenindamine antagonist
77 P35367_DB01620 n/a DB01620 n/a n/a Pheniramine inverse agonist
78 P35367_DB01624 n/a DB01624 n/a n/a Zuclopenthixol antagonist
79 P35367_DB04837 n/a DB04837 n/a n/a Clofedanol antagonist
80 P35367_DB04841 n/a DB04841 n/a n/a Flunarizine antagonist
81 P35367_DB04890 n/a DB04890 n/a n/a Bepotastine antagonist
82 P35367_DB04905 n/a DB04905 n/a n/a Tesmilifene antagonist
83 P35367_DB04946 n/a DB04946 n/a n/a Iloperidone antagonist Ki(nM) = 12.3
84 P35367_NP1 NP1 DB05492 5276854 CHEMBL609728 Epicept NP-1 n/a
85 P35367_7RU 7RU DB06016 n/a CHEMBL2028019 Cariprazine antagonist Ki(nM) = 23.0
86 P35367_DB06148 n/a DB06148 n/a n/a Mianserin antagonist
87 P35367_DB06153 n/a DB06153 n/a n/a Pizotifen antagonist
88 P35367_DB06216 n/a DB06216 n/a n/a Asenapine antagonist Ki(nM) = 0.16
89 P35367_DB06229 n/a DB06229 n/a n/a Ocaperidone n/a
90 P35367_LCR LCR DB06282 1549000;28145931; CHEMBL1201191 Levocetirizine antagonist
91 P35367_DB06678 n/a DB06678 n/a n/a Esmirtazapine inverse agonist
92 P35367_DB06691 n/a DB06691 n/a n/a Mepyramine antagonist Ki(nM) = 0.71
IC50(nM) = 0.014
EC50(nM) = 2.6
93 P35367_DB06698 n/a DB06698 n/a n/a Betahistine agonist
94 P35367_DB06766 n/a DB06766 n/a n/a Alcaftadine antagonist
95 P35367_DB08799 n/a DB08799 n/a n/a Antazoline antagonist
96 P35367_DB08800 n/a DB08800 n/a n/a Chloropyramine antagonist
97 P35367_DB08801 n/a DB08801 n/a n/a Dimetindene antagonist Ki(nM) = 0.691831
98 P35367_DB08802 n/a DB08802 n/a n/a Isothipendyl antagonist
99 P35367_DB08922 n/a DB08922 n/a n/a Perospirone inverse agonist
100 P35367_DB08936 n/a DB08936 n/a n/a Chlorcyclizine antagonist
101 P35367_DB09167 n/a DB09167 n/a n/a Dosulepin antagonist
102 P35367_DB09185 n/a DB09185 n/a n/a Viloxazine antagonist
103 P35367_DB09195 n/a DB09195 n/a n/a Lorpiprazole antagonist
104 P35367_DB09488 n/a DB09488 n/a n/a Acrivastine antagonist
105 P35367_DB09555 n/a DB09555 n/a n/a Dexchlorpheniramine maleate antagonist
106 P35367_DB11235 n/a DB11235 n/a n/a Thonzylamine antagonist
107 P35367_DB11591 n/a DB11591 n/a n/a Bilastine antagonist
108 P35367_DB11614 n/a DB11614 n/a n/a Rupatadine antagonist
109 P35367_DB14185 n/a DB14185 n/a n/a Aripiprazole lauroxil antagonist