P35372 OPRM_HUMAN
Gene name: OPRM1
Protein name: Mu-type opioid receptor

List of molecules and drugs that interact with protein P35372

#	DrugDomain Data	PBD ligand	DrugBank Accession	PubChem	ChEMBL	Name	Drug action	Affinity data
1	P35372_7V7	7V7	DB00813	3345	CHEMBL596	N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide	agonist	Ki(nM) = 0.051 IC50(nM) = 1.3 EC50(nM) = 0.51
2	P35372_8QY	8QY	DB14030	121596705	CHEMBL4467777	N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea	n/a
3	P35372_CLR	CLR	DB04540	5997	CHEMBL112570	CHOLESTEROL	n/a
4	P35372_ETA	ETA	DB03994	700	CHEMBL104943	ETHANOLAMINE	n/a
5	P35372_MOI	MOI	DB00295	5288826	CHEMBL70	(7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL	agonist	Ki(nM) = 0.14 IC50(nM) = 0.57 EC50(nM) = 3.0
6	P35372_WH2	WH2	DB14881	66553195	CHEMBL2443262	N-[(3-methoxythiophen-2-yl)methyl]-2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethan-1-amine	agonist
7	P35372_WH9	WH9	n/a	130431397	CHEMBL4452384	5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one	n/a
8	P35372_DB00193	n/a	DB00193	n/a	n/a	Tramadol	agonist	Ki(nM) = 1600.0 IC50(nM) = 5300.0 EC50(nM) = 1000.0
9	P35372_DB00318	n/a	DB00318	n/a	n/a	Codeine	agonist	IC50(nM) = 105.0
10	P35372_TP0	TP0	DB00321	2160	CHEMBL629	Amitriptyline	binder
11	P35372_DB00327	n/a	DB00327	n/a	n/a	Hydromorphone	agonist	Ki(nM) = 0.28 EC50(nM) = 2.6
12	P35372_DB00333	n/a	DB00333	n/a	n/a	Methadone	agonist	Ki(nM) = 0.6 IC50(nM) = 4.1
13	P35372_DB00454	n/a	DB00454	n/a	n/a	Meperidine	agonist	Ki(nM) = 920.0 IC50(nM) = 315.0 EC50(nM) = 9400.0
14	P35372_DB00497	n/a	DB00497	n/a	n/a	Oxycodone	agonist	Ki(nM) = 12.0 EC50(nM) = 17.0
15	P35372_DB00504	n/a	DB00504	n/a	n/a	Levallorphan	partial agonist	Ki(nM) = 0.48
16	P35372_DB00514	n/a	DB00514	n/a	n/a	Dextromethorphan	agonist
17	P35372_DB00611	n/a	DB00611	n/a	n/a	Butorphanol	antagonist	Ki(nM) = 0.12 IC50(nM) = 14.0 EC50(nM) = 3.3
18	P35372_DB00647	n/a	DB00647	n/a	n/a	Dextropropoxyphene	agonist
19	P35372_DB00652	n/a	DB00652	n/a	n/a	Pentazocine	antagonist	Ki(nM) = 2.7 IC50(nM) = 280.0 EC50(nM) = 61.0
20	P35372_DB00704	n/a	DB00704	n/a	n/a	Naltrexone	antagonist	Ki(nM) = 0.07 IC50(nM) = 0.59 EC50(nM) = 0.38
21	P35372_DB00708	n/a	DB00708	n/a	n/a	Sufentanil	agonist	Ki(nM) = 0.15 EC50(nM) = 1.3
22	P35372_DB00802	n/a	DB00802	n/a	n/a	Alfentanil	agonist
23	P35372_DB00836	n/a	DB00836	n/a	n/a	Loperamide	agonist	Ki(nM) = 0.268 IC50(nM) = 1.5
24	P35372_DB00844	n/a	DB00844	n/a	n/a	Nalbuphine	antagonist	Ki(nM) = 0.89 IC50(nM) = 1.0 EC50(nM) = 14.0
25	P35372_DB00854	n/a	DB00854	n/a	n/a	Levorphanol	agonist	Ki(nM) = 0.08 IC50(nM) = 0.13
26	P35372_DB00899	n/a	DB00899	n/a	n/a	Remifentanil	agonist
27	P35372_S87	S87	DB00904	4595	CHEMBL46	Ondansetron	other/unknown
28	P35372_DB00913	n/a	DB00913	n/a	n/a	Anileridine	agonist
29	P35372_DB00921	n/a	DB00921	n/a	n/a	Buprenorphine	partial agonist	Ki(nM) = 0.21 IC50(nM) = 0.59 EC50(nM) = 0.11
30	P35372_DB00956	n/a	DB00956	n/a	n/a	Hydrocodone	agonist	Ki(nM) = 9.5
31	P35372_DB01081	n/a	DB01081	n/a	n/a	Diphenoxylate	agonist	Ki(nM) = 12.0
32	P35372_DB01183	n/a	DB01183	n/a	n/a	Naloxone	antagonist	Ki(nM) = 0.23 IC50(nM) = 2.0
33	P35372_DB01192	n/a	DB01192	n/a	n/a	Oxymorphone	agonist	Ki(nM) = 1.8 EC50(nM) = 7.8
34	P35372_DB01209	n/a	DB01209	n/a	n/a	Dezocine	agonist	Ki(nM) = 0.54 IC50(nM) = 130.0 EC50(nM) = 20.0
35	P35372_DB01221	n/a	DB01221	n/a	n/a	Ketamine	binder
36	P35372_DB01227	n/a	DB01227	n/a	n/a	Levacetylmethadol	agonist
37	P35372_9SC	9SC	DB01238	60795	CHEMBL1112	Aripiprazole	ligand	Ki(nM) = 10000.0
38	P35372_DB01433	n/a	DB01433	n/a	n/a	Methadyl acetate	agonist
39	P35372_DB01439	n/a	DB01439	n/a	n/a	3-Methylthiofentanyl	agonist
40	P35372_DB01444	n/a	DB01444	n/a	n/a	Dimethylthiambutene	agonist
41	P35372_DB01452	n/a	DB01452	n/a	n/a	Diamorphine	agonist
42	P35372_DB01466	n/a	DB01466	n/a	n/a	Ethylmorphine	agonist
43	P35372_DB01497	n/a	DB01497	n/a	n/a	Etorphine	agonist
44	P35372_DB01535	n/a	DB01535	n/a	n/a	Carfentanil	agonist	Ki(nM) = 0.024 EC50(nM) = 0.0049
45	P35372_DB01548	n/a	DB01548	n/a	n/a	Diprenorphine	antagonist	Ki(nM) = 0.18
46	P35372_DB01565	n/a	DB01565	n/a	n/a	Dihydromorphine	agonist
47	P35372_DB01571	n/a	DB01571	n/a	n/a	3-Methylfentanyl	agonist
48	P35372_NP1	NP1	DB05492	5276854	CHEMBL609728	Epicept NP-1	n/a
49	P35372_DB06204	n/a	DB06204	n/a	n/a	Tapentadol	agonist	Ki(nM) = 160.0 EC50(nM) = 670.0
50	P35372_DB06230	n/a	DB06230	n/a	n/a	Nalmefene	antagonist
51	P35372_NG0	NG0	DB06274	5488548;51397022;	CHEMBL270190	Alvimopan	antagonist	Ki(nM) = 0.316228 IC50(nM) = 3.0
52	P35372_DB06288	n/a	DB06288	n/a	n/a	Amisulpride	agonist	Ki(nM) = 10000.0
53	P35372_DB06409	n/a	DB06409	n/a	n/a	Morphine glucuronide	agonist
54	P35372_DB06738	n/a	DB06738	n/a	n/a	Ketobemidone	agonist
55	P35372_DB06800	n/a	DB06800	n/a	n/a	Methylnaltrexone	antagonist	Ki(nM) = 2.0 IC50(nM) = 170.0 EC50(nM) = 10000.0
56	P35372_DB09049	n/a	DB09049	n/a	n/a	Naloxegol	antagonist
57	P35372_P0T	P0T	DB09061	644019	CHEMBL190461	Cannabidiol	n/a
58	P35372_DB09089	n/a	DB09089	n/a	n/a	Trimebutine	agonist
59	P35372_DB09173	n/a	DB09173	n/a	n/a	Butyrfentanyl	agonist
60	P35372_DB09209	n/a	DB09209	n/a	n/a	Pholcodine	antagonist
61	P35372_DB09272	n/a	DB09272	n/a	n/a	Eluxadoline	agonist
62	P35372_DB09289	n/a	DB09289	n/a	n/a	Tianeptine	agonist
63	P35372_DB11186	n/a	DB11186	n/a	n/a	Pentoxyverine	antagonist
64	P35372_DB11691	n/a	DB11691	n/a	n/a	Naldemedine	antagonist
65	P35372_DB12543	n/a	DB12543	n/a	n/a	Samidorphan	antagonist
66	P35372_DB12668	n/a	DB12668	n/a	n/a	Metenkefalin	agonist
67	P35372_DB14011	n/a	DB14011	n/a	n/a	Nabiximols	n/a
68	P35372_DB14146	n/a	DB14146	n/a	n/a	Loxicodegol	agonist