Gene name: GCK
Protein name: Hexokinase-4 (HK4) (EC
List of molecules and drugs that interact with protein P35557
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P35557_0H4 | 0H4 | n/a | 44628876 | n/a | (2S)-3-cyclopentyl-N-(5-methylpyridin-2-yl)-2-[2-oxo-4-(trifluoromethyl)pyridin-1(2H)-yl]propanamide | n/a | |
| 2 | P35557_0H5 | 0H5 | n/a | 56596555 | n/a | 6-methoxy-N-(1-methyl-1H-pyrazol-3-yl)quinazolin-4-amine | n/a | |
| 3 | P35557_0H6 | 0H6 | DB11765 | 46181428 | CHEMBL2165620 | 6-({(2S)-3-cyclopentyl-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propanoyl}amino)pyridine-3-carboxylic acid | activator | |
| 4 | P35557_1FW | 1FW | n/a | 71295771 | CHEMBL2346889 | (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide | n/a | |
| 5 | P35557_1FX | 1FX | n/a | 71295772 | CHEMBL2346899 | (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide | n/a | |
| 6 | P35557_1FY | 1FY | n/a | 71295773 | n/a | (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide | n/a | |
| 7 | P35557_1J9 | 1J9 | n/a | 57504402 | CHEMBL3221508 | (2S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(5-chloropyridin-2-yl)-3-(2-hydroxyethoxy)propanamide | n/a | |
| 8 | P35557_1JD | 1JD | n/a | 57504313 | CHEMBL3221489 | (2S)-2-{[1-(3-chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(5-methylpyridin-2-yl)-3-(propan-2-yloxy)propanamide | n/a | |
| 9 | P35557_2N8 | 2N8 | n/a | 10432339 | CHEMBL1783734 | (2R)-2-[3-chloro-4-(methylsulfonyl)phenyl]-3-[(1R)-3-oxocyclopentyl]-N-(pyrazin-2-yl)propanamide | n/a | |
| 10 | P35557_3LZ | 3LZ | n/a | 78350461 | CHEMBL3338060 | 1-{3-[(2-ethylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}-3-methylurea | n/a | |
| 11 | P35557_4DC | 4DC | n/a | 9886086 | CHEMBL1096435 | (2R)-3-cyclopentyl-2-[4-(methylsulfonyl)phenyl]-N-(1,3-thiazol-2-yl)propanamide | n/a | |
| 12 | P35557_8WJ | 8WJ | n/a | 24962880 | n/a | (2S)-3-cyclohexyl-2-[4-(cyclopentylsulfonyl)-2-oxopyridin-1(2H)-yl]-N-(1,3-thiazol-2-yl)propanamide | n/a | |
| 13 | P35557_8WM | 8WM | n/a | 57964129 | CHEMBL4083428 | (2S)-2-[4-(cyclopropylsulfonyl)-1H-indazol-1-yl]-N-(5-fluoro-1,3-thiazol-2-yl)-3-(oxan-4-yl)propanamide | n/a | |
| 14 | P35557_926 | 926 | n/a | 71627422 | CHEMBL2408108 | 6-{3-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}pyridin-2(1H)-one | n/a | |
| 15 | P35557_AGS | AGS | DB02930 | 440317;444377; | CHEMBL131890 | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | n/a | |
| 16 | P35557_AJB | AJB | DB07358 | 9819610 | CHEMBL489514 | 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide | n/a | Kd(nM) = 440.0 EC50(nM) = 140.0 |
| 17 | P35557_AJI | AJI | DB07359 | 10411846 | CHEMBL551043 | 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide | n/a | EC50(nM) = 250.0 |
| 18 | P35557_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 19 | P35557_BGC | BGC | DB02379 | 64689 | CHEMBL1614854 | beta-D-glucopyranose | inhibitor | |
| 20 | P35557_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 21 | P35557_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 22 | P35557_G1S | G1S | n/a | 58265877 | CHEMBL5072532 | diethyl {[3-(3-{[5-(azetidine-1-carbonyl)pyrazin-2-yl]oxy}-5-[(propan-2-yl)oxy]benzamido)-1H-pyrazol-1-yl]methyl}phosphonate | n/a | |
| 23 | P35557_G2T | G2T | n/a | 23649243 | CHEMBL5091943 | diethyl {[2-(3-[4-(methanesulfonyl)phenoxy]-5-{[(2S)-1-methoxypropan-2-yl]oxy}benzamido)-1,3-thiazol-4-yl]methyl}phosphonate | n/a | |
| 24 | P35557_GLC | GLC | n/a | 79025 | CHEMBL423707 | alpha-D-glucopyranose | n/a | |
| 25 | P35557_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 26 | P35557_HKG | HKG | n/a | 59291641 | CHEMBL4644628 | 1-{4-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-[(pyridin-2-yl)sulfanyl]pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]piperidin-1 -yl}ethan-1-one | n/a | |
| 27 | P35557_HKM | HKM | n/a | 16752714 | CHEMBL4648916 | 2-({2-[(4-methyl-1,3-thiazol-2-yl)amino]pyridin-3-yl}oxy)benzonitrile | n/a | |
| 28 | P35557_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 29 | P35557_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 30 | P35557_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 31 | P35557_MRK | MRK | DB08210 | 449003 | CHEMBL608393 | 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE | n/a | Kd(nM) = 360.0 EC50(nM) = 67.11 |
| 32 | P35557_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 33 | P35557_S41 | S41 | DB15009 | 46916694 | CHEMBL2165615 | N,N-dimethyl-5-({2-methyl-6-[(5-methylpyrazin-2-yl)carbamoyl]-1-benzofuran-4-yl}oxy)pyrimidine-2-carboxamide | modulator | |
| 34 | P35557_TK1 | TK1 | n/a | 49867741 | n/a | 1-({5-[4-(methylsulfonyl)phenoxy]-2-pyridin-2-yl-1H-benzimidazol-6-yl}methyl)pyrrolidine-2,5-dione | n/a | |
| 35 | P35557_VO1 | VO1 | n/a | 16660015 | CHEMBL2430868 | 3-(benzyloxy)-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine | n/a | |
| 36 | P35557_VO2 | VO2 | n/a | 59225669 | CHEMBL2430855 | 3-(benzyloxy)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine | n/a | |
| 37 | P35557_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 38 | P35557_LOI | LOI | DB08118 | 25229552 | CHEMBL490961 | 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide | n/a | EC50(nM) = 330.0 |