Gene name: KDR
Protein name: Vascular endothelial growth
List of molecules and drugs that interact with protein P35968
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P35968_00J | 00J | n/a | 11236560 | CHEMBL1738697 | N,2-DIMETHYL-6-{[7-(2-MORPHOLIN-4-YLETHOXY)QUINOLIN-4-YL]OXY}-1-BENZOFURAN-3-CARBOXAMIDE | n/a | |
| 2 | P35968_03X | 03X | n/a | 56604907 | CHEMBL2031893 | N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide | n/a | |
| 3 | P35968_0JA | 0JA | n/a | 25206185 | CHEMBL2063743 | 2-chloro-3-(1-cyanocyclopropyl)-N-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide | n/a | |
| 4 | P35968_0KF | 0KF | n/a | 57505507 | CHEMBL2348996 | N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide | n/a | |
| 5 | P35968_276 | 276 | DB06938 | 11167118 | CHEMBL394826 | 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide | n/a | Ki(nM) = 9.0 |
| 6 | P35968_2RL | 2RL | n/a | 11375301 | CHEMBL270548 | N-(4-CHLOROPHENYL)-7-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]-2,3-DIHYDRO-1,4-BENZOXAZINE-4-CARBOXAMIDE | n/a | |
| 7 | P35968_42Q | 42Q | n/a | 15949613 | CHEMBL1254007 | 1-{2-fluoro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[3-(trifluoromethyl)phenyl]urea | n/a | |
| 8 | P35968_4TT | 4TT | n/a | 135566619 | CHEMBL1929485 | 4,5,6,11-tetrahydro-1H-pyrazolo[4',3':6,7]cyclohepta[1,2-b]indole | n/a | |
| 9 | P35968_5T2 | 5T2 | n/a | 6398883 | CHEMBL153843 | 2-(pyridin-4-ylmethylamino)-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 10 | P35968_608 | 608 | DB07183 | 16040289 | CHEMBL385178 | N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide | n/a | Ki(nM) = 10.0 IC50(nM) = 38.0 |
| 11 | P35968_706 | 706 | DB05575 | 11667893 | CHEMBL572881 | N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide | inhibitor | |
| 12 | P35968_857 | 857 | n/a | 11620410 | CHEMBL231568 | 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide | n/a | |
| 13 | P35968_887 | 887 | DB07274 | 11441375 | CHEMBL272198 | N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide | n/a | IC50(nM) = 0.6 |
| 14 | P35968_900 | 900 | n/a | 24757938 | CHEMBL429743 | N-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide | n/a | |
| 15 | P35968_994 | 994 | n/a | 16040288 | CHEMBL218057 | 4-(2-anilinopyridin-3-yl)-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine | n/a | |
| 16 | P35968_A96 | A96 | DB07326 | 23658582 | CHEMBL491429 | 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide | n/a | IC50(nM) = 353.0 |
| 17 | P35968_AAX | AAX | DB07333 | 4369498 | n/a | N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE | n/a | IC50(nM) = 38.0 |
| 18 | P35968_AAZ | AAZ | DB07334 | 4369497 | CHEMBL194176 | N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE | n/a | IC50(nM) = 17.0 |
| 19 | P35968_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 20 | P35968_AV9 | AV9 | DB11800 | 9911830 | CHEMBL1289494 | TIVOZANIB | inhibitor | |
| 21 | P35968_AXI | AXI | DB06626 | 6450551 | CHEMBL1289926 | AXITINIB | inhibitor | |
| 22 | P35968_B49 | B49 | DB01268 | 5329102 | CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide | inhibitor | Ki(nM) = 2.9 IC50(nM) = 0.4 Kd(nM) = 0.13 |
| 23 | P35968_BAX | BAX | DB00398 | 216239 | CHEMBL1336 | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE | inhibitor | Ki(nM) = 0.021 IC50(nM) = 0.06 Kd(nM) = 33.0 EC50(nM) = 500.0 |
| 24 | P35968_BPK | BPK | n/a | 11140977 | CHEMBL2069625 | {3-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol | n/a | |
| 25 | P35968_C19 | C19 | DB07514 | 24812717 | CHEMBL493986 | 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one | n/a | IC50(nM) = 48.0 |
| 26 | P35968_C52 | C52 | DB07528 | 24812719 | CHEMBL504805 | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one | n/a | IC50(nM) = 5000.0 |
| 27 | P35968_C92 | C92 | DB07537 | 24812718 | CHEMBL487431 | N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide | n/a | IC50(nM) = 25000.0 |
| 28 | P35968_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 29 | P35968_CAC | CAC | n/a | 167250 | n/a | CACODYLATE ION | n/a | |
| 30 | P35968_CS | CS | n/a | 104967 | n/a | CESIUM ION | n/a | |
| 31 | P35968_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
| 32 | P35968_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 33 | P35968_F82 | F82 | n/a | 134814266 | CHEMBL4212563 | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide | n/a | |
| 34 | P35968_F88 | F88 | n/a | 134814267 | CHEMBL4213606 | ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | n/a | |
| 35 | P35968_F8B | F8B | n/a | 134814268 | CHEMBL4214769 | ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | n/a | |
| 36 | P35968_GIG | GIG | n/a | 9935852 | CHEMBL396056 | METHYL (5-{4-[({[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-1H-BENZIMIDAZOL-2-YL)CARBAMATE | n/a | |
| 37 | P35968_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 38 | P35968_HG | HG | n/a | 26623 | n/a | MERCURY (II) ION | n/a | |
| 39 | P35968_K11 | K11 | n/a | 16731782 | CHEMBL463323 | N-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine | n/a | |
| 40 | P35968_KIM | KIM | DB08042 | 24941243 | n/a | N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine | n/a | |
| 41 | P35968_LEV | LEV | DB09078 | 9823820 | CHEMBL1289601 | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | inhibitor | |
| 42 | P35968_LIF | LIF | DB04727 | 5326956 | CHEMBL194911 | N-{4-[4-AMINO-6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-5-YL]PHENYL}-N'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA | n/a | |
| 43 | P35968_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 44 | P35968_O35 | O35 | n/a | 146037621 | n/a | ~{N}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | n/a | |
| 45 | P35968_O3E | O3E | n/a | 146037624 | n/a | ~{N}-(4,4-dimethyl-2-prop-1-ynyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | n/a | |
| 46 | P35968_RAJ | RAJ | n/a | 11497471 | CHEMBL221484 | N-{3-[3-(DIMETHYLAMINO)PROPYL]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]BENZAMIDE | n/a | |
| 47 | P35968_SAV | SAV | DB08519 | 9822610 | CHEMBL479079 | N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine | n/a | IC50(nM) = 6.3 |
| 48 | P35968_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 49 | P35968_XIN | XIN | DB09079 | 9809715 | CHEMBL502835 | methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate | inhibitor | |
| 50 | P35968_DB04849 | n/a | DB04849 | n/a | n/a | Cediranib | inhibitor | Ki(nM) = 0.5 IC50(nM) = 0.5 Kd(nM) = 1.1 |
| 51 | P35968_DB04879 | n/a | DB04879 | n/a | n/a | Vatalanib | inhibitor | IC50(nM) = 15.0 Kd(nM) = 62.0 |
| 52 | P35968_DB05075 | n/a | DB05075 | n/a | n/a | TG-100801 | n/a | |
| 53 | P35968_55J | 55J | DB05984 | 11656518 | CHEMBL558752 | RAF-265 | modulator | |
| 54 | P35968_DB06080 | n/a | DB06080 | n/a | n/a | Linifanib | n/a | |
| 55 | P35968_X2M | X2M | DB06436 | 5329098 | CHEMBL276711 | Semaxanib | inhibitor | |
| 56 | P35968_DB06589 | n/a | DB06589 | n/a | n/a | Pazopanib | inhibitor | IC50(nM) = 30.0 Kd(nM) = 14.0 |
| 57 | P35968_2K2 | 2K2 | DB06595 | 9829523 | CHEMBL608533 | Midostaurin | antagonist | |
| 58 | P35968_DB08875 | n/a | DB08875 | n/a | n/a | Cabozantinib | antagonist | |
| 59 | P35968_DB08896 | n/a | DB08896 | n/a | n/a | Regorafenib | inhibitor | Ki(nM) = 4.2 IC50(nM) = 4.0 |
| 60 | P35968_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | Ponatinib | inhibitor | Ki(nM) = 1.5 IC50(nM) = 1.5 |
| 61 | P35968_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 62 | P35968_5SF | 5SF | DB12147 | 67462786 | CHEMBL3545376 | Erdafitinib | substrate | |
| 63 | P35968_88Z | 88Z | DB12307 | 42642645 | CHEMBL1230609 | Foretinib | modulator | |
| 64 | P35968_DB14840 | n/a | DB14840 | n/a | n/a | Ripretinib | inhibitor | |
| 65 | P35968_Q4J | Q4J | DB15822 | n/a | CHEMBL4297597 | Pralsetinib | inhibitor |