Gene name: FLT3
Protein name: Receptor-type tyrosine-protein kinase
List of molecules and drugs that interact with protein P36888
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P36888_A9R | A9R | n/a | 137348911 | n/a | 7-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(pyridin-2-yl)imidazo[1,2-a]pyridine | n/a | |
| 2 | P36888_C6F | C6F | DB12141 | 49803313 | CHEMBL3301622 | 6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide | inhibitor | |
| 3 | P36888_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 4 | P36888_CXS | CXS | DB02219 | 70815;12546061; | n/a | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID | n/a | |
| 5 | P36888_F6M | F6M | DB16050 | 90052320 | CHEMBL4650283 | N-[(2S)-1-[5-[2-[(4-cyanophenyl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxidanylidene-propan-2-yl]-4-(dimethylamino)-N-methyl-but-2-enamide | inhibitor | |
| 6 | P36888_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 7 | P36888_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 8 | P36888_P30 | P30 | DB12874 | 24889392 | CHEMBL576982 | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea | inhibitor | |
| 9 | P36888_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 10 | P36888_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 11 | P36888_BAX | BAX | DB00398 | 216239 | CHEMBL1336 | Sorafenib | inhibitor | IC50(nM) = 1.3 Kd(nM) = 4.5 |
| 12 | P36888_B49 | B49 | DB01268 | 5329102 | CHEMBL535 | Sunitinib | inhibitor | IC50(nM) = 0.7 Kd(nM) = 0.22 |
| 13 | P36888_DB05465 | n/a | DB05465 | n/a | n/a | Tandutinib | inhibitor | IC50(nM) = 0.22 Kd(nM) = 1.5 |
| 14 | P36888_DB06080 | n/a | DB06080 | n/a | n/a | Linifanib | n/a | |
| 15 | P36888_DB06469 | n/a | DB06469 | n/a | n/a | Lestaurtinib | modulator | |
| 16 | P36888_2K2 | 2K2 | DB06595 | 9829523 | CHEMBL608533 | Midostaurin | antagonist | |
| 17 | P36888_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | Ponatinib | inhibitor | IC50(nM) = 0.3 |
| 18 | P36888_XIN | XIN | DB09079 | 9809715 | CHEMBL502835 | Nintedanib | inhibitor | |
| 19 | P36888_6T3 | 6T3 | DB11697 | 46216796 | CHEMBL2035187 | Pacritinib | inhibitor | |
| 20 | P36888_AV9 | AV9 | DB11800 | 9911830 | CHEMBL1289494 | Tivozanib | inhibitor | |
| 21 | P36888_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 22 | P36888_6GY | 6GY | DB12267 | 68165256 | CHEMBL3545311 | Brigatinib | inhibitor | |
| 23 | P36888_2TA | 2TA | DB12500 | 16722836 | CHEMBL1287853 | Fedratinib | inhibitor | |
| 24 | P36888_DB12742 | n/a | DB12742 | n/a | n/a | Amuvatinib | n/a | |
| 25 | P36888_P31 | P31 | DB12978 | 25151352 | CHEMBL3813873 | Pexidartinib | inhibitor | |
| 26 | P36888_Q4J | Q4J | DB15822 | n/a | CHEMBL4297597 | Pralsetinib | inhibitor |