Gene name: TGFBR1
Protein name: TGF-beta receptor type-1
List of molecules and drugs that interact with protein P36897
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P36897_085 | 085 | n/a | 4521392 | CHEMBL440084 | 4-[5-(1,3-benzodioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide | n/a | |
| 2 | P36897_3WA | 3WA | n/a | 2763439;5706788; | CHEMBL122927 | 4-aminopyrido[2,3-d]pyrimidin-5(8H)-one | n/a | |
| 3 | P36897_3WJ | 3WJ | n/a | 11402538 | CHEMBL3353016 | 4-amino-8-(4-aminophenyl)pyrido[2,3-d]pyrimidin-5(8H)-one | n/a | |
| 4 | P36897_3WK | 3WK | n/a | 137348185 | n/a | 4-[(4-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6H)-one | n/a | |
| 5 | P36897_3WN | 3WN | n/a | 118719396 | CHEMBL3353018 | 4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(8H)-one | n/a | |
| 6 | P36897_3WO | 3WO | n/a | 137348187 | n/a | 4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6H)-one | n/a | |
| 7 | P36897_460 | 460 | DB04434 | 5287512 | n/a | 2-[5-(6-METHYLPYRIDIN-2-YL)-2,3-DIHYDRO-1H-PYRAZOL-4-YL]-1,5-NAPHTHYRIDINE | n/a | |
| 8 | P36897_55F | 55F | DB07152 | 25138294 | CHEMBL519939 | N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide | n/a | Ki(nM) = 7.1 EC50(nM) = 180.0 |
| 9 | P36897_580 | 580 | DB04480 | 5287525 | CHEMBL121790 | 3-(4-FLUOROPHENYL)-2-(6-METHYLPYRIDIN-2-YL)-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOLE | n/a | IC50(nM) = 1320.0 |
| 10 | P36897_5L4 | 5L4 | n/a | 118988613 | n/a | 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide | n/a | |
| 11 | P36897_855 | 855 | DB07267 | 10267580 | CHEMBL570533 | 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine | n/a | IC50(nM) = 25.0 Kd(nM) = 10.0 |
| 12 | P36897_8LY | 8LY | n/a | 54671256 | CHEMBL4096361 | N-[2-(5-chloro-2-fluorophenyl)pyridin-4-yl]-2-[(piperidin-4-yl)methyl]-2H-pyrazolo[4,3-b]pyridin-7-amine | n/a | |
| 13 | P36897_D0A | D0A | n/a | 126537450 | CHEMBL4217699 | N-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 14 | P36897_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 15 | P36897_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 16 | P36897_J2M | J2M | n/a | 134821987 | n/a | N-{4-[3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide | n/a | |
| 17 | P36897_J2V | J2V | n/a | 121411874 | CHEMBL4279160 | N-{4-[3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide | n/a | |
| 18 | P36897_J2Y | J2Y | n/a | 121411739 | CHEMBL4288634 | N-{4-[3-(5-methoxypyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide | n/a | |
| 19 | P36897_JZO | JZO | n/a | 16730825 | CHEMBL606919 | 4-[3-(methoxymethyl)phenyl]-1,2-dimethyl-5-quinoxalin-6-yl-1,2-dihydro-3H-pyrazol-3-one | n/a | |
| 20 | P36897_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 21 | P36897_PY1 | PY1 | DB03921 | 447966 | CHEMBL261454 | 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE | inhibitor | IC50(nM) = 27.0 Kd(nM) = 5.0 EC50(nM) = 40.0 |
| 22 | P36897_QIG | QIG | DB08450 | 9998128 | CHEMBL537968 | N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine | n/a | IC50(nM) = 25.0 |
| 23 | P36897_QMV | QMV | n/a | 122510453 | CHEMBL4514379 | 6-[4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazol-5-yl]imidazo[1,2-b]pyridazine-3-carbonitrile | n/a | |
| 24 | P36897_QMY | QMY | n/a | 135233366 | CHEMBL4458215 | 6-[1-(2,2-difluoroethyl)-4-(6-methylpyridin-2-yl)-1H-imidazol-5-yl]imidazo[1,2-a]pyridine | n/a | |
| 25 | P36897_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 26 | P36897_TRS | TRS | DB03754 | 3777159;88088752;152743085; | n/a | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | n/a | |
| 27 | P36897_ZOP | ZOP | n/a | 23507055 | CHEMBL496862 | (3Z)-N-ETHYL-N-METHYL-2-OXO-3-(PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-6-CARBOXAMIDE | n/a | |
| 28 | P36897_ZUQ | ZUQ | n/a | 121232401 | CHEMBL3818173 | N-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide | n/a | |
| 29 | P36897_ZZF | ZZF | n/a | 25192277 | CHEMBL585367 | 4-({4-[(2,6-DIMETHYLPYRIDIN-3-YL)OXY]PYRIDIN-2-YL}AMINO)BENZENESULFONAMIDE | n/a | |
| 30 | P36897_ZZG | ZZG | n/a | 44201376 | CHEMBL575099 | 4-[(5,6-DIMETHYL-2,2'-BIPYRIDIN-3-YL)OXY]-N-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-2-AMINE | n/a | |
| 31 | P36897_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | |
| 32 | P36897_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |