Gene name: AKR1C3
Protein name: Aldo-keto reductase family
List of molecules and drugs that interact with protein P42330
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P42330_0HV | 0HV | n/a | 56851703 | CHEMBL2023820 | 3-[(4-nitronaphthalen-1-yl)amino]benzoic acid | n/a | |
| 2 | P42330_0SL | 0SL | n/a | 7063083 | CHEMBL2172078 | (3R)-1-(naphthalen-2-ylsulfonyl)piperidine-3-carboxylic acid | n/a | |
| 3 | P42330_0SZ | 0SZ | n/a | 712934 | CHEMBL1566492 | 3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acid | n/a | |
| 4 | P42330_0T0 | 0T0 | n/a | 1217101 | CHEMBL2172072 | 3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)-N-methylbenzamide | n/a | |
| 5 | P42330_10H | 10H | n/a | 137347927 | n/a | 1-(4-{[(2R)-2-methylpiperidin-1-yl]sulfonyl}phenyl)-1,3-dihydro-2H-pyrrol-2-one | n/a | |
| 6 | P42330_15M | 15M | DB00905 | 5311027 | CHEMBL1200963 | (5Z)-7-{(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3S)-3-HYDROXY-5-PHENYLPENT-1-ENYL]CYCLOPENTYL}-N-ETHYLHEPT-5-ENAMIDE | n/a | IC50(nM) = 5000.0 |
| 7 | P42330_16J | 16J | n/a | 976980 | CHEMBL3103347 | [4-(4-chlorophenyl)piperazin-1-yl](morpholin-4-yl)methanone | n/a | |
| 8 | P42330_4IV | 4IV | n/a | 166449413 | CHEMBL5393759 | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(2-methoxyphenyl)benzamide | n/a | |
| 9 | P42330_4R6 | 4R6 | n/a | 9465498 | CHEMBL5407958 | ~{N}-(3-chlorophenyl)-2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]benzamide | n/a | |
| 10 | P42330_4ZI | 4ZI | n/a | 25163346 | CHEMBL1475833 | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(3-methoxyphenyl)benzamide | n/a | |
| 11 | P42330_511 | 511 | n/a | 4711697 | CHEMBL503179 | [1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl]acetic acid | n/a | |
| 12 | P42330_65D | 65D | n/a | 61253 | CHEMBL277346 | octyl 3,4,5-trihydroxybenzoate | n/a | |
| 13 | P42330_8FO | 8FO | n/a | n/a | n/a | (2~{R})-2-[4-(3-fluoranyl-4-methyl-phenyl)-3-(trifluoromethyl)phenyl]butanoic acid | n/a | |
| 14 | P42330_8IH | 8IH | n/a | 166638137 | n/a | (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-(trifluoromethyl)phenyl]butanoic acid | n/a | |
| 15 | P42330_8IT | 8IT | n/a | 166638138 | n/a | (2~{R})-2-(3-fluoranyl-4-pyrimidin-5-yl-phenyl)butanoic acid | n/a | |
| 16 | P42330_9S0 | 9S0 | n/a | 1721374 | n/a | (4R)-6-amino-4-(4-hydroxy-3-methoxy-5-nitrophenyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | n/a | |
| 17 | P42330_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | inhibitor | |
| 18 | P42330_ASD | ASD | DB01536 | 6128 | CHEMBL274826 | 4-ANDROSTENE-3-17-DIONE | substrate | |
| 19 | P42330_BT9 | BT9 | n/a | 51346826 | CHEMBL1682202 | 3-{[4-(trifluoromethyl)phenyl]amino}benzoic acid | n/a | |
| 20 | P42330_CJ2 | CJ2 | n/a | 137349099 | CHEMBL4174786 | 3-[(4-methoxyphenyl)methyl]-5-oxidanyl-~{N}-[3-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxamide | n/a | |
| 21 | P42330_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 22 | P42330_CVN | CVN | n/a | 132473032 | CHEMBL4238437 | 4-[[3,5-bis(trifluoromethyl)phenyl]amino]-1,2-benzoxazol-3-one | n/a | |
| 23 | P42330_DMF | DMF | DB01844 | 6228 | CHEMBL268291 | DIMETHYLFORMAMIDE | n/a | |
| 24 | P42330_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 25 | P42330_E04 | E04 | DB07700 | 11987804 | CHEMBL521703 | 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN | n/a | Ki(nM) = 6.9 |
| 26 | P42330_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 27 | P42330_FFW | FFW | n/a | 138115373 | CHEMBL4434843 | 4-[[1-(4-chlorophenyl)carbonyl-5-methoxy-2-methyl-indol-3-yl]methyl]-1,2,5-oxadiazol-3-one | n/a | |
| 28 | P42330_FJR | FJR | n/a | n/a | n/a | 2-azanylidene-N-(4-methylphenyl)-8-oxidanyl-chromene-3-carboxamide | n/a | |
| 29 | P42330_FJU | FJU | n/a | n/a | n/a | 2-azanylidene-N-(3-ethylphenyl)-8-oxidanyl-chromene-3-carboxamide | n/a | |
| 30 | P42330_FLF | FLF | DB02266 | 3371 | CHEMBL23588 | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID | inhibitor | Ki(nM) = 140.0 IC50(nM) = 50.0 |
| 31 | P42330_FLR | FLR | DB05289 | 92337 | CHEMBL190083 | (2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic acid | n/a | |
| 32 | P42330_GBM | GBM | DB01016 | 3488 | CHEMBL472 | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide | n/a | |
| 33 | P42330_GCZ | GCZ | DB01120 | 667431 | n/a | N-[(3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl]-4-methylbenzenesulfonamide | n/a | |
| 34 | P42330_GMR | GMR | n/a | n/a | n/a | 3-ethyl-4-methyl-N-[2-(4-{[(cis-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-car boxamide | n/a | |
| 35 | P42330_ID8 | ID8 | DB00784 | 4044 | CHEMBL686 | 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID | n/a | Ki(nM) = 300.0 IC50(nM) = 560.0 |
| 36 | P42330_IMN | IMN | DB00328 | 3715 | CHEMBL6 | INDOMETHACIN | inhibitor | Ki(nM) = 270.0 IC50(nM) = 100.0 |
| 37 | P42330_IZP | IZP | n/a | 114864 | CHEMBL427526 | (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid | n/a | |
| 38 | P42330_JMS | JMS | DB00939 | 4037 | CHEMBL509 | 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid | n/a | IC50(nM) = 512.0 |
| 39 | P42330_JTN | JTN | n/a | 11674243 | CHEMBL5438441 | 1-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]cyclopropane-1-carboxylic acid | n/a | |
| 40 | P42330_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 41 | P42330_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 42 | P42330_NAP | NAP | DB03461 | 5885;57525501; | CHEMBL295069 | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 43 | P42330_NDP | NDP | DB02338 | 5884;134821689; | CHEMBL407009 | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 44 | P42330_NPS | NPS | DB00788 | 156391 | CHEMBL154 | (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | n/a | IC50(nM) = 180.0 |
| 45 | P42330_NPX | NPX | n/a | 169118 | CHEMBL1618254 | (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid | n/a | |
| 46 | P42330_P6G | P6G | n/a | 17472 | CHEMBL1235082 | HEXAETHYLENE GLYCOL | n/a | |
| 47 | P42330_PG2 | PG2 | DB02056 | 448457 | CHEMBL1235252 | PROSTAGLANDIN D2 | n/a | |
| 48 | P42330_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 49 | P42330_QAP | QAP | n/a | 5281787 | CHEMBL319244 | 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | n/a | |
| 50 | P42330_QBO | QBO | n/a | 166638198 | CHEMBL5279391 | (4~{R})-4-[(1~{R},2~{S},5~{R},6~{R},13~{S},14~{S},17~{R},19~{R})-6,14-dimethyl-17-oxidanyl-7,8,9,10-tetrazapentacyclo[11.8.0.0^{2,6}.0^{7,11}.0^{14,19}]henicosa-8,10-dien-5-yl]pentanoic acid | n/a | |
| 51 | P42330_RUT | RUT | DB01698 | 5280805 | CHEMBL226335 | RUTIN | inhibitor | |
| 52 | P42330_UNX | UNX | n/a | |||||
| 53 | P42330_VJJ | VJJ | n/a | 19539 | CHEMBL663 | 3-phenoxybenzoic acid | n/a | |
| 54 | P42330_WDS | WDS | n/a | 16804777 | n/a | 3-pentyl-2-[(pyridin-2-ylmethyl)sulfanyl]-7-(pyrrolidin-1-ylcarbonyl)quinazolin-4(3H)-one | n/a | |
| 55 | P42330_WDT | WDT | n/a | 2799682 | n/a | 2-nitro-5-(phenylsulfonyl)phenol | n/a | |
| 56 | P42330_WDU | WDU | n/a | 3620613;135407999; | CHEMBL1342833 | 4-chloro-N-(4-chlorobenzyl)-5-nitro-1H-pyrazole-3-carboxamide | n/a | |
| 57 | P42330_WDV | WDV | n/a | 1376219;7440803; | n/a | 4-nitro-2-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}methyl)phenol | n/a | |
| 58 | P42330_WDW | WDW | n/a | 73352188 | CHEMBL2413862 | 3,6-dihydropyridin-1(2H)-yl(5-methyl-1H-indol-2-yl)methanone | n/a | |
| 59 | P42330_WDX | WDX | n/a | 59529932 | CHEMBL2413863 | [4-(2-hydroxyethyl)piperidin-1-yl](5-methyl-1H-indol-2-yl)methanone | n/a | |
| 60 | P42330_YY1 | YY1 | n/a | 81688;1538728;70261143; | CHEMBL1935505 | 5-methyl-4H-1,2,4-triazole-3-thiol | n/a | |
| 61 | P42330_YY2 | YY2 | n/a | 28966894 | n/a | 2-[4-(aminomethyl)-2-chloro-6-methoxyphenoxy]-N-tert-butylacetamide | n/a | |
| 62 | P42330_ZOM | ZOM | DB04828 | 5733 | CHEMBL19490 | [5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetic acid | n/a | |
| 63 | P42330_SUZ | SUZ | n/a | 16046677 | CHEMBL4525719 | [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid | n/a | |
| 64 | P42330_NAI | NAI | DB00157 | 439153 | CHEMBL1234616 | NADH | n/a | |
| 65 | P42330_09L | 09L | DB09074 | 23725625 | CHEMBL521686 | Olaparib | inhibitor |