Gene name: PIK3CA
Protein name: Phosphatidylinositol 4,5-bisphosphate 3-kinase
List of molecules and drugs that interact with protein P42336
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P42336_144 | 144 | DB03570 | 4468930 | n/a | TRIS-HYDROXYMETHYL-METHYL-AMMONIUM | n/a | |
| 2 | P42336_1LT | 1LT | DB12015 | 56649450 | CHEMBL2396661 | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide | inhibitor | |
| 3 | P42336_2IX | 2IX | n/a | 163183772 | CHEMBL5268290 | N-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-N-methyl-1-(prop-2-enoyl)piperidine-4-carboxamide | n/a | |
| 4 | P42336_2Q7 | 2Q7 | n/a | 163183773 | CHEMBL5273641 | N-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-1-(prop-2-enoyl)piperidine-4-carboxamide | n/a | |
| 5 | P42336_2ZV | 2ZV | n/a | 243166 | CHEMBL3981727 | 4-methyl-3-nitropyridin-2-amine | n/a | |
| 6 | P42336_3K6 | 3K6 | n/a | 86306050 | CHEMBL3355071 | N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide | n/a | |
| 7 | P42336_4Q2 | 4Q2 | n/a | 49854158 | CHEMBL3609525 | (2S,3R)-N~1~-(8-tert-butyl-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide | n/a | |
| 8 | P42336_5H2 | 5H2 | n/a | 44242164 | CHEMBL3770332 | methyl {2-[4-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepin-8-yl}carbamate | n/a | |
| 9 | P42336_5H5 | 5H5 | n/a | 58204997 | CHEMBL3771364 | (2S)-2-({2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}oxy)propanamide | n/a | |
| 10 | P42336_5XV | 5XV | n/a | 59252009 | n/a | ~{N}-[6-[5-azanyl-6-[(2~{S})-1,1,1-tris(fluoranyl)propan-2-yl]oxy-pyrazin-2-yl]imidazo[1,2-a]pyridin-2-yl]ethanamide | n/a | |
| 11 | P42336_6CY | 6CY | n/a | 86732669 | CHEMBL3977066 | 5-{4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}-2-methoxypyridine-3-carbonitrile | n/a | |
| 12 | P42336_70S | 70S | n/a | 88012 | CHEMBL17551 | 2H-indazol-5-amine | n/a | |
| 13 | P42336_70T | 70T | n/a | 280313 | n/a | 2-methyl-5-nitro-1H-indole | n/a | |
| 14 | P42336_70V | 70V | n/a | 70945 | CHEMBL191688 | 2-methylcyclohexane-1,3-dione | n/a | |
| 15 | P42336_70W | 70W | n/a | 1268291 | CHEMBL3904068 | tert-butyl 4-aminopiperidine-1-carboxylate | n/a | |
| 16 | P42336_718 | 718 | n/a | 4679494 | CHEMBL3288306 | 6-hydroxy-3,4-dihydronaphthalen-1(2H)-one | n/a | |
| 17 | P42336_71A | 71A | n/a | 7971 | CHEMBL237847 | pyridin-3-ol | n/a | |
| 18 | P42336_71B | 71B | n/a | 581110 | n/a | 3-fluoro-4-methoxyaniline | n/a | |
| 19 | P42336_71F | 71F | n/a | 11370 | CHEMBL192311 | 2-methoxybenzoic acid | n/a | |
| 20 | P42336_71G | 71G | n/a | 16702 | CHEMBL326475 | 3-aminobenzonitrile | n/a | |
| 21 | P42336_71J | 71J | n/a | n/a | n/a | trans-cyclohexane-1,4-diol | n/a | |
| 22 | P42336_71K | 71K | n/a | 13205 | CHEMBL1489438 | 2-methylbenzene-1,3-diamine | n/a | |
| 23 | P42336_71L | 71L | n/a | 21507 | CHEMBL59925 | 4,6-dimethylpyridin-2-amine | n/a | |
| 24 | P42336_71M | 71M | n/a | 15765 | CHEMBL61591 | 6-methylpyridin-2-amine | n/a | |
| 25 | P42336_71N | 71N | n/a | 19345 | CHEMBL1625689 | 2-(trifluoromethyl)-1H-benzimidazol-5-amine | n/a | |
| 26 | P42336_799 | 799 | DB12108 | 51001932 | CHEMBL2387080 | 2-methyl-2-(4-{2-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-1H-pyrazol-1-yl)propanamide | modulator | |
| 27 | P42336_7TZ | 7TZ | n/a | 168475475 | n/a | N-[(2S)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide | n/a | |
| 28 | P42336_7U5 | 7U5 | n/a | 168477799 | n/a | N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide | n/a | |
| 29 | P42336_84R | 84R | n/a | 133053537 | n/a | 3-azanyl-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol | n/a | |
| 30 | P42336_84U | 84U | n/a | 133053536 | n/a | 3-[(4-fluorophenyl)methylamino]-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol | n/a | |
| 31 | P42336_84X | 84X | n/a | 133053538 | n/a | 3-(4-morpholin-4-ylfuro[3,2-d]pyrimidin-2-yl)-5-[(phenylmethyl)amino]phenol | n/a | |
| 32 | P42336_85S | 85S | n/a | 132209868 | CHEMBL4071580 | 1-[4-(3-{4-amino-5-[1-(oxan-4-yl)-1H-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)piperazin-1-yl]ethan-1-one | n/a | |
| 33 | P42336_8DV | 8DV | n/a | 46244706 | n/a | (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine | n/a | |
| 34 | P42336_8DY | 8DY | n/a | 95392293 | n/a | 3-amino-6-(4-{[(2S)-1-(dimethylamino)propan-2-yl]sulfonyl}phenyl)-N-phenylpyrazine-2-carboxamide | n/a | |
| 35 | P42336_AX7 | AX7 | n/a | 13624 | CHEMBL305513 | 1H-benzimidazol-2-amine | n/a | |
| 36 | P42336_BHO | BHO | DB01924 | 10313 | CHEMBL16300 | BENZHYDROXAMIC ACID | n/a | |
| 37 | P42336_CAQ | CAQ | DB02232 | 289 | CHEMBL280998 | CATECHOL | n/a | IC50(nM) = 33000.0 |
| 38 | P42336_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 39 | P42336_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 40 | P42336_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 41 | P42336_ES3 | ES3 | n/a | 96125 | CHEMBL1232569 | 4-bromo-1H-imidazole | n/a | |
| 42 | P42336_FB1 | FB1 | n/a | 81410 | CHEMBL367983 | 2-CHLOROBENZENESULFONAMIDE | n/a | |
| 43 | P42336_FCZ | FCZ | n/a | 139207772 | CHEMBL4475845 | 5-(6-azanyl-4-methyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine | n/a | |
| 44 | P42336_FDH | FDH | n/a | 139207773 | CHEMBL4549761 | 5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine | n/a | |
| 45 | P42336_FDW | FDW | n/a | 139207774 | CHEMBL4529672 | 3-(2-azanyl-1,3-benzoxazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-d]pyrimidine-4,6-diamine | n/a | |
| 46 | P42336_FE5 | FE5 | DB11836 | 45375953 | CHEMBL3545097 | 5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine | n/a | |
| 47 | P42336_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 48 | P42336_HPP | HPP | DB03897 | 10394 | CHEMBL1172560 | HYDROXYPHENYL PROPIONIC ACID | n/a | |
| 49 | P42336_KKR | KKR | n/a | 58441401 | CHEMBL2316958 | 1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methyl-hept-5-ene-1,4- dione | n/a | |
| 50 | P42336_KVJ | KVJ | n/a | 71682837 | n/a | (4S,5R)-3-[2'-amino-2-(morpholin-4-yl)-4'-(trifluoromethyl)[4,5'-bipyrimidin]-6-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one | n/a | |
| 51 | P42336_KWT | KWT | DB08059 | 312145 | CHEMBL428496 | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE | n/a | Ki(nM) = 120.0 IC50(nM) = 1.0 Kd(nM) = 5.4 |
| 52 | P42336_L2V | L2V | n/a | 168477305 | n/a | N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[3-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide | n/a | |
| 53 | P42336_LUZ | LUZ | n/a | 10250;5280577; | CHEMBL1234104 | pteridine-2,4(1H,3H)-dione | n/a | |
| 54 | P42336_M1J | M1J | n/a | 121334433 | CHEMBL4453693 | 4-(difluoromethyl)-5-{4-[(3S)-3-methylmorpholin-4-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}pyridin-2-amine | n/a | |
| 55 | P42336_ML9 | ML9 | DB11974 | n/a | CHEMBL1234354 | 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one | n/a | |
| 56 | P42336_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 57 | P42336_P5J | P5J | n/a | 145946114 | CHEMBL4452905 | (3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one | n/a | |
| 58 | P42336_P6G | P6G | n/a | 17472 | CHEMBL1235082 | HEXAETHYLENE GLYCOL | n/a | |
| 59 | P42336_PBU | PBU | n/a | 9543519 | n/a | (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE | n/a | |
| 60 | P42336_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 61 | P42336_QIH | QIH | n/a | 166451134 | n/a | 1-[7-[[2-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyridin-4-yl]amino]-2,3-dihydroindol-1-yl]ethanone | n/a | |
| 62 | P42336_SAL | SAL | DB00936 | 338;118212070; | CHEMBL424 | 2-HYDROXYBENZOIC ACID | n/a | |
| 63 | P42336_SCN | SCN | n/a | 9322 | n/a | THIOCYANATE ION | n/a | |
| 64 | P42336_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 65 | P42336_UE9 | UE9 | n/a | 169410451 | n/a | 5-[3-fluoro-5-(trifluoromethyl)benzamido]-N-methyl-6-(2-methylanilino)pyridine-3-carboxamide | n/a | |
| 66 | P42336_UIW | UIW | n/a | 169410452 | n/a | 5-(3-bromo-5-fluorobenzamido)-N-methyl-6-(2-methylanilino)pyridine-3-carboxamide | n/a | |
| 67 | P42336_UJC | UJC | n/a | 166821975 | n/a | (1S)-7-[3-fluoro-5-(trifluoromethyl)benzamido]-N-methyl-1-(2-methylphenyl)-3-oxo-2,3-dihydro-1H-isoindole-5-carboxamide | n/a | |
| 68 | P42336_URF | URF | DB00544 | 3385;5281053; | CHEMBL185 | 5-FLUOROURACIL | n/a | |
| 69 | P42336_VBS | VBS | n/a | 131964682 | CHEMBL4744546 | (3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one | n/a | |
| 70 | P42336_VXY | VXY | n/a | 124193915 | CHEMBL4756555 | 2,2-difluoroethyl (3S)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)[4,5'-bipyrimidin]-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate | n/a | |
| 71 | P42336_VY1 | VY1 | n/a | 118444235 | CHEMBL3919768 | (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-N-methylpyrrolidine-1-sulfonamide | n/a | |
| 72 | P42336_VY4 | VY4 | n/a | 118436056 | CHEMBL3901131 | tert-butyl (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-3-methylpyrrolidine-1-carboxylate | n/a | |
| 73 | P42336_VYP | VYP | n/a | 53326637 | CHEMBL1672331 | 2-(morpholin-4-yl)[4,5'-bipyrimidin]-2'-amine | n/a | |
| 74 | P42336_X3N | X3N | DB15275 | 124173720 | CHEMBL4650215 | N~2~-{(4S,11aP)-2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-alaninamide | degradation | |
| 75 | P42336_X3R | X3R | n/a | 165430682 | CHEMBL5182371 | (2S)-2-cyclopropyl-2-({(4S,11aM)-2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}amino)acetamide | n/a | |
| 76 | P42336_X3W | X3W | n/a | 165430683 | CHEMBL5199631 | 1-{(4S,11aM)-2-[(4R)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-prolinamide | n/a | |
| 77 | P42336_X6K | X6K | DB17046 | 9884685 | CHEMBL573339 | 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL | n/a | |
| 78 | P42336_XUZ | XUZ | n/a | 166822065 | n/a | N-{(3R,6M)-3-(2-chloro-5-fluorophenyl)-6-[(4S)-5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}-3-fluoro-5-(trifluoromethyl)benzamide | n/a | |
| 79 | P42336_XXK | XXK | n/a | 72376504 | CHEMBL3109185 | 3-amino-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol | n/a | |
| 80 | P42336_ZHY | ZHY | n/a | 11696578 | CHEMBL484307 | 4-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]benzamide | n/a | |
| 81 | P42336_ZTV | ZTV | n/a | 168429814 | n/a | (2M)-7-[(3R)-3-methylmorpholin-4-yl]-5-[(3S)-3-methylmorpholin-4-yl]-2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine | n/a | |
| 82 | P42336_ZUO | ZUO | n/a | 168429815 | CHEMBL5431805 | (2M)-7-[(3R)-3-methylmorpholin-4-yl]-5-[(3S)-3-methylmorpholin-4-yl]-2-(1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridine | n/a | |
| 83 | P42336_ZWE | ZWE | n/a | 166532451 | CHEMBL5421037 | N-(2-aminopyrimidin-5-yl)-N'-[(1R)-1-(5,7-difluoro-3-methyl-1-benzofuran-2-yl)-2,2,2-trifluoroethyl]urea | n/a | |
| 84 | P42336_SOA | SOA | DB03058 | 21439 | CHEMBL1235999 | ISATOIC ANHYDRIDE | n/a | |
| 85 | P42336_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ATP | n/a | |
| 86 | P42336_CFF | CFF | DB00201 | 2519 | CHEMBL113 | Caffeine | inhibitor | |
| 87 | P42336_DB11772 | n/a | DB11772 | n/a | n/a | Pilaralisib | n/a | |
| 88 | P42336_6E2 | 6E2 | DB12483 | 24989044 | CHEMBL3218576 | Copanlisib | inhibitor |