Gene name: CASP3
Protein name: Caspase-3 (CASP-3) (EC
List of molecules and drugs that interact with protein P42574
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P42574_0ZZ | 0ZZ | n/a | 137347926 | n/a | 5-S-benzyl-3-({N-[(5-bromo-2-methoxyphenyl)acetyl]-L-valyl}amino)-2,3-dideoxy-5-thio-D-erythro-pentonic acid | n/a | |
| 2 | P42574_158 | 158 | n/a | 5287427 | n/a | 3-(2-MERCAPTO-ACETYLAMINO)-4-OXO-PENTANOIC ACID | n/a | |
| 3 | P42574_159 | 159 | DB06862 | 447400 | n/a | 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID | n/a | |
| 4 | P42574_160 | 160 | n/a | 447402 | n/a | 3-(3-{2-[(5-METHANESULFONYL-THIOPHENE-2-CARBONYL)-AMINO]-ETHYLDISULFANYLMETHYL}- BENZENESULFONYLAMINO)-4-OXO-PENTANOIC ACID | n/a | |
| 5 | P42574_161 | 161 | DB03124 | 5287429 | n/a | 5-[4-(1-CARBOXYMETHYL-2-OXO-PROPYLCARBAMOYL)-BENZYLSULFAMOYL]-2-HYDROXY-BENZOIC ACID | n/a | |
| 6 | P42574_3CY | 3CY | n/a | 5287496 | n/a | (3S)-3-[({(2S)-5-[(N-ACETYL-L-ALPHA-ASPARTYL)AMINO]-4-OXO-1,2,4,5,6,7-HEXAHYDROAZEPINO[3,2,1-HI]INDOL-2-YL}CARBONYL)AMINO]-5-(BENZYLSULFANYL)-4-OXOPENTANOIC ACID | n/a | |
| 7 | P42574_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 8 | P42574_APR | APR | n/a | 445794 | CHEMBL1231026 | ADENOSINE-5-DIPHOSPHORIBOSE | n/a | |
| 9 | P42574_AZI | AZI | n/a | 33558 | CHEMBL79455 | AZIDE ION | n/a | |
| 10 | P42574_B92 | B92 | n/a | 49866675 | n/a | (3S)-3-({[(5S,10aS)-2-{(2S)-4-carboxy-2-[(phenylacetyl)amino]butyl}-1,3-dioxo-2,3,5,7,8,9,10,10a-octahydro-1H-[1,2,4]triazolo[1,2-a]cinnolin-5-yl]carbonyl}amino)-4-oxopentanoic acid | n/a | |
| 11 | P42574_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 12 | P42574_CNE | CNE | n/a | 5287959 | CHEMBL81038 | (3S)-5-[(2-CHLORO-6-FLUOROBENZYL)SULFANYL]-3-{[N-({2-ETHOXY-5-[(1E)-3-METHOXY-3-OXOPROP-1-ENYL]PHENYL}ACETYL)-D-VALYL]AMINO}-4-OXOPENTANOIC ACID | n/a | |
| 13 | P42574_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
| 14 | P42574_DZE | DZE | DB07696 | 46937089 | n/a | methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate | n/a | |
| 15 | P42574_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 16 | P42574_H0E | H0E | n/a | 49867075 | n/a | (10S)-3,3-dimethyl-8-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol | n/a | |
| 17 | P42574_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 18 | P42574_MRD | MRD | n/a | 5288845 | n/a | (4R)-2-METHYLPENTANE-2,4-DIOL | n/a | |
| 19 | P42574_MSI | MSI | DB08213 | 5288850 | CHEMBL293034 | 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE | n/a | Ki(nM) = 11.0 IC50(nM) = 2.4 EC50(nM) = 7670.0 |
| 20 | P42574_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 21 | P42574_NA3 | NA3 | n/a | 5288877 | CHEMBL67955 | (3S)-3-{[(5-BROMOPYRIDIN-3-YL)CARBONYL]AMINO}-4-OXOBUTANOIC ACID | n/a | |
| 22 | P42574_NA4 | NA4 | DB08251 | 5288878 | CHEMBL310554 | 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID | n/a | IC50(nM) = 1735.0 |
| 23 | P42574_NAD | NAD | DB14128 | 5892;5288979;10897651;73415790; | CHEMBL1234613 | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | n/a | |
| 24 | P42574_PZN | PZN | n/a | 5289238 | n/a | 3-(2-{5-TERT-BUTYL-3-[(4-METHYL-FURAZAN-3-YLMETHYL)-AMINO]-2-OXO-2H-PYRAZIN-1-YL}-BUTYRYLAMINO)-5-(HEXYL-METHYL-AMINO)-4-OXO-PENTANOIC ACID ANION | n/a | |
| 25 | P42574_RXA | RXA | n/a | 10640 | CHEMBL206435 | isoquinoline-1,3,4(2H)-trione | n/a | |
| 26 | P42574_RXB | RXB | DB08497 | 24883486 | n/a | (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate | n/a | |
| 27 | P42574_RXC | RXC | DB08498 | 46937155 | n/a | (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate | n/a | |
| 28 | P42574_RXD | RXD | DB08499 | 24883488 | n/a | N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide | n/a | |
| 29 | P42574_TQ8 | TQ8 | n/a | 439647 | CHEMBL60718 | N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]-4-methyl-benzenesulfonamide | n/a | |
| 30 | P42574_TQ9 | TQ9 | n/a | 189182 | n/a | 5-CHLORO-4-OXOPENTANOIC ACID | n/a | |
| 31 | P42574_XVE | XVE | n/a | 99625 | CHEMBL303579 | PHENYLMETHYL N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]CARBAMATE | n/a | |
| 32 | P42574_210 | 210 | DB00282 | 4674;44400012; | CHEMBL834 | Pamidronic acid | activator | |
| 33 | P42574_AIN | AIN | DB00945 | 2244 | CHEMBL25 | Acetylsalicylic acid | inhibitor | |
| 34 | P42574_MIY | MIY | DB01017 | n/a | CHEMBL1434 | Minocycline | negative modulator | |
| 35 | P42574_DB05408 | n/a | DB05408 | n/a | n/a | Emricasan | n/a | |
| 36 | P42574_DB06255 | n/a | DB06255 | n/a | n/a | Incadronic acid | activator | |
| 37 | P42574_MY1 | MY1 | DB08229 | n/a | n/a | [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid | n/a | |
| 38 | P42574_NTK | NTK | DB12709 | 6050 | CHEMBL118722 | Tributyrin | activator | |
| 39 | P42574_DB12843 | n/a | DB12843 | n/a | n/a | Oleandrin | regulator | |
| 40 | P42574_DB13048 | n/a | DB13048 | n/a | n/a | PAC-1 | activator | |
| 41 | P42574_DB13751 | n/a | DB13751 | n/a | n/a | Glycyrrhizic acid | antagonist |