Gene name: CTSK
Protein name: Cathepsin K (EC
List of molecules and drugs that interact with protein P43235
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P43235_0D6 | 0D6 | n/a | 23585968 | n/a | N-{(1R)-3-phenyl-1-[2-(phenylsulfonyl)ethyl]propyl}-N~2~-(piperazin-1-ylcarbonyl)-L-leucinamide | n/a | |
| 2 | P43235_0LB | 0LB | n/a | 70278898 | CHEMBL2070936 | (1R,2R)-N-(1-cyanocyclopropyl)-2-{[4-(4-fluorophenyl)piperazin-1-yl]carbonyl}cyclohexanecarboxamide | n/a | |
| 3 | P43235_0LC | 0LC | n/a | 25142042 | CHEMBL2164678 | (1R,2R)-N-(1-cyanocyclopropyl)-2-[(8-fluoro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]cyclohexanecarboxamide | n/a | |
| 4 | P43235_1XF | 1XF | n/a | 224665 | CHEMBL1458632 | 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid | n/a | |
| 5 | P43235_2CA | 2CA | DB03642 | 5287468 | CHEMBL286364 | BENZOFURAN-2-CARBOXYLIC ACID {(S)-3-METHYL-1-[3-OXO-1-(PYRIDIN-2-YLSULFONYL)AZEPAN-4-YLCARBAMOYL]BUTYL}AMIDE | n/a | |
| 6 | P43235_3FC | 3FC | n/a | 5287498 | CHEMBL365822 | (1R)-2,2-DIMETHYL-1-({5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2-YL}METHYL)PROPYL (1S)-1-{OXO[(2-OXO-1,3-OXAZOLIDIN-3-YL)AMINO]ACETYL}PENTYLCARBAMATE | n/a | |
| 7 | P43235_3XT | 3XT | n/a | n/a | n/a | 4-amino-3-fluoro-N-(1-{[(2Z)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide | n/a | |
| 8 | P43235_3Y1 | 3Y1 | n/a | 91885636 | CHEMBL3605410 | 2-amino-4-bromo-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}benzamide | n/a | |
| 9 | P43235_3Y2 | 3Y2 | n/a | n/a | n/a | 2-amino-4-chloro-N-(1-{[(2E)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide | n/a | |
| 10 | P43235_4PR | 4PR | n/a | 11840909 | n/a | (3S)-1-{[(3,5-DIMETHYLISOXAZOL-4-YL)AMINO]CARBONYL}-4,4-DIMETHYLPYRROLIDIN-3-YL{(1S)-1-[1-HYDROXY-2-OXO-2-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL]PENTYL}CARBAMATE | n/a | |
| 11 | P43235_6HM | 6HM | n/a | 261865 | CHEMBL1595667 | [([1,1'-biphenyl]-2-yl)methyl]propanedioic acid | n/a | |
| 12 | P43235_750 | 750 | n/a | 5287549 | CHEMBL284939 | 5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ACID ((S)-3-METHYL-1-{(S)-3-OXO-1-[2-(3-PYRIDIN-2-YLPHENYL)ACETYL]AZEPAN-4-YLCARBAMOYL}BUTYL)AMIDE | n/a | |
| 13 | P43235_7AS | 7AS | n/a | n/a | n/a | 4-fluoro-N-{1-[(Z)-iminomethyl]cyclopropyl}-N~2~-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl }-L-leucinamide | n/a | |
| 14 | P43235_9ZG | 9ZG | n/a | 162422439 | n/a | (phenylmethyl) ~{N}-[(2~{S})-1-[[aminomethyl(methyl)amino]-methyl-amino]-1-oxidanylidene-3-phenyl-propan-2-yl]carbamate | n/a | |
| 15 | P43235_A0U | A0U | n/a | n/a | n/a | ~{tert}-butyl ~{N}-[iminomethyl-[2-[methyl-(phenylmethyl)amino]-2-oxidanylidene-ethyl]amino]carbamate | n/a | |
| 16 | P43235_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 17 | P43235_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 18 | P43235_CKE | CKE | DB07563 | 46937081 | n/a | 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine | n/a | |
| 19 | P43235_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 20 | P43235_CT1 | CT1 | DB07592 | 10062713 | CHEMBL113948 | (1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATE | n/a | IC50(nM) = 0.5 |
| 21 | P43235_CT2 | CT2 | DB07593 | 10062714 | CHEMBL117658 | 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE | inhibitor | IC50(nM) = 0.35 |
| 22 | P43235_E64 | E64 | DB04276 | 5288145 | n/a | N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE | n/a | |
| 23 | P43235_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 24 | P43235_FSP | FSP | DB01858 | 5288259 | CHEMBL185097 | [1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE | n/a | IC50(nM) = 0.83 |
| 25 | P43235_G4B | G4B | n/a | 138753217 | n/a | THALASSOSPIRAMIDE C | n/a | |
| 26 | P43235_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 27 | P43235_HFH | HFH | n/a | 145946002 | n/a | ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{S},6~{a}~{S})-6-fluoranyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | n/a | |
| 28 | P43235_HKH | HKH | n/a | 145946003 | n/a | ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{S},6~{a}~{S})-6-fluoranyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-thiophen-2-yl-benzamide | n/a | |
| 29 | P43235_HVW | HVW | n/a | 137349535 | n/a | (2~{S})-4-methyl-~{N}-prop-2-enyl-2-[[(1~{S})-2,2,2-tris(fluoranyl)-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide | n/a | |
| 30 | P43235_I10 | I10 | DB04244 | 5288593 | n/a | 1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE | n/a | |
| 31 | P43235_I37 | I37 | n/a | 91885514 | CHEMBL3605413 | 4-amino-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-3-fluorobenzamide | n/a | |
| 32 | P43235_IHE | IHE | DB07965 | 5288616 | CHEMBL363847 | 6-(CYCLOHEXYLAMINO)-9-[2-(4-METHYLPIPERAZIN-1-YL)-ETHYL]-9H-PURINE-2-CARBONITRILE | n/a | IC50(nM) = 6.0 |
| 33 | P43235_IHI | IHI | DB07967 | 11464526 | CHEMBL188865 | 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE | n/a | IC50(nM) = 3.5 |
| 34 | P43235_IHJ | IHJ | n/a | 5288618 | CHEMBL188139 | 9-CYCLOPENTYL-6-{2-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPOXY]-PHENYLAMINO}-9H-PURINE-2-CARBONITRILE | n/a | |
| 35 | P43235_IN3 | IN3 | n/a | 5288632 | CHEMBL340191 | 1-(N-BENZYLOXYCARBONYL-L-LEUCINYL)-5-(3-BENZYLOXY BENZOYL)CARBOHYDRAZIDE | n/a | |
| 36 | P43235_IN6 | IN6 | n/a | 5288633 | CHEMBL57836 | N-[2-[1-(N-BENZYLOXYCARBONYLAMINO)-3-METHYLBUTYL]THIAZOL-4-YLCARBONYL]-N'-(BENZYLOXYCARBONYL-L-LEUCINYL)HYDRAZIDE | n/a | |
| 37 | P43235_INA | INA | DB03891 | 5288634 | CHEMBL115357 | 1,5-BIS(N-BENZYLOXYCARBONYL-L-LEUCINYL)CARBOHYDRAZIDE | n/a | |
| 38 | P43235_INP | INP | n/a | 5288640 | n/a | 4-[[N-[(PHENYLMETHOXY)CARBONYL]-/NL/N-LEUCYL]AMINO]-1[(2S)-2-[[[4-(PYRIDINYLMETHOXY)CARBONYL]AMINO]-4-METHYLPENT/NYL]-3-PYRROLIDINONE/N | n/a | |
| 39 | P43235_J0V | J0V | n/a | 125782 | CHEMBL1621346 | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonic acid | n/a | |
| 40 | P43235_J5N | J5N | n/a | 145946013 | n/a | ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-ethynyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-[5-fluoranyl-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | n/a | |
| 41 | P43235_J5T | J5T | n/a | 145946015 | n/a | ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{R},6~{a}~{S})-6-chloranyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-[5-fluoranyl-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | n/a | |
| 42 | P43235_J6B | J6B | n/a | 145946016 | n/a | ~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{R},6~{a}~{R})-6-azanyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-3-fluoranyl-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | n/a | |
| 43 | P43235_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 44 | P43235_KWZ | KWZ | n/a | 11516307 | CHEMBL1084400 | 4-(3-piperidin-1-ylpropyl)-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile | n/a | |
| 45 | P43235_KX1 | KX1 | n/a | 11669355 | CHEMBL1084403 | 4-cycloheptyl-6-(3-piperidin-1-ylpropyl)pyrimidine-2-carbonitrile | n/a | |
| 46 | P43235_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 47 | P43235_MHA | MHA | DB02810 | 117765;15899343; | n/a | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID | n/a | |
| 48 | P43235_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 49 | P43235_MYE | MYE | DB04234 | 5288867 | n/a | N2-({[(4-BROMOPHENYL)METHYL]OXY}CARBONYL)-N1-[(1S)-1-FORMYLPENTYL]-L-LEUCINAMIDE | n/a | |
| 50 | P43235_MYQ | MYQ | n/a | 9547902;139031359; | n/a | (S)-(1,2-DICARBOXYETHYLTHIO)GOLD | n/a | |
| 51 | P43235_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 52 | P43235_NBL | NBL | DB03456 | 5288988 | n/a | N2-[(BENZYLOXY)CARBONYL]-N1-[(3S)-1-CYANOPYRROLIDIN-3-YL]-L-LEUCINAMIDE | n/a | |
| 53 | P43235_NFT | NFT | DB08270 | 46937137 | n/a | N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE | n/a | |
| 54 | P43235_NO3 | NO3 | DB14049 | 943 | CHEMBL186200 | NITRATE ION | n/a | |
| 55 | P43235_O47 | O47 | n/a | n/a | n/a | 3-{2-[(E)-iminomethyl]-6-propylpyrimidin-4-yl}-N,N-dimethyl-5-(trifluoromethyl)benzamide | n/a | |
| 56 | P43235_O75 | O75 | n/a | 49867423 | CHEMBL1234898 | N-benzyl-3-(2-cyano-6-propylpyrimidin-4-yl)-N-[2-(dimethylamino)ethyl]-5-(trifluoromethyl)benzamide | n/a | |
| 57 | P43235_O96 | O96 | n/a | 49867424 | n/a | N-[(1S)-3-amino-1-ethyl-2,3-dioxopropyl]-2-chloro-4-(pyridin-2-ylmethoxy)-3-(trifluoromethyl)benzamide | n/a | |
| 58 | P43235_ORG | ORG | n/a | 11471738 | CHEMBL1084679 | 4-(cyclohexylamino)-6-piperazin-1-yl-1,3,5-triazine-2-carbonitrile | n/a | |
| 59 | P43235_ORH | ORH | n/a | 46865101 | CHEMBL1084114 | 3,5-dioxo-4-(3-piperidin-1-ylpropyl)-2-[3-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile | n/a | |
| 60 | P43235_PCM | PCM | DB03405 | 5289122 | n/a | 1-[N[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-4-[[N/N-[(PHENYLMETHOXY)CARBONYL]-/NL-LEUCYL]AMINO]-3-PYRROLIDINONE/N | n/a | |
| 61 | P43235_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 62 | P43235_PGO | PGO | DB04349 | 439846 | n/a | S-1,2-PROPANEDIOL | n/a | |
| 63 | P43235_POS | POS | n/a | 5289188 | n/a | 1-[[(4-PHENOXYPHENYL)SULFONYL]AMINO]-3-[[N/N-(4-PYRIDINYLCARBONYL)-L-LEUCYL]AMINO]-2-PROPANOL | n/a | |
| 64 | P43235_SDK | SDK | n/a | 5289345 | CHEMBL281540 | 1,3-BIS[[N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL]AMINO]-2-PROPANONE | n/a | |
| 65 | P43235_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 66 | P43235_TCO | TCO | DB04523 | 448022 | CHEMBL92567 | TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE | inhibitor | IC50(nM) = 26.0 |
| 67 | P43235_TFA | TFA | n/a | 6422;23138861; | CHEMBL506259 | trifluoroacetic acid | n/a | |
| 68 | P43235_UUK | UUK | n/a | 156595846 | n/a | tert-butyl (1-((4-(dibenzylamino)-4-oxobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate | n/a | |
| 69 | P43235_UUW | UUW | n/a | 156596349 | n/a | N-(4-(dibenzylamino)-4-oxobutyl)-2-(5-(dimethylamino)pentanamido)-4-methylpentanamide | n/a | |
| 70 | P43235_T2M | T2M | DB08594 | 5289428 | n/a | TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE | inhibitor | |
| 71 | P43235_CNN | CNN | DB02679 | 9864 | CHEMBL56279 | Cyanamide | n/a | |
| 72 | P43235_DB02869 | n/a | DB02869 | n/a | n/a | 3-amino-5-phenylpentane | n/a | |
| 73 | P43235_DB06367 | n/a | DB06367 | n/a | n/a | Relacatib | inhibitor | |
| 74 | P43235_DB06670 | n/a | DB06670 | n/a | n/a | Odanacatib | inhibitor | |
| 75 | P43235_NOQ | NOQ | DB08287 | 11840970 | n/a | (1R,2R)-N-(2-Aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamide | n/a | |
| 76 | P43235_DB12239 | n/a | DB12239 | n/a | n/a | Balicatib | inhibitor |