Gene name: SYK
Protein name: Tyrosine-protein kinase SYK
List of molecules and drugs that interact with protein P43405
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P43405_057 | 057 | DB06834 | 9968957 | CHEMBL1229525 | N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide | n/a | IC50(nM) = 570.0 |
| 2 | P43405_0JE | 0JE | n/a | 135566617 | CHEMBL2017551 | 3-[5-(5-ethoxy-6-fluoro-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-diethylurea | n/a | |
| 3 | P43405_0K0 | 0K0 | n/a | 56947174 | CHEMBL2017998 | 3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-N-(piperidin-4-ylmethyl)pyrazine-2-carboxamide | n/a | |
| 4 | P43405_0K1 | 0K1 | n/a | n/a | n/a | 3-amino-6-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]-N-[(1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide | n/a | |
| 5 | P43405_0SB | 0SB | n/a | 56947354 | CHEMBL2069346 | N-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine | n/a | |
| 6 | P43405_0VE | 0VE | n/a | 69492761 | n/a | 3-[8-({4-[ethyl(2-hydroxyethyl)amino]phenyl}amino)imidazo[1,2-a]pyrazin-5-yl]phenol | n/a | |
| 7 | P43405_0VF | 0VF | n/a | 70680736 | CHEMBL4104392 | 4-{[(3S)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid | n/a | |
| 8 | P43405_0VG | 0VG | n/a | 71525988 | CHEMBL3920431 | N-{6-[(2S)-2-methylpyrrolidin-1-yl]pyridin-2-yl}-6-phenylimidazo[1,2-b]pyridazin-8-amine | n/a | |
| 9 | P43405_0VH | 0VH | n/a | 71598532 | CHEMBL3237556 | 6-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(6-ethylpyridin-2-yl)amino]pyridazine-3-carboxamide | n/a | |
| 10 | P43405_0XF | 0XF | n/a | 71626896 | CHEMBL3237561 | 6-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(5,6-dimethylpyridin-2-yl)amino]pyridazine-3-carboxamide | n/a | |
| 11 | P43405_1B4 | 1B4 | n/a | 44205381 | CHEMBL2348850 | N-(propan-2-yl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | n/a | |
| 12 | P43405_1B5 | 1B5 | n/a | 71279939 | CHEMBL2348852 | 2-(6-chloro-1-methyl-1H-indazol-3-yl)-N-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | n/a | |
| 13 | P43405_1B6 | 1B6 | n/a | 71280008 | CHEMBL2347996 | N-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | n/a | |
| 14 | P43405_2X6 | 2X6 | n/a | 73659204;135566923; | CHEMBL3262356 | 7-{[(1R,2S)-2-aminocyclohexyl]amino}-5-(1H-indol-7-ylamino)pyrido[4,3-d]pyrimidin-4(3H)-one | n/a | |
| 15 | P43405_3RT | 3RT | n/a | 46175187 | n/a | N~3~-(tetrahydro-2H-pyran-4-yl)-N~6~-[5-(tetrahydro-2H-pyran-4-ylmethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indazole-3,6-diamine | n/a | |
| 16 | P43405_3YT | 3YT | n/a | 44462758 | CHEMBL2177736 | 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide | n/a | |
| 17 | P43405_3YV | 3YV | n/a | 72703033 | CHEMBL3416025 | 3-{[(1R,2S)-2-aminocyclohexyl]amino}-5-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide | n/a | |
| 18 | P43405_3YX | 3YX | n/a | 72202597 | CHEMBL3416026 | 3-{[(1R,2S)-2-aminocyclohexyl]amino}-5-(1H-indol-7-ylamino)-1,2,4-triazine-6-carboxamide | n/a | |
| 19 | P43405_477 | 477 | n/a | 135566612 | CHEMBL2017556 | 3-{2-[5-(difluoromethyl)-2H-thieno[3,2-c]pyrazol-3-yl]-1H-indol-6-yl}pentan-3-ol | n/a | |
| 20 | P43405_4DF | 4DF | n/a | 15979348 | n/a | 5-chloro-N~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-N~4~-ethyl-N~4~-(1H-indazol-4-yl)pyrimidine-2,4-diamine | n/a | |
| 21 | P43405_4DJ | 4DJ | n/a | 24751024 | n/a | 3-(1H-indazol-4-yl{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}amino)propan-1-ol | n/a | |
| 22 | P43405_4DK | 4DK | n/a | 24751023 | n/a | 3-[1H-indazol-4-yl(2-{[3-(4-methyl-1,3-oxazol-5-yl)phenyl]amino}pyrimidin-4-yl)amino]propan-1-ol | n/a | |
| 23 | P43405_4DL | 4DL | n/a | 24750883 | n/a | 2-[{2-[(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)amino]pyrimidin-4-yl}(1H-indazol-4-yl)amino]ethanol | n/a | |
| 24 | P43405_4DN | 4DN | n/a | 24750726 | n/a | 3-[{2-[(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)amino]pyrimidin-4-yl}(1H-indazol-4-yl)amino]propan-1-ol | n/a | |
| 25 | P43405_4DO | 4DO | n/a | 15979351 | n/a | N~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-5-fluoro-N~4~-(1H-indazol-4-yl)-N~4~-methylpyrimidine-2,4-diamine | n/a | |
| 26 | P43405_4DQ | 4DQ | n/a | 15979347 | n/a | N~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-N~4~-ethyl-5-fluoro-N~4~-(1H-indazol-4-yl)pyrimidine-2,4-diamine | n/a | |
| 27 | P43405_4DT | 4DT | n/a | 137348228 | n/a | 3-[6-({4-[ethyl(1H-indazol-4-yl)amino]-5-fluoropyrimidin-2-yl}amino)-2,4-dihydro-1H-indazol-1-yl]propan-1-ol | n/a | |
| 28 | P43405_4MG | 4MG | n/a | 71698379 | CHEMBL3622958 | 1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol | n/a | |
| 29 | P43405_50H | 50H | n/a | 69000930 | CHEMBL3265005 | 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzamide | n/a | |
| 30 | P43405_50J | 50J | n/a | 57856440 | n/a | 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}-N-[4-(methylcarbamoyl)phenyl]benzamide | n/a | |
| 31 | P43405_55M | 55M | n/a | 91885526 | CHEMBL3622208 | (4R)-4-[(1R)-1-{[6-(3,4-dimethoxyphenyl)[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy}ethyl]pyrrolidin-2-one | n/a | |
| 32 | P43405_55U | 55U | n/a | 9818573 | CHEMBL30678 | N-{7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl}propane-1,3-diamine | n/a | |
| 33 | P43405_55Y | 55Y | n/a | 91885527 | CHEMBL3622209 | (5R)-5-[(1R)-1-{[6-(1-methyl-1H-pyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy}ethyl]-1,3-oxazolidin-2-one | n/a | |
| 34 | P43405_585 | 585 | DB07159 | 11213558 | CHEMBL475251 | 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one | inhibitor | Ki(nM) = 30.0 IC50(nM) = 5.5 Kd(nM) = 19.0 EC50(nM) = 10.0 |
| 35 | P43405_5JG | 5JG | n/a | 92045136 | CHEMBL3746463 | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-amine | n/a | |
| 36 | P43405_685 | 685 | DB07194 | 25113172 | CHEMBL512172 | 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide | n/a | Ki(nM) = 9.0 IC50(nM) = 6.0 |
| 37 | P43405_6ZF | 6ZF | n/a | 66555698 | CHEMBL4528289 | 7-[6-(dimethylamino)pyridin-3-yl]-~{N}-[[(3~{S})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine | n/a | |
| 38 | P43405_6ZG | 6ZG | n/a | 66556536 | CHEMBL4436576 | ~{N}'-[7-(4-methylphenyl)pyrido[3,4-b]pyrazin-5-yl]butane-1,4-diamine | n/a | |
| 39 | P43405_77V | 77V | n/a | 67130050 | CHEMBL4062803 | N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine | n/a | |
| 40 | P43405_7CU | 7CU | n/a | 118368188 | CHEMBL3951922 | 5-{[(2S)-2-aminopropyl]amino}-3-(1H-indol-2-yl)pyrazine-2-carboxamide | n/a | |
| 41 | P43405_7KF | 7KF | n/a | 53251797 | CHEMBL3943295 | 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one | n/a | |
| 42 | P43405_7KG | 7KG | DB16849 | 53252276 | CHEMBL3979920 | 6-{[(1R,2S)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one | inhibitor | |
| 43 | P43405_8OR | 8OR | n/a | 60147619 | n/a | 2-[[(1S,2S)-2-azanylcyclohexyl]amino]-4-[(4-methylsulfonylphenyl)amino]-6H-pyrido[4,3-d]pyrimidin-5-one | n/a | |
| 44 | P43405_8OU | 8OU | n/a | 137348734 | n/a | 4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8H-pyrido[4,3-d]pyrimidin-5-one | n/a | |
| 45 | P43405_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 46 | P43405_BR | BR | n/a | 259 | n/a | BROMIDE ION | n/a | |
| 47 | P43405_CG4 | CG4 | n/a | 44189262 | CHEMBL3264995 | 4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid | n/a | |
| 48 | P43405_CG9 | CG9 | DB12121 | 59473233 | CHEMBL3265032 | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine | inhibitor | |
| 49 | P43405_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 50 | P43405_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 51 | P43405_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 52 | P43405_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 53 | P43405_FPU | FPU | n/a | 60147014 | n/a | 1-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-3-[(1R,2S)-2-phenylcyclopropyl]urea | n/a | |
| 54 | P43405_FPW | FPW | n/a | 60147015 | CHEMBL3125861 | 1-benzyl-N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide | n/a | |
| 55 | P43405_FPX | FPX | n/a | 60147016 | CHEMBL4065618 | N-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide | n/a | |
| 56 | P43405_GDH | GDH | n/a | 60194098 | CHEMBL4291402 | 7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1~{H}-3-benzazepine | n/a | |
| 57 | P43405_GDK | GDK | n/a | 134817809 | CHEMBL4285648 | 2-(4-methylphenyl)-3-(pyridin-2-ylmethoxy)pyridine | n/a | |
| 58 | P43405_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 59 | P43405_LUE | LUE | n/a | 154700505 | CHEMBL4753164 | ~{N}-[4-[5-[(dimethylamino)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-yl]-3-methyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)imidazo[1,5-a]pyridin-7-amine | n/a | |
| 60 | P43405_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 61 | P43405_P4G | P4G | DB08357 | 8179 | CHEMBL1235106 | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE | n/a | |
| 62 | P43405_P5C | P5C | DB08361 | 11493841 | CHEMBL1235110 | 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide | inhibitor | IC50(nM) = 4.0 EC50(nM) = 2500.0 |
| 63 | P43405_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 64 | P43405_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 65 | P43405_QDZ | QDZ | n/a | 155925931 | CHEMBL4747780 | ~{N},~{N}-dimethyl-1-[1-[2-(1-methylindol-4-yl)-3~{H}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]methanamine | n/a | |
| 66 | P43405_QF8 | QF8 | n/a | 155925937 | CHEMBL4753097 | ~{N},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{R})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide | n/a | |
| 67 | P43405_QFB | QFB | n/a | 155925934 | CHEMBL4763433 | 7-[[4-[4-[[(3~{R},4~{R})-3-azanyloxan-4-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{N},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide | n/a | |
| 68 | P43405_QFE | QFE | n/a | 155925935 | CHEMBL4740065 | (3~{R},4~{R})-~{N}4-[1-[2-(1-methylindol-4-yl)-3~{H}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]oxane-3,4-diamine | n/a | |
| 69 | P43405_QFK | QFK | n/a | 155925933 | CHEMBL4800498 | 7-[[4-[4-[(dimethylamino)methyl]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{N},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide | n/a | |
| 70 | P43405_QFQ | QFQ | n/a | 155925936 | CHEMBL4760325 | ~{N},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{R})-piperidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide | n/a | |
| 71 | P43405_QR7 | QR7 | n/a | 168451683 | n/a | 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one | n/a | |
| 72 | P43405_R6D | R6D | DB14770 | 118161062 | CHEMBL3986824 | 6-(6-aminopyrazin-2-yl)-N-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine | inhibitor | |
| 73 | P43405_S19 | S19 | n/a | 46865656 | CHEMBL1835071 | 2-{[(3R,4R)-3-aminotetrahydro-2H-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide | n/a | |
| 74 | P43405_SCN | SCN | n/a | 9322 | n/a | THIOCYANATE ION | n/a | |
| 75 | P43405_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 76 | P43405_X3G | X3G | n/a | 87228651 | n/a | 4-{[5-fluoro-4-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate | n/a | |
| 77 | P43405_X4G | X4G | n/a | 53233425 | n/a | (3R)-1-{[1-(5-fluoro-2-{[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]amino}pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl]methyl}pyrrolidin-3-ol | n/a | |
| 78 | P43405_X5G | X5G | n/a | 102515519 | CHEMBL3622942 | 1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1H-pyrrol-3-yl}methyl)azetidin-3-ol | n/a | |
| 79 | P43405_X6G | X6G | n/a | 102515520 | CHEMBL3622929 | 1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol | n/a | |
| 80 | P43405_X7G | X7G | n/a | 71698642 | CHEMBL3622959 | 1-[(3-methyl-1-{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol | n/a | |
| 81 | P43405_X8G | X8G | n/a | 71698643 | CHEMBL3622961 | 1-[(1-{2-[(3-chloro-1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol | n/a | |
| 82 | P43405_X9G | X9G | n/a | 71698376 | CHEMBL3622956 | 1-[(1-{2-[(3-chloro-1,2-dimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol | n/a | |
| 83 | P43405_STI | STI | DB00619 | 5291 | CHEMBL941 | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | n/a | Ki(nM) = 5000.0 IC50(nM) = 5000.0 Kd(nM) = 10000.0 |
| 84 | P43405_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | |
| 85 | P43405_REF | REF | DB08846 | 5281855 | CHEMBL6246 | Ellagic acid | inhibitor | |
| 86 | P43405_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |