Gene name: MMP13
Protein name: Collagenase 3 (EC
List of molecules and drugs that interact with protein P45452
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P45452_033 | 033 | n/a | 6852146 | CHEMBL187523 | N-({4'-[(1-BENZOFURAN-2-YLCARBONYL)AMINO]-1,1'-BIPHENYL-4-YL}SULFONYL)-L-VALINE | n/a | |
| 2 | P45452_1UA | 1UA | n/a | 2072958;5310608;135412231; | CHEMBL1371684 | 2-[(4-methylbenzyl)sulfanyl]-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one | n/a | |
| 3 | P45452_24F | 24F | n/a | 44123600 | CHEMBL466059 | (2R)-({[5-(4-ethoxyphenyl)thiophen-2-yl]sulfonyl}amino){1-[(1-methylethoxy)carbonyl]piperidin-4-yl}ethanoic acid | n/a | |
| 4 | P45452_347 | 347 | DB07013 | 24768528 | CHEMBL236573 | TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE | n/a | IC50(nM) = 860.0 |
| 5 | P45452_3EJ | 3EJ | n/a | 46225419 | CHEMBL593034 | 4-[(5-{2-[(3-fluorobenzyl)carbamoyl]pyridin-4-yl}-2H-tetrazol-2-yl)methyl]benzoic acid | n/a | |
| 6 | P45452_3EK | 3EK | n/a | n/a | n/a | trans-4-[(3-{2-[(4-fluorobenzyl)carbamoyl]-6-methylpyridin-4-yl}-1H-1,2,4-triazol-1-yl)methyl]cyclohexanecarboxylic acid | n/a | |
| 7 | P45452_3KE | 3KE | n/a | 11319396 | CHEMBL603623 | 4-{[({3-[2-(4-methoxybenzyl)-2H-tetrazol-5-yl]phenyl}carbonyl)amino]methyl}benzoic acid | n/a | |
| 8 | P45452_3KR | 3KR | n/a | 49866490 | n/a | 1-(2-methoxyethyl)-N-oxo-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide | n/a | |
| 9 | P45452_3MP | 3MP | DB01996 | 7970 | CHEMBL15722 | 3-METHYLPYRIDINE | inhibitor | |
| 10 | P45452_3O2 | 3O2 | n/a | 20620240 | CHEMBL1771216 | N-hydroxy-1-(2-methoxyethyl)-4-{[4-(3-{5-[4-(trifluoromethoxy)phenyl]-2H-tetrazol-2-yl}propoxy)phenyl]sulfonyl}piperidine-4-carboxamide | n/a | |
| 11 | P45452_3W4 | 3W4 | n/a | 54669609 | n/a | N-[(3R)-1,1-dioxidotetrahydro-2H-thiopyran-3-yl]-4-(4-{[(3S)-3-hydroxy-1-azabicyclo[2.2.2]oct-3-yl]ethynyl}phenoxy)benzamide | n/a | |
| 12 | P45452_3W5 | 3W5 | n/a | 54669608 | n/a | N-[(3S)-1,1-dioxidotetrahydro-2H-thiopyran-3-yl]-4-(4-{[(3S)-3-hydroxy-1-azabicyclo[2.2.2]oct-3-yl]ethynyl}phenoxy)benzamide | n/a | |
| 13 | P45452_4UE | 4UE | n/a | 56850408 | CHEMBL1939872 | ethyl 5-(1-methyl-1H-imidazol-5-yl)-1H-indole-2-carboxylate | n/a | |
| 14 | P45452_4UF | 4UF | n/a | 45376872 | CHEMBL1939876 | 4-{[({5-[2-(ethoxycarbonyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}carbonyl)amino]methyl}benzoic acid | n/a | |
| 15 | P45452_4UM | 4UM | n/a | 47162079 | CHEMBL1939862 | ethyl 5-carbamoyl-1H-indole-2-carboxylate | n/a | |
| 16 | P45452_518 | 518 | n/a | 44182307 | CHEMBL576431 | N-[4-(5-{[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]carbamoyl}furan-2-yl)phenyl]-1-benzofuran-2-carboxamide | n/a | |
| 17 | P45452_5EL | 5EL | n/a | 53245646 | CHEMBL1738748 | 4-(4-{[(3S)-3-HYDROXY-1-AZABICYCLO[2.2.2]OCT-3-YL]ETHYNYL}PHENOXY)-N-(PYRIDIN-4-YLMETHYL)BENZAMIDE | n/a | |
| 18 | P45452_732 | 732 | n/a | 44182306 | CHEMBL577910 | 5-(4-chlorophenyl)-N-[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]furan-2-carboxamide | n/a | |
| 19 | P45452_8O7 | 8O7 | n/a | 129012126;135567320; | CHEMBL4081997 | N-(2-aminoethyl)-4'-(((4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)thio)methyl)-[1,1'-biphenyl]-4-sulfonami de | n/a | |
| 20 | P45452_8OA | 8OA | n/a | 137348731 | CHEMBL4090820 | (R)-N-(3-methyl-1-(methylamino)-1-oxobutan-2-yl)-5-(4-(((4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)thio)methyl)phenyl)furan-2-carboxamide | n/a | |
| 21 | P45452_8OJ | 8OJ | n/a | 137348732 | CHEMBL4069824 | (S)-N-(3-methyl-1-(methylamino)-1-oxobutan-2-yl)-5-(4-(((4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)thio)methyl)phenyl)furan-2-carboxamide | n/a | |
| 22 | P45452_8OM | 8OM | n/a | 137348733 | CHEMBL4062836 | (S)-3-methyl-2-(4'-(((4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)thio)methyl)-[1,1'-biphenyl]-4-ylsulfonamido)butanoic acid | n/a | |
| 23 | P45452_9DY | 9DY | n/a | 1471810 | n/a | 4-(1,2,3-thiadiazol-4-yl)pyridine | n/a | |
| 24 | P45452_AZ4 | AZ4 | n/a | 73010383 | n/a | N-[(2S)-4-(5-fluoropyrimidin-2-yl)-1-({4-[5-(2,2,2-trifluoroethoxy)pyrimidin-2-yl]piperazin-1-yl}sulfonyl)butan-2-yl]-N-hydroxyformamide | n/a | |
| 25 | P45452_AZ6 | AZ6 | n/a | 71815036 | CHEMBL2409696 | 3-[({2-[4-({[(4S)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl}sulfonyl)piperazin-1-yl]pyrimidin-5-yl}oxy)methyl]benzonitrile | n/a | |
| 26 | P45452_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 27 | P45452_CBP | CBP | DB02049 | 5111 | CHEMBL93687 | 2-{4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYL]-TETRAHYDRO-PYRAN-4-YL}-N-HYDROXY-ACETAMIDE | n/a | |
| 28 | P45452_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 29 | P45452_E3P | E3P | n/a | 57336493 | n/a | N~2~-[3-(1,1':4',1''-terphenyl-4-yl)propanoyl]-L-alpha-glutamine | n/a | |
| 30 | P45452_E41 | E41 | n/a | 53389286 | CHEMBL1916644 | N-hydroxy-N^2^-(3-methylbutyl)-N^2^-(naphthalen-2-ylsulfonyl)-D-valinamide | n/a | |
| 31 | P45452_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 32 | P45452_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 33 | P45452_FA4 | FA4 | n/a | 6914601 | n/a | SM-25453 | n/a | |
| 34 | P45452_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 35 | P45452_GG1 | GG1 | DB07827 | 10224181 | CHEMBL496942 | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | n/a | IC50(nM) = 0.67 |
| 36 | P45452_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 37 | P45452_HAE | HAE | DB00551 | 1990 | CHEMBL734 | ACETOHYDROXAMIC ACID | n/a | |
| 38 | P45452_HAV | HAV | DB02697 | 444599 | n/a | HYDROXYAMINOVALINE | inhibitor | |
| 39 | P45452_LA3 | LA3 | n/a | 10005114 | CHEMBL8432 | (2R)-2-[4-(1,3-benzodioxol-5-yl)benzyl]-N~4~-hydroxy-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide | n/a | |
| 40 | P45452_MSB | MSB | DB03033 | 5171961 | n/a | 1-METHYLOXY-4-SULFONE-BENZENE | inhibitor | |
| 41 | P45452_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 42 | P45452_PB3 | PB3 | DB04759 | 5289109 | CHEMBL511942 | N,N'-BIS(3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE | n/a | IC50(nM) = 72.0 |
| 43 | P45452_PB4 | PB4 | DB04760 | 5289110 | CHEMBL514794 | N,N'-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE | n/a | IC50(nM) = 0.67 |
| 44 | P45452_PB5 | PB5 | DB04761 | 5289111 | CHEMBL468900 | N,N'-BIS(PYRIDIN-3-YLMETHYL)PYRIMIDINE-4,6-DICARBOXAMIDE | n/a | IC50(nM) = 6600.0 |
| 45 | P45452_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 46 | P45452_PFD | PFD | DB08388 | 657061 | CHEMBL222002 | 5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE | inhibitor | IC50(nM) = 0.6 |
| 47 | P45452_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 48 | P45452_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 49 | P45452_PGO | PGO | DB04349 | 439846 | n/a | S-1,2-PROPANEDIOL | n/a | |
| 50 | P45452_RS1 | RS1 | DB08490 | 3342298 | CHEMBL440498 | 4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE | inhibitor | Ki(nM) = 0.28 IC50(nM) = 0.01 |
| 51 | P45452_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 52 | P45452_WAY | WAY | DB02071 | 4368 | CHEMBL70176 | N-HYDROXY-2-[(4-METHOXY-BENZENESULFONYL)-PYRIDIN-3-YLMETHYL-AMINO]-3-METHYL-BENZAMIDE | inhibitor | IC50(nM) = 7.9 |
| 53 | P45452_WGG | WGG | n/a | 68724549;135566625; | CHEMBL3337869 | N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide | n/a | |
| 54 | P45452_WHH | WHH | n/a | 11576807;135438561; | CHEMBL3359091 | 4-[2-({6-fluoro-2-[(3-methoxybenzyl)carbamoyl]-4-oxo-3,4-dihydroquinazolin-5-yl}oxy)ethyl]benzoic acid | n/a | |
| 55 | P45452_WLL | WLL | n/a | 68738441 | CHEMBL3337881 | N-(3-methoxybenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide | n/a | |
| 56 | P45452_WMM | WMM | n/a | 2366268 | CHEMBL1511860 | N-phenyl-4-[(4H-1,2,4-triazol-3-ylsulfanyl)methyl]-1,3-thiazol-2-amine | n/a | |
| 57 | P45452_WNN | WNN | n/a | 57708822;135567051; | CHEMBL4083954 | 4-oxo-N-{3-[2-(1H-1,2,4-triazol-3-ylsulfanyl)ethoxy]benzyl}-3,4-dihydroquinazoline-2-carboxamide | n/a | |
| 58 | P45452_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 59 | P45452_SP6 | SP6 | DB08561 | 9896504 | CHEMBL409536 | BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE | n/a | Ki(nM) = 64.0 IC50(nM) = 23.0 |
| 60 | P45452_097 | 097 | DB00786 | 119031 | CHEMBL279785 | Marimastat | inhibitor | IC50(nM) = 0.74 |