Gene name: MAPK8
Protein name: Mitogen-activated protein kinase
List of molecules and drugs that interact with protein P45983
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P45983_0NR | 0NR | n/a | n/a | CHEMBL2152392 | methyl 3-(4-{[(1R,2S,3S,5S,7s)-5-aminotricyclo[3.3.1.1~3,7~]dec-2-yl]carbamoyl}benzyl)-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-2-carboxylate | n/a | |
| 2 | P45983_1V5 | 1V5 | n/a | n/a | CHEMBL2420555 | N-[1-(4-fluorophenyl)cyclopropyl]-4-[(trans-4-hydroxycyclohexyl)amino]imidazo[1,2-a]quinoxaline-8-carboxamide | n/a | |
| 3 | P45983_38Z | 38Z | n/a | 24866313 | CHEMBL3590107 | (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide | n/a | |
| 4 | P45983_46A | 46A | n/a | 15658026 | CHEMBL90825 | N-butyl-4,6-dimethyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}pyrimidin-2-amine | n/a | |
| 5 | P45983_537 | 537 | DB01782 | 8515 | CHEMBL7064 | 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE | inhibitor | IC50(nM) = 40.0 Kd(nM) = 100.0 |
| 6 | P45983_73Q | 73Q | DB07218 | 6540289 | CHEMBL207228 | 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE | n/a | IC50(nM) = 1220.0 |
| 7 | P45983_859 | 859 | DB07268 | 16058637 | CHEMBL242237 | 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE | n/a | IC50(nM) = 9.0 |
| 8 | P45983_877 | 877 | DB07272 | 6852206 | CHEMBL382639 | N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE | n/a | IC50(nM) = 77.0 |
| 9 | P45983_893 | 893 | DB07276 | 9543521 | CHEMBL209740 | 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE | n/a | IC50(nM) = 230.0 |
| 10 | P45983_ADN | ADN | DB00640 | 60961 | CHEMBL477 | ADENOSINE | n/a | |
| 11 | P45983_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 12 | P45983_AQ2 | AQ2 | n/a | 59744451 | CHEMBL2164411 | N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-4-[2-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide | n/a | |
| 13 | P45983_CFK | CFK | n/a | 10220851 | CHEMBL1831214 | 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide | n/a | |
| 14 | P45983_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 15 | P45983_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 16 | P45983_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 17 | P45983_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 18 | P45983_GS7 | GS7 | DB07845 | 25113171 | n/a | 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide | n/a | |
| 19 | P45983_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 20 | P45983_MYU | MYU | n/a | 5281680 | CHEMBL413552 | 3,5,6,7-TETRAHYDROXY-2-(3,4-DIHYDROXYPHENYL)-4H-CHROMEN-4-ONE | n/a | |
| 21 | P45983_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 22 | P45983_CTX | CTX | DB00675 | 2733526 | CHEMBL83 | Tamoxifen | modulator |