Gene name: MAPKAPK2
Protein name: MAP kinase-activated protein
List of molecules and drugs that interact with protein P49137
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P49137_05B | 05B | n/a | 53326866 | CHEMBL1738702 | 2'-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one | n/a | |
| 2 | P49137_39G | 39G | n/a | 2812918 | CHEMBL3393296 | N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | n/a | |
| 3 | P49137_793 | 793 | DB07234 | 15295578 | CHEMBL466496 | 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione | n/a | IC50(nM) = 8900.0 |
| 4 | P49137_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 5 | P49137_B18 | B18 | DB07406 | 16741237 | n/a | (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE | n/a | |
| 6 | P49137_B97 | B97 | DB07430 | 44631903 | CHEMBL1231206 | (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one | inhibitor | Ki(nM) = 5.0 IC50(nM) = 2.0 |
| 7 | P49137_B98 | B98 | DB07431 | 45273683 | CHEMBL555205 | (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one | n/a | IC50(nM) = 5.0 |
| 8 | P49137_CD2 | CD2 | n/a | 9826115 | CHEMBL1738780 | 1-(2-aminoethyl)-3-[2-(quinolin-3-yl)pyridin-4-yl]-1H-pyrazole-5-carboxylic acid | n/a | |
| 9 | P49137_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 10 | P49137_F10 | F10 | DB07728 | 11992146 | CHEMBL226471 | 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | n/a | IC50(nM) = 126.0 EC50(nM) = 372.0 |
| 11 | P49137_HG | HG | n/a | 26623 | n/a | MERCURY (II) ION | n/a | |
| 12 | P49137_HGF | HGF | n/a | 25066416 | CHEMBL1614995 | 2-[5-(2-methoxyethoxy)pyridin-3-yl]-8,9,10,11-tetrahydro-7H-pyrido[3',4':4,5]pyrrolo[2,3-f]isoquinolin-7-one | n/a | |
| 13 | P49137_L8I | L8I | n/a | 42646698 | CHEMBL1233942 | 2'-(2-fluorophenyl)-1-methyl-6',8',9',11'-tetrahydrospiro[azetidine-3,10'-pyrido[3',4':4,5]pyrrolo[2,3-f]isoquinolin]-7'(5'H)-one | n/a | |
| 14 | P49137_LX9 | LX9 | n/a | 44593854 | CHEMBL597839 | 6-{3-amino-1-[3-(1H-indol-6-yl)phenyl]-1H-pyrazol-4-yl}-3,4-dihydroisoquinolin-1(2H)-one | n/a | |
| 15 | P49137_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 16 | P49137_MK2 | MK2 | n/a | 44543658 | CHEMBL590110 | N~4~-[7-(1-benzofuran-2-yl)-1H-indazol-5-yl]pyrimidine-2,4-diamine | n/a | |
| 17 | P49137_MK3 | MK3 | n/a | 49867314 | n/a | 6-{5-[(2-aminopyrimidin-4-yl)amino]-2-hydroxyphenyl}-N-methylidene-1-benzothiophene-2-carboxamide | n/a | |
| 18 | P49137_MLA | MLA | DB02175 | 867;23511544; | CHEMBL7942 | MALONIC ACID | n/a | |
| 19 | P49137_MLI | MLI | DB02201 | 9084 | n/a | MALONATE ION | n/a | |
| 20 | P49137_MW8 | MW8 | n/a | 155907491 | n/a | 5-(4-bromophenyl)-~{N}-(4-piperazin-1-ylphenyl)-~{N}-(pyridin-2-ylmethyl)furan-2-carboxamide | n/a | |
| 21 | P49137_P4O | P4O | DB08358 | 10389239 | CHEMBL226403 | 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | inhibitor | IC50(nM) = 8.5 EC50(nM) = 49.0 |
| 22 | P49137_PDY | PDY | n/a | 49867482 | CHEMBL1235213 | N~7~-(4-ethoxyphenyl)-6-methyl-N~5~-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine | n/a | |
| 23 | P49137_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 24 | P49137_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 25 | P49137_YRZ | YRZ | n/a | 137350197 | n/a | N-[(3S)-piperidin-3-yl]-7,8-dihydro-6H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-amine | n/a | |
| 26 | P49137_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a |