Gene name: CDK8
Protein name: Cyclin-dependent kinase 8
List of molecules and drugs that interact with protein P49336
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P49336_0SO | 0SO | n/a | 71305045 | CHEMBL4649097 | tert-butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)propyl]carbamate | n/a | |
| 2 | P49336_0SQ | 0SQ | n/a | 22618347 | CHEMBL5279965 | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea | n/a | |
| 3 | P49336_0SR | 0SR | n/a | 71305041 | n/a | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]urea | n/a | |
| 4 | P49336_0SS | 0SS | n/a | 71305042 | CHEMBL3401551 | N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-4-[2-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine-1-carboxamide | n/a | |
| 5 | P49336_0ST | 0ST | n/a | 71305043 | CHEMBL3401550 | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea | n/a | |
| 6 | P49336_0SU | 0SU | n/a | 71305044 | n/a | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(2-hydroxyethyl)urea | n/a | |
| 7 | P49336_0SV | 0SV | n/a | 71305046 | n/a | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(5-hydroxypentyl)urea | n/a | |
| 8 | P49336_0SW | 0SW | n/a | 198909 | CHEMBL117804 | N-(2-phenylethyl)quinazolin-4-amine | n/a | |
| 9 | P49336_4TV | 4TV | n/a | 77050682 | CHEMBL3408213 | 8-{3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyridin-4-yl}-2,8-diazaspiro[4.5]decan-1-one | n/a | |
| 10 | P49336_50R | 50R | n/a | 11761387 | CHEMBL3806024 | 4-(4-iodophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide | n/a | |
| 11 | P49336_5XG | 5XG | n/a | 117072459 | CHEMBL3797855 | 8-[3-(3-azanyl-2~{H}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | n/a | |
| 12 | P49336_5Y6 | 5Y6 | n/a | 117072461 | CHEMBL3799307 | 8-[3-chloranyl-5-[1-methyl-2,2-bis(oxidanylidene)-3~{H}-2,1-benzothiazol-5-yl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | n/a | |
| 13 | P49336_5Y7 | 5Y7 | n/a | 117072462 | CHEMBL3798778 | 5-[5-chloranyl-4-[1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3~{H}-2,1-benzothiazole 2,2-dioxide | n/a | |
| 14 | P49336_5Y8 | 5Y8 | n/a | 74222277 | CHEMBL3798382 | 8-[2-azanyl-3-chloranyl-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | n/a | |
| 15 | P49336_62M | 62M | n/a | 135567139;154063851; | n/a | [6-hydroxy-3-(3-methylbenzyl)-1H-indazol-5-yl][(3S)-3-hydroxypyrrolidin-1-yl]methanone | n/a | |
| 16 | P49336_66X | 66X | n/a | 117995570 | CHEMBL4532382 | N-{(3S)-1-[2-(methylamino)pyrimidin-4-yl]pyrrolidin-3-yl}-N'-{4-[(morpholin-4-yl)methyl]-3-(trifluoromethyl)phenyl}urea | n/a | |
| 17 | P49336_68U | 68U | n/a | 118660787 | CHEMBL3828637 | N-methyl-8-(1-methyl-2,2-dioxo-2,3-dihydro-1H-2lambda~6~,1-benzothiazol-5-yl)-1,6-naphthyridine-2-carboxamide | n/a | |
| 18 | P49336_69Z | 69Z | n/a | 134149698 | CHEMBL3938208 | [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl](5-methylimidazo[5,1-b][1,3,4]thiadiazol-2-yl)methanone | n/a | |
| 19 | P49336_6A6 | 6A6 | n/a | 118879516 | CHEMBL3984494 | (3-amino-1H-indazol-5-yl)[(2S)-2-(4-fluorophenyl)piperidin-1-yl]methanone | n/a | |
| 20 | P49336_6A7 | 6A7 | n/a | 118879529 | CHEMBL3903492 | [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone | n/a | |
| 21 | P49336_8CC | 8CC | n/a | 129316487 | CHEMBL4104570 | N-methyl-4-pyridin-4-yl-1H-pyrrole-2-carboxamide | n/a | |
| 22 | P49336_8D6 | 8D6 | n/a | 81689726 | CHEMBL4072496 | 3-chloranyl-4-pyridin-4-yl-1H-pyrrole-2-carboxamide | n/a | |
| 23 | P49336_BAX | BAX | DB00398 | 216239 | CHEMBL1336 | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE | n/a | IC50(nM) = 30.0 Kd(nM) = 310.0 |
| 24 | P49336_C1I | C1I | n/a | 11561907 | CHEMBL4080906 | CORTISTATIN A | n/a | |
| 25 | P49336_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 26 | P49336_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 27 | P49336_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 28 | P49336_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 29 | P49336_JH8 | JH8 | n/a | 132180482 | CHEMBL4455382 | 2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-~{N},~{N}-dimethyl-ethanamide | n/a | |
| 30 | P49336_JHK | JHK | n/a | 139519627 | n/a | ~{N},~{N}-dimethyl-2-[4-[4-(2,6-naphthyridin-4-yl)phenyl]pyrazol-1-yl]ethanamide | n/a | |
| 31 | P49336_JRE | JRE | n/a | 146018261 | n/a | 6-[5-chloranyl-4-[(1~{S})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide | n/a | |
| 32 | P49336_MFE | MFE | n/a | 5328014 | CHEMBL117554 | ~{N}-[(4-chlorophenyl)methyl]quinazolin-4-amine | n/a | |
| 33 | P49336_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 34 | P49336_NZ5 | NZ5 | n/a | 641012 | n/a | (2~{R})-butane-1,2-diol | n/a | |
| 35 | P49336_NZ8 | NZ8 | n/a | 154815588 | CHEMBL4792974 | 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-(5-oxidanylidene-6-pyridin-4-yl-pyrido[2,3-b][1,5]benzoxazepin-9-yl)urea | n/a | |
| 36 | P49336_CPB | CPB | DB03496 | 5287969 | CHEMBL428690 | Alvocidib | n/a | Kd(nM) = 120.0 |