Gene name: FNTA
Protein name: Protein farnesyltransferase/geranylgeranyltransferase type-1
List of molecules and drugs that interact with protein P49354
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P49354_3MN | 3MN | n/a | 11963504 | n/a | 3-({3-[3-(1H-IMIDAZOL-1-YL)PROPYL]-5-METHYL-5-(1-NAPHTHYL)-2,4-DIOXOIMIDAZOLIDIN-1-YL}METHYL)BENZONITRILE | n/a | |
| 2 | P49354_739 | 739 | n/a | 5287548 | n/a | 2(S)-{2(S)-[2(R)-AMINO-3-MERCAPTO]PROPYLAMINO-3(S)-METHYL}PENTYLOXY-3-PHENYLPROPIONYLMETHIONINE SULFONE | n/a | |
| 3 | P49354_778 | 778 | DB07227 | 216454 | CHEMBL279433 | 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE | modulator | IC50(nM) = 2.0 EC50(nM) = 6800.0 |
| 4 | P49354_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 5 | P49354_ACY | ACY | DB03166 | 176;21980959;160748163; | CHEMBL539 | ACETIC ACID | n/a | |
| 6 | P49354_BNE | BNE | n/a | 5287820 | CHEMBL294888 | 2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE | n/a | |
| 7 | P49354_ED5 | ED5 | n/a | 25181319 | n/a | tert-butyl 4-({(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)[(2-methylphenyl)sulfonyl]amino}methyl)piperidine-1-carboxylate | n/a | |
| 8 | P49354_FAR | FAR | n/a | 444108 | n/a | FARNESYL | n/a | |
| 9 | P49354_FII | FII | DB07771 | 445015 | n/a | [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID | n/a | |
| 10 | P49354_FPP | FPP | DB07780 | 445713 | CHEMBL69330 | FARNESYL DIPHOSPHATE | n/a | |
| 11 | P49354_GER | GER | n/a | 446073 | n/a | GERAN-8-YL GERAN | n/a | |
| 12 | P49354_JAN | JAN | DB04960 | 159324 | CHEMBL289228 | 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE | modulator | IC50(nM) = 0.9 |
| 13 | P49354_S48 | S48 | n/a | 15942674 | n/a | METHYL N-{(3S)-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-6-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-3-YL}-N-[(1-METHYL-1H-IMIDAZOL-4-YL)SULFONYL]GLYCINATE | n/a | |
| 14 | P49354_U49 | U49 | DB08674 | 23646577 | CHEMBL496879 | (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRI AZA-CYCLOOCTADECOSINE-9-CARBONITRILE | n/a | IC50(nM) = 1.6 |
| 15 | P49354_U66 | U66 | DB08676 | 131704313 | n/a | (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIA ZACYCLONOADECOSINE-9-CARBONITRILE | n/a | |
| 16 | P49354_336 | 336 | DB06448 | 148195 | CHEMBL298734 | Lonafarnib | inhibitor | |
| 17 | P49354_2C5 | 2C5 | DB06953 | 5287467 | n/a | 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE | n/a | |
| 18 | P49354_736 | 736 | DB07216 | 9547909 | CHEMBL372164 | (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE | n/a | |
| 19 | P49354_BUE | BUE | DB07841 | 735 | n/a | Geranylgeranyl diphosphate | inhibitor | |
| 20 | P49354_HFP | HFP | DB07895 | 46937103 | n/a | ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID | n/a | |
| 21 | P49354_MGM | MGM | DB08180 | 447278 | CHEMBL71360 | 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE | n/a |