Gene name: CLK1
Protein name: Dual specificity protein
List of molecules and drugs that interact with protein P49759
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P49759_06N | 06N | n/a | 156009109 | n/a | 4-[2-(propylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenol | n/a | |
| 2 | P49759_3NG | 3NG | DB15408 | 24748573 | CHEMBL1230165 | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | n/a | |
| 3 | P49759_5ID | 5ID | DB04604 | 97297 | CHEMBL99203 | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL | n/a | |
| 4 | P49759_6FB | 6FB | n/a | 118988440 | CHEMBL3823505 | pyrido[3,4-g]quinazolin-2-amine | n/a | |
| 5 | P49759_6FD | 6FD | n/a | 118988439 | CHEMBL3823483 | pyrido[3,4-g]quinazoline-2,10-diamine | n/a | |
| 6 | P49759_7A7 | 7A7 | n/a | n/a | n/a | methyl 9-[(2-fluoranyl-4-methoxy-phenyl)amino]-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate | n/a | |
| 7 | P49759_BR | BR | n/a | 259 | n/a | BROMIDE ION | n/a | |
| 8 | P49759_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 9 | P49759_DBQ | DBQ | DB04367 | 5288032;135451156; | CHEMBL255465 | DEBROMOHYMENIALDISINE | n/a | |
| 10 | P49759_E6T | E6T | n/a | 133084136 | n/a | 3-(3-hydroxyphenyl)-1~{H}-pyrrolo[3,4-g]indol-8-one | n/a | |
| 11 | P49759_E6W | E6W | n/a | 133084137 | n/a | 2-bromanyl-3-phenyl-1~{H}-pyrrolo[3,4-g]indol-8-one | n/a | |
| 12 | P49759_EAE | EAE | n/a | 1893668 | CHEMBL408982 | (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one | n/a | |
| 13 | P49759_EAQ | EAQ | n/a | n/a | n/a | 6-~{tert}-butyl-~{N}-[6-(1~{H}-pyrazol-4-yl)-1~{H}-imidazo[1,2-a]pyridin-2-yl]pyridine-3-carboxamide | n/a | |
| 14 | P49759_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 15 | P49759_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 16 | P49759_FG9 | FG9 | n/a | 137332125 | CHEMBL4748345 | ~{N}2-(3-morpholin-4-ylpropyl)pyrido[3,4-g]quinazoline-2,10-diamine | n/a | |
| 17 | P49759_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 18 | P49759_H3E | H3E | n/a | 135567465 | n/a | 5-(1-methylpyrazol-4-yl)-3-[1-(phenylmethyl)pyrazol-4-yl]furo[3,2-b]pyridine | n/a | |
| 19 | P49759_H3H | H3H | n/a | 135567466 | n/a | 5-(1-methylpyrazol-4-yl)-3-(3-propan-2-yloxyphenyl)furo[3,2-b]pyridine | n/a | |
| 20 | P49759_H3N | H3N | n/a | 135747626 | CHEMBL4751637 | 5-(1-methylpyrazol-4-yl)-3-(3-phenoxyphenyl)furo[3,2-b]pyridine | n/a | |
| 21 | P49759_H3Q | H3Q | n/a | 135567467 | n/a | 3-(3-cyclobutylphenyl)-5-(1-methylpyrazol-4-yl)furo[3,2-b]pyridine | n/a | |
| 22 | P49759_HQB | HQB | n/a | 137332126 | CHEMBL4778413 | ~{N}-methyl-10-nitro-pyrido[3,4-g]quinazolin-2-amine | n/a | |
| 23 | P49759_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 24 | P49759_IYZ | IYZ | DB04715 | 5459373 | CHEMBL200528 | 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE | n/a | |
| 25 | P49759_JQW | JQW | n/a | 146018260 | n/a | 4-[6,7-bis(chloranyl)-1~{H}-indol-3-yl]pyrimidin-2-amine | n/a | |
| 26 | P49759_JTQ | JTQ | n/a | 146027029 | n/a | 5-[6,7-bis(chloranyl)-1-methyl-indol-3-yl]pyrimidin-4-amine | n/a | |
| 27 | P49759_JU8 | JU8 | n/a | 146027030 | n/a | 5-(1-methylindol-3-yl)pyrimidin-4-amine | n/a | |
| 28 | P49759_JUW | JUW | n/a | 16751790 | n/a | 4-(1-methylindol-3-yl)pyrimidin-2-amine | n/a | |
| 29 | P49759_JWN | JWN | n/a | 132585205 | CHEMBL4531334 | 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{N}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide | n/a | |
| 30 | P49759_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 31 | P49759_KHC | KHC | n/a | 124504856 | n/a | (4~{S})-7,8-bis(chloranyl)-9-methyl-1-oxidanylidene-spiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile | n/a | |
| 32 | P49759_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 33 | P49759_PKB | PKB | n/a | 6539390 | CHEMBL188426 | 4-(6-ethoxypyrazolo[1,5-b]pyridazin-3-yl)-~{N}-[3-methoxy-5-(trifluoromethyl)phenyl]pyrimidin-2-amine | n/a | |
| 34 | P49759_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 35 | P49759_PQ5 | PQ5 | n/a | 136932878 | CHEMBL4795226 | 7,10-Dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid | n/a | |
| 36 | P49759_Q7K | Q7K | n/a | 59442278 | n/a | 11,15-dimethyl-6-(oxan-4-yloxy)-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one | n/a | |
| 37 | P49759_RH8 | RH8 | n/a | 154815694 | n/a | ~{N}-[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine | n/a | |
| 38 | P49759_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 39 | P49759_V25 | V25 | DB08691 | 44237094 | CHEMBL1236620 | ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate | inhibitor | |
| 40 | P49759_V5T | V5T | n/a | 400433 | CHEMBL48082 | 4-(1~{H}-indol-3-yl)pyrimidin-2-amine | n/a | |
| 41 | P49759_WAK | WAK | n/a | n/a | n/a | (4~{Z})-2-(1-adamantylamino)-4-(1,3-benzothiazol-6-ylmethylidene)-1~{H}-imidazol-5-one | n/a | |
| 42 | P49759_WAZ | WAZ | n/a | 162346700 | CHEMBL5426285 | (4~{Z})-4-(1,3-benzothiazol-6-ylmethylidene)-2-[[(2~{R})-1-methoxy-4-methyl-pentan-2-yl]amino]-1~{H}-imidazol-5-one | n/a | |
| 43 | P49759_SQZ | SQZ | n/a | 129318964 | CHEMBL4083249 | 5-[1-[(1S)-1-(4-fluorophenyl)ethyl]-[1,2,3]triazolo[4,5-c]quinolin-8-yl]-1,3-benzoxazole | n/a | |
| 44 | P49759_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |