Gene name: GSK3B
Protein name: Glycogen synthase kinase-3
List of molecules and drugs that interact with protein P49841
# | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
---|---|---|---|---|---|---|---|---|
1 | P49841_0KD | 0KD | n/a | 56603827 | CHEMBL2048674 | N-(pyridin-3-yl)-2-(thiophen-3-yl)-3H-imidazo[4,5-b]pyridine-7-carboxamide | n/a | |
2 | P49841_1JX | 1JX | n/a | 92974617 | CHEMBL3984982 | (2R)-2-methyl-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one | n/a | |
3 | P49841_2HT | 2HT | n/a | 12104 | CHEMBL1229944 | 3-methylbenzonitrile | n/a | |
4 | P49841_2WE | 2WE | n/a | 73333976 | CHEMBL3410089 | 2-[2-(cyclopropylcarbonylamino)pyridin-4-yl]-4-methoxy-1,3-thiazole-5-carboxamide | n/a | |
5 | P49841_2WF | 2WF | n/a | 91667413 | CHEMBL3410100 | N-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide | n/a | |
6 | P49841_2WG | 2WG | n/a | 91667414 | CHEMBL3410110 | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide | n/a | |
7 | P49841_34O | 34O | DB07014 | 2079916 | CHEMBL456218 | 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole | n/a | IC50(nM) = 65.0 |
8 | P49841_39I | 39I | n/a | 49830886 | CHEMBL1997924 | ~{N}4-(3-cyclopropyl-1~{H}-pyrazol-5-yl)-~{N}2-(phenylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine | n/a | |
9 | P49841_3HT | 3HT | DB07058 | 25181321 | CHEMBL1230134 | 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione | n/a | |
10 | P49841_3NG | 3NG | DB15408 | 24748573 | CHEMBL1230165 | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | n/a | |
11 | P49841_3UO | 3UO | n/a | 117072455 | CHEMBL4213175 | 2-[(cyclopropylcarbonyl)amino]-N-(4-methoxypyridin-3-yl)pyridine-4-carboxamide | n/a | |
12 | P49841_3UP | 3UP | n/a | 117072456 | CHEMBL5270581 | 2-[(cyclopropylcarbonyl)amino]-N-(4-phenylpyridin-3-yl)pyridine-4-carboxamide | n/a | |
13 | P49841_553 | 553 | DB07149 | 16757525 | CHEMBL524266 | (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one | inhibitor | |
14 | P49841_55E | 55E | DB07151 | 135908253 | n/a | 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one | n/a | |
15 | P49841_65A | 65A | n/a | 75648635 | CHEMBL5419370 | 4-(2-methoxyphenyl)-3,7,7-trimethyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one | n/a | |
16 | P49841_65C | 65C | n/a | 9956119 | CHEMBL412142 | CHIR99021 | n/a | |
17 | P49841_679 | 679 | DB01793 | 448008 | CHEMBL156987 | 2-CHLORO-5-[4-(3-CHLORO-PHENYL)-2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-3-YLAMINO]-BENZOIC ACID | inhibitor | IC50(nM) = 76.0 Kd(nM) = 40.0 |
18 | P49841_6LQ | 6LQ | n/a | 56962316 | n/a | 2-AMINO-5-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-[4-(PYRROLIDIN-1-YLMETHYL)PYRIDIN-3-YL]PYRIDINE-3-CARBOXAMIDE | n/a | |
19 | P49841_6QH | 6QH | n/a | 60148521 | CHEMBL5173945 | 5-(3-chloranyl-4-methoxy-phenyl)-~{N}-[3-(1,2,4-triazol-1-yl)propyl]-1,3-oxazole-4-carboxamide | n/a | |
20 | P49841_6VK | 6VK | n/a | 117883700;135567204; | CHEMBL5426906 | (4~{S})-3-cyclopropyl-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one | n/a | |
21 | P49841_6VL | 6VL | n/a | 117883712;136980453; | CHEMBL4438334 | (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one | n/a | |
22 | P49841_6VM | 6VM | n/a | 132471728;135567205; | n/a | (4~{S})-3-(2,2-dimethylpropyl)-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one | n/a | |
23 | P49841_7YG | 7YG | n/a | 56962315 | CHEMBL2177166 | 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE | n/a | |
24 | P49841_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
25 | P49841_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
26 | P49841_ADZ | ADZ | n/a | 69689 | CHEMBL65976 | 9-METHYL-9H-PURIN-6-AMINE | n/a | |
27 | P49841_AG1 | AG1 | n/a | n/a | n/a | RUTHENIUM PYRIDOCARBAZOLE | n/a | |
28 | P49841_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
29 | P49841_ATU | ATU | DB04014 | 5005498 | CHEMBL50894 | 9-NITRO-5,12-DIHYDRO-7H-BENZO[2,3]AZEPINO[4,5-B]INDOL-6-ONE | n/a | IC50(nM) = 4.0 |
30 | P49841_B4K | B4K | n/a | 135443289 | n/a | ~{N}-[6-[3,4-bis(oxidanyl)phenyl]-1~{H}-pyrazolo[3,4-b]pyridin-3-yl]ethanamide | n/a | |
31 | P49841_BIM | BIM | n/a | 16734945 | CHEMBL1231352 | BIS-(INDOLE)MALEIMIDE PYRIDINOPHANE | n/a | |
32 | P49841_BRW | BRW | DB03444 | n/a | CHEMBL409450 | 6-BROMOINDIRUBIN-3'-OXIME | n/a | IC50(nM) = 1500.0 |
33 | P49841_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
34 | P49841_CO | CO | n/a | 104729 | n/a | COBALT (II) ION | n/a | |
35 | P49841_CWT | CWT | n/a | 53310986;136086893; | CHEMBL1802844 | (5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-(propan-2-ylamino)imidazol-4-one | n/a | |
36 | P49841_D1E | D1E | n/a | n/a | n/a | (4S,5R,8R)-4-ethyl-8-fluoro-4-[3-(3-fluoro-5-methoxypyridin-4-yl)phenyl]-7,7-dimethyl-4,5,6,7,8,9-hexahydro-2H-pyrazolo[3,4-b]quinolin-5-ol | n/a | |
37 | P49841_DFN | DFN | DB01772 | 448238 | CHEMBL1232189 | 3-[3-(2,3-DIHYDROXY-PROPYLAMINO)-PHENYL]-4-(5-FLUORO-1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE | n/a | |
38 | P49841_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
39 | P49841_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
40 | P49841_DW1 | DW1 | n/a | n/a | n/a | Ruthenium pyridocarbazole | n/a | |
41 | P49841_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
42 | P49841_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
43 | P49841_F1B | F1B | n/a | 11710555 | n/a | (3~{Z})-5-ethanoyl-3-[[(1-methylpiperidin-4-yl)amino]-phenyl-methylidene]-1~{H}-indol-2-one | n/a | |
44 | P49841_F4N | F4N | DB17047 | 10275789 | CHEMBL393525 | ~{N}-[(~{E})-(6-bromanylimidazo[1,2-a]pyridin-3-yl)methylideneamino]-~{N},2-dimethyl-5-nitro-benzenesulfonamide | n/a | |
45 | P49841_FKB | FKB | n/a | 138753207 | n/a | (2~{R})-3-[7-azanyl-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl]-2-cyano-propanamide | n/a | |
46 | P49841_FLC | FLC | n/a | 31348 | n/a | CITRATE ANION | n/a | |
47 | P49841_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
48 | P49841_G3B | G3B | n/a | 44247646 | CHEMBL1232916 | 2-methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole | n/a | |
49 | P49841_G8B | G8B | n/a | 10052336 | CHEMBL2177175 | 3-azanyl-~{N}-(2-methoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamide | n/a | |
50 | P49841_G8E | G8E | n/a | 10297008 | CHEMBL2177165 | 3-azanyl-6-(4-morpholin-4-ylsulfonylphenyl)-~{N}-pyridin-3-yl-pyrazine-2-carboxamide | n/a | |
51 | P49841_G8N | G8N | n/a | 10367481 | CHEMBL2177179 | 3-azanyl-~{N}-(2-methoxyethyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamide | n/a | |
52 | P49841_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
53 | P49841_GR9 | GR9 | n/a | 10138980 | CHEMBL2177161 | 3-AMINO-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE | n/a | |
54 | P49841_HBM | HBM | n/a | 16758212 | CHEMBL436837 | 2-(2,4-DICHLORO-PHENYL)-7-HYDROXY-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID [2-(4-METHANESULFONYLAMINO-PHENYL)-ETHYL]-AMIDE | n/a | |
55 | P49841_I5R | I5R | n/a | 134153953 | CHEMBL3969394 | (2R)-2-(1H-indol-3-ylmethyl)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one | n/a | |
56 | P49841_IMD | IMD | DB03366 | 444234;4434133;21983501; | n/a | IMIDAZOLE | n/a | |
57 | P49841_IQ6 | IQ6 | n/a | 49843482 | CHEMBL2322677 | 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine | n/a | |
58 | P49841_IXM | IXM | DB02052 | n/a | CHEMBL216543 | (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME | n/a | IC50(nM) = 22.0 |
59 | P49841_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
60 | P49841_KDI | KDI | n/a | 10254786 | CHEMBL2177180 | 3-AMINO-N-(3-METHOXYPROPYL)-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}PYRAZINE-2-CARBOXAMIDE | n/a | |
61 | P49841_L7C | L7C | n/a | 95805090 | n/a | (3R)-1-[3-(2-fluorophenyl)propanoyl]-N-(pyridin-2-yl)pyrrolidine-3-carboxamide | n/a | |
62 | P49841_L7I | L7I | n/a | 95805022 | CHEMBL3448046 | 5-(4-fluorophenyl)-4-[1-(methanesulfonyl)azetidin-3-yl]pyrimidin-2-amine | n/a | |
63 | P49841_L7R | L7R | n/a | 118740072 | CHEMBL3448145 | 3-[2-amino-5-(4-fluorophenyl)pyrimidin-4-yl]-N,N-dimethylazetidine-1-sulfonamide | n/a | |
64 | P49841_L7W | L7W | n/a | 92633338 | n/a | (3S)-1-[(2-fluorophenoxy)acetyl]-N-(pyridin-2-yl)pyrrolidine-3-carboxamide | n/a | |
65 | P49841_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
66 | P49841_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
67 | P49841_MLA | MLA | DB02175 | 867;23511544; | CHEMBL7942 | MALONIC ACID | n/a | |
68 | P49841_MLI | MLI | DB02201 | 9084 | n/a | MALONATE ION | n/a | |
69 | P49841_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
70 | P49841_N1Q | N1Q | n/a | 71680628 | CHEMBL3735506 | 5-[2,3-bis(fluoranyl)phenyl]-~{N}-[[1-(2-methoxyethyl)piperidin-4-yl]methyl]-1~{H}-indazole-3-carboxamide | n/a | |
71 | P49841_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
72 | P49841_O9C | O9C | n/a | 167714241 | n/a | 8-morpholin-4-yl-2-pyridin-3-yl-[1,3]oxazolo[5,4-f]quinoxaline | n/a | |
73 | P49841_O9L | O9L | n/a | 167714242 | n/a | 2-pyridin-3-yl-8-thiomorpholin-4-yl-[1,3]oxazolo[5,4-f]quinoxaline | n/a | |
74 | P49841_OFT | OFT | n/a | n/a | n/a | (3Z)-N,N-diethyl-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide | n/a | |
75 | P49841_OH8 | OH8 | n/a | 146036038 | n/a | ~{N}-[[1-(2-methoxyethyl)piperidin-4-yl]methyl]-5-(5-propan-2-yloxypyridin-3-yl)-1~{H}-indazole-3-carboxamide | n/a | |
76 | P49841_OHK | OHK | n/a | 146672946 | CHEMBL5397508 | ~{N}-(oxan-4-ylmethyl)-6-(5-propan-2-yloxypyridin-3-yl)imidazo[1,5-a]pyridine-3-carboxamide | n/a | |
77 | P49841_OS1 | OS1 | n/a | 49867446 | n/a | Ruthenium octasporine | n/a | |
78 | P49841_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
79 | P49841_QQA | QQA | n/a | 11548266 | CHEMBL1242830 | 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one | n/a | |
80 | P49841_SJJ | SJJ | n/a | 56643097 | CHEMBL1957085 | 5-(4-METHOXYPHENYL)-N-(PYRIDIN-4-YLMETHYL)-1,3-OXAZOLE-4-CARBOXAMIDE | n/a | |
81 | P49841_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
82 | P49841_TMU | TMU | DB01950 | 448014 | CHEMBL259850 | N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA | inhibitor | Ki(nM) = 38.0 IC50(nM) = 42.0 |
83 | P49841_TRS | TRS | DB03754 | 3777159;88088752;152743085; | n/a | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | n/a | |
84 | P49841_TSK | TSK | n/a | 24825779 | CHEMBL523435 | 3-(5-fluoro-6-iodo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione | n/a | |
85 | P49841_U3E | U3E | n/a | 118064760 | CHEMBL5284249 | 2-[(cyclopropanecarbonyl)amino]-N-(5-phenylpyridin-3-yl)pyridine-4-carboxamide | n/a | |
86 | P49841_U6S | U6S | n/a | 134551721 | CHEMBL5272860 | (4S)-3-[(cyclopropylmethyl)amino]-N-(4-phenylpyridin-3-yl)imidazo[1,2-b]pyridazine-8-carboxamide | n/a | |
87 | P49841_UAU | UAU | n/a | 167311801 | CHEMBL5266553 | (4S)-N-{4-[(2S)-2-methylmorpholin-4-yl]pyridin-3-yl}-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide | n/a | |
88 | P49841_UGJ | UGJ | n/a | 51348276 | CHEMBL2313832 | 3,6-Diamino-4-(2-chlorophenyl)thieno[2,3-b]pyridine-2,5-dicarbonitrile | n/a | |
89 | P49841_XV0 | XV0 | n/a | 134542788 | CHEMBL5404581 | 2-(4-cyanoanilino)-N-(4-phenylpyridin-3-yl)pyrimidine-4-carboxamide | n/a | |
90 | P49841_YT3 | YT3 | n/a | 168049 | n/a | YTTRIUM (III) ION | n/a | |
91 | P49841_Z48 | Z48 | n/a | 44480711 | CHEMBL565459 | N-[(1S)-2-hydroxy-1-phenylethyl]-4-[5-methyl-2-(phenylamino)pyrimidin-4-yl]-1H-pyrrole-2-carboxamide | n/a | |
92 | P49841_Z92 | Z92 | n/a | 9885165 | CHEMBL1088012 | (4E)-4-[(4-chlorophenyl)hydrazono]-5-(3,4-dimethoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one | n/a | |
93 | P49841_ZRK | ZRK | n/a | 53245729 | CHEMBL1738951 | 2-(4-PYRIDINYL)FURO[3,2-C]PYRIDIN-4(5H)-ONE | n/a | |
94 | P49841_ZRL | ZRL | n/a | 53245730 | CHEMBL1738952 | 7-BROMO-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE | n/a | |
95 | P49841_ZRM | ZRM | n/a | 53245731 | CHEMBL1738953 | 7-(4-HYDROXYPHENYL)-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE | n/a | |
96 | P49841_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | |
97 | P49841_SZW | SZW | n/a | 155289352 | CHEMBL5081917 | 3-[(3~{S})-3-[(7-chloranyl-9~{H}-pyrimido[4,5-b]indol-4-yl)-methyl-amino]piperidin-1-yl]propanenitrile | n/a | |
98 | P49841_LI | LI | None | 28486 | CHEMBL1234004 | Lithium cation | n/a | |
99 | P49841_A0P | A0P | DB04395 | 44462678 | n/a | Phosphoaminophosphonic Acid-Adenylate Ester | n/a | |
100 | P49841_CQU | CQU | DB07584 | 24798741 | CHEMBL428963 | N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
101 | P49841_CQW | CQW | DB07585 | 24798742 | CHEMBL259833 | 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine | n/a | |
102 | P49841_DRK | DRK | DB07676 | 24894167 | n/a | 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one | n/a | |
103 | P49841_G95 | G95 | DB07812 | 24963048 | n/a | N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide | n/a | |
104 | P49841_GVP | GVP | DB07859 | 11175137 | CHEMBL428462 | 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE | n/a | |
105 | P49841_I5S | I5S | DB07947 | 5327109 | CHEMBL227381 | ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE | n/a | |
106 | P49841_L20 | L20 | DB08073 | 10172943 | CHEMBL379300 | (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE | n/a | |
107 | P49841_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
108 | P49841_DB12129 | n/a | DB12129 | n/a | n/a | Tideglusib | antagonist | |
109 | P49841_DB14507 | n/a | DB14507 | n/a | n/a | Lithium citrate | n/a | |
110 | P49841_DB14508 | n/a | DB14508 | n/a | n/a | Lithium succinate | n/a | |
111 | P49841_DB14509 | n/a | DB14509 | n/a | n/a | Lithium carbonate | n/a |