Gene name: METAP2
Protein name: Methionine aminopeptidase 2
List of molecules and drugs that interact with protein P50579
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P50579_52T | 52T | n/a | 105539835 | n/a | (4R,7R)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1H-benzotriazol-4-yl propan-2-ylcarbamate | n/a | |
| 2 | P50579_57R | 57R | n/a | 137348318 | n/a | (4S,7R)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1H-benzotriazol-4-yl propan-2-ylcarbamate | n/a | |
| 3 | P50579_6KN | 6KN | n/a | 71735206 | CHEMBL3798034 | 4-(3-methylpyridin-4-yl)-6-(trifluoromethyl)-1H-indazole | n/a | |
| 4 | P50579_6KO | 6KO | n/a | 137348477 | n/a | [(2R)-1-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-2-yl]methyl 2-methoxybenzoate | n/a | |
| 5 | P50579_6KP | 6KP | n/a | 73426341 | CHEMBL3797399 | 7-fluoro-4-(5-methyl-3H-imidazo[4,5-b]pyridin-6-yl)-2,4-dihydropyrazolo[4,3-b]indole | n/a | |
| 6 | P50579_7BF | 7BF | n/a | 46865596 | n/a | 5-[[(2~{R})-1-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-2-yl]methoxy]isoquinoline | n/a | |
| 7 | P50579_7BH | 7BH | n/a | 16005070 | CHEMBL4097198 | 6-[(2~{R})-2-[(2-methylphenoxy)methyl]pyrrolidin-1-yl]-7~{H}-purine | n/a | |
| 8 | P50579_94A | 94A | n/a | 137348784 | n/a | (4R,7S)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1H-benzotriazol-4-yl propan-2-ylcarbamate | n/a | |
| 9 | P50579_A19 | A19 | DB07309 | 1069140 | CHEMBL212522 | 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID | inhibitor | IC50(nM) = 9100.0 |
| 10 | P50579_A41 | A41 | DB07313 | 6102684 | CHEMBL378927 | 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID | inhibitor | IC50(nM) = 1000.0 |
| 11 | P50579_A75 | A75 | DB07322 | 6102685 | CHEMBL380394 | 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID | n/a | IC50(nM) = 9.0 |
| 12 | P50579_A84 | A84 | DB07323 | 6102686 | n/a | 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID | n/a | IC50(nM) = 19.0 |
| 13 | P50579_AO1 | AO1 | DB04108 | 5287684 | n/a | (2S,3R)-3-AMINO-2-HYDROXY-5-(ETHYLSULFANYL)PENTANOYL-((S)-(-)-(1-NAPHTHYL)ETHYL)AMIDE | n/a | |
| 14 | P50579_AO2 | AO2 | DB03086 | 448288 | CHEMBL354739 | N'-(2S,3R)-3-AMINO-4-CYCLOHEXYL-2-HYDROXY-BUTANO-N-(4-METHYLPHENYL)HYDRAZIDE | n/a | IC50(nM) = 170.0 |
| 15 | P50579_AO5 | AO5 | DB07377 | 448285 | CHEMBL352764 | N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE | inhibitor | IC50(nM) = 110.0 |
| 16 | P50579_CIT | CIT | DB04272 | 311;19782904;88113319; | CHEMBL1261 | CITRIC ACID | n/a | |
| 17 | P50579_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 18 | P50579_CO | CO | n/a | 104729 | n/a | COBALT (II) ION | n/a | |
| 19 | P50579_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 20 | P50579_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 21 | P50579_F77 | F77 | DB07746 | 23647763 | CHEMBL230172 | 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID | n/a | IC50(nM) = 16.0 |
| 22 | P50579_F79 | F79 | n/a | 23647776;44629443; | CHEMBL230492 | 2-(2-AMINOETHOXY)-3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}BENZOIC ACID | n/a | |
| 23 | P50579_FUG | FUG | DB02640 | 5326445 | n/a | FUMAGILLIN | ligand | |
| 24 | P50579_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 25 | P50579_HZE | HZE | n/a | 138105970 | CHEMBL4746468 | 5,6-bis(fluoranyl)-3-(4-piperazin-1-yl-2-propan-2-yloxy-phenyl)-1~{H}-indole-2-carboxamide | n/a | |
| 26 | P50579_HZK | HZK | n/a | 89893622 | CHEMBL4475680 | (3~{S})-~{N}-[(3-chloranyl-5-fluoranyl-phenyl)methyl]-3-oxidanyl-2-oxidanylidene-1-(2-oxidanylidene-3,4-dihydro-1~{H}-quinolin-6-yl)pyrrolidine-3-carboxamide | n/a | |
| 27 | P50579_HZQ | HZQ | DB15933 | 2817 | CHEMBL225164 | 5-chloranylquinolin-8-ol | n/a | |
| 28 | P50579_HZT | HZT | n/a | 46209555 | n/a | ~{N}-[(4-fluorophenyl)methyl]-~{N}-(1~{H}-1,2,4-triazol-5-ylmethyl)thiophene-2-sulfonamide | n/a | |
| 29 | P50579_HZW | HZW | n/a | 89893711 | CHEMBL4552396 | (3~{S})-~{N}-[(3-chloranyl-5-fluoranyl-phenyl)methyl]-3-oxidanyl-2-oxidanylidene-1-phenyl-pyrrolidine-3-carboxamide | n/a | |
| 30 | P50579_I96 | I96 | n/a | 16129576 | CHEMBL230641 | N-(2-ISOPROPYLPHENYL)-3-[(2-THIENYLMETHYL)THIO]-1H-1,2,4-TRIAZOL-5-AMINE | n/a | |
| 31 | P50579_K4K | K4K | n/a | 56959820 | CHEMBL4566670 | (3~{S})-3-oxidanyl-2-oxidanylidene-1-phenyl-~{N}-(2-thiophen-2-ylethyl)pyrrolidine-3-carboxamide | n/a | |
| 32 | P50579_MED | MED | DB02893 | 84815;6992109; | CHEMBL1234268 | D-METHIONINE | inhibitor | |
| 33 | P50579_MET | MET | DB00134 | 6137;6992087; | CHEMBL42336 | METHIONINE | product of | |
| 34 | P50579_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 35 | P50579_OVA | OVA | DB04324 | 5289086 | n/a | 3,4-DIHYDROXY-2-METHOXY-4-METHYL-3-[2-METHYL-3-(3-METHYL-BUT-2-ENYL) -OXIRANYL]-CYCLOHEXANONE | n/a | |
| 36 | P50579_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 37 | P50579_QV5 | QV5 | n/a | 154585764 | CHEMBL4762949 | 5-chloranyl-6-fluoranyl-3-(4-piperazin-1-yl-2-propan-2-yloxy-phenyl)-1~{H}-indole-2-carboxamide | n/a | |
| 38 | P50579_QVB | QVB | n/a | 154585763 | CHEMBL4796852 | 5-chloranyl-6-fluoranyl-3-(2-propan-2-yloxyphenyl)-1~{H}-indole-2-carboxamide | n/a | |
| 39 | P50579_QVK | QVK | n/a | 3721490 | CHEMBL4744483 | 5-chloranyl-3-phenyl-1~{H}-indole-2-carboxamide | n/a | |
| 40 | P50579_QW5 | QW5 | n/a | 154585762 | n/a | 5-chloranyl-3-(3-methoxyphenyl)-1~{H}-indole-2-carboxamide | n/a | |
| 41 | P50579_R20 | R20 | n/a | 6419227 | CHEMBL194853 | 4-(3-METHYLPHENYL)-1H-1,2,3-TRIAZOLE | n/a | |
| 42 | P50579_TBU | TBU | DB03900 | 6386 | CHEMBL16502 | TERTIARY-BUTYL ALCOHOL | inhibitor | |
| 43 | P50579_TDE | TDE | DB03396 | 448235 | CHEMBL1236230 | (E)-(2R,3R,4S,5R)-3,4,5-TRIHYDROXY-2-METHOXY-8,8-DIMETHYL-NON-6-ENOIC ACID ((3S,6R)-6-HYDROXY-2-OXO-AZEPAN-3-YL)-AMIDE | n/a | |
| 44 | P50579_TN4 | TN4 | DB08633 | 5326425 | n/a | (1R,2S,3S,4R)-4-hydroxy-2-methoxy-4-methyl-3-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]cyclohexyl (chloroacetyl)carbamate | inhibitor | Ki(nM) = 1.0 IC50(nM) = 1.0 |
| 45 | P50579_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 46 | P50579_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 47 | P50579_DB00134 | n/a | DB00134 | n/a | n/a | Methionine | product of | |
| 48 | P50579_HNQ | HNQ | DB01422 | 19910 | CHEMBL1454910 | Nitroxoline | inhibitor | IC50(nM) = 55.0 |
| 49 | P50579_DB02310 | n/a | DB02310 | n/a | n/a | 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium | inhibitor | |
| 50 | P50579_DB02640 | n/a | DB02640 | n/a | n/a | Fumagillin | ligand | |
| 51 | P50579_DB05864 | n/a | DB05864 | n/a | n/a | PPI-2458 | inhibitor | |
| 52 | P50579_DB08633 | n/a | DB08633 | n/a | n/a | TNP-470 | inhibitor | Ki(nM) = 1.0 IC50(nM) = 1.0 |